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RATIONALE: Exposure to low-level benzene in the work place may affect the risk of developing cancer later in life. Learning about the long-term effects of benzene exposure may help the study of cancer and related disorders in the future.
PURPOSE: This clinical trial is studying benzene exposure as a risk factor for hematological cancer or related disorders or lung cancer in Chinese workers.
- Evaluate health risks from lower levels of benzene exposure, particularly as present in factories during the 1990s.
OUTLINE: Participants complete questionnaires to collect information on potential confounders to the analysis of benzene's effects and information on work experience outside of the study cohort factories.
Patients undergo buccal cell and blood sample collection periodically for biological studies. Samples are analyzed for genetic polymorphisms potentially associated with benzene metabolism and disease status via polymorphism analysis.
Brain and Central Nervous System Tumors
polymorphism analysis, laboratory biomarker analysis, questionnaire administration
Enrolling by invitation
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-07-24T14:20:38-0400
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The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.
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Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
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