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Phase III Trial of CUV1647 in Polymorphic Light Eruption (PLE)

2014-07-23 21:29:30 | BioPortfolio

Summary

The purpose of this study is to determine whether the afamelanotide (CUV1647) formulation is effective in preventing PLE episodes or reducing the severity of PLE symptoms in patients with a well documented history of the disease. The study also aims to determine whether treatment with afamelanotide (CUV1647) can reduce the use of rescue medication in this group.

Description

Polymorphic Light Eruption (PLE) is a prevalent photosensitivity disorder, occurring in up to 20% of the European and US populations and up to 5% of the Australian population. The disease is characterised by a rash that is intensely itchy with blisters, bumps and patches presenting on areas of the skin that have been exposed to the sun. There is a lack of effective treatment available for the condition but the most common available forms of therapy include sun avoidance and the use of the use of steroids and/or phototherapy.

Study Design

Time Perspective: Prospective

Conditions

Polymorphic Light Eruption (PLE)

Intervention

Afamelanotide (CUV1647)

Location

St Vincents Hospital
Melbourne
Australia
A1090

Status

Completed

Source

Clinuvel Pharmaceuticals Limited

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:29:30-0400

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Medical and Biotech [MESH] Definitions

An abnormality in the direction of a TOOTH ERUPTION.

A disseminated vesicular-pustular eruption caused by the herpes simplex virus (HERPESVIRUS HOMINIS), the VACCINIA VIRUS, or Varicella zoster (HERPESVIRUS 3, HUMAN). It is usually superimposed on a preexisting, inactive or active, atopic dermatitis (DERMATITIS, ATOPIC).

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