Ranibizumab as Adjuvant Therapy for the Treatment of Choroidal Melanoma

2014-08-27 03:35:42 | BioPortfolio


A one year interventional study to test the safety and tolerability of monthly basis intravitreal injection of ranibizumab combined with Transpupillary Thermo Therapy + ICG-based photodynamic therapy in the treatment of choroidal melanoma.


10 patients with clinical evaluation, A-B scan and Fluorescein Angiogram proven choroidal melanoma will be recruited for this single-center, non-randomized, open-label, active treatment study of intravitreal ranibizumab combined with TTT + ICG-based photodynamic therapy . They will receive intravitreal injections of 0.5 mg ranibizumab administered every 30 days (+/- 7 days) for the first 6 months and as necessary in the succeeding 6 months if there is no decrease or instability in tumor size. They will also receive 1 session of TTT + ICG-based photodynamic therapy at the first month and as needed in the following month.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Choroidal Melanoma




New England Retina Associates
United States




New England Retina Associates

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:35:42-0400

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Melanoma is a highly malignant tumor of melanin-forming cells (melanocytes) There are most commonly found in the skin (resulting from sunlight exposure), but also in the eyes and mucous membranes. Metastasis to other regions of the body is also common....

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