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Women's Health Research

10:17 EST 22nd January 2019 | BioPortfolio

Association of chemotherapy and radiotherapy sequence with overall survival in locoregionally advanced endometrial cancer.

The optimal adjuvant management of women with FIGO Stage III-IVA endometrial cancer (EC) is unclear. While recent prospective data suggest that treatment with pelvic radiotherapy (RT) prior to chemotherapy (CT) is not associated with a survival benefit compared to CT alone, no prospective randomized trial has included a treatment arm in which CT is given before RT.

Effect of Lavender Oil on the Anxiety of Patients Before Breast Surgery.

Anxiety is a common problem before surgery. This study aimed to investigate the effects of inhaling lavender oil on anxiety levels in patients before breast surgery.

Level of exposure to fluorides by the consumption of different types of milk in residents from an area of Mexico with endemic hydrofluorosis.

Several studies have shown the presence of fluorosis (DF) in primary dentition, suggesting an exposure to fluorides (F) in early childhood. Breast milk is recommended as an exclusive food until 6 months of age. Although it is mentioned that only a small amount of F can be eliminated by breast milk, studies have shown the presence of this element in milk of women living in contaminated areas, as we...

Relationship between unexplained recurrent pregnancy loss and 5,10-methylenetetrahydrofolate reductase) polymorphisms.

To investigate the relationship between unexplained recurrent pregnancy loss (URPL) and polymorphisms of folate metabolism-related genes.

Safety of 9-valent human papillomavirus vaccine administration among pregnant women: Adverse event reports in the Vaccine Adverse Event Reporting System (VAERS), 2014-2017.

9-valent human papillomavirus vaccine (9vHPV) was approved by the Food and Drug Administration (FDA) in December 2014. 9vHPV is not recommended during pregnancy, but some women of childbearing age may be inadvertently exposed. This study aims to evaluate reports submitted to the Vaccine Adverse Event Reporting System (VAERS) of pregnant women exposed to 9vHPV.

The Effect of a Subsequent Pregnancy After Ovarian Vein Embolization in Patients with Infertility Caused by Pelvic Congestion Syndrome.

To report the effect of pregnancy on patients who have undergone pelvic vein embolization with pelvic congestion syndrome, which was suspected to be the only cause of infertility.

Initial Clinical Experience with Stationary Digital Breast Tomosynthesis.

A linear array of carbon nanotube-enabled x-ray sources allows for stationary digital breast tomosynthesis (sDBT), during which projection views are collected without the need to move the x-ray tube. This work presents our initial clinical experience with a first-generation sDBT device.

Correlation between pre-admission blood pressure and outcome in a large telestroke cohort.

Telemedicine rapidly connects patients, with acute ischemic stroke symptoms, with neurovascular specialists for assessment to reduce chemical thrombolysis delivery times. Management of AIS includes maintaining target systolic blood pressures (SBP). In this retrospective study, we assess the efficacy of the telestroke (TS) system at a primary stroke center and the prognostic value of SBP throughout...

The effect of length of follow-up on substantial clinical benefit thresholds in patients undergoing surgery for cervical degenerative myelopathy.

Patient-reported outcome measures are increasingly used to access pain, disability, physical function, and mental status to quantify effectiveness of surgical intervention in cervical myelopathy, yet each score has little meaning without established thresholds linked to clinical benefit. We set out to develop thresholds for substantial clinical benefit (SCB) in patients undergoing surgery for cerv...

Efficacy of Thyrotropin-Releasing Hormone Analog for Protracted Disturbance of Consciousness due to Aneurysmal Subarachnoid Hemorrhage.

The efficacy of thyrotropin-releasing hormone tartrate (TRH-T) for treating prolonged disturbance of consciousness due to aneurysmal subarachnoid hemorrhage (SAH) remains unclear. The purpose of the present study was to determine whether TRH-T was really effective, and what was the recovery factor when it was valid. This was a retrospective study of a single facility.

Clinical Characteristics of Borderzone Infarction in Egyptian Population.

In this research we wanted to highlight the importance of defining Borderzone infarctions (BZI) as a separate subtype in stroke classifications. We thus studied cases of isolated BZI, small vessel disease (SVD), and large vessel disease (LVD), to identify their points of similarities and difference in a sample of Egyptian patients.

Contralateral Approach Based on a Preoperative 3-Dimensional Virtual Osteotomy Technique for Anterior Circulation Aneurysms.

Our objective was to review 15 consecutive patients with anterior circulation aneurysms managed through a contralateral approach. Individualized surgical simulation using three-dimensional (3D) imaging was adopted to enable safe performance of clipping surgery.

Mean treatment cost of incident cases of penile cancer for privately insured patients in the United States.

The aims of this study were to estimate the short-term cost of treating newly diagnosed penile cancer and determine the correlates of penile cancer treatment cost in the United States.

Systematic Review of the Effect of Topical Application of Human Breast Milk on Early Umbilical Cord Separation.

To evaluate the efficacy of topical application of human breast milk to reduce umbilical cord separation time.

Perspectives on geriatric oncology research presented at the 2018 San Antonio Breast Cancer Symposium.

Using patient support programs for pregnancy surveillance: Current paradigm, emerging opportunity.

The anticancer properties and mechanism of action of tablysin-15, the RGD-containing disintegrin, in breast cancer cells.

αβ integrin expressed on cancer cell surfaces is associated with important cancer hallmarks including survival and metastasis and is thus a potential anticancer drug target. Tablysin-15 contains the RGD motif and is a high-affinity αβ integrin antagonist. The aim of this study was to investigate the antitumor effect and mechanism of action of tablysin-15 against αβ integrin high-expressing b...

Acetonitrile-assisted enzymatic digestion can facilitate the bottom-up identification of proteins of cancer origin.

The main objective of this study was to develop an effective in-gel trypsin digestion protocol using aqueous-acetonitrile solvent system to facilitate MS analysis and maximize the number of identified proteins from biological samples. The procedure, where 80% acetonitrile was present in the trypsin reaction mixture, increased the number of matched peptides, and allowed the identification of more p...

The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells.

Breast cancer is the most prevalent cancer diagnosis in women, with triple-negative and human epidermal growth factor 2 (HER2)-enriched advanced breast cancers having the poorest prognoses. The morbidity and mortality associated with advanced disease, as well as the emergence of multi-drug resistant variants, highlights the urgency to develop novel therapeutic agents. Artesunate (ART) is a semi-sy...

Melosuavine I, an apoptosis-inducing bisindole alkaloid from Melodinus suaveolens.

A new bisindole alkaloid, melosuavine I (1) possessing an aspidosperma- aspidosperma dimeric skeleton, was isolated from the leaves of Melodinus suaveolens. The structure with absolute configuration of 1 was elucidated by a combination of MS, NMR and computational methods. MTT assays indicated that 1 exhibited significant cytotoxicity on human breast cancer BT549 cells with an IC value of 0.89 ...

Role of Endometrial Sampling in Cases with Asymptomatic Cervical Polyps.

Cervical polyps are benign neoplasms of the cervix and frequently asymptomatic; however, they may cause intermenstrual, postcoital, and postmenopausal bleeding. The excision of cervical polyps and necessity of endometrial sampling is remain controversial. The objective of our study was to determine the association between cervical polyps and smear and endometrial pathologies. 221 patients were inc...

Transcranial direct current stimulation in post-stroke aphasia rehabilitation: a systematic review.

Transcranial direct current stimulation (tDCS) is a non-invasive tool that induces neuromodulation in the brain. Several studies have shown the effectiveness of tDCS in improving language recovery in post-stroke aphasia. However, this innovative technique is not currently used in routine speech and language therapy (SLT) practice.

Role of insulin, adenosine, and adipokine receptors in the foetoplacental vascular dysfunction in gestational diabetes mellitus.

Gestational diabetes mellitus (GDM) is a disease of pregnancy associated with maternal and foetal hyperglycaemia and altered foetoplacental vascular function. Human foetoplacental microvascular and macrovascular endothelium from GDM pregnancy show increased maximal l-arginine transport capacity via the human cationic amino acid transporter 1 (hCAT-1) isoform and nitric oxide (NO) synthesis by the ...

Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active targeting to breast cancer.

An ideal cancer therapy targets the tumor cells selectively without damaging healthy tissues. Even though the tumor-specific markers are limited, these molecules can be used for the delivery of anti-cancer drugs as an active targeting strategy. Since the lymphatic system plays a critical role in the dissemination of cancer cells, the drugs directed through lymphatics can feasibly reach to the site...

Personality and preventive healthcare utilisation: Evidence from the IRISH Longitudinal Study on Ageing.

There is extensive empirical evidence that personality is associated with many outcomes and behaviours, such as educational outcomes, labour market participation, savings behaviour, health behaviours, physical health status and mortality. Use of preventive healthcare services (e.g., vaccinations, screening, etc.) is a potential pathway explaining the link between personality and health, and is an ...

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