Efficacy and Safety of NT 201 in the Treatment of Lateral Periorbital Wrinkles

2010-07-15 17:00:00 | BioPortfolio


To investigate the efficacy and safety of NT 201 in comparison to placebo in the treatment of moderate to severe lateral periorbital wrinkles at maximum smile and to compare two different application schemes of NT 201. Each subject will be treated on the right and left eye area, using the same dose but different application schemes (i.e. 3 or 4 injections).


Conducted in Europe

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind


Lateral Periorbital Wrinkles


NT 201


Merz Pharmaceuticals GmbH




Merz Pharmaceuticals GmbH

Results (where available)

View Results


Published on BioPortfolio: 2010-07-15T17:00:00-0400

Clinical Trials [595 Associated Clinical Trials listed on BioPortfolio]

Reducing Wrinkles Around the Eyes Using the Ulthera® System

The purpose of this prospective, multi-center, single treatment study is to evaluate the clinical outcomes associated with the non-invasive treatment to reduce wrinkles around the eyes uti...

Silk'n HST for Wrinkle Reduction - Clinical Study Protocol

The objective of the study is to evaluate the safety, efficacy and usage compliance of the home-use device Silk'n HST for self-treatment of periorbital wrinkles and skin laxity and improve...

Evaluation of Ocular Surface Changes Following RF Electrocoagulation Treatment of the Periorbital Region

This protocol will evaluate THERMIeyes® for its ability to treat periorbital skin laxity and wrinkles and monitor ocular surface changes and their effect on evaporative dry eye associated...

A 4-Arm Efficacy and Safety Study of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults

The purpose of this study is to find out if an investigational drug, called RT001 Topical Gel, is safe and useful in minimizing the wrinkles between the eye and hairline called lateral can...

Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study

The objective of the study is to compare the time to onset of Dysport® versus Botox® in the treatment of lateral orbital rhytids ("crow's feet"). Thirty subjects were enrolled in the stu...

PubMed Articles [1653 Associated PubMed Articles listed on BioPortfolio]

Subbrow Blepharoplasty Combined with Periorbital Muscle Manipulation for Periorbital Rejuvenation in Asian Women.

With advancing age, Asian women are often plagued by lateral hooding of the upper eyelid skin, eyebrow ptosis and obvious periorbital wrinkles. We propose a novel technique to revive the natural eyeli...

Comparison of efficacy and safety of fractional radiofrequency and fractional Er:YAG laser in facial and neck wrinkles: Six-year experience with 333 patients.

Lasers and other light sources are popular treatment options for facial rejuvenation in recent years. In this study, we aimed to compare the efficacy and safety of fractional radiofrequency (RF) and f...

The Critical Stable Length in Wrinkles of Two-Dimensional Materials.

The emergent two-dimensional (2D) materials are atomically thin and ultra-flexible, promising for a variety of miniaturized, high-performance and flexible devices in applications. On one hand, the ult...

Total Eyelid Transplantation in a Face Transplant: Analysis of Postoperative Periorbital Function.

Prolonged impairment of protective ocular functions can compromise vision and lead to blindness if uncorrected. Several facial transplants have incorporated periorbital structures with variable eyelid...

Case report of periorbital metastasis from rectal cancer.

Periorbital metastasis of colorectal cancer is rare. Therefore, herein, we report a patient with rectal cancer who presented with periorbital metastasis without any systemic metastasis.

Medical and Biotech [MESH] Definitions

Plastic surgery performed, usually by excision of skin, for the elimination of wrinkles from the skin.

A narrow strip of cell groups on the dorsomedial surface of the thalamus. It includes the lateral dorsal nucleus, lateral posterior nucleus, and the PULVINAR.

This area is bounded medially by the mammillothalamic tract and the anterior column of fornix. The medial edge of the internal capsule and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p710)

There are two lateral ligaments of the ankle - internal and external. The internal lateral ligament is attached to the apex and anterior and posterior bodies of the inner malleolus and inserted into the navicular bone, the inferior calcaneo-navicular ligament, the sustentaculum tali of the os calcis, and the inner side of the astragalus. The external lateral ligament, also called the lateral collateral ligament, consists of three distinct fasciculi - the calcaneofibular, the anterior talofibular, and the posterior talofibular.

Formation or presence of a blood clot (THROMBUS) in the LATERAL SINUSES. This condition is often associated with ear infections (OTITIS MEDIA or MASTOIDITIS) without antibiotic treatment. In developed nations, lateral sinus thrombosis can result from CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; NEUROSURGICAL PROCEDURES; THROMBOPHILIA; and other conditions. Clinical features include HEADACHE; VERTIGO; and increased intracranial pressure.

More From BioPortfolio on "Efficacy and Safety of NT 201 in the Treatment of Lateral Periorbital Wrinkles"

Quick Search

Searches Linking to this Trial