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Retrospective Study Assessing Molecular Features Predicting Response to Cetuximab

2014-08-27 03:37:48 | BioPortfolio

Summary

The primary objective is to identify molecular features predicting response or resistance to cetuximab

Description

Secondary objective is to investigate association of genomic status of EGFR and HER-2 genes with clinical outcome, including objective response, time to progression and survival

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Conditions

Colorectal Neoplasms

Intervention

Gene mutations analysis and FISH

Location

Istituto Clinico Humanitas
Rozzano
Milan
Italy
20089

Status

Completed

Source

Istituto Clinico Humanitas

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:37:48-0400

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A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.

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Hereditary nonpolyposis colorectal neoplasms associated with other malignancies, more commonly of ovarian or uterine origin. When also associated with SEBACEOUS GLAND NEOPLASMS, it is called MUIR-TORRE SYNDROME.

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