Advertisement

Topics

Eligard - Biotech, Pharma and Life Science Channel

21:15 EST 18th January 2017 | BioPortfolio

Eligard® is a hormone compound for the treatment of advanced, hormone-dependent prostate cancer. The active ingredient (leuprolide acetate) significantly reduces the level of the male sex hormone testosterone, thus suppressing testosterone-dependent tumor growth. The established active ingredient is combined with a novel drug delivery system known as Atrigel® depot technology. The liquid drug is injected subcutaneously and Eligard® forms a gel-like implant which slowly disintegrates, steadily releasing the drug over a period of one, three or six months, depending on the dosage administered.

Medigene acquired the European marketing rights to Eligard® from Atrix Laboratories, Inc. (now Tolmar Therapeutics, Inc.) and successfully brought the drug through the market approval procedure in Germany. The European market launch of Eligard® by Medigene’s partner Astellas Pharma Europe, Ltd. started as early as 2004. Eligard® in its one-month, three-month and six-month dosage forms is now available in most European countries.

In mid-2010, Medigene sold the exclusive European marketing and distribution rights for Eligard® to Astellas Pharma Europe Ltd. against payment of €25 million and royalties of 2% on product sales. With the sale of the Eligard® rights, Medigene no longer bears any obligations or risks associated with the supply of Eligard® to Astellas. In addition, Medigene will no longer be liable for any procurement costs and license payments to Tolmar.

In June 2012, Medigene transferred its two percent royalty share of Eligard® European net sales to US-based investor, Cowen Healthcare Royalty Partners II, L.P., for a cash payment of appr. €14.1 million. Medigene plans to invest these proceeds in further strengthening the company’s pipeline.

Source: http://www.medigene.com/products-pipeline/products/eligard

News Articles [46 Associated News Articles listed on BioPortfolio]

Allergan and Gedeon Richter Announce Positive Phase III Results for Ulipristal Acetate 5 and 10 mg in the Treatment of Uterine Fibroids

DUBLIN and BUDAPEST, Hungary, Jan. 17, 2017 /PRNewswire/ -- Allergan Plc (NYSE: AGN) and Gedeon Richter Plc. today announced positive results from Venus II, the second of two pivotal phase III cl...

Adhesives Sealants Market by Technology Water, Solvent, HotMelt, Reactive Others, by Chemistry PAE, PVA, VAE, EVA, SBS, Synthetic Rubber, Polyamide, Polyurethane, Epoxy, Cyanoacrylate, Others, by Application Global Forecast to 2020 Prices from USD $7

The report covers the global adhesives sealants market and further segments the market on the basis of chemistry type, formulating technology, application, and region. The market data for these types...

Human medicines European public assessment report (EPAR): ellaOne, ulipristal acetate, Revision: 14, Authorised

Eco Fibers Market by Type Organic Fibers, Recycled Fibers, Regenerated Fibers, and Others, by Application Clothing/Textile, Household Furnishings, Industrial, Medical, and Others, and by Region North America, Europe, AsiaPacific, and Rest of the World G

The global eco fibers market is projected to reach USD 74.65 billion by 2020, registering a CAGR of 11.46% from 2015 to 2020. Environmental degradation is of a major concern among all the developed co...

Europe NButanol Market By Applications Butyl Acrylate, Butyl Acetate, Glycol Ethers, and Others GeographyGlobal Trends Forecasts to 2019 Prices from USD $2650

The European nButanol market is estimated to grow at a CAGR of more than 4% from 2014 to 2019. The market in Germany accounted the largest share of the nbutanol market, while the market in Belgium is ...

NButanol Market by Application Butyl Acrylate, Butyl Acetate, Glycol Ethers, Direct Solvent, Plasticizers and by Region North America, AsiaPacific, Europe, RoW Global Trends Forecasts to 2020 Prices from USD $5650

Nbutanol C4H9OH or nbutyl alcohol or normal butanol is a clear colorless flammable liquid. It is readily biodegradable with low level of toxicity. Nbutanol is used as a feedstock for manufacturing var...

Adhesive Resin Market by Technology Water, Solvent, HotMelt, Reactive Others, by Chemistry PAE, PVA, VAE, EVA, SBS, Synthetic Rubber, Polyamide, Polyurethane, Epoxy, Cyanoacrylate, Others, by Application Global Forecast to 2020 Prices from USD $5650

The report covers the global adhesive resins market and further segments the market on the basis of resin type, formulating technology, application, and region. The market data for these types is give...

Chongqing Lummy Pharmaceutical Co Ltd 300006 Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryChongqing Lummy Pharmaceutical Co Ltd Lummy is a pharmaceutical company that provides drugs and pharmaceutical ingredients. The company offers products such as tumor drugs, antibacterial drugs,...

Does discovery of 'severe PMS genes' offer hope of a cure?

"Women who suffer from severe mood swings before their period have a different genetic make-up," The Sun reports. New research has found a link between a gene complex called ESC/E(Z) and se...

Innovate Biopharmaceuticals, Targeting Celiac Disease and Ulcerative Colitis, Meeting with Potential Investors, Partners During J.P. Morgan Healthcare Conference

RALEIGH, N.C., Jan. 4, 2017 /PRNewswire/ -- Executives from Innovate Biopharmaceuticals Inc., which has drug candidates entering Phase 3 and Phase 2 clinical trials, respectively, for the treatme...

Events [0 Results]

None

Companies [4 Associated Companies listed on BioPortfolio]

Sunovion Pharmaceuticals, Inc.

Sunovion is a leading pharmaceutical company dedicated to discovering, developing and commercializing therapeutic products that advance the science of medicine in the Psychiatry &...

Celanese Corporation

We are an integrated global producer of value-added industrial chemicals and have the first or second market positions worldwide in products comprising the majority of our sales. We are the world’s ...

Graceway Pharmaceuticals, LLC

Graceway Pharmaceuticals, LLC ("Graceway"), headquartered in Bristol, TN, is a pharmaceutical company focused on acquiring, in-licensing, and developing branded prescription pharm...

Proof Eyewear

Proof was established in 2010 by three brothers in Boise, Idaho. They were inspired by their entrepreneur grandfather who started a wood sawmill and also by the outdoors around th...

Clinical Trials [558 Associated Clinical Trials listed on BioPortfolio]

A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer

This is a randomized, open-label, three-arm, phase 3 study in men with biochemically recurrent prostate cancer and PSA doubling time ≤ 9 months at the time of study entry.

A Phase II Clinical Trial of Radium-223 Activity in Patients With Metastatic Castration-resistant Prostate Cancer (mCRPC) With Asymptomatic Progression While on Abiraterone Acetate or Enzalutamide Besides AR-V7 Mutational Status (EXCAAPE)

Radium-223 is indicated for the treatment of patients with mCRPC with symptomatic bone metastases and no known visceral metastatic disease. However, very few data have been reported in pat...

Novel Isotope Dilution Technique to Assess Vitamin A Status and Hypervitaminosis A

Background: 1. Burden: Recently Bangladesh has introduced mandatory vitamin A (VA) fortification of refined edible oil while high dose VA supplementations for infants and children ...

Assessing Model Parameters for Applying the Retinol Isotope Dilution (RID) Method

For assessing body retinol pools in preschool children, it is recommended that a blood sample is taken 14-21 days after isotope dosing. During this period, dietary intake of vitamin A shou...

Pembrolizumab and Exemestane/ Leuprolide in Premenopausal HR+/ HER2- Locally Advanced or Metastatic Breast Cancer

This is an open-label, single-arm, multicenter, pilot study of pembrolizumab, exemestane, and leuprolide for subjects being resistant for front-line hormonal therapy for inoperable locally...

[11C]Acetate PET in Patients With Glioma

At each point that the patient will have [11C]-Acetate PET study, this will be compared with standard clinical MR imaging. Abbreviations: XRT - radiation therapy; TMZ - temozolomide (chemo...

Takayasu Arteritis Clinical Trial in China

The purpose of this study is to investigate the efficacy and Safety of Leflunomide in Patients With Active Phase of Takayasu's Arteritis

Megestrol Acetate Against Cancer-related Critical Body Weight Loss in Patients With H&N Cancer Who Receiving CCRT

Primary Objective: To evaluate the population prevalence of critical body weight loss ( more than 5% from baseline) in patients with Head and Neck cancer. Secondary Objectives: ...

Fecal Calprotectin Levels in Mycophenolate Mofetil Induced Diarrhea and Treatment With Octreotide

Prospective, observational pilot study of ten post-transplant patients presenting with diarrhea while taking Mycophenolate Mofetil (MMF). These patients will undergo a standard workup to c...

A Study of Rucaparib Verses Physician's Choice of Therapy in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatmen...

PubMed Articles [693 Associated PubMed Articles listed on BioPortfolio]

Evaluation of volatile compounds from Chinese dwarf cherry (Cerasus humilis (Bge.) Sok.) germplasms by headspace solid-phase microextraction and gas chromatography-mass spectrometry.

The types and amounts of volatiles in denucleated fruit of 30 Chinese dwarf cherry germplasms were determined by headspace solid-phase microextraction and gas chromatography-mass spectrometry to asses...

Influence of barley grain particle size and treatment with citric acid on digestibility, ruminal fermentation and microbial protein synthesis in Holstein calves.

Chemical and physical treatments of barley grain increase ruminally resistant starch and can improve the rumen fermentation pattern. The objective of the present study was to evaluate the effects of c...

First UHPLC MS/MS method coupled with automated on-line SPE for quantification both of tacrolimus and everolimus in peripheral blood mononuclear cells and its application on samples from co-treated pediatric patients.

Tacrolimus (TAC, FK-506) and everolimus (EVE, RAD001) are immunosuppressors used to treat pediatric patients undergoing liver transplantation. Their hematic TDM by liquid chromatography became standar...

Integrated photo-grafted molecularly imprinted polymers with a cellulose acetate membrane for the extraction of melamine from dry milk before HPLC analysis.

In this study, a new separation technique based on membrane extraction is described for the determination of melamine in dry milk. The water-compatible cellulose acetate membrane, which is photo-graft...

Abnormal levels of seven amino neurotransmitters in depression rat brain and determination by HPLC-FLD.

The determination of amino acids with the actions-like neurotransmitters or modulators have been increasingly important for diagnose in many neuropsychiatric diseases. A rapid and simple high performa...

The role of glutamine synthetase in energy production and glutamine metabolism during oxidative stress.

Oxidative stress is known to severely impede aerobic adenosine triphosphate (ATP) synthesis. However, the metabolically-versatile Pseudomonas fluorescens survives this challenge by invoking alternativ...

Activation of TRPM2 and TRPV1 Channels in Dorsal Root Ganglion by NADPH Oxidase and Protein Kinase C Molecular Pathways: a Patch Clamp Study.

Despite considerable research, the mechanisms of neuropathic pain induced by excessive oxidative stress production and overload calcium ion (Ca(2+)) entry in dorsal root ganglion (DRG) remain subst...

Self-Supported 3D PdCu Alloy Nanosheets as a Bifunctional Catalyst for Electrochemical Reforming of Ethanol.

3D PdCu alloy nanosheets exhibit enhanced electrocatalytic activity toward hydrogen evolution reaction and ethanol oxidation reaction in alkaline media. Simultaneous hydrogen and acetate production vi...

Anti-inflammatory potential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum.

Punica granatum (pomegranate), an edible fruit originating in the Middle East, has been used as a traditional medicine for treatment of pain and inflammatory conditions such as peptic ulcer. The numer...

A Liquid Chromatography - Tandem Mass Spectrometry Approach for the Identification of Mebendazole Residue in Pork, Chicken, and Horse.

A confirmatory and quantitative method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the determination of mebendazole and its hydrolyzed and reduced metabolites in pork, chicken, an...

Videos

None available.

Medical and Biotech [MESH] Definitions

An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC 3.1.1.6.

Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

A 6-methyl PROGESTERONE acetate with reported glucocorticoid activity and effect on ESTRUS.

An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.

An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. EC 2.7.2.1.

Quick Search
Advertisement
 

Relevant Topics

Endocrinology
Diabetes Diabetes Endocrine Obesity Oxycontin Renal Disease Thyroid Disorders Endocrinology is the study of the endocrine glands and the hormones that they secrete (Oxford Medical Dictionary). There are several groups of h...

Endocrine Disorders
Endocrine disorders are grouped into two categories: hormone imbalance - when a gland produces too much or too little of an endocrine hormone development of lesions (such as nodules or tumors) in the endocrine system, which may or may not affect...

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

review and buy Eligard market research data and corporate reports here

Channels Quicklinks