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DNA-FISH Probes - Biotech, Pharma and Life Science Channel

05:43 EDT 25th March 2017 | BioPortfolio

Fluorescent in situ hybridization (FISH) is a sensitive and accurate technique that allows the detection of chromosome aberrations. In this method, a single-stranded fluorescent-labeled nucleic acid sequence (probe) complementary to a target genomic sequence is hybridized to metaphase chromosomes and interphase nuclei to detect the presence and absence of a given abnormality. FISH complements traditional cytogenetic karyotype analysis.  The chief advantage of FISH is that is can be applied to non-dividing cells and a variety of specimen types.  FISH is a method of choice for diagnosis, prognosis, treatment response, and minimal residual disease detection in hematopoietic neoplasms (leukemia, lymphomas, multiple myeloma, and myelodysplasia) and solid tumors (breast cancer, non-small cell lung cancer, colorectal cancer, and cervical cancer).

Source: http://cancergenetics.com/cgi-research/dna-fish-probes/

PubMed Articles [4772 Associated PubMed Articles listed on BioPortfolio]

Development of a SYBR Green I real-time PCR for the detection of the orf virus.

Orf is a non-systemic, ubiquitous disease of sheep and goats caused by the orf virus (ORFV). ORFV occasionally causes cutaneous lesions in humans in contact with infected animals. In the present study...

Fullerene C60 Penetration into Leukemic Cells and Its Photoinduced Cytotoxic Effects.

Fullerene C60 as a representative of carbon nanocompounds is suggested to be promising agent for application in photodynamic therapy due to its unique physicochemical properties. The goal of this stud...

Mechanism of anti-Vibrio activity of marine probiotic strain Bacillus pumilus H2, and characterization of the active substance.

Vibriosis is a major epizootic disease that impacts free-living and farmed fish species worldwide. Use of probiotics is a promising approach for prevention of Vibrio infections in aquaculture. A probi...

PCM and TAT co-modified liposome with improved myocardium delivery: in vitro and in vivo evaluations.

In this study, PCM and TAT co-modified liposome was developed as a novel drug carrier for myocardium delivery with evaluation of its in vitro and in vivo properties. Liposomes containing fluorescent p...

A comparative assessment of fatty acids in Antarctic organisms from the Ross Sea: Occurrence and distribution.

Lipids are important energy source and structural component for cellular membranes and tissues, involved in the osmoregulation and immune response, and are very important in the bioaccumulation of lip...

Environmentally friendly procedure for in-situ coating of regenerated cellulose fibres with silver nanoparticles.

This study introduces a novel green in-situ procedure for introduction of silver nanoparticles (Ag NPs) on and into cellulose fibres in a three-stage process. First-stage of the process includes the a...

Fabrication of bacterial cellulose/polyaniline/single-walled carbon nanotubes membrane for potential application as biosensor.

Electrically conductive polymeric membranes of BC with polyaniline (PAni) were fabricated through ex situ oxidative polymerization. PAni was densely arrayed along BC fibers and SWCNTs were uniformly d...

Facile green synthesis of silver nanodendrite/cellulose acetate thin film electrodes for flexible supercapacitors.

In this study, we present a highly efficient and economical solution called as 'in situ hydrogenation' for preparation of highly conductive thin film electrode based on silver nanodendrites. The silve...

Generation of LIF-independent induced pluripotent stem cells from canine fetal fibroblasts.

Takahashi and Yamanaka established the first technique in which transcription factors related to pluripotency are incorporated into the genome of somatic cells to enable reprogramming of these cells. ...

Presence and localization of bacteria in the bovine endometrium postpartum using fluorescence in situ hybridization.

The aim of this study was to investigate bacterial invasiveness of the bovine endometrium during the postpartum period. Fluorescence in situ hybridization was applied to endometrial biopsies using pro...

News Articles [791 Associated News Articles listed on BioPortfolio]

Lakes Farm Raised Catfish, Inc. Recalls Siluriformes Fish Products Due To Possible Adulteration

Lakes Farm Raised Catfish Inc., a Dundee, Miss. establishment, is recalling approximately 1,695 pounds of siluriformes fish (catfish) products that may be adulterated with residues of public health co...

Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer

Fatty acids: How do all those omegas affect your health?

Morning Report: Fish Oil and Heart Disease--Science Advisory

Dr Arefa Cassoobhoy highlights one of the week's important news stories for primary care. Medscape Internal Medicine

Using the placenta to understand how complex organs evolve

Considering how different they look from the outside, it might be surprising that all vertebrates – animals with a backbone – share the same, conserved set of organs. Chickens, fish, human beings ...

A fluorogenic probe can detect the activity of multidrug-resistant pathogens in an assay system

Carbapenems are among the "antibiotics of last resort" and can fight infections for which other drugs have long lost their effectiveness. However, even carbapenem-resistant pathogenic strains have eme...

Mlynarek Insurance Agencies Announces Joint Charity Event with Oxford/Orion FISH Food Pantry to Feed Hungry Families

Lake Orion, MI (PRWEB) March 24, 2017 Mlynarek Insurance Agencies, a Detroit area firm providing insurance assistance, financial pla...

Ultivue Inc. Announces Expansion of Executive Team

Ultivue has appointed Philippe Mourere as Senior Vice President, Commercial Operations. Mourere previously served as Vice President of Global Sales and Marketing at Cell Signaling...

MSU lands $727,000 NIH grant to improve use of fish as disease models for human medicine

Michigan State University has landed a $727,000 grant from the National Institutes of Health to improve the use of fish as disease models for human medicine.

Capacity shortfalls hinder the performance of marine protected areas globally

Although 71% of marine protected areas are benefiting fish populations, their effects are highly variable, with staff capacity proving to be the most important explanatory variable.

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Companies [33 Associated Companies listed on BioPortfolio]

Immunetics Incorporated

Our accomplishments include the development of patented instruments such as the MiniblotterÒ for Western Blot, spoligotyping, and other multi-probe membrane assays, a new Flow Cell for microarray hyb...

Orion Energy Systems, Inc.

Orion is leading the transformation of commercial and industrial buildings with state-of-the-art energy efficient lighting systems and retrofit lighting solutions. Orion manufactu...

Catabasis Pharmaceuticals

Catabasis is dedicated to the discovery and development of innovative, effective and safe medicines to treat inflammatory and metabolic diseases. The company has assembled a team ...

Allele Biotechnology & Pharmaceuticals, Inc.

Allele Biotechnology and Pharmaceuticals, Inc. is a private, San Diego-based company that explores the mechanisms of biological processes to develop technologies and products for ...

In-Situ Inc.

Nutter McClennen & Fish LLP

Nutter McClennen & Fish LLP represents an international roster of innovative clients involved in a range of sophisticated technologies in the medical device, biotechnology and pha...

Verlasso

Verlasso®, the world’s first provider of harmoniously raised fish, is the first and only ocean-raised farmed Atlantic salmon to receive the yellow “Good Alternativeâ...

ENAMINE Ltd.

Enamine is one of the top providers of custom chemistry services and screening libraries for pre-clinical drug discovery and agro chemistry worldwide. Currently Enamine offers its customers one of the...

CSI Laboratories

CSI Laboratories is a specialized cancer diagnostic laboratory focused specifically on meeting the unique needs and challenges of pathologists and community hospitals. The company...

Intensity Therapeutics, Inc.

Intensity Therapeutics, Inc. is a specialty pharmaceutical company whose mission is to greatly extend the lives of patients with solid tumor cancers. Intensity Therapeutics is pio...

Clinical Trials [580 Associated Clinical Trials listed on BioPortfolio]

Trial of a Nutritional Blend to Prevent Cognitive Decline in Older Adults

To show the efficacy of a 4-year intervention with nutritional blend of ingredients to prevent cognitive decline.

Estimation of Vascularization After Treatment of Deep Rectovaginal Endometriosis Node by Rectal Shaving

Indocyanine green is a dye, using in surgery to bring out the intraoperative evaluation of tissue perfusion. After intravenous injection of indocyanine green, using a near infrared light,...

Fish Oil to Reduce Tobacco Use iN Expectant Mothers Study

The purpose of this feasibility study is to obtain pilot data in preparation for an upcoming R01 submission. The goals of that submission will be to conduct a clinical trial of n-3 LCPUFAs...

Islet Transplantation Using PKX-001

Islet Transplantation is a procedure used in people with difficult to control Type 1 Diabetes. Insulin producing cells (islets) are isolated from a deceased donor pancreas. After the cells...

PORTAL: Patient-reported Outcomes After Routine Treatment of Atypical Lesions

This research study is evaluating how patients feel physically and emotionally after a prior breast biopsy for specific breast conditions (including atypical lesions such as atypical ducta...

Investigating the Use of Fluorescent Lectins to Identify Dysplasia and Cancer During Endoscopy and Surgery

This is a feasibility study investigating the use of a fluorescently conjugated lectin to identify colorectal dysplasia and cancer during colonoscopy and surgery.

Immune Response After Pancreatic Cancer Treatment

The aim of this project is to describe the differential immunologic responses of patients who undergo in situ IRE, margin accentuation IRE with surgical resection of the primary tumor, and...

Antioxidant Use in Diabetes to Reduce Oxidative Stress

Dietary supplementation with antioxidant vitamins, such as Vitamin C and Vitamin E, reduces malformation rates in embryos of diabetic animals. However, human trials exploring the benefits ...

Precise Local Injection of Anti-cancer Drugs Using Presage's CIVO™ Device in Soft Tissue Sarcoma

This is a feasibility study in patients with localized or metastatic soft tissue sarcoma undergoing surgery to determine how sarcoma in situ responds to injected microdoses of anti-cancer ...

SMOFLipid in Intralipid Intolerant

Soybean oil based IV fat emulsion (IVFE) has been one of the sole sources of IVFE in the US. Soybean oil based IVFE has higher ratio of omega-6 to omega-3 fatty acids and can be associated...

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Medical and Biotech [MESH] Definitions

A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.

The simultaneous identification of all chromosomes from a cell by fluorescence in situ hybridization (IN SITU HYBRIDIZATION, FLUORESCENCE) with chromosome-specific florescent probes that are discerned by their different emission spectra.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

Fish of the genera ONCORHYNCHUS and Salmo in the family SALMONIDAE. They are anadromous game fish, frequenting the coastal waters of both the North Atlantic and Pacific. They are known for their gameness as a sport fish and for the quality of their flesh as a table fish. (Webster, 3d ed).

A technique that labels specific sequences in whole chromosomes by in situ DNA chain elongation or PCR (polymerase chain reaction).

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