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Rheumatology Research

09:29 EST 19th November 2017 | BioPortfolio

Metabolic Profile in Patients with Mild Obstructive Sleep Apnea.

Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults. However, it is not clear whether mild OSA has significant metabolic complications. This study examined the prevalence of metabolic syndrome (MS) in patients with mild OSA compared to control group.

Respiratory Muscle Weakness, a Major Contributor to Pediatric Extubation Failure: Does Low Serum Phosphorus Contribute to Muscle Weakness?

Optimal design and control of an electromechanical transfemoral prosthesis with energy regeneration.

In this paper, we present the design of an electromechanical above-knee active prosthesis with energy storage and regeneration. The system consists of geared knee and ankle motors, parallel springs for each motor, an ultracapacitor, and controllable four-quadrant power converters. The goal is to maximize the performance of the system by finding optimal controls and design parameters. A model of th...

Rheumatoid arthritis patients treated in trial and real world settings: comparison of randomized trials with registries.

To investigate whether patients with RA enrolled in randomized controlled trials (RCTs) and observational studies may differ in terms of characteristics that could modify treatment effects, leading to an efficacy-effectiveness gap.

Tumour TIF1 mutations and loss of heterozygosity related to cancer-associated myositis.

To analyse the influence of genetic alterations and differential expression of transcription intermediary factor 1 ( TIF1 ) genes in the pathophysiology of cancer-associated myositis (CAM).

Biosimilars Forum Applauds Food and Drug Administration on New Educational Program Promoting Safety and Effectiveness of Biosimilars.

Shaken baby syndrome: what certainty do we have?

Shaken baby syndrome is a common and devastating disease in infants. In spite of its frequency, many controversies persist, regarding the pathophysiology, diagnosis, and management.

Integrating Soft and Hard Tissues via Interface Tissue Engineering.

The enthesis, or interface between bone and soft tissues such as ligament and tendon, is prone to injury and often does not heal post-surgical intervention. Interface tissue engineering represents an integrative strategy for regenerating the native enthesis by functionally connecting soft and hard tissues and thereby improving clinical outcome. This review focuses on integrative and cell-instructi...

Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice.

Dried plum (DP), a rich source of polyphenols has been shown to have bone-preserving properties in both animal models of osteoporosis and postmenopausal women. We evaluated if DP alleviated the destruction of joints in transgenic mice (TG) that overexpress human tumor necrosis factor (TNF), a genetic model of rheumatoid arthritis (RA). A four-week treatment of 20% DP diet in TG slowed the onset of...

Correction to: Effect of patient positioning in axillary nerve safety during arthroscopic inferior glenohumeral ligament plication.

The author claims that his name is incorrectly listed on PubMed. The first name should be Jorge and the last name should be Díaz Heredia. On SpringerLink the name is listed correctly, but on PubMed he is listed as Heredia JD.

Correction to: Young athletes return too early to knee-strenuous sport, without acceptable knee function after anterior cruciate ligament reconstruction.

The author claims that his name is incorrectly listed on PubMed. The first name should be Eric and the last name should be Hamrin Senorski. On SpringerLink the name is listed correctly, but on PubMed he is listed as Senorski EH.

Update on the Treatment of Uveitis in Patients with Juvenile Idiopathic Arthritis: A Review.

Chronic uveitis is a common extra-articular manifestation of juvenile idiopathic arthritis. The classic clinical picture is one of chronic anterior uveitis, which usually remains asymptomatic until ocular complications arise. The risk of uveitis is increased in girls with an early onset of oligoarthritis and positive antinuclear antibodies. Even though the inflammation in patients with juvenile id...

Long-term effectiveness of tocilizumab in patients with rheumatoid arthritis, stratified by number of previous treatment failures with biologic agents: results from the German RABBIT cohort.

In Germany, Tocilizumab (TCZ) is used for the treatment of rheumatoid arthritis both in biologic-naïve patients and those with previous failures of biologic disease-modifying antirheumatic drugs (bDMARDs). The long-term effectiveness and retention rates of TCZ in patients with different numbers of prior bDMARD failures has rarely been investigated. We included 885 RA patients in the analyses, enr...

Navigated retrograde endoscopic myotomy (REM) for the treatment of therapy-resistant achalasia.

In achalasia, muscle spasm may involve the proximal esophagus. When the muscle spasm is located in the proximal esophagus, conventional per oral endoscopic myotomy (POEM) may not be sufficient to relieve symptoms. In this paper, we describe retrograde endoscopic myotomy (REM) as a novel approach to perform myotomy of the proximal esophagus, with the application of a navigation tool for anatomical ...

Neck circumference, a valuable anthropometric measurement to detect metabolic syndrome among different age groups in China.

The aim of this study was to investigate the correlation between neck circumference (NC) and metabolic syndrome (MS) in Chinese residents and to explore the cut-off points of NC for MS in different age groups.

Considerations in surgical management of a Buschke-Lowenstein tumor in Netherton syndrome: A case report.

Netherton syndrome is an autosomal recessive ichthyosis caused by mutations in SPINK5, with the classic triad of linearis circumflexa, trichorrhexis invaginata, and atopy. There are few reports of surgical management in individuals with Netherton syndrome and clinicians may be reluctant to operate for fear of wound-healing complications. This report describes a pediatric case of a Buschke-Lowenste...

Long-term treatment with etanercept monotherapy in a hemodialyzed patient with moderate-to-severe plaque-type psoriasis and psoriatic arthritis.

Effect of stabilization exercise on back pain, disability and quality of life in adult with scoliosis: a systematic review.

Adult Scoliosis (AS) is the most common spine deformity in adults. Back pain is the main symptom leading patients to seek medical consultation. Stabilization exercise has been shown effective for reducing back pain. No literature review has examined the effects of such exercises in adults with scoliosis.

Effects of Active Immunization Against Akirin2 on Muscle Fiber-type Composition in Pigs.

The objective of this study was to investigate effects of active immunization against Akirin2 on muscle fiber-type composition in pigs. Here we showed that the titer of Akirin2 antibody in pigs immunized with porcine Akirin2 (pAkirin2) was significantly increased. Active immunization against pAkirin2 decreased succinic dehydrogenase and malate dehydrogenase activities and increased lactate dehydro...

Creatine kinase: how an obsolete test for skeletal muscle disease became a risk factor for hypertension.

Autoimmune diseases and breast cancer risk by tumor hormone-receptor status among elderly women.

The female preponderance of many autoimmune diseases suggests a possible hormonal etiology. Little research exists on systemic and organ-specific autoimmune diseases and risk of breast cancer by tumor estrogen receptor (ER)- and progesterone receptor (PR)- status. Here we evaluate associations between selected systemic and organ-specific autoimmune diseases and breast cancer risk overall and by tu...

The impact of volumetric muscle loss injury on persistent motoneuron axotomy.

Volumetric muscle loss (VML) occurs following significant traumatic injury or surgical removal of skeletal muscle, resulting in non-recoverable loss of tissue and long-term dysfunction. Perhaps less recognized is that VML injuries inherently disrupt the neuromuscular unit, resulting in fiber denervation and presumptive motor unit rearrangement, expansion, and/or loss. To characterize neural dysfun...

Association of oxidative stress with clinical characteristics in patients with rheumatoid arthritis.

Few studies examining the association between oxidative stress and clinical parameters or disease activity in rheumatoid arthritis (RA) patients are available. Therefore, the objective of this study was to test whether oxidative stress has any association with clinical parameters and disease activity in patients with RA.

Kinematic analysis of pressing situations in female collegiate football games: New insight into ACL injury causation.

The most common events during which anterior cruciate ligament (ACL) injuries occur in football are pressing situations. This study aimed to describe the knee and hip joint kinematics during pressing situations in football games in order to identify kinematic patterns in actions with a high risk for ACL injuries. We filmed 5 female collegiate football matches and identified 66 pressing situations....

3D Printed Anchoring Sutures for Permanent Shaping of Tissues.

Sutures are one of the most widely used devices for adhering separated tissues after injury or surgery. However, most sutures require knotting, which can create a risk of inflammation, and can act as mechanically weak points that often result in breakage and slipping. Here, an anchoring suture is presented with a design that facilitates its propagation parallel to the suturing direction, while max...

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