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NeoCart Phase 2 Clinical Trial

2010-07-15 17:00:00 | BioPortfolio

Summary

The objective of this study is to gather additional information regarding the performance of NeoCart to fill articular cartilage defects in the knee.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Articular Cartilage Damage

Intervention

NeoCart, microfracture

Location

UCSF
San Francisco
California
United States
94143

Status

Active, not recruiting

Source

Histogenics Corporation

Results (where available)

View Results

Links

Published on BioPortfolio: 2010-07-15T17:00:00-0400

Clinical Trials [525 Associated Clinical Trials listed on BioPortfolio]

Confirmatory Study of NeoCart in Knee Cartilage Repair

This confirmatory study is a prospective randomized trial comparing the efficacy and safety of an autologous chondrocyte tissue implant (NeoCart) to the surgical intervention microfracture...

Comparison of Efficacy and Safety of Microfracture and Modified Microfracture

This study was designed to evaluate the efficacy and safety of a modified microfracture using collagen, and to compare them with those of a simple microfracture to prove the non-inferiorit...

Study to Compare the Efficacy and Safety of Cartistem® and Microfracture in Patients With Knee Articular Cartilage Injury or Defect

The purpose of the study is to assess and compare the safety and efficacy of the allogeneic-unrelated umbilical cord blood-derived mesenchymal stem cell product (Cartistem®) to that of a ...

the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Ankle

This study was designed to evaluate the efficacy and safety of a modified microfracture using collagen, and to compare them with those of a simple microfracture in patients with cartilage ...

Autologous Cell-derived Tissue Engineered Cartilage for Repairing Articular Cartilage Lesions

This study is aimed at evaluating the feasibility and effectiveness of a completely natural tissue engineered cartilage, composed of a self-made tissue engineered oriented scaffold and aut...

PubMed Articles [4461 Associated PubMed Articles listed on BioPortfolio]

Is Implantation of Autologous Chondrocytes Superior to Microfracture for Articular-cartilage Defects of the Knee? A Systematic Review of 5-Year Follow-up Data.

Autologous chondrocyte implantation (ACI) and microfracture are two of the main surgical treatment options for articular cartilage lesions of the knee. Consensus regarding the best clinical options to...

Microfracture for cartilage repair in the knee: a systematic review of the contemporary literature.

To systematically review and evaluate novel clinical data following microfracture treatment of knee articular cartilage defects.

The Pattern of Acetabular Cartilage Wear Is Hip Morphology-dependent and Patient Demographic-dependent.

Acetabular cartilage damage has been described in patients with femoroacetabular impingement (FAI). However, most reports of articular cartilage damage in hip FAI have been focused on the acetabular c...

Surgeon Ability to Appropriately Address the Calcified Cartilage Layer: An In Vitro Study of Arthroscopic and Open Techniques.

Microfracture is a commonly utilized cartilage restoration technique for articular cartilage defects. While the removal of the calcified cartilage layer (CCL) has been shown to be critical with in viv...

Defective WNT Signaling May Protect From Articular Cartilage Deterioration - A Quantitative Mri Study On Subjects With A Heterozygous WNT1 Mutation.

WNT signaling is of key importance in chondrogenesis and defective WNT signaling may contribute to the pathogenesis of osteoarthritis and other cartilage diseases. Biochemical composition of articular...

Medical and Biotech [MESH] Definitions

Surgical techniques used to correct or augment healing of chondral defects in the joints (CARTILAGE, ARTICULAR). These include abrasion, drilling, and microfracture of the subchondral bone to enhance chondral resurfacing via autografts, allografts, or cell transplantation.

Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.

A degenerative joint disease involving the SPINE. It is characterized by progressive deterioration of the spinal articular cartilage (CARTILAGE, ARTICULAR), usually with hardening of the subchondral bone and outgrowth of bone spurs (OSTEOPHYTE).

A type of CARTILAGE characterized by a homogenous amorphous matrix containing predominately TYPE II COLLAGEN and ground substance. Hyaline cartilage is found in ARTICULAR CARTILAGE; LARYNGEAL CARTILAGES; and the NASAL SEPTUM.

A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.

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