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Eligard - Biotech, Pharma and Life Science Channel

12:26 EDT 26th July 2017 | BioPortfolio

Eligard® is a hormone compound for the treatment of advanced, hormone-dependent prostate cancer. The active ingredient (leuprolide acetate) significantly reduces the level of the male sex hormone testosterone, thus suppressing testosterone-dependent tumor growth. The established active ingredient is combined with a novel drug delivery system known as Atrigel® depot technology. The liquid drug is injected subcutaneously and Eligard® forms a gel-like implant which slowly disintegrates, steadily releasing the drug over a period of one, three or six months, depending on the dosage administered.

Medigene acquired the European marketing rights to Eligard® from Atrix Laboratories, Inc. (now Tolmar Therapeutics, Inc.) and successfully brought the drug through the market approval procedure in Germany. The European market launch of Eligard® by Medigene’s partner Astellas Pharma Europe, Ltd. started as early as 2004. Eligard® in its one-month, three-month and six-month dosage forms is now available in most European countries.

In mid-2010, Medigene sold the exclusive European marketing and distribution rights for Eligard® to Astellas Pharma Europe Ltd. against payment of €25 million and royalties of 2% on product sales. With the sale of the Eligard® rights, Medigene no longer bears any obligations or risks associated with the supply of Eligard® to Astellas. In addition, Medigene will no longer be liable for any procurement costs and license payments to Tolmar.

In June 2012, Medigene transferred its two percent royalty share of Eligard® European net sales to US-based investor, Cowen Healthcare Royalty Partners II, L.P., for a cash payment of appr. €14.1 million. Medigene plans to invest these proceeds in further strengthening the company’s pipeline.

Source: http://www.medigene.com/products-pipeline/products/eligard

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Medical and Biotech [MESH] Definitions

An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC 3.1.1.6.

Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

A 6-methyl PROGESTERONE acetate with reported glucocorticoid activity and effect on ESTRUS.

An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.

An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. EC 2.7.2.1.

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