Advertisement

Topics

Stress Research

00:10 EST 18th January 2019 | BioPortfolio

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.

The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. Unfolding leads to the exposure of a hydrophobic β-strand and nucleates aggregation which results in pathologies through loss of function and dominant negative/gain of function effects. Inspired by the hypothesis that structu...

Improved General and Height-Specific Quality of Life in Children with Short Stature after One Year on Growth Hormone.

Short stature in children and adolescents may lead to social and emotional stress with negative effects on quality of life (QoL). Growth hormone (GH) treatment may improve QoL through height normalisation. Our objective here was to evaluate general and height-specific QoL after one year of GH treatment.

Roles of Cytosolic Glutamine Synthetases in Arabidopsis Development and Stress Responses.

Glutamine (Gln) serves as a central role in nitrogen (N) and carbon (C) metabolism. It is synthesized during assimilation of ammonium by cytosolic and plastidial glutamine synthetases (GS; EC 6.1.1.3). Arabidopsis thaliana has 5 cytosolic GS (GS1) encoding genes designated as GLN1;1 through GLN1;5 and one plastidial GS (GS2) gene. In this report that concerns cytosolic GS, we show by analyzing sin...

A feedback loop between CaWRKY41 and H2O2 coordinates pepper's response to Ralstonia solanacearum and excess cadmium.

WRKY transcription factors have been implicated in both plant immunity and plant responses to cadmium (Cd); however, the mechanism underlying the crosstalk between these processes is unclear. Here, we characterized the roles of CaWRKY41, a groupⅢ WRKY TF, in immunity against the pathogenic bacterium Ralstonia solanacearum and Cd stress responses in pepper (Capsicum annuum). CaWRKY41 was transcri...

Sub-Chronic Exposure to Di(2-ethylhexyl) Phthalate and Diisononyl Phthalate During Adulthood Has Immediate and Long-Term Reproductive Consequences in Female Mice.

Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in a variety of consumer products. This is concerning because DEHP is an endocrine disruptor and ovarian toxicant. Diisononyl phthalate (DiNP) is a DEHP replacement that is a rising human toxicant due to its increased use as a DEHP substitute. However, little is known about the effects of DEHP or DiNP exposure during adulthood on female repro...

Employment Status and the Association of Sociocultural Stress Severity and Stress Burden with Sleep in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

We examined the association of sociocultural stress severity (i.e., acculturation stress, ethnic discrimination) and chronic stress burden with multiple dimensions of sleep in a population-based sample of US Hispanics/Latinos. We also explored whether employment status modified stress-sleep associations.

A comparison of the prevalence of psychiatric disorders in Puerto Rico with the United States and the Puerto Rican population of the United States.

The manuscript compares the rates of psychiatric disorder among island Puerto Ricans, the US population and US Puerto Ricans in order to examine whether social support explains differences in psychiatric disorder among these three groups.

Beta-carotene, telomerase activity and Alzheimer's disease in old age subjects.

Advancing age represents the strongest risk factor for Alzheimer's disease (AD), and the identification of biomarkers able to define what characterizes physiological aging from AD may represent a potential starting point for novel preventive strategies. Among these biomarkers, telomeres seem to be a promising target. Interestingly, high intake of carotenoid-rich food may play a role in protecting ...

Differential transcriptional responses of carotenoid biosynthesis genes in the marine green alga Tetraselmis suecica exposed to redox and non-redox active metals.

The green microalga, Tetraselmis suecica, is commonly used in scientific, industrial, and aquacultural purposes because of its high stress tolerance and ease of culture in wide spectrums of environments. We hypothesized that carotenoids help to protect Tetraselmis cells from environmental stress by regulating genes in biosynthetic pathways. Here, we determined three major carotenogenic genes, phyt...

Conditions of Poverty, Parent-Child Interactions, and Toddlers' Early Language Skills in Low-Income Families.

Objectives The study examined the relations between parent-child interaction in the first year of life to toddlers' language skills at age 2 years for a sample of children reared in poverty; of specific interest was testing the Family Stress Model, which proposes that the conditions of poverty influence children's language skills through caregiver well-being (e.g., distress, depression) and inter...

Isolation and Expression Analysis of Three Types of α-Carbonic Anhydrases from the Antarctic Alga Chlamydomonas sp. ICE-L under Different Light Stress Treatments.

Carbonic anhydrases (CAs) are a class of zinc-containing metalloenzymes that can reversibly catalyse the hydration reaction of carbon dioxide. Antarctic algae are the most critical component of the Antarctic ecosystem; algae can enter the carbon cycle food chain by fixing carbon dioxide from the air. In this study, the complete open reading frames (ORFs) of CA1 (GenBank ID KY826431), CA2 (GenBank ...

Structural and functional insights into TRiC chaperonin from a psychrophilic yeast, Glaciozyma antarctica.

Studies on TCP1-1 ring complex (TRiC) chaperonin have shown its indispensable role in folding cytosolic proteins in eukaryotes. In a psychrophilic organism, extreme cold temperature creates a low-energy environment that potentially causes protein denaturation with loss of activity. We hypothesized that TRiC may undergo evolution in terms of its structural molecular adaptation in order to facilitat...

Traumatic Sequestrated Thoracic Disc Herniation; A Case Report.

Traumatic thoracic disc herniation is an extremely rare pathology. We will present a case (3rd report in the literature, 1st case with sequestrated-extruded disc herniation) of thoracic disc herniation that was sequestrated only by ligamentous injury without thoracic osseous pathology.

Large hemorrhagic cerebral venous infarction due to deep brain stimulation leads placement. Report of 2 cases.

The true incidence of hemorrhagic venous infarctions in deep brain stimulation (DBS) procedures is very difficult to determine. These hemorrhagic venous complications are very rare and often grouped as all hemorrhagic complications. We report the clinical cases of 2 patients with Parkinson's disease (PD) who received unilateral globus pallidus DBS and developed hemorrhagic venous infarctions. In t...

The Relationship Between Vasoactive-Inotropic Score and Mortality in the Adult Patients with Traumatic Brain Injury Managed in the Intensive Care Unit.

Traumatic Brain Injury(TBI) is one of the leading causes of mortality. Vasoactive and inotropic drugs are commonly administered in these patients in case of hypotension. We aim to assess the feasibility of the Vasoactive-Inotropic Score(VIS) in determining the amount of vasoactive support and its relationship with the mortality rate.

Addressing occupational stress among health staff in nongovernment controlled Northern Syria: Supporting resilience in a dangerous workplace.

Syrian medical staff working in non-government controlled areas of Syria operate in situations that expose them to great personal danger, while they must often face the same challenges as the people they help. Supporting the wellbeing of these staff is crucial to the operation of health services for internally displaced Syrians given the large-scale destruction of healthcare infrastructure.

SIRT4 regulates PTEN stability through IDE in response to cellular stresses.

Tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) plays a critical role in regulating cell survival, cell growth, and proliferation by antagonizing the PI3K-AKT-mTOR pathway. The regulatory mechanism of PTEN protein is still not completely understood. Here, we found that Sirtuin 4 (SIRT4) interacts with PTEN and regulates its stability. Overexpression of SIRT4 in cell...

Expert Preferences for Categorical, Dimensional, and Mixed/Hybrid Approaches to Personality Disorder Diagnosis.

The authors asked 361 personality disorder experts to rank order their preferences for a categorical, dimensional, or mixed/hybrid approach to personality disorder diagnosis in manuals such as the DSM and ICD. Respondents reported a general preference for the mixed/hybrid approach over a purely dimensional approach, and a clear preference against a categorical model. Although there were some stati...

A Meta-Structural Model of Common Clinical Disorder and Personality Disorder Symptoms.

A large and consistent research literature demonstrates the superiority of dimensional models of mental disorder. Factor analytic research has mapped the latent dimensions underlying separate sets of mental disorders (e.g., emotional disorders), but a common framework-unencumbered by arbitrary historical boundaries between disorder groups-requires additional research. Using empirically derived mea...

"I just want to be skinny.": A content analysis of tweets expressing eating disorder symptoms.

There is increasing concern about online communities that promote eating disorder (ED) behaviors through messages and/or images that encourage a "thin ideal" (i.e., promotion of thinness as attractive) and harmful weight loss/weight control practices. The purpose of this paper is to assess the content of body image and ED-related content on Twitter and provide a deeper understanding of EDs that ma...

Non-Apnea Sleep Disorder associates with increased risk of incident heart failure-A nationwide population-based cohort study.

Non-apnea sleep disorder (NASD) increases the risk of cardiovascular events, such as hypertension and ischemic heart disease (IHD). Patients with heart failure (HF) are at higher risk for sleep disorder; however, there is no documentation on NASD's association with HF to date. Therefore, our study aimed to determine whether NASD increases the risk of incident HF.

Genome-scale identification, classification, and tissue specific expression analysis of late embryogenesis abundant (LEA) genes under abiotic stress conditions in Sorghum bicolor L.

Late embryogenesis abundant (LEA) proteins, the space fillers or molecular shields, are the hydrophilic protective proteins which play an important role during plant development and abiotic stress. The systematic survey and characterization revealed a total of 68 LEA genes, belonging to 8 families in Sorghum bicolor. The LEA-2, a typical hydrophobic family is the most abundant family. All of them ...

Low CO2 induces urea cycle intermediate accumulation in Arabidopsis thaliana.

The non-proteinogenic amino acid ornithine links several stress response pathways. From a previous study we know that ornithine accumulates in response to low CO2. To investigate ornithine accumulation in plants, we shifted plants to either low CO2 or low light. Both conditions increased carbon limitation, but only low CO2 also increased the rate of photorespiration. Changes in metabolite profiles...

Ion Torrent and lllumina, two complementary RNA-seq platforms for constructing the holm oak (Quercus ilex) transcriptome.

Transcriptome analysis is widely used in plant biology research to explore gene expression across a large variety of biological contexts such as those related to environmental stress and plant-pathogen interaction. Currently, next generation sequencing platforms are used to obtain a high amount of raw data to build the transcriptome of any plant. Here, we compare Illumina and Ion Torrent sequencin...

Housing and road transport modify the brain neurotransmitter systems of pigs: Do pigs raised in different conditions cope differently with unknown environments?

How housing and transport conditions may affect welfare in porcine production is a leading topic in livestock research. This study investigated whether pigs present a different neurological response to management conditions and to ascertain whether pigs living partially outdoors cope differently with road transport-associated stress. Twenty-four female pigs were divided in two groups: one living i...

Advertisement
Quick Search
Advertisement
Advertisement

 

review and buy Stress market research data and corporate reports here