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The chimeric anti-CD20 antibody rituximab (Rituxan & MabThera) from Biogen Idec and Genentech/Roche is one of the world’s commercially most successful antibodies (2007 sales of over US$ 5 bl...
Lysosomal storage disorders (LSDs) represent a group of about 50 genetic disorders caused by deficiencies of lysosomal proteins. Most involve genetic mutations causing loss of function of key catabo...
SERAPHIN - STUDY WITH ENDOTHELIN RECEPTOR ANTAGONIST IN PULMONARY ARTERIAL HYPERTENSION TO IMPROVE CLINICAL OUTCOME. SERAPHIN (Study with an Endothelin Rece...
NewsAn expert in the clinical use of the drug for mood and anxiety disorders says that, in some cases, it has started to alleviate patients’ symptoms after one infusion, as opposed to most anti-depr...
In a randomized, placebo-controlled trial, adding ketamine at a dose of 0.15 mg/kg reduced pain and morphine requirements.
Ketamine alone was associated with fewer serious adverse events and interventions in children compared with propofol alone or ketamine combined with propofol or fentanyl, a study found. Medscape M...
However, reductions in suicidal behavior remain to be proven.
After receiving a solicitation from a ketamine clinic, Dr Jeffrey Lieberman did some digging. What he found troubled him. Medscape Psychiatry
A world-first systematic review into the safety of ketamine as a treatment for depression, published in the prestigious Lancet Psychiatry, shows the risks of long-term ketamine treatment remain unclea...
Low doses of ketamine didn’t reduce delirium, postoperative pain, or other complications related to major surgeries. The results challenge a common practice.
Ketamine and a key metabolite block the NMDA receptor, which sets off a cascade of events that have antidepressant effects, a finding that could aid in developing safer alternatives. Medscape Medica...
A prospective randomized, double-dummy trial comparing intravenous push dose of low dose ketamine to short infusion of low dose ketamine for treatment of moderate to severe pain in the emergency department.
Compare adverse effects and analgesic efficacy of low-dose ketamine for acute pain in the ED administered either by single intravenous push (IVP) or short infusion (SI).
Ketamine is a racemic mixture of the enantiomers R-ketamine and S-ketamine (esketamine). S-ketamine has greater analgesic and anesthetic effects than R-ketamine and is less likely to cause psychotomim...
The goal of our study was to compare the frequency and severity of recovery reactions between ketamine and ketamine-propofol 1:1 admixture ("ketofol").
BackgroundN-methyl-D-aspartate receptor activation has been implicated in the pathobiology of inflammatory, nociceptive and neuropathic pain, opioid tolerance, opioid-induced hyperalgesia, and central...
Total thyroidectomy is recommended as a line of management of thyroid cancer in a lot of cases. Our aim was to compare postoperative analgesic effect of local ketamine 1 mg/kg instilled in the wound t...