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04:19 EST 20th November 2017 | BioPortfolio

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Bioprocessing survey report: Is the CHO CHO train slowing down?

Nearly half the respondents of our second state of the global biomanufacturing survey believe we are too reliant on Chinese Hamster Ovary (CHO) expression systems.

Researchers probe brain disease-causing proteins at the atomic level

(Ohio State University) Researchers studying a protein that causes a hereditary degenerative brain disease in humans have discovered that the human, mouse and hamster forms of the protein, which have ...

The body relies on thousands of sugar–protein complexes to stay healthy

Over two weeks in 2004, Song Zhiwei witnessed the slow death of a colony of cells. Song, a bioengineer at the A*STAR Bioprocessing Technology Institute (BTI), had bathed a plate of Chinese hamster ova...

ChromaTan Wins $2.5M FDA Contract to Develop CCTC Continuous Purification Platform

ChromaTan has won a $2.5 million FDA contract to develop an integrated, continuous downstream purification platform for production of monoclonal antibodies (mAbs). The two-year project will entail...

ChromaTan Wins $2.5M FDA Contract to Develop Integrated Continuous Purification Platform

ChromaTan has won a $2.5 million FDA contract to develop an integrated, continuous downstream purification platform for production of monoclonal antibodies (mAbs). The two-year project will entail...

CHO‐omics Review: The Impact of Current and Emerging Technologies on Chinese Hamster Ovary Based Bioproduction

CHO cells are the most prevalent platform for modern bio‐therapeutic production. Currently, there are several CHO cell lines used in bioproduction with distinct characteristics and unique genotypes ...

Engineered and natural promoters and chromatin‐modifying elements for recombinant protein expression in CHO cells

Promoters play a pivotal role in integrating and processing the signals related to transcription initiation. Strong natural viral promoters, such as hCMV or SV40E, have been routinely employed to achi...

Growth rate changes in CHO host cells are associated with karyotypic heterogeneity

Chinese hamster ovary (CHO) cell line instability and clonality issues can affect cell culture phenotypes such as cell growth, productivity, or product quality and remain challenges for biopharmaceuti...

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Genetic characterization of the Turkish gray hamster (Cricetulus migratorius) based on mitochondrial cytochrome b and 12S rRNA sequences.

Although genetic diversity and phylogenetic status of the gray hamster (Cricetulus migratorius) have been investigated from different regions in previous studies, genetic data on this species from Tur...

HAdV-C6 Is a More Relevant Challenge Virus than HAdV-C5 for Testing Antiviral Drugs with the Immunosuppressed Syrian Hamster Model.

Adenovirus infections of immunocompromised patients can cause a severe multi-organ disease that often results in the patients' death. Presently, there are no drugs specifically approved to treat adeno...

Ameloblastoma of the Jaw in Three Species of Rodent: a Domestic Brown Rat (Rattus norvegicus), Syrian Hamster (Mesocricetus auratus) and Amargosa Vole (Microtus californicus scirpensis).

Ameloblastoma is a locally aggressive tumour derived from the odontogenic epithelium of the developing tooth germ. This uncommon odontogenic tumour is generally considered benign, but rarely, both dis...

Lessons from the hamster: Cricetulus griseus tissue and CHO cell line proteome comparison.

Chinese hamster ovary cells represent the dominant host for therapeutic recombinant protein production. However, few large-scale datasets have been generated to characterize this host organism and der...

Karyotype Evolution and Phylogenetic Relationships of Cricetulus sokolovi Orlov et Malygin 1988 (Cricetidae, Rodentia) Inferred from Chromosomal Painting and Molecular Data.

Sokolov's dwarf hamster (Cricetulus sokolovi) is the least studied representative of the striped hamsters (Cricetulus barabensis species group), the taxonomy of which remains controversial. The specie...

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