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The Top 100 Pharmaceutical Companies Research

03:56 EST 14th December 2018 | BioPortfolio

Multiple-therapy-resistant major depressive disorder: a clinically important concept.

SummaryMany novel therapeutic options for depression exist that are either not mentioned in clinical guidelines or recommended only for use in highly specialist services. The challenge faced by clinicians is when it might be appropriate to consider such 'non-standard' interventions. This analysis proposes a framework to aid this decision.Declaration of interestIn the past 3 years R.H.M.W. has rece...

Over-the-counter Weight-Loss Herbal Supplements in Egypt: Label Claim, Microbiological, Pharmaceutical Quality and Safety Assessments.

Nutraceuticals are advertised and sold with the label claim of being natural and safe herbal products. Due to the absence of clear regulations and guidelines for safety assessments of these products, nutraceuticals are commonly adulterated in order to increase sales. The objective of the current study was to design a comprehensive evaluation system to assess the safety, efficacy, authenticity acco...

When results matter: reliable creatinine concentrations in hyperbilirubinemia patients.

Background Failure to report a creatinine concentration, especially in icteric patients who are eligible for a liver transplant, can result in a life-threatening situation. We assessed the influence of bilirubin interference on several creatinine assays and investigated ways to circumvent icteric interference without interfering with our normal automated sample logistics. Methods Using icteric pat...

How to Join a Board: A Practical Guide.

In October 2010, the Institute of Medicine and the Robert Wood Johnson Foundation released The Future of Nursing report. One way that "Recommendation 7: Prepare and enable nurses to lead change and advance health" has been operationalized has been placing nurses on boards, and nursing organizations have urged their constituents to serve in this capacity. This article outlines steps for obtaining a...

Severe Dry Eye With Combined Mechanisms is Involved in the Ocular Sequelae of SJS/TEN at the Chronic Stage.

Stevens-Johnson syndrome (SJS), and its more severe variant, toxic epidermal necrolysis (TEN), are life-threatening diseases of the skin and mucous membranes. After the acute-stage damage subsides, serious visual impairment and severe dry eye remains as ocular sequelae. At the acute stage, ocular complications occur in 77% of SJS/TEN patients. In cases with pseudomembranous formation and/or epithe...

Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute inflammatory vesiculobullous reactions of the mucosa of the ocular surface, oral cavity, and genitals, and of the skin. Severe ocular complications (SOC) are present in about half of SJS/TEN patients diagnosed by dermatologists. We review our group's findings on the genetic predisposition for and the etiology of SJS/TEN ...

U.S. county prevalence of retail prescription opioid sales and opioid-related hospitalizations from 2011 to 2014.

The role of prescription opioids in the opioid crisis has been well established. How the prevalence of prescription opioids relates to opioid hospitalizations has been understudied. Hospitalizations due to opioids are a distinct indicator of opioid misuse, have cost implications for health care systems, and may be an entry point into substance use treatment.

Blue skies over China: The effect of pollution-control on solar power generation and revenues.

Air pollution is the single most important environmental health risk, causing about 7 million premature deaths annually worldwide. China is the world's largest emitter of anthropogenic air pollutants, which causes major negative health consequences. The Chinese government has implemented several policies to reduce air pollution, with success in some but far from all sectors. In addition to the hea...

An algorithm for fragment-aware virtual network reconfiguration.

In view of the fact that the current online virtual network embedding algorithms do not consider the fragment resources generated in the embedding process deeply enough, resulting in the problem that the acceptance ratio and the revenue to cost ratio are both low, a mathematical model for virtual network reconfiguration is constructed and a heuristic algorithm for fragment-aware virtual network re...

Establishing company level fishing revenue and profit losses from fisheries: A bottom-up approach.

A third of global fish stocks are overexploited and many are economically underperforming, resulting in potential unrealized net economic benefits of USD 51 to 83 billion annually. However, this aggregate view, while useful for global policy discussion, may obscure the view for those actors who engage at a regional level. Therefore, we develop a method to associate large companies with their fishi...

Crop diversity and stability of revenue on farms in Central Europe: An analysis of big data from a comprehensive agricultural census in Bavaria.

Diversity of agricultural landscapes is important to maintain the provision of ecosystem services. In face of decreasing support measures for agricultural markets in the European Union, diversified crop portfolios could also offer a possibility to stabilize revenue at farm level (portfolio effect). We hypothesize that (i) diversity of crop portfolios changes along spatial gradients in the study ar...

Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study.

Cutaneous adverse reactions are frequently induced by mogamulizumab. Cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and severe photosensitivity related to mogamulizumab have been reported. This study investigated whether severe radiation-induced dermatitis occurred in patients undergoing radiotherapy after the administration of mogamulizumab for adult T-cell leukaemia/lymphoma.

Citation for the 2017 Down Surgical Prize - Paul Johnson.

The relationship between pharmacy benefit managers (PBMs) and the cost of therapies in the US pharmaceutical market: A policy primer for clinicians.

Pharmaceutical benefit managers (PBMs) are playing an increasingly important role in establishing access to pharmaceutical products for patients. PBMs set retail prices for pharmaceutical products, negotiate "rebates" from manufacturers based on total sales volume of products, and achieve several types of postsale price concessions and payments from pharmacies. All of these activities describe a c...

Maintaining vs. milking good reputation when customer feedback is inaccurate.

In Internet transactions, customers and service providers often interact once and anonymously. To prevent deceptive behavior a reputation system is particularly important to reduce information asymmetries about the quality of the offered product or service. In this study we examine the effectiveness of a reputation system to reduce information asymmetries when customers may make mistakes in judgin...

Vape shop location and marketing in the context of the Food and Drug Administration regulation.

A range of electronic nicotine delivery systems (ENDSs; e.g. e-cigarettes, e-hookahs) have emerged in the US market, with rapid increases in use. While ENDSs may facilitate harm reduction in smokers, they may represent risks to health and addiction in the nicotine naïve. Vape shops account for a substantial proportion of ENDS sales/distribution.

32 Shades of Neuroethics-A Review of the Routledge Handbook of Neuroethics, edited by L. Syd M Johnson and Karen S. Rommelfanger.

Optimization of DNA isolation method from Formalin-Fixed-Paraffin-Embedded tissues (FFPE) and comparative performance of four different Polymerase Chain Reaction (PCR) kits.

The tissue sample may have important genetic information in diagnostic, prognostic and counselling issues. Formalin-Fixed-Paraffin-Embedded (FFPE) is a routine method for preserving tissues. However, DNA isolated from FFPE tissue is often difficult to be amplified in PCR due to fragmentation and DNA-protein crosslinks. This study aimed to optimize the DNA isolation method from FFPE tissue and comp...

Childbirth-Specific Patient-Reported Outcomes as Predictors of Hospital Satisfaction.

Under value-based payment programs, patient-reported experiences and outcomes (PROs) can impact hospital and physician revenue. To enable obstetrical providers to improve the childbirth experience, a framework for understanding what women expect and desire during childbirth is needed.

The revenue from finger replantation and revision amputation: Is it cost-covering?

Finger amputation injuries are frequently treated conditions in occupational accident hospitals. They are either treated by replantation or revision amputation. The costs of these two treatment options differ significantly. This study aims to determine if the revenue generated from the treatment of finger amputation injuries in the German DRG system is cost-covering and if there are differences de...

Emicizumab for routine prophylaxis to prevent bleeding episodes in patients with hemophilia A.

Hemophilia A is an X-linked bleeding disorder caused by defects in the gene encoding factor VIII (FVIII). Routine prophylaxis with exogenous FVIII requires frequent intravenous injections. One of the most challenging issues in the treatment of hemophilia A is the development of alloantibodies against infused FVIII. Presence of inhibitors results in an ineffective factor replacement therapy and inc...

Life sciences licensing deals in the second quarter of 2018: updates and trends.

During the second quarter of 2018, Cortellis Competitive Intelligence registered 985 new deals (excluding mergers and acquisitions) with a total disclosed deal value of USD 19.5 billion as part of its ongoing coverage of licensing activity in the life sciences sector compared to 964 and USD 35.6 billion in the first quarter and 1,104 and USD 13.6 billion in the second quarter of 2017. Total deal v...

Stevens-Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: An analysis of the US Food and Drug Administration Adverse Event Reporting System.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and potentially fatal adverse skin reactions that are most commonly triggered by certain medications. One class of medications that has been highly associated with SJS/TEN reactions is antiepileptic drugs (AEDs). We sought to quantify the risk of SJS/TEN associated with AEDs as a class, as well as individual AEDs, in the ...

Idiopathic Stevens-Johnson syndrome and toxic epidermal necrolysis: prevalence and patients characteristics.

Law enforcement practices in the first two states in U.S. to legalize recreational marijuana.

There is a lack of research regarding law enforcement practices where recreational marijuana sales are legal. Given that legalization of recreational marijuana is expanding, lessons learned from areas with existing legalization can help inform future practices. This pilot study is an evaluation of enforcement of marijuana laws in the first two states in the U.S. to legalize sales of recreational m...

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