Clinical Trials About "Burn Wound Bacteriological Profiles Patient Outcomes Tangential Excision" RSS

13:00 EDT 23rd March 2019 | BioPortfolio

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Showing "Burn Wound Bacteriological Profiles Patient Outcomes Tangential Excision" Clinical Trials 1–25 of 16,000+

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Surgery Timing In Outcome Burn Patients

Prognosis of burn patients has improved over the last decades. Early excision of full thickness burns is thought to be one of the key factors which have led to prognostic improvement. Best timing for burn excision remain uncertain however. In this multicenter observational study, we aim at exploring the impact of timing of surgery on outcome in severely ill patients using a propensity analysis.

The Technique of Skin Stretching for Acute Burn Treatment and Scar Reconstruction

Objective: A randomized controlled trial is performed to evaluate the clinical effectiveness of the skin stretching technique for two categories: 1. acute burn wounds: wound closure by means of skin stretching should lead to a significant reduction of scar surface area in comparison to the standard technique, the split skin grafting; 2. scar reconstructions: wound closure by means of skin stretching during one operative procedure should lead to...

HIF-1 Regulated Endothelial Progenitor Cell (EPC) Recruitment in Burn Wound Healing

This research is being done to increase knowledge about wound healing and different factors that may affect healing in burn patients.

A Clinical Evaluation of an Esterified Hyaluronic Acid Matrix in Burn Patients for STSG

Burn patients meeting inclusion criteria will receive the esterified hyaluronic acid matrix as the primary matrix to manage their wound, in conjunction with the standard of care for managing these types of wounds. The study will be divided into two phases. Phase I will entail intervention with the wound matrix and will continue until one of the following occur, sufficient granulation has occurred and the patient can receive a STSG, the patient's physician determines an STSG is ...

Trial of Different Wound Dressings in Split-skin Grafted Third Degree Burns

In plastic and reconstructive surgery, treatment strategies of second-degree burn wounds and split-skin grafted third-degree burn wounds aim at reducing infection and improving reepithelialization. Although previous studies indicate that burn patients benefit from newer wound dressings, only a few studies comparing different wound dressings can be found. Therefore, the aim of this study is to evaluate time to reepithelialization, pain, microbiology, handling and costs of differ...

Evaluation of ACell Hydrated Wound Dressing for Autogenous Skin Donor Sites

The purpose of this study is to see if treating a donor site wound with the ACell dressing is as good as or better than the dressings we currently treat harvested donor sites with. This will be tested on consenting burn patients who require excision and grafting surgery for their burn wounds. Hypothesis: The mean healing time for wounds treated with the ACell dressing will be less than the mean healing time for wounds treated with the Standard of Care dressing.


Indocyanine Green (ICG) and SPY Imaging for Assessment of Burn Healing

Hypothesis: Higher levels of perfusion on indocyanine green (ICG) fluoroscopy indicate higher likelihood of burns healing whole lower levels of perfusion correlate with lower likelihood of healing Consented patients with burn injuries will be evaluated daily and along with continued wound care will receive 5 mg of ICG (FDA approved dose) and their burns assessed fluoroscopically. Perfusion will be quantified numerically as a percentage of normally perfused skin. No chang...

The Effect of Topical Tranexamic Acid on Postoperative Bleeding and Effusions From Superficial Wounds

After surgical procedures, interventions to reduce postoperative bleeding are of great importance. In this study, the effect will be investigated of administering tranexamic acid, which is designed for injection, directly onto the raw wound surface (topical application) created during surgery. In this way only a small amount of drug is to reach a large wound area. There will be a higher drug concentration of it in the exposed wound surface than after injection, but only a very ...

Virtual Reality Analgesia for Pediatric Burn Survivors

Many children with large severe burns report severe pain during burn wound cleaning. The current study explores whether adjunctive immersive Virtual Reality distraction may help reduce the intensity of pain experienced by children during burn wound cleaning by taking the patient's mind off their pain.

Pirfenidone and Its Role in Burn Wound Healing

Burn patients which skin has been lost a rapid growth of the skin is a foremost in their treatment. Due to the injury, burn patients undergo a systemic inflammation that helps the skin heal faster. However, several studies have shown that this inflammation increases the levels of several inflammatory molecules that impairs skin growing, which further delays the recovery of burn patients. As such, by inhibiting these inflammatory molecules with the administration of a medication...

Virtual Reality for Burn Wound Care Pain Control

We propose to study the effects of virtual reality (VR) on patients' pain perception during burn wound care. Such variables include psychiatric diagnosis and standard pain coping (i.e. pain catastophizer vs. non-pain catastrophizer).Aims: We intend to evaluate the use of virtual reality in pain distraction for burn patients undergoing burn wound care. To that end our aims are: 1) To determine if pain perception will be less during the portion of the procedure ...

Quantification and Derivation of Metabolic Needs in Children During Burn Rehabilitation

The investigators are collecting information on the calorie needs of patients in the first year postburn. The investigators hypothesize that increased energy needs continue for up to a year following wound closure from burn injury.

The Effects of Viscoelastometry Guided Resuscitation During Burn Excision on Post Resuscitation Infections

This is a randomized controlled trial to compare viscoelastometric (VE) guided transfusion to standard practice transfusion in severe thermal injury burn excision on the utilization of blood products, effects on coagulation and inflammatory mediators, and how these strategies affect post resuscitation infections.

VRH Pain Reduction During Burn Wound Care and Physical Therapy

Using Virtual Reality Hypnosis to relief pain and anxiety for burn patients.

Juvista (Avotermin) in the Prevention or Improvement of Scar Appearance Following Scar Revision Surgery.

This study is being undertaken to investigate the efficacy and safety of Juvista (given as an intradermal injection of 200ng/100µl per linear centimetre of wound margin) in the prevention or improvement of scar appearance when administered intradermally to approximated wound margins following surgical scar revision. In addition, this study will compare the scar revision techniques of complete excision (excision of the entire scar during one surgical procedure) and staged exci...

Interest in the Use of Dressings With Honey for Wound Healing After Excision of Pilonidal Cyst

The management of pilonidal cysts is a skin excision and under deep skin. Scarring requires regular dressings (daily for 15 days and then every 48 hours) until complete healing. This healing is obtained on average in 68 days. Some patients have difficulties in healing with a final healing achieved on average in 95 days. Some teams use honey to promote wound cavitary wounds (wound infection, pressure ulcers, varicose wound). The acceleration of wound healing is due to antibacter...

Burn Wound Management of Betafoam® and Allevyn® Ag Dressing

This is a randomized, controlled, multi-centre, open-label phase IV study. A total of 40 patients will be enrolled in this study. Patients will be randomly assigned to Betafoam® or Allevyn® Silver dressing for burn wounds after acute burn injury.

Study of the Treatment of Burn Wounds With Various Antimicrobial Topical Soaks

Determine effectiveness of various antimicrobial solutions on burn wounds (infections, wound healing, length of hospital stay).

Bacterial Control in Partial Thickness Burns Using Silver-Containing Wound Dressings

This study is to compare the treatment with two different silver-containing wound dressings: aquacel AG hydrofiber versus acticoat burn dressing.

Safety and Efficacy Study of FS 4 IU VH S/D (Fibrin Sealant With 4IU/mL Thrombin, Vapor Heated, Solvent/Detergent Treated) to Adhere Split Thickness Skin Grafts and Improve Wound Healing in Burn Patients

The primary objective of this study is to evaluate skin graft adherence and wound healing in burn patients to evaluate whether FS 4IU VH S/D is equivalent or superior to the current standard of care (staples). The primary endpoint is achievement of complete (100%) wound closure within 28 days.

Manuka Honey in Second- and Grafted Third-degree Burns

Treatment strategies of II. degree burn wounds and split-skin grafted III. degree burn wounds aim at reducing infection and improving reepithelialization. The aim of this study is to evaluate time to reepithelialization, pain, microbiology and handling of manuka honey dressings with second-degree burn wounds and split-skin grafted burn wounds.

Non-Powered Negative Pressure Wound Therapy vs Open Technique for Pilonidal Disease

Pilonidal Disease is disease of young patients with significant morbidity and is difficult to treat. Currently multiple methods are practiced for the treatment of the disease, two of them are preferred over others and practice extensively. First one involves excision of pilonidal sinus and dressings while the second one is excision of the pilonidal sinus with application of negative pressure wound therapy. None of these approaches is considered superior to the other, as not eno...

Use of Plasma Rich in Growth Factors (PRGF) in Pilonidal Sinus Excision

The use of plasma rich in growth factors in wound excision pilonidal sinus could improve the healing process of the wound, when compared with the usual technique of daily local healing. The investigators propose the objective of evaluating the efficacy of intra- and postoperative application of plasma rich in growth factors, to reduce healing time and complications, arising from its removal, compared to the standard surgical treatment.

Biofilm Infection in Adults and Children Burn Injury

The objective of the study is to analyze the different implications (such as graft loss and conversion of indeterminate depth burns) of biofilm infections in burn patients. Additionally, it also aims at comparing children's resistance to biofilm infection at wound site than adults'. 300 subjects from 3 different age groups will be enrolled in 3 arms.

Study of Arginine Metabolism and Nitric Oxide Formation in Relation to Glutamine Supply in Severely Burned Patients

The purpose of the study is to understand the way the body uses amino acids and proteins in burned patient during the time they cannot eat normally. This study aims to understand the metabolism of the amino acid arginine in the body after burn injury. The results of this study will help determine the best composition of food needed during an acute burn injury so that body can more efficiently use the supplied nutrient for optimal burn wound healing and early recovery.

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