Clinical Trials About "Comment International view genetic frontotemporal dementia" RSS

07:43 EST 20th January 2020 | BioPortfolio

We list hundreds of Clinical Trials about "Comment International view genetic frontotemporal dementia" on BioPortfolio. We draw our references from global clinical trials data listed on and refresh our database daily.

More Information about "Comment International view genetic frontotemporal dementia" on BioPortfolio

We have published hundreds of Comment International view genetic frontotemporal dementia news stories on BioPortfolio along with dozens of Comment International view genetic frontotemporal dementia Clinical Trials and PubMed Articles about Comment International view genetic frontotemporal dementia for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Comment International view genetic frontotemporal dementia Companies in our database. You can also find out about relevant Comment International view genetic frontotemporal dementia Drugs and Medications on this site too.

Showing "Comment International view genetic frontotemporal dementia" Clinical Trials 1–25 of 7,100+

Extremely Relevant

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects

This study is being done to learn more about normal thinking and behavior, mild thinking and behavior problems, Frontotemporal Dementia and other forms of dementia in families in which one or more relatives have a mutation associated with Frontotemporal Dementia.

Intranasal Insulin in Frontotemporal Dementia (FTD)

This project will study intranasal (IN) insulin in Frontotemporal dementia (FTD) in 12 patients. Study Investigators aim to evaluate the feasibility of the EXAMINER cognitive battery as a cognitive outcome measure in FTD, the ability of the HealthPartners Center for Memory and Aging's ability to sufficiently recruit subjects with FTD, and the safety of IN regular insulin administered 20 IU twice per day in two specific variants of FTD (behavioral variant frontotemporal dementia...

Efficacy of Tablet-Based Social-Cognitive Interventions in Right Hemisphere Stroke and Frontotemporal Dementia

This study is being done to test the feasibility and effectiveness of iPad-based social-cognitive training exercises in treating social-emotional deficits in patients with stroke or frontotemporal dementia (FTD).

Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD)

The purpose of this clinical trial is to test whether or not the medication amantadine is effective in reducing behavioral disturbances in patients with frontotemporal dementia.

Intranasal Oxytocin for Frontotemporal Dementia

The purpose of this study is to assess the safety, tolerability and effects on behaviour of Syntocinon given intranasally (by a spray into the nostrils) compared to placebo (an inactive saline substance that contains no medication) in participants with frontotemporal dementia/Pick's disease. This study will take place in approximately 15 centres across Canada and the United States. Approximately 112 patients in total will be enrolled in this study. In the first phase we will ex...

Efficacy and Tolerability of Memantine in Frontotemporal Dementia (FTD) Patients

The purpose of this trial is to assess the efficacy and tolerability of memantine (anti-excitotoxic, neuroprotective treatment currently used in Alzheimer's disease [AD]) in frontotemporal dementia patients after a one-year treatment.

Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia

Memantine has been approved for use in Alzheimer's disease. Its mechanism of action raises questions of whether it can also be effective for non-Alzheimer's dementias such as frontotemporal dementia (FTD), which currently has no disease-modifying treatment. This is an open-label study to probe the effects of memantine in 12 outpatients diagnosed with FTD, as shown objectively by comparing PET scans performed before and after use of the medication. The specific type of PET scan...

Flortaucipir PET Imaging in Subjects With FTD

This study is designed to assess the usefulness of 18F-AV-1451 in Positron Emission Tomography imaging for subjects diagnosed with Frontotemporal Dementia.

A Study to Evaluate Safety of Long-term AL001 Dosing in FTD Patients

A Phase 2 open label study evaluating the safety, tolerability, PK and PD of AL001 in participants with a Granulin mutation or C9orf72 mutation causative of frontotemporal dementia.

The Neural Basis for Frontotemporal Degeneration

This is an observational study that aims to better understand the genetic causes of frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead to better diagnostics and future treatments.

Treatment Study of Frontotemporal Dementia

Objectives. The proposed clinical study has two goals: First, to assess the efficacy of a central nervous system stimulant and an atypical antipsychotic in treating the behavioral symptoms of FTD and second, to further characterize the biological markers, including genetic, imaging, and CSF proteins, of FTD in relation to our existing group of Alzheimer's patients. Rationale. Frontotemporal dementia (FTD) is increasingly recognized as an important neuropsychiatric diso...

Clinical Utility of Flutemetamol in the Differential Diagnosis and Prognosis of Alzheimer's and Frontotemporal Dementia

The study examines subjects with a differential diagnosis of frontotemporal lobe dementia and Alzheimer's dementia. In these subjects the impact of a Flutemetamol-PET-Scan on clinical management and disease course will be studied over one year. A group of subjects with probable AD in whom the diagnosis was made without information on cerebral amyloid-Status serves for comparison.

Voices Of Individuals: Challenges and Experiences Of bvFTD

The VOICE Of bvFTD study is a telephone interview research study about life with or at risk for behavioral variant frontotemporal dementia (bvFTD). The study aims to understand how bvFTD impacts individuals' day to day lives, how people think about themselves, and what challenges they face.

Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias

Neuroinflammation is increasingly implicated as a potential critical pathogenic mechanism in a variety of neurologic and psychiatric disorders. This study will use hybrid PET/MRI imaging to evaluate neuroinflammation and its relationship to cerebral perfusion in frontotemporal dementia (FTD). Patients with FTD will be recruited from the Cognitive Neurology and Aging Brain clinics at Parkwood Institute and will undergo neurocognitive assessment and MRI/PET using the PET ligand F...

Oxytocin and Social Cognition in Frontotemporal Dementia

Investigations into the components of cognition damaged in frontotemporal dementia (FTD) demonstrate that patients with FTD show deficits in facial and verbal expression recognition, lack insight into what others think or might do (theory of mind skills), and in decision making tasks requiring processing of positive versus negative feedback. These cognitive functions are thought to be critical for appropriate social behavioural regulation (Blair, 2003). Recent studies in animal...


A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin Mutation

A first in human phase 1, single dose and multiple dose study in healthy volunteers and Granulin mutation causative of frontotemporal dementia to assess AL001 safety, tolerability, pharmacokinetics, and pharmacodynamics

Evaluation and Characterization of Behavioural Disorders and Dementias by the Behavioural Dysexecutive Syndrome Inventory (BDSI)

Behavioural disorders are very common right from the initial stage of dementia and contribute to loss of autonomy. Behavioural dysexecutive disorders have a particular status due to their prevalence and their diagnostic importance, as they often constitute the initial symptoms of Frontotemporal Dementia (FTD), Semantic Dementia (SD) and Huntington's disease (HD) and they are classically more frequent in vascular dementia (VaD) than in Alzheimer's disease (AD). The presence of t...

Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia

Frontotemporal dementia (FTD) is a progressive neurodegenerative illness that affects the frontal and anterior temporal lobes of the brain. Changes in behavior, including agitation, aggression, and repetitive behaviors, are common symptoms in FTD. The investigators currently do not have good medications to treat these symptoms in FTD, and the medications the investigators use often have side effects. In this project, the investigators will test the use of low-dose lithium, comp...

SPECT/CT in the Diagnosis of Dementia

Aim of the study is to evaluate whether Tc-99m-ECD-SPECT/CT enhances early diagnosis of dementia in two specific patient groups: (1) patient with mild cognitive impairment, and (2) patient with possible symptoms and signs of frontotemporal dementia. Evaluation of SPECT/CT data is performed both by visual and quantitative voxel-based analyses (Statistical Parametric Mapping). The final diagnosis is based on up to four years clinical follow-up.

F 18 T807 Tau PET Imaging of Frontotemporal Dementia (FTD)

The purpose of this research study is to evaluate tau distribution in the brain of subjects with: FTD caused by different genetic mutations, any mutation carriers (with or without symptoms), any non-mutation carrier, any sporadic FTD, normal controls.

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Frontotemporal Lobar Degeneration (FTLD) is the neuropathological term for a collection of rare neurodegenerative diseases that correspond to four main overlapping clinical syndromes: frontotemporal dementia (FTD), primary progressive aphasia (PPA), corticobasal degeneration syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). The goal of this study is to build a FTLD clinical research consortium to support the development of FTLD therapies for new clinical trial...

Multidisciplinary and Personalized Care of Behavioral Disorders in Frontotemporal Lobar Degeneration.

Fronto-Temporal Lobar Degeneration (FTLD) is neurodegenerative disease which comes in three clinical categories: Fronto-Temporal Dementia behavioral variant (FTD), Primary Progressive Aphasia (PPA), Semantic Dementia (SD). This group of neurodegenerative diseases usually occurs between 55 and 65 years and is characterized by prominent behavioral disorders and personality changes. FTLD is currently unknown to the general public but also conventional care. Thus, the French health...

In-Home Technology for Dementia Caregivers

This study aims to develop and evaluate in-home assistive technology that is designed to alleviate anxiety, burden, and loneliness in spousal and familial caregivers of individuals with Alzheimer's disease and frontotemporal dementia.

P75NTR, Diagnostic Biomarker for Alzheimer's Disease: Quantification Study in Cerebrospinal Fluid

This research will be achieved by the assessment of p75NTR-ECD expression (total and linked to different species of Aβ (Aβ1-40 and Aβ-1-42)) within the cerebrospinal fluid (CSF) of patients with AD dementia, mild cognitive impairment (MCI) due to AD, frontotemporal dementia and non-neurodegenerative dementia.

Safety, Tolerability and Efficacy of AVP-786 for the Treatment of Disinhibition

Treatment of disinhibition syndrome in patients with Neurodegenerative Disorder including frontotemporal dementia, Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies, vascular cognitive disorders, or Huntington's disease.

More From BioPortfolio on "Comment International view genetic frontotemporal dementia"

Quick Search