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Spinal Cord Disorders Research

07:52 EDT 16th October 2018 | BioPortfolio

Cryptococcal meningitis following umbilical cord blood transplantation, association between the occurrence of cryptococcal infection and tacrolimus discontinuation among allogeneic hematopoietic stem cell recipients.

Few cases of cryptococcal infection following umbilical cord blood transplantation (UCBT) have been reported. We report a case, where cryptococcal infection occurred soon after rapidly reducing the dose of tacrolimus in a UCBT recipient who received micafungin prophylaxis during the early phase of transplantation. The etiology of cryptococcal infection following allogeneic hematopoietic stem cell ...

PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues.

We investigated whether PPARγ modulates adipose tissue BCAA metabolism, and whether this mediates the attenuation of obesity-associated insulin resistance induced by pharmacological PPARγ activation.

Differences in glucose metabolism among women with spinal cord injury may not be fully explained by variations in body composition.

To investigate the differences in glucose metabolism among women with paraplegic, and tetraplegic spinal cord injury (SCI) in comparison to their able-bodied (AB) counterparts after adjusting for differences in body composition.

Effects of synergistic fungal pretreatment on structure and thermal properties of lignin from corncob.

Synergistic fungal pretreatment involving white-rot and brown-rot fugal pretreatment has shown great potential for enhancing the yield of sugars from biomass time-effectively and environmentally benign. In this work, the effects of this integrated fungal pretreatment on lignin characteristics and thermal behavior of corncob were examined in the view of whole plant valorization. The results show th...

Renal Cell Carcinoma with Venous Thrombus: Should Surgery Be Offered When Metastasis Is Present at Diagnosis?

Renal cell carcinoma (RCC) reveals a tendency towards venous invasion in its advanced stages, making clinical management challenging. Survival may be improved following surgery, but is less clear if it applies to patients with metastatic disease at diagnosis.

Normal variations in cerebral venous anatomy and their potential pitfalls on 2D TOF MRV examination: Results from a private tertiary care hospital in Karachi.

To assess normal venous anatomy of the cranium and its anatomical variants.

Synovial sarcoma of cervicodorsal spine: A case report.

Synovial sarcoma is a soft-tissue sarcoma. Its involvement of the spine is extremely rare. We report a 40 year old male who presented with shoulder pain and progressive weakness in all four limbs for six months with a visible, slowly growing bulge in his upper back. On examination he had quadriparesis and diffuse sensory deficit. MRI of the cervical spine showed a large soft tissue mass, iso to hy...

Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy.

Neuropathic pain is a complication of cancer and diabetes mellitus and the most commonly used drugs in the treatment of the diabetic neuropathic pain have only limited efficacy. The aim of this study was to evaluate the role of the biomarker interleukin-1beta (IL-1ß) in the pharmacological interaction of gabapentin with tramadol in a model of diabetic neuropathic pain. CF-1 male mice, pretreated ...

Small-molecule-based generation of functional cardiomyocytes from human umbilical cord-derived induced pluripotent stem cells.

The purpose of this study was to investigate the cardiac-differentiation potential of induced pluripotent stem cells (iPSCs) generated from human umbilical cord-derived mesenchymal cells. Spontaneous beating colonies were observed at day 7 after the sequential addition of CHIR99021 and IWP-4. The combined use of CHIR99021 and IWP-4 downregulated the expression of pluripotency markers while upregul...

Prokaryotic SPHINX 1.8 REP protein is tissue-specific and expressed in human germline cells.

Small circular DNAs of 1.8 and 2.4 kb were initially discovered in highly infectious Creutzfeldt-Jakob Disease (CJD) and scrapie particles from mammalian brain and cultured cells. Surprisingly, these protected cytoplasmic "SPHINX" DNAs contained replication (REP) initiation sequences resembling those of Acinetobacter phage viruses. An antibody was generated against a REP peptide encoded by the S...

Floating thrombus in the ascending aorta causing repeated arterial embolisms.

Free-floating thrombus in an otherwise normal ascending aorta is a rare finding. We report the case of a 61-year-old woman admitted for brain and peripheral arterial embolisms. Echocardiography was not able to detect the source of embolus. Computed tomographic scan demonstrated a large floating mass attached to the posterior wall of the distal ascending aorta. The thrombus was successfully removed...

Vocal fold paralysis due to intracranial hypotension following spinal anesthesia.

Cranial nerve palsy is a rare neurological complication of epidural and subarachnoid blocks. Most of these complications are attributed to secondary intracranial hypotension due to cerebrospinal fluid leakage following dural puncture. Vocal fold paralysis (VFP) seems more likely to be overlooked and underreported due to delayed onset of symptoms and lack of attribution of dysphonia to spinal anes...

Correction to: Prenatal Ultrasonic Diagnosis and Prognostic Analysis of Isolated Left Subclavian Artery (ILSCA) and Left Brachiocephalic Trunk (ILBCT) Malformation.

The article Prenatal Ultrasonic Diagnosis and Prognostic Analysis of Isolated Left Subclavian Artery (ILSCA) and Left Brachiocephalic Trunk (ILBCT)Malformation, written by Yuntao Li, Xiaohong Zhang, Yani Yan and Qiuyan Pei, was originally published electronically on the publisher's internet portal (currently SpringerLink) on August 2018 with open access.

Tumor-to-tumor metastasis of lung adenocarcinoma into a spinal intradural solitary fibrous tumor: a case report.

Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms commonly involving visceral or parietal pleura. We present the first report of tumor-to-tumor metastasis involving a pulmonary adenocarcinoma donor and an intradural SFT recipient. The patient presented with a 1 year history of diffuse back pain. A spinal intradural contrast-enhancing mass at the T9/10 level and a tumor of the lung wer...

Hypothermia Used in Medical Applications for Brain and Spinal Cord Injury Patients.

Despite more than 80 years of animal experiments and clinical practice, efficacy of hypothermia in improving treatment outcomes in patients suffering from cell and tissue damage caused by ischemia is still ongoing. This review will first describe the history of utilizing cooling in medical treatment, followed by chemical and biochemical mechanisms of cooling that can lead to neuroprotection often ...

Clinical implication of renal allograft volume to recipient body surface area ratio in pediatric renal transplant.

Our study aims to assess the clinical implication of RAV/rBSA ratio in PRT as a predictor for attained renal function at 1 year post-transplantation and its association with surgical complications. A retrospective cohort was performed for PRT cases from January 2000 to December 2015 in our institution. Extracted clinical information includes the recipient's demographics, donor type, renal allogra...

Altered neurovascular coupling in neuromyelitis optica.

Neurovascular coupling reflects the close relationship between neuronal activity and cerebral blood flow (CBF), providing a new mechanistic insight into health and disease. Neuromyelitis optica (NMO) is an autoimmune inflammatory demyelinating disease of the central nervous system and shows cognitive decline-related brain gray matter abnormalities besides the damage of optic nerve and spinal cord....

Blood sampling guidelines with focus on patient safety and identification - a review.

It has been well documented over recent years that the pre-analytical phase is a leading contributor to errors in the total testing process (TTP). There has however been great progress made in recent years due to the exponential growth of working groups specialising in the field. Patient safety is clearly at the forefront of any healthcare system and any reduction in errors at any stage will impro...

Distinct roles of angiotensin receptors in autonomic dysreflexia following high-level spinal cord injury in mice.

Autonomic dysreflexia (AD), a syndrome caused by loss of supraspinal control over sympathetic activity and amplified vascular reflex upon sensory stimuli below injury level, is a major health problem in high-level spinal cord injury (SCI). After supraspinal sympathetic control of the vasculature below the lesion is lost, the renin-angiotensin system (RAS) is thought to be involved in AD by regulat...

MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1.

Venous thromboembolism (VTE), encompassing deep venous thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular disease. miR-150 is one of important microRNAs which play critical role in various cellular function such as endothelial progenitor cells (EPCs). In this study, we investigate the effect of miR-150 on EPCs function ex vivo and thrombus resolution in vivo. We ...

Pre-phrenic interneurons: characterization and role in phrenic pattern formation and respiratory recovery following spinal cord injury.

The phrenic motor system receives excitatory inspiratory bulbospinal drive from inspiratory pre-motor neurons in the rostral ventral respiratory group and descending inhibition from bulbospinal Bötzinger complex units in the brainstem. While phrenic motoneurons have been extensively studied, a thorough understanding of the role of pre-phrenic interneurons is only beginning to emerge. Pre-phrenic ...

Intra- and Extramedullary Thoracic Spinal Lipomas without Spinal Dysraphism: Clinical Presentation and Surgical Management.

French-Canadian adaptation and validation of the Swiss Spinal Stenosis Questionnaire for patients with lumbar spinal stenosis.

Observational prospective study.

Alert Timing and Corresponding Intervention with Intraoperative Spinal Cord Monitoring for High Risk Spinal Surgery.

Prospective multicenter study OBJECTIVE.: To analyze the incidence of intraoperative spinal neuromonitoring (IONM) alerts and neurological complications, as well as to determine which interventions are most effective at preventing postoperative neurological complications following IONM alerts in high risk spinal surgeries.

Coronal Imbalance in Adult Spinal Deformity Following Posterior Spinal Fusion With Instrument: A Related Parameters Analysis.

A retrospective radiographic study.

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