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The Top 100 Pharmaceutical Companies Research

09:46 EDT 19th August 2018 | BioPortfolio

Kinetics and growth mechanism of the photoinduced synthesis of silver nanoparticles stabilized with lysozyme.

A fast and single-step procedure is reported for the preparation of stable solutions of spherical-shaped silver nanoparticles (AgNPs) coated with lysozyme (LZ). The preparation of the AgNP@LZ nanocomposites was based on the reduction of Ag with ketyl radicals photo-generated by the UVA-photolysis of the benzoin I-2959. Both reaction precursors bind to LZ, modifying its superficial charge and confo...

Regulation of Vasoactive Intestinal Peptide Receptor (VPAC) Signaling in Undifferentiated Hen Granulosa Cells.

Ovarian follicle granulosa cells (GC) and theca tissue from the domestic hen express the vasoactive intestinal peptide (VIP) receptors, VPAC1 and VPAC2, from the early stages of follicle growth (3-5 mm diameter) through the time of ovulation (Kim and Johnson, 2016). This article is protected by copyright. All rights reserved.

Small-scale forestry and carbon offset markets: An empirical study of Vermont Current Use forest landowner willingness to accept carbon credit programs.

This study investigates the preferences of small forest landowners regarding forest carbon credit programs while documenting characteristics of potentially successful frameworks. We designed hypothetical carbon credit programs with aggregated carbon offset projects and requirements of existing voluntary and compliance protocols in mind. We administered a mail survey to 992 forest landowners in Ver...

Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients.

Phenytoin (PHE) and carbamazepine (CBZ) are first rank causative drugs that can induce drug rash with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Identification of anti-epileptic drugs as a culprit drug has been problematic; hence, in vitro tests could be promising methods to define causative drugs without clinical risk. The aim of ...

Novel compound heterozygous ABCC2 variants in patients with Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy.

A novel "six stitches" procedures for pediatric and adult buried penis.

The buried penis, if not treated before adolescence, will lead to psychological and physical disorders in adulthood. Therefore, early surgical intervention is necessary. At present, the common surgical methods include the penile corpus fixation, the Johnson's operation, the Devine's method, the modified Devine's method, Shiraki's method, etc. However, we found that these traditional surgeries show...

Assessing the Economic Benefits of Flood Defenses: A Repeat-Sales Approach.

In this article we identify the impact of the construction of flood defenses on property prices using a difference-in-differences repeat-sales methodology. Our data set contains information on over 12 million individual property transactions, which is merged with GIS data identifying the spatial location and main characteristics of 1,666 flood defenses built in England between 1995 and 2014. Resul...

Aluminum phosphide poisoning in Saudi Arabia over a nine-year period.

Aluminum phosphide (AlP) is an insecticide and rodenticide used to protect stored grains from rodents and other household pests. This substance is highly toxic to humans and has been the cause of many accidental and intentional deaths due in part to poor regulation of sales and distribution in many countries.

Challenges toward achieving universal health coverage in Ghana, Kenya, Nigeria, and Tanzania.

Although many sub-Saharan African countries have made efforts to provide universal health coverage (UHC) for their citizens, several of these initiatives have achieved little success. This study aims to review the challenges facing UHC in Ghana, Kenya, Nigeria, and Tanzania, and to suggest program or policy changes that might bolster UHC. Routine data reported by the World Bank and World Health Or...

Direct, indirect and total effectiveness of bivalent HPV vaccine in women in Galicia, Spain.

Bivalent human papillomavirus (HPV) vaccine was incorporated into the childhood vaccination calendar in Galicia, Spain in 2008. The objectives of this study were to estimate direct, indirect and total effectiveness of HPV vaccine and to identify sexual habits changes in the post-vaccination period in Galicia, Spain.Endocervical scrapings of 745 women attending 7 Health Areas of the Galician Public...

Are All Teaching Activities Valued the Same? Their Relative Worth Is in the Eye of the Beholder.

The pressures for generating revenue from clinical activities dissuade clinician-educators from teaching; taking the steps to develop an educational value system is a way to recognize and perhaps support education. We compared the perceived educational value of diverse pedagogical activities during clinical training from students, residents, and faculty in medical and surgical specialties.

Assessing the feasibility of carbon payments and Payments for Ecosystem Services to reduce livestock grazing pressure on saltmarshes.

Saltmarshes provide important services including flood control, climate regulation, and provisioning services when grazed by livestock for agriculture and conservation purposes. Grazing diminishes aboveground carbon, creating a trade-off between these two services. Furthermore, saltmarshes are threatened by overgrazing. To provide saltmarsh protection and ensure the continuing delivery of ecosyste...

Stevens-Johnson Syndrome: A Challenging Diagnosis.

Stevens-Johnson syndrome is a rare, yet life-threatening, delayed-type hypersensitivity reaction characterized by mucocutaneous epidermal necrolysis. Toxic epidermal necrolysis is a severe manifestation of Stevens-Johnson syndrome, defined as greater than 30% skin detachment. Stevens-Johnson syndrome with toxic epidermal necrolysis is characterized as an adverse cutaneous drug reaction and is asso...

E-cigarettes in airports and on flights: Europe and the US.

While progress has been made to create smoke-free airports, sales of e-cigarettes at airports and airplanes and the presence of advertisements might detract from these smoke-free policies. The objective of this study is to describe the presence of policies, advertising, sales and use of e-cigarettes in airports and on flights in Europe and the US.

Greening the Operating Room: Results of a Scalable Initiative to Reduce Waste and Recover Supply Costs.

Operating rooms generate 42% of a hospital's revenue and 30% of hospital waste. Supply costs are 56% of a total operating room (OR) budget. US academic medical centers use 2 million pounds ($15 million) of recoverable medical supplies annually. Forming a multidisciplinary leadership team, we analyzed sources of waste focusing on our Department of Neurosurgery. We developed an 8-wk pilot project to...

A summative evaluation of productivity and accomplishments of Robert Wood Johnson Foundation Nurse Faculty Scholars Program participants.

From 2008 to 2017, the Robert Wood Johnson Foundation Nurse Faculty Scholars Program inspired, developed, and supported cohorts of next generation national leaders in academic nursing through career development awards. With support from mentors, scholars in the program created individual development plans focused on scholarship, teaching, service, and leadership. The curriculum of the scholar deve...

Open access? Widening access to Chimeric Antigen Receptor (CAR) therapy for ALL.

T cells that are genetically modified to express chimeric antigen receptors (CARs) specific for CD19 show great promise for the treatment of relapsed/refractory acute lymphoblastic leukaemia (ALL). The first FDA approval of a cellular cancer therapy in 2017, i.e. Novartis' CD19-targeting CAR T cell product Kymriah™ within the context of relapsed/refractory paediatric ALL, followed rapidly by app...

Correction: Cost and Revenue Relationship in Orthopaedic and Trauma Surgery Patients in Relation to Body Mass Index.

Introduction of Pieter T. J. Johnson, recipient of the Henry Baldwin Ward Medal for 2018.

Not applicable.

Adoption and learning across hospitals: The case of a revenue-generating practice.

Performance-raising practices tend to diffuse slowly in the health care sector. To understand how incentives drive adoption, I study a practice that generates revenue for hospitals: submitting detailed documentation about patients. After a 2008 reform, hospitals could raise their Medicare revenue over 2% by always specifying a patient's type of heart failure. Hospitals only captured around half of...

Pricing Mechanism With Noncooperative Game and Revenue Sharing Contract in Electricity Market.

In this paper, a pricing mechanism is proposed for the electricity supply chain, which is consisting of one generation company (GC), multiple consumers, and competing utility companies (UCs). The UC participates in electricity supply chain management by a revenue sharing contract (RSC). In the electricity supply chain, the electricity real-time balance has an important role in the stable operation...

Severe skin toxicity with organ damage under the combination of targeted therapy following immunotherapy in metastatic melanoma.

Targeted therapy combination (TTC: antiRAF+antiMEK) is known to improve metastatic melanoma survival. Few severe skin toxicities (grade ≥3) are described with first-line TTC (17% for vemurafenib+cobimetinib and none for dabrafenib+trametinib) in a phase III trial. Among our 42 patients treated by TTC between January 2014 and March 2017, 4.8% (2/42) of those treated in the first line presented se...

'A smile is most important.' Why chains are not currently the answer to quality concerns in the Indian retail pharmacy sector.

Chain pharmacies are expanding in many low and middle-income countries (LMICs). Historically practices of independent pharmacies in these settings have been poor, and there is a need to understand how these new organisational arrangements are affecting the functioning of pharmacies, and the implications for public health. Drawing on economics literature, we develop a set of hypotheses as to how ch...

Microbial keratitis in Stevens-Johnson syndrome: Clinical and microbiological profile.

To study the clinical and microbiological profile of microbial keratitis in Stevens-Johnson syndrome (SJS).

Internal quality assurance of HIL indices on Roche Cobas c702.

Automatic assessment of hemoglobin (H), lipaemia (L) and icterus (I) in serum or plasma (HIL indices) is the mainstay for evaluating sample quality. We planned this study to verify whether in-house prepared internal quality control (IQC) materials may be suitable for quality assurance of HIL indices. Pools containing different values of each of the three HIL indices were prepared from routine plas...

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