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Steatohepatitis fatty liver disease) is a type of liver disease, characterized by inflammation of the liver with concurrent fat accumulation in liver. Seen in alcoholics as part of alcoholic liver disease, steatohepatitis also is frequently found in people with diabetes and obesity and it is related to metabolic syndrome. When not associated with excessive alcohol intake, it is referred to as nonalcoholic steatohepatitis, or NASH and is the progressive form of the relatively benign non-alcoholic fatty liver disease
Steatohepatitis of either etiology may progress to cirrhosis, and NASH is now believed to be a frequent cause of unexplained cirrhosis. NASH is also associated with lysosomal acid lipase deficiency.