Clinical Trials About "Open Innovation Challenge introduced Vetter" RSS

13:32 EDT 18th March 2019 | BioPortfolio

We list hundreds of Clinical Trials about "Open Innovation Challenge introduced Vetter" on BioPortfolio. We draw our references from global clinical trials data listed on and refresh our database daily.

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Showing "Open Innovation Challenge introduced Vetter" Clinical Trials 1–25 of 11,000+


Innovation Adoption in Medical Robotic Surgery: Case of Royal Bournemouth Hospital

This research sets to address two key areas. The first is identified by the researcher in academic literature that there is a lack of a comprehensive innovation adoption model in UK National Health System (NHS), specifically for Medical Robotic Surgery. Existing frameworks are mainly developed in the US or in other fields. The second problem was identified by surgeons involved in Robotic Surgery in Royal Bournemouth Hospital (RBH). The project started by offering RBH a deeper u...

Safety and Efficacy of NF135 CPS Immunization

This is an open label, randomized, controlled clinical trial. The primary aim of this project is to determine the safety and tolerability of NF135.C10 sporozoite immunization under chemoprophylaxis against homologous and heterologous challenge infection.

Exercise Challenge in a Cold Chamber

The purpose of this study is to compare the exercise-challenge in a cold chamber at 2-4°C to the gold standard the metacholine challenge in subjects showing symptoms of exercise-induced bronchoconstriction. The sensitivity and repeatability of the exercise test will be measured.

Phase I Study to Determine the Optimal Human Challenge Dose for a Norovirus GII.4 Challenge Stock (CIN-1)

This is phase I, double blind, placebo-controlled safety and infectivity study of experimental human Norovirus genogroup GII.4 administered to healthy adults 18-49 years of age. Subjects susceptible to the human norovirus GII.4 challenge strain. The challenge study will be conducted in 2-3 cohorts of approximately 20 subjects each.Subjects will remain in the inpatient facility for at least four days following challenge and assessed daily for clinical and virologic evidence of n...

Comparison of 250 ml Versus 500 ml of Fluid Challenge

The objective of fluid challenge is to increase oxygen delivery (DO2) in order to improve/restore tissue oxygen consuption (VO2). However the fluid challenge volume to administer stills in debate, some studies recommend to administer 250 mL. Previous studies suggested that 500 mL of fluid challenge administration may improve cardiac output and oxygen delivery. The relation between the amount of fluid expansion and oxygen delivery and oxygen consumption was not yet been studied ...

Childhood Obesity Prevention Trough Education Innovation in Primary School: A Quasi-experimental Trial

This study evaluates the effect of the education innovation program"chiquichefs" on anthropometric variables, quality of life and nutritional habits in an elementary school children. Compared with a control group of the same age but in another school.

Aerosol BCG Challenge Trial in Healthy UK Adults

TB041 is a clinical challenge trial primarily to evaluate the safety of BCG challenge administered by the aerosol inhaled route in healthy, BCG naive UK adults. The trial will also look to evaluate and compare the amount of BCG recovered from the lungs and from the skin, following challenge by either the aerosol or the intradermal route.

Study Confirming A Human Challenge Model and Investigating The Safety Of VLA1701

This is a single-center, double-blind, placebo-controlled, Phase II vaccination and challenge study designed to confirm a human challenge model with E. coli strain LSN03-016011/A.

A Study to Evaluate Gluten Challenge on Immune Responses in Subjects With Celiac Disease

This is a model development, open label, no therapeutic treatment, three sequential group, short term-gluten challenge study in subjects with celiac disease. Immune responses are evaluated following gluten challenge. Approximately fifteen subjects with celiac disease will be enrolled in up to three sequential groups (5 subjects per group).

Adjusting Challenge-Skill Balance to Improve the Elderly's Quality of Life

The purpose of this study was to clarify the effects on health-related QOL of occupational therapy involving the adjustment of challenge-skill balance in the activity of elderly clients.

Response of Natriuretic Peptides to Glucose Challenge

The purpose of the study is to discover any racial dissimilarity in the response of Natriuretic peptide (NP) system to acute metabolic influences such as a high carbohydrate challenge

Bordetella Pertussis Colonisation Challenge Study

This is a prospective controlled human challenge study consisting of two phases; Phase A: Development of a B. pertussis human challenge model; pilot to establish the standard inoculum Phase B: Development of a modified B. pertussis human challenge model

Food Allergy Diagnostic Test Response to Previous Oral Challenge Response

The objective of this study is to compare the ocular response to CAC (using food allergen sensitive patients) to the systemic response of a previously performed oral food allergen challenge in the same subjects. This study will investigate the potential utility of CAC as a predictive tool for identifying patient response to food allergen challenge and maximum tolerated dose.

Methacholine Challenge: Comparison of Doubling and Quadrupling Methacholine Dose Regimes Using the Tidal Volume Method

The purpose of this study is to determine the difference (if any) in the result of the methacholine challenge (a test used by physicians in diagnosing asthma) when concentrations of methacholine are quadrupled versus doubled.

Safety of Bronchial Allergen Challenge and Predictors for Positive Reaction.

The present study is aimed to evaluate a bronchial allergen challenge with house dust mite and alternaria. Firstly, the years 2005, 2006, 2007, 2008 and 2009 will be retrospectively reviewed. Secondly, in 2010-2013, in the prospective part of the study the patients will undergo the bronchial allergen challenge to examine safety of the bronchial allergen challenge and change of allergen specific bronchial hyperreactivity before and after allergen specific immunotherapy.

Safety and Repeatability of Bronchial Challenge With Grass-pollen

The study is meant to establish a one-step challenge with grass-pollen in patients sensitized for grass-pollen. Therefore the investigators compare a multi-step challenge with grass-pollen with an one-step challenge in order to survey the repeatability and safety.

Mini-fluid Challenge in Predicting Fluid Responsiveness During Prone Position Spine Surgery

Perioperative fluid management is crucial for patients' outcome. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.

AsthMatic Inflammation and Neurocircuitry Activation (MINA)

We have identified areas of the brain that are activated in response to disease-related emotional information, following whole lung allergen challenge in asthma. We propose that activity in these central nervous system locations, as measured by fMRI, is associated with the intensity of allergic inflammation, provoked by segmental bronchial challenge, in the absence of significant airflow obstruction. We predict that this relationship will be mediated by changes in expression of...

Hookworm Therapy for Coeliac Disease

This trial is a phase 2 multicentre, multinational, randomised, double-blinded, placebo-controlled, sequentially phased trial comparing the clinical efficacy and safety of two potential treatments for Coeliac Disease (CeD): (1) Gluten micro-challenge alone (following placebo infection), and (2) Gluten micro-challenge following infection with hookworm. Our 4 aims for the study are: Aim 1: To evaluate the efficacy of hookworm infection combined with escalating gluten ...

Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2

This is a single-center, open label study. The primary aim of this project is to develop a controlled human malaria infection transmission model ("CHMI-trans") or "challenge model" to evaluate the capacity of vaccines, biologics (monoclonal antibodies, or mAbs), and drugs to block malaria parasite transmission by assessing infectiousness of Plasmodium falciparum (Pf) gametocyte carriers for Anopheles mosquitoes.

The Asthma Bronchial Challenge Study

This is a randomised, controlled, cross-over study to determine the effect of indirect bronchial challenge testing upon volatile organic compounds (VOCs) in the exhaled breath of adults with well-controlled, mild-to-moderate asthma. Participants will undergo baseline evaluation including clinical history, spirometry, exhaled nitric oxide measurement (FeNO), phlebotomy (blood eosinophil count), and sampling of exhaled breath VOCs. Participants will be randomised to receive eith...

Satiety Innovation- Study 793. University of Aberdeen

The proposed study will address the effect of developed novel food products through processing innovation on motivation to eat, biomarkers of satiety, nutrient bioavailability and gut health using in vivo studies and validating new in vivo approaches. Specifically in this protocol we will address, in a short human intervention study the effect of a potentially satiating product on appetite, appetite biomarkers, particularly the influence on gut microbiota, tolerance and safety...

To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis

Allergic rhinitis is a common condition characterize by inflammation of the upper airways. Third generation antihistamines have been demonstrated effective in the treatment of this condition. Allergen challenge can be use to assess the effects of drugs in allergic rhinitis, adenosine monophosphate may also be used as a means to investigate these effects but as yet its effects have yet to be compared to allergen challenge. We intend to compare the effects of levocetirizine at a ...

SATIN: Satiety Innovation. Study 2- University of Aberdeen

The proposed study will address the effect of developed novel food products through processing innovation on motivation to eat, biomarkers of satiety, nutrient bioavailability and gut health using in vivo studies and validating new in vivo approaches. Specifically in this protocol the investigators will address, in a short human intervention study the effect of a potentially satiating product on appetite, appetite biomarkers, particularly the influence on gut microbiota, toler...

The Challenge Study: A Dietary Personalization Protocol for Patients With Crohn's Disease and Deep Remission

The Challenge study is a prospective, open label, pilot trial in patients in deep remission on dietary maintenance therapy. The purpose of this study is to determine whether they can consume some of the products that were eliminated from their diet, named the Crohn's Disease Exclusion Diet (CDED), and to evaluate if low dose exposure is harmful.

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