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The Top 100 Pharmaceutical Companies Research

22:49 EDT 25th May 2018 | BioPortfolio

Metagenomic analysis of viruses associated with maize lethal necrosis in Kenya.

Maize lethal necrosis is caused by a synergistic co-infection of Maize chlorotic mottle virus (MCMV) and a specific member of the Potyviridae, such as Sugarcane mosaic virus (SCMV), Wheat streak mosaic virus (WSMV) or Johnson grass mosaic virus (JGMV). Typical maize lethal necrosis symptoms include severe yellowing and leaf drying from the edges. In Kenya, we detected plants showing typical and at...

Debunking key assumptions about teams: The role of culture.

Scholars have argued that if psychologists are to gain a true understanding of human behavior, culture should be central to research and theory. The research on teams is an area where better integration between the mainstream and cross-cultural literatures is critically needed, given the increasing prevalence of multicultural teams. The purpose of this article is therefore to demonstrate how resea...

First grade classroom-level adversity: Associations with teaching practices, academic skills, and executive functioning.

Using data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development and a model-building approach, the authors examined direct and indirect associations between first-grade (G1) classroom-level adversity (CLA), G1 teaching practices, and student (N = 1,073; M = 6.64 years; 49% girls; 82% White) academic skills and executive functioning in G1...

Energy drink exposures reported to Texas poison centers: Analysis of adverse incidents in relation to total sales, 2010-2014.

The ill-defined term "energy drink" includes a disparate group of products (beverages, shots, concentrates, and workout powders) having large differences in caffeine content and concentration and intended use. Hence, inaccurate conclusions may be drawn when describing adverse events associated with "energy drinks". The FDA is considering new regulation of these products but product specificity is ...

The molecular allergology of subtropical grass pollen.

Grass pollens are amongst the most important aeroallergen sources world-wide triggering allergic rhinoconjunctivitis and asthma in sensitised patients. Much of what we know about the allergen components of grasses is informed by research on pollen of temperate (Pooideae) species that are abundant in the temperate climate zones. However, climate changes are altering the biogeographical distribution...

Management of postpartum hemorrhage with free-flow pressure controlled uterine balloon.

The free-flow pressure controlled uterine balloon (Ellavi UBT; Sinapi biomedical, Stellenbosch, South Africa) allows the expulsion of water from the balloon to reduce volume and pressure control by adjusting the height of the supply bag above the patient. The balloon can be filled to a capacity of 750 mL without requiring expansion pressure. The device is affordable for use in lesser resourced cou...

Developmental Transactions Between Self-Regulation and Academic Achievement Among Low-Income African American and Latino Children.

This study examined the development of emerging self-regulation (SR) skills across the preschool years and relations to academic achievement in kindergarten and first grade. SR skills of 403 low-income African American and Latino children were measured at 2&1/2, 3&1/2, and 5 years (kindergarten). Reading and math skills were measured at 5 and 6 years (first grade) using the Woodcock-Johnson. Tra...

Case Study: Developing an In-House Magnetic Resonance Imaging Maintenance Program.

In 2015, the Children's Hospital of Eastern Ontario (CHEO) developed an in-house magnetic resonance imaging service team. Within two years, the team achieved substantial savings in operational costs, generated new revenue, improved uptime and response time, and improved customer satisfaction within the hospital. Through careful planning and collaboration, the Clinical Engineering Department at CHE...

Evaluation of the Impact of Shandong Illegal Vaccine Sales Incident on Immunizations in China.

A case of illegal vaccine sales in Shandong province, China, (hereinafter, the incident), which caused a lack of confidence among vaccination recipients and public panic, was uncovered in March 2016. We conducted a study comprising two cross-sectional surveys: at two months (May 2016) and seven months (October 2016) after the incident. The study aimed to evaluate the impact on immunizations; inves...

Mild Bilateral Hemorrhagic Occlusive Retinal Vasculitis Following Intracameral Vancomycin Administration in Cataract Surgery.

A patient underwent cataract surgery with prophylactic intracameral vancomycin (Vancocin; Pfizer, New York City, NY) in each eye, 2 weeks apart. Four weeks after, the patient presented with a mild bilateral hemorrhagic occlusive retinal vasculitis (HORV). A systemic work-up was negative for syphilis, toxoplasmosis, Bartonella, tuberculosis, and sarcoidosis. The patient was treated with oral steroi...

Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis: a multicenter retrospective study of 377 adult patients from the United States.

Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported. This multicenter retrospective study included patients with SJS/TEN seen by inpatient consultative dermatologists at 18 academic medical centers in the United States. 377 adult patients with SJS/TEN between 1/1/2000 and 6/1/2015 were entered, including 69.0% fro...

Pollen Collection, Honey Production, and Pollination Services: Managing Honey Bees in an Agricultural Setting.

Hybrid canola seed production is an important pollination market in Canada; typically both honey bees (Apis mellifera L. (Hymenoptera: Apidae)) and Alfalfa Leafcutting bees (Megachile rotundata Fab. (Hymenoptera: Megachilidae)) are concurrently managed to ensure pollination in this high-value crop. Beekeepers are paid to provide pollination services, and the colonies also produce a honey crop from...

Vismodegib and the Hedgehog Pathway Inhibitors: A Historical Perspective to Current Clinical Application.

Vismodegib (Erivedge, Genentech-Roche) is the first in class of Hedgehog pathway inhibitors approved for treatment of metastatic basal cell carcinoma (BCC), or locally advanced BCC that has recurred after surgery or is not amenable to surgery or radiation. Its path to discovery has been unique and traces its origin to corn lilies, sheep, Drosophila flies, and the Hedgehog signaling pathway. J Drug...

The Unsustainable Cost of Medicaid: Insights from a Hospital-Based Academic Dermatology Practice.

To investigate the lost revenue associated with Medicaid patients in a university-based dermatology practice over a one-year period compared to non-Medicaid patients. Specifically, the goal was to investigate the change in revenue if Medicaid visits were associated with a range of copayments.

Measurement Differences Between Two Immunoassay Systems for LH and FSH: A Comparison of Roche Cobas e601 vs. Abbott Architect i2000sr.

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) regulate the growth and reproductive activity of gonadal tissue and determine the concentration of LH is essential for the prediction of ovulation. Collectively, FSH and LH are important measurements to ascertain the causes of infertility as well as diagnosing disorders such as polycystic ovary syndrome and pituitary and gonadal dysfu...

Response: The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs: Comment on data sparsity.

The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs: Comment on data sparsity.

Direct Sodium Channel Regulation by Calmodulin.

Many aspects of the sophisticated mechanism of sodium channel regulation by Ca and calmodulin remain unresolved and controversial. In this issue of Structure, Johnson et al. (2018) provide compelling structural and functional evidence clarifying considerably how calmodulin engages the inactivation gate of the sodium channel and the consequences for regulation.

A Pilot Experiment in Responding to Individual Patient Requests for Compassionate Use of an Unapproved Drug: The Compassionate Use Advisory Committee (CompAC).

Janssen Research & Development, LLC, part of the Janssen pharmaceutical companies of Johnson & Johnson, and NYU School of Medicine partnered to establish the Compassionate Use Advisory Committee (CompAC) to evaluate the use of an independent, external, expert committee in ensuring transparent, fair, beneficent, evidence-based, and patient-focused compassionate access to investigational medicines, ...

How Often Do Safety Signals Occur by Chance in First-in-Human Trials?

Clinicians working on first-in-human clinical studies need to be able to judge whether safety signals observed on an investigational drug were more likely to have occurred by chance or to have been caused by the drug. We retrospectively reviewed 84 Novartis studies including 1,234 healthy volunteers receiving placebo to determine the expected incidence of changes in commonly measured laboratory pa...

Short-Term effect of outdoor mold spore exposure on prescribed allergy medication sales in Central France.

Outdoor molds are classically associated with exacerbations of asthma.

Letter--Incorporating Real-World Evidence and Patient Value Criteria into Value-Based Frameworks for Relapsed/Refractory Multiple Myeloma.

Orlowski has received research funding from Amgen, BioTheryX, Bristol-Myers Squibb, Celgene Corporation, and Takeda Pharmaceuticals; honoraria from Amgen, Bristol-Myers Squibb, Celgene Corporation, Janssen, Millennium Pharmaceuticals, and Onyx Pharmaceuticals; and is a member of advisory boards for Amgen, Bristol-Myers Squibb, Celgene Corporation, Incyte, Kite, Legend Biotech, Sanofi-Aventis, and ...

A comprehensive examination of own- and cross-price elasticities of tobacco and nicotine replacement products in the U.S.

While much is known about the demand for cigarettes, research on the demand for non-cigarette tobacco products and the cross-price impacts among those products is limited. This study aims to comprehensively examine the own- and cross-price elasticities of demand for tobacco and nicotine replacement products (NRPs) in the U.S. We analyzed market-level quarterly data on sales and prices of 15 differ...

Measurement of emotional contagion using synchronization of heart rhythm pattern between two persons: Application to sales managers and sales force synchronization.

The purpose of this study was to measure emotional contagion, determine its direction, and compare the intensity between positive and negative contagion using the synchronization of heart rhythm pattern (HRP). A total of 64 undergraduate students (32 women and 32 men) participated in the experiment, and were randomly categorized as either leaders or followers. Followers were required to imitate th...

Donated chemical probes for open science.

Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated da...

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