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Natural Killer Cells in Older Patients With Acute Myeloid Leukemia

2014-08-27 03:35:46 | BioPortfolio

Summary

RATIONALE: Studying natural killer cells in samples of blood from patients with cancer may help doctors find out how these cells are effected by chemotherapy.

PURPOSE: This clinical trial is studying natural killer cells in older patients with acute myeloid leukemia.

Description

OBJECTIVES:

Primary

- Determine the evolution of functional receptors of natural killer (NK) cells after completion of chemotherapy in elderly patients with acute myeloid leukemia in first remission.

Secondary

- Measure the kinetics of cytotoxic functional recovery of NK cells.

- Determine activation markers of NK cells.

OUTLINE: This is a multicenter study.

Patients receive 1 course of consolidation therapy comprising an anthracycline and cytarabine to induce first remission.

Blood is collected on day 0 of the consolidation course and then every 2 weeks for 8 weeks.

Study Design

Masking: Open Label, Primary Purpose: Treatment

Conditions

Leukemia

Intervention

cytarabine, laboratory biomarker analysis

Location

Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
Marseille
France
13273

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:35:46-0400

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