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Top Pharmaceutical Companies in India Research

00:37 EST 14th November 2018 | BioPortfolio

Significant allelic dropout phenomenon of Oncomine BRCA Research Assay on Ion Torrent S5.

Effect of an Emollient on the Mycobiome of Atopic Dermatitis Patients.

Atopic dermatitis (AD) is associated with changes in skin bacterial microbiome. Emollient treatment induces change in bacterial microbiome in AD, but its effect on fungal microbiome ("mycobiome") and their inter-kingdom correlations is unknown. We used Ion-Torrent sequencing to characterize the mycobiome of AD patients in response to emollient treatment.

Lupin seed hydrolysate promotes G-protein-coupled receptor, intracellular Ca and enhanced glycolytic metabolism-mediated insulin secretion from BRIN-BD11 pancreatic beta cells.

Lupin seed proteins have been reported to exhibit hypoglycaemic effects in animals and humans following oral administration, however little is known about its mechanism of action. This study investigated the signalling pathway(s) responsible for the insulinotropic effect of the hydrolysate obtained from lupin (Lupinus angustifolius L.) seed extracts utilizing BRIN-BD11 β-cells. The extract was tr...

Interaction of γ-conglutin from Lupinus albus with model phospholipid membranes: Investigations on structure, thermal stability and oligomerization status.

Interaction with model phospholipid membranes of lupin seed γ-conglutin, a glycaemia-lowering protein from Lupinus albus seeds, has been studied by means of Fourier-Transform infrared spectroscopy at pH 7.0 and at pH 4.5. The protein maintains the same secondary structure both at pH 7.0 and at pH 4.5, but at pH 7.0 a higher H/H exchange was observed, indicating a greater solvent accessibility. Th...

Lupin: An Emerging Food Allergen in the United States.

Promising effect of rapamycin on multiple sclerosis.

The routine therapies for relapsing-remitting multiple sclerosis (RRMS) are common disease-modifying medications, yet are not effective in all patients. The aim of the present clinical trial was to evaluate the therapeutic effects of rapamycin on the clinical and radiological aspects, regulatory T cells proliferation and FOXP3 and GARP gene expression in the patients with RRMS. In this study, eigh...

Biocon's target factory.

Suitability of open-access elevation models for micro-scale watershed planning.

Watershed planning is a major issue in Turkey and other parts of the world. Surrounded by seawater on almost three-quarters of its international borders and by sheer mountains along the coastal regions and throughout the country, Turkey experiences a range of climatic changes, which constantly shape its topography. Recently, the occurrences of floods, landslides, and torrents have increased, forci...

Assessing plant-available glyphosate in contrasting soils by diffusive gradient in thin-films technique (DGT).

Glyphosate represents one quarter of global herbicide sales, with growing interest in both its fate in soils and potential to cause non-target phytotoxicity to plants. However, assessing glyphosate bioavailability to plants from soil residues remains challenging. Here we demonstrate that the diffusive gradient in thin-films technique (DGT) can effectively measure available glyphosate across bounda...

Honoring eight senior distinguished plant biologists from India.

We summarize here research contributions of eight stalwarts in photosynthesis research from India. These distinguished scientists (Shree Kumar Apte, Basanti Biswal, Udaya C. Biswal, Agepati S. Raghavendra, Attipalli Ramachandra Reddy, Prafullachandra Vishnu (Raj) Sane, Baishnab Charan Tripathy, and Dinesh C. Uprety) were honored on November 2, 2017, at the School of Life Sciences, University of Hy...

The Case: Chronic Kidney Disease Unmasked by Single-Subject Research.

We present a 42-year-old man with a BMI of 32, who was referred because of proteinuria and decreased renal function. We were impressed by his markedly muscular physique. A renal biopsy was performed, which showed focal segmental glomerular sclerosis (FSGS). Is this patient merely an obese person with FSGS or is something else going on here? We performed extensive clinical and laboratory examinatio...

Evaluating the effects of check dams on channel geometry, bed sediment size and riparian vegetation in Mediterranean mountain torrents.

In mountain streams possible negative impacts of check dams on soil, water and riparian vegetation due to check dam installation can be noticed. In spite of the ample literature on the qualitative effects of engineering works on channel hydrology, morphology, sedimentary effects and riparian vegetation characteristics, quantitative evaluations of the changes induced by check dams on headwater char...

Biomolecules-mediated synthesis of selenium nanoparticles using Aspergillus oryzae fermented Lupin extract and gamma radiation for hindering the growth of some multidrug-resistant bacteria and pathogenic fungi.

Biosynthesis of nanoparticles by fermented plants using microbes is an eco-friendly and cost-effective process. In this study, we used the fungus Aspergillus orayzae for the fermentation process. The aqueous extract of fermented Lupin (AEFL) possesses the ability to reduce selenium ion in the presence of gamma rays evidenced by the color changes to red. Elemental composition, surface morphology, a...

Super High Resolution for Single Molecule-Sequence-Based Typing of Classical HLA Loci Using Ion Torrent PGM.

Super high resolution-single molecule-sequence-based typing (SS-SBT) is an HLA DNA typing method to the field 4 level of allelic resolution (formerly known as 8-digit typing) to efficiently detect novel and null alleles without phase ambiguity by combination of long ranged PCR amplification and next-generation sequencing (NGS) technologies. In this chapter, we describe three basic steps, long rang...

iHART: methodological inconsistency precludes hypoglycemia conclusions.

Recently Diabetic Medicine, Reddy and colleagues published the original article 'A randomized controlled pilot study of continuous glucose monitoring and flash glucose monitoring in people with Type 1 diabetes and impaired awareness of hypoglycaemia' [1]. In the randomized, non-masked parallel group study, 40 adults with Type 1 diabetes using a multiple-dose insulin-injection regimen with a Gold ...

Adaptation of an amplicon-based human cancer next-generation sequencing panel assay for murine tumors.

Unlike humans, inbred genetically engineered mice have minimal inter-individual variation and, consequently, offer substantially increased statistical power for robust definition of recurrent cooperating cancer mutations. While technically feasible, whole exome sequencing is expensive and extremely data-intensive. Somatic mutation analysis using panels of 25-75 genes now provides detailed insight ...

Non-small cell lung cancers with Isocitrate dehydrogenase 1 or 2 (IDH1/2) mutations.

Isocitrate dehydrogenase 1 and 2 (IDH1/2) are important metabolic enzymes that convert isocitrate to α-ketoglutarate. IDH1/2 mutations are associated with the development of multiple malignancies. In this study, we examine the prevalence and features of non-small cell lung cancers (NSCLC) with IDH1/2 mutations. From May 2013 - March 2017, 800 lung cancer samples were successfully sequenced for so...

INDEL variation in the regulatory region of the major flowering time gene LanFTc1 is associated with vernalisation response and flowering time in narrow-leafed lupin (Lupinus angustifolius L.).

Narrow-leafed lupin (Lupinus angustifolius L.) cultivation was transformed by two dominant vernalisation-insensitive, early flowering time loci known as Ku and Julius (Jul), which allowed expansion into shorter season environments. However, reliance on these loci has limited genetic and phenotypic diversity for environmental adaptation in cultivated lupin. We recently predicted that a 1,423 bp del...

Phenolic contents and antioxidant capacities of wild and cultivated white lupin (Lupinus albus L.) seeds.

The aim of this study was to compare the antioxidant capacities and phenolic compound profiles of wild and cultivated Lupinus albus L. seeds. The total phenolic content (TPC), radical scavenging activity, ferric-reducing antioxidant power (FRAP) and antioxidant activity in an β-carotene-linoleic acid emulsion were determined. Liquid chromatography-mass spectrometry was used to identify phenolics....

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