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DNA-FISH Probes - Biotech, Pharma and Life Science Channel

18:27 EST 19th January 2017 | BioPortfolio

Fluorescent in situ hybridization (FISH) is a sensitive and accurate technique that allows the detection of chromosome aberrations. In this method, a single-stranded fluorescent-labeled nucleic acid sequence (probe) complementary to a target genomic sequence is hybridized to metaphase chromosomes and interphase nuclei to detect the presence and absence of a given abnormality. FISH complements traditional cytogenetic karyotype analysis.  The chief advantage of FISH is that is can be applied to non-dividing cells and a variety of specimen types.  FISH is a method of choice for diagnosis, prognosis, treatment response, and minimal residual disease detection in hematopoietic neoplasms (leukemia, lymphomas, multiple myeloma, and myelodysplasia) and solid tumors (breast cancer, non-small cell lung cancer, colorectal cancer, and cervical cancer).

Source: http://cancergenetics.com/cgi-research/dna-fish-probes/

PubMed Articles [4876 Associated PubMed Articles listed on BioPortfolio]

Development of a SYBR Green I real-time PCR for the detection of the orf virus.

Orf is a non-systemic, ubiquitous disease of sheep and goats caused by the orf virus (ORFV). ORFV occasionally causes cutaneous lesions in humans in contact with infected animals. In the present study...

Fullerene C60 Penetration into Leukemic Cells and Its Photoinduced Cytotoxic Effects.

Fullerene C60 as a representative of carbon nanocompounds is suggested to be promising agent for application in photodynamic therapy due to its unique physicochemical properties. The goal of this stud...

Mechanism of anti-Vibrio activity of marine probiotic strain Bacillus pumilus H2, and characterization of the active substance.

Vibriosis is a major epizootic disease that impacts free-living and farmed fish species worldwide. Use of probiotics is a promising approach for prevention of Vibrio infections in aquaculture. A probi...

Zika Virus RNA Replication and Persistence in Brain and Placental Tissue.

Zika virus is causally linked with congenital microcephaly and may be associated with pregnancy loss. However, the mechanisms of Zika virus intrauterine transmission and replication and its tropism an...

Occurrence of two novel actinospore types (Cnidaria: Myxosporea) in Brazilian fish farms, and the creation of a novel actinospore collective group, Seisactinomyxon.

The involvement of oligochaetes in the life cycles of fresh water myxozoan parasites in Brazil was investigated. Of 333 oligochaetes collected in a fish farm in the State of São Paulo, three (0.9%) r...

Flow injection microfluidic device with on-line fluorescent derivatization for the determination of Cr(III) and Cr(VI) in water samples after solid phase extraction.

In this paper, a rapid and simple method using magnetic multi-walled carbon nanotubes (MWCNTS), as a solid-phase extraction (SPE) sorbent, was successfully developed for extraction and preconcentratio...

Application of matrix solid-phase dispersion followed by GC-MS/MS to the analysis of emerging contaminants in vegetables.

A multiresidue method for the determination of 17 emerging contaminants in vegetables was developed based on ultrasound-assisted matrix solid-phase dispersion (MSPD). The analysis was performed using ...

A precise and efficient detection of Beta-Cyfluthrin via fluorescent molecularly imprinted polymers with ally fluorescein as functional monomer in agricultural products.

In this study, an effective and precise fluorescent molecularly imprinted polymers (FMIPs) for the determination of Beta-Cyfluthrin (BC) was synthesized via precipitation polymerization with SiO2 as t...

Effect of hydroxytyrosol and olive leaf extract on 1,2-dicarbonyl compounds, hydroxymethylfurfural and advanced glycation endproducts in a biscuit model.

The antiglycative activity of hydroxytyrosol (HT) and olive leaf extract (OLE) was investigated in wheat-flour biscuits. Quercetin (QE) and gallic acid (GA) were used as reference of antiglycative act...

Quantitative analyses of the bacterial microbiota of rearing environment, tilapia and common carp cultured in earthen ponds and inhibitory activity of its lactic acid bacteria on fish spoilage and pathogenic bacteria.

The present study aimed to evaluate the bacterial load of water, Nile Tilapia and common Carp intestines from earthen ponds, isolate lactic acid bacteria (LAB) and assess their antimicrobial activity ...

News Articles [811 Associated News Articles listed on BioPortfolio]

Holy mackerel: FDA warns which fish to avoid when pregnant, breastfeeding

The FDA is out with new guidelines on fish consumption for pregnant women or those who might become pregnant and breastfeeding mothers.

FDA’s new guidelines on fish consumption for pregnant and breastfeeding women

The FDA is out with new guidelines on fish consumption for pregnant women or those who might become pregnant and breastfeeding mothers.

PQ Bypass Announces Schedule of Presentations at LINC 2017

PQ Bypass, a medical technology company pioneering a fully percutaneous bypass treatment for patients with long, complex arterial blockages in the leg due to peripheral artery dis...

Balance May Rely on the Timing of Movement

NEW YORK, Jan. 19, 2017 /PRNewswire-USNewswire/ -- Zebrafish learn to balance by darting forward when they feel wobbly, a principle that may also apply to humans, according to a study led by researche...

Scientists harness rabies viruses for assessing connectivity of nerve cell transplants

Scientists under the leadership of the University of Bonn have harnessed rabies viruses for assessing the connectivity of nerve cell transplants: coupled with a green fluorescent protein, the viruses ...

Morning Break: More Fallout from ACA Repeal; Harvard Lab Follies; How Much Fish?

(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff

AquaBounty Announces Completion of NASDAQ Listing and Equity Subscription from Intrexon

MAYNARD, Mass., Jan. 19, 2017 /PRNewswire/ -- AquaBounty Technologies, Inc. (AIM: ABTU; NASDAQ: AQB), a biotechnology company focused on enhancing productivity in aquaculture and a majority-owned subs...

Rabies viruses reveal wiring in transparent brains

(University of Bonn) Scientists under the leadership of the University of Bonn have harnessed rabies viruses for assessing the connectivity of nerve cell transplants: coupled with a green fluorescent ...

U.S. Gives "Fishy" Advice that Will Expose Babies to Too Much Mercury; Consuming Tuna Not Worth the Risk for Pregnant Women, say Advocates

WASHINGTON, Jan. 18, 2017 /PRNewswire-USNewswire/ -- Pregnant women who follow the new U.S. fish advice will be exposed to far too much mercury, say scientists and advocates.  They maintain that ...

Seal Whiskers Can Detect Weak Water Currents

The marine predators may use the mechanosensory hairs to detect fish that are hiding motionless on the seafloor.

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Companies [33 Associated Companies listed on BioPortfolio]

Immunetics Incorporated

Our accomplishments include the development of patented instruments such as the MiniblotterÒ for Western Blot, spoligotyping, and other multi-probe membrane assays, a new Flow Cell for microarray hyb...

Orion Energy Systems, Inc.

Orion is leading the transformation of commercial and industrial buildings with state-of-the-art energy efficient lighting systems and retrofit lighting solutions. Orion manufactu...

Catabasis Pharmaceuticals

Catabasis is dedicated to the discovery and development of innovative, effective and safe medicines to treat inflammatory and metabolic diseases. The company has assembled a team ...

Allele Biotechnology & Pharmaceuticals, Inc.

Allele Biotechnology and Pharmaceuticals, Inc. is a private, San Diego-based company that explores the mechanisms of biological processes to develop technologies and products for ...

In-Situ Inc.

Nutter McClennen & Fish LLP

Nutter McClennen & Fish LLP represents an international roster of innovative clients involved in a range of sophisticated technologies in the medical device, biotechnology and pha...

Verlasso

Verlasso®, the world’s first provider of harmoniously raised fish, is the first and only ocean-raised farmed Atlantic salmon to receive the yellow “Good Alternativeâ...

ENAMINE Ltd.

Enamine is one of the top providers of custom chemistry services and screening libraries for pre-clinical drug discovery and agro chemistry worldwide. Currently Enamine offers its customers one of the...

CSI Laboratories

CSI Laboratories is a specialized cancer diagnostic laboratory focused specifically on meeting the unique needs and challenges of pathologists and community hospitals. The company...

Intensity Therapeutics, Inc.

Intensity Therapeutics, Inc. is a specialty pharmaceutical company whose mission is to greatly extend the lives of patients with solid tumor cancers. Intensity Therapeutics is pio...

Clinical Trials [560 Associated Clinical Trials listed on BioPortfolio]

Evaluation of the Fluorescent Green of Indocyanine in the Detection of Sentinel Lymph Node in Endometrial Cancer

Selective lymphadenectomy Sentinel (LSS). This technique is already well established in breast cancer and melanoma and more recently in vulvar and cervical cancer. Compared to lymphadenec...

Detection of Heterogeneity in Central Lung Cancer - EBUS-TBNA and ctDNA Analysis vs. Endobronchial Forceps Biopsy

Study participants will be selected from clinical routine patients with endobronchial infiltration of a central lung cancer and indication for bronchoscopic sampling. Consented patients w...

The Histological Effect of Various Microfracture Techniques on Human Chondral & Sub-chondral Tissue - an Ex-Vivo Study

The subchondral bone, formed by the subchondral bone plate and the subarticular spongiosa, plays a key role in supporting the articular cartilage. Marrow stimulation techniques such as sub...

Fish Oil vs. Placebo on Subjective Effects of Alcohol

This project represents a first step in examining the potential use of fish oil for the treatment of alcohol use disorder (AUD). The investigators will be testing for attenuation of alcoho...

Exteriorization Versus Non-exteriorization of the Uterus During Repair of Uterine Incision in a Repeated Cesarean Section

Cesarean section is one of the most frequently performed major operations worldwide. It accounts for between 1% and 70% of deliveries depending on the facilities or country assessed. In Eg...

Flavonoid-rich Supplement Influence on the Human Metabolome

This study will measure the effect of ingesting a flavonoid-rich supplement on various biomarkers in overweight/obese women during a 12-week period. The flavonoid-rich supplement contains ...

SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLC

This is a Phase II trial to determine the efficacy and safety of stereotactic body radiation therapy (SBRT) and in situ oncolytic virus therapy used as a window of opportunity treatment be...

Ten Years Results of a Score System to Address Adjuvant Therapies After Breast Conserving Surgery for Ductal Carcinoma in Situ of the Breast

By this non-randomized prospective study, it's evaluated the outcome of patients underwent BCS for DCIS at whom an established score system to address adjuvant therapies have been prospect...

Code Blue Outcomes & Process Improvement Through Leadership Optimization Using Teleintensivists-Simulation

This multicenter randomized trial will employ in-situ cardiac arrest simulations ("mock codes") to test whether using telemedicine technology to add an intensive care physician as the "cop...

Comparison of Topography Guided LASIK With WaveLight® EX500 to SMILE With Zeiss VisuMax

The purpose of this study is to compare Topography Guided Laser In Situ Keratomileusis (LASIK) corneal surgery to Small Incision Lenticule Extraction (SMILE) corneal surgery for the treatm...

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Medical and Biotech [MESH] Definitions

A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.

The simultaneous identification of all chromosomes from a cell by fluorescence in situ hybridization (IN SITU HYBRIDIZATION, FLUORESCENCE) with chromosome-specific florescent probes that are discerned by their different emission spectra.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

Fish of the genera ONCORHYNCHUS and Salmo in the family SALMONIDAE. They are anadromous game fish, frequenting the coastal waters of both the North Atlantic and Pacific. They are known for their gameness as a sport fish and for the quality of their flesh as a table fish. (Webster, 3d ed).

A technique that labels specific sequences in whole chromosomes by in situ DNA chain elongation or PCR (polymerase chain reaction).

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