Amyotrophic lateral sclerosis ALS - Biotech, Pharma and Life Science Channel
PubMed Articles
The process of templating a manganese nanocluster with the 12 × 12 moiré and other two slightly distorted graphene/Ru(0001) moirés was investigated by scanning tunneling microscopy (STM). At the...
The lateral root of Aconitum has been popularly used in traditional Chinese medicine (TMC) known as Fuzi which is beneficial for the treatment of various diseases, such as rheumatism, painful joints,...
Effects of Hominis placenta on LPS-induced cell toxicity in BV2 microglial cells.
ETHONOPHARMACOLOGICAL RELEVANCE: Hominis placenta (HP) dried placenta extracted from pregnant women after delivery has been widely used to treat chronic inflammatory diseases. HP has been reported to...
The lateral habenula (LHb) is part of the habenular complex in the dorsal diencephalon. The LHb is an important regulator of several neurotransmitter systems in the midbrain; disturbances in this regu...
Three times weekly glatiramer acetate in relapsing-remitting multiple sclerosis.
Objective: To assess the efficacy and safety of glatiramer acetate (GA) 40 mg administered three times weekly (tiw) compared with placebo in patients with relapsing-remitting multiple sclerosis (RRMS)...
Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.
Objective: To see if the distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropat...
Serrated adenoma of the stomach: Case report and literature review.
Gastric serrated adenomas are histologically characterized by protruding glands with lateral saw tooth-like indentations lined with stratified dysplastic cells containing abundant eosinophilic cytopla...
Oxidative stress is revealed as the main contributor in the pathophysiology of neuroinflammation. Analyzing plasma and cerebrospinal fluid (CSF) of patients with different clinical phenotypes of neuro...
Changes in third ventricular size in pediatric patients undergoing endoscopic third ventriculostomy.
PURPOSE: Optimal methods of evaluating radiographic data following endoscopic third ventriculostomy (ETV) are not yet known. This study analyzes imaging parameters, including third ventricular width a...
Computed tomography (CT) performance assessments relating to patient dose to the body are made conventionally in 320 mm diameter cylindrical acrylic phantoms. The cross section of the human trunk is...
News Articles
MDA/ALS Center in New Orleans to provide medical and health care support services to individuals and families living with ALS, also known as Lou Gehrig's disease. New Orleans (PRWEB) May 21, 2013...
Synergy Resources provides mid-year update
Synergy Resources (NYSEMKT: SYRG) says its proved reserves has risen 40 per cent. In its mid-year update, the Platteville, Colorado-based oil company says its discounted present value of estimated fut...
Biogen Idec files BLA for MS drug Plegridy in USA
US biotech company Biogen Idec (Nasdaq: BIIB) has submitted a Biologics License Application (BLA) to the US Food and Drug Administration for approval of Plegridy (peginterferon beta-1a), the company's...
In tracks of Tecfidera success, Biogen seeks Plegridy nod in MS
With Tecfidera (dimethyl fumarate; BG-12) looking to be a success in the multiple sclerosis marketplace, Biogen Idec is ready to take the plunge with its next product – Plegridy (peginterferon...
XenoPort drops MS drug after poor trial results
USA-based XenoPort (Nasdaq: XNPT) saw its shares fall 12.7% to $5.89 in mid-morning trading on Monday (May 20), after it revealed top-line results from its pivotal Phase III clinical trial of arbaclof...
Synthetic Biologics to Present at the 2nd Annual Marcum LLP MicroCap Conference
ROCKVILLE, Md., May 21, 2013 /PRNewswire/ -- Synthetic Biologics, Inc. (NYSE MKT: SYN), a developer of biologics focused on the prevention and treatment of serious infectious diseases, ann...
Biogen Idec seeks FDA BLA approval for PLEGRIDY to treat multiple sclerosis
Today Biogen Idec announced it has submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for approval of PLEGRIDY (peginterferon beta-1a), the company's pegyla...
Researchers Able To Prevent And Cure Type 1 Diabetes In Animal Models
Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destr...
New Approach To Improving Treatment For Multiple Sclerosis And Other Conditions
Working with lab mice models of multiple sclerosis (MS), UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-appr...
Events
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Companies
Acorda Therapeutics, Inc. was established in March 1995 to develop therapeutic products for spinal cord injury ("SCI") and other central nervous system disorders. Acorda is focusing its initial develo...
Scientific excellence that achieves new standards of care drives the company's work. 17 products are currently in clinical development addressing a variety of key medical needs.With patients in more t...
Elan Corporation, plc is a neuroscience-based biotechnology company focused on discovering and developing advanced therapies in neurodegeneration and autoimmune diseases, and real...
The Myelin Repair Foundation (MRF)
The Myelin Repair Foundation (MRF) - http://www.myelinrepair.org - is a Northern California-based, non-profit research organization focused on accelerating discovery and developme...
The International Society for Interferon and Cytokine Research (ISICR), based in Bethesda, Md., is a non-profit organization devoted to interferon, cytokine and chemokine r...
** Lateral implants launched for commercial use outside of the USA. These implants are not yet available for use in the United States.
Accelerated Cure Project for Multiple Sclerosis, www.acceleratedcure.org, is a national nonprofit organization dedicated to curing Multiple Sclerosis (MS) by determining its cause...
National Multiple Sclerosis Society Utah-Southern Idaho Chapter
MS stops people from moving. The National MS Society exists to make sure it doesnât. The Society addresses the challenges of each person affected by MS by funding cutting-edg...
Biogen Idec uses cutting-edge science to discover, develop, manufacture and market therapies for serious diseases with a focus on neurology, immunology and hemophilia. Founded in...
Biogen Idec and Portola Pharmaceuticals
Biogen Idec uses cutting-edge science to discover, develop, manufacture and market therapies for serious diseases with a focus on neurology, immunology and hemophilia. Founded in...
Clinical Trials
Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis
This study will use positron emission tomography (PET) to measure a brain protein called peripheral benzodiazepine receptor (PBR) in patients with multiple sclerosis. PBR is created during...
The primary objective is to demonstrate that early intervention with Teriflunomide in patients presenting with their first clinical episode consistent with MS prevents or delays conversio...
Study assessing cognitive function and physical activity in people with relapsing remitting multiple sclerosis.
1. To determine the safety and tolerability of oral Cellcept when used in combination with weekly intramuscular Avonex in early MS. 2. To document changes in exacerbation frequency...
Fatigue is a symptom present in 76 to 92% of people with multiple sclerosis (MS). Fatigue is usually described as an overwhelming sense of tiredness, lack of energy, and feeling of exhaust...
The purpose of this study is to evaluate the safety and efficacy of autologous bone marrow-derived stem cells("HYNR-CS inj"), through intrathecal delivery for the treatment in patients wit...
Hip Pathomorphology in Collegiate Athletes and Controls
In a previous study, the investigators have shown that 95% of the University of Utah football players had at least one radiographic abnormality consistent of FAI (IRB #40479). Siebenrock e...
Tamoxifen Therapy in Amyotrophic Lateral Sclerosis [ALS]
This is a single-center, phase 2 randomized clinical trial of tamoxifen on mean percent predicted isometric muscle strength in patients with amyotrophic lateral sclerosis (ALS). The purpos...
Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-Year Manometric Follow-Up
Small bowel involvement is still recognized to be associated with great morbidity and mortality in SSc patients, leading particularly to malabsorption and intestinal pseudo-obstruction. In...
Type II Supracondylar Fractures in Children
Supracondylar fractures are the most common elbow fractures in children. In the current orthopedic literature crossed pinning and lateral-only entry techniques are co-gold standards of op...
Videos
Amyotrophic Lateral Sclerosis
This patient education video explains Amyotrophic Lateral Sclerosis, or ALS, also called Lou Gehrigs disease. Included are the following sections: Anatomy, A...
Medical and Biotech [MESH] Definitions
Fluorescence Recovery After Photobleaching
A method used to study the lateral movement of MEMBRANE PROTEINS and LIPIDS. A small area of a cell membrane is bleached by laser light and the amount of time necessary for unbleached fluorescent marker-tagged proteins to diffuse back into the bleached site is a measurement of the cell membrane's fluidity. The diffusion coefficient of a protein or lipid in the membrane can be calculated from the data. (From Segen, Current Med Talk, 1995).
Oligoclonal Bands
Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.
Hermaphroditism, True
A rare condition of sexual ambiguity in which the individual possesses gonadal tissues of both SEXES, tissues from the OVARY and the TESTIS. There can be a testis on one side and an ovary on the other (lateral), or there may be combined ovarian and testicular tissue (ovotestes) on each side (bilateral). Most common karyotype is 46,XX. Others include 46,XY and 45,X/XY.
Monckeberg Medial Calcific Sclerosis
Thickening and loss of elasticity of the walls of muscular ARTERIES due to calcification of the TUNICA MEDIA, the concentric layers of helically arranged SMOOTH MUSCLE CELLS.
Retinal Bipolar Cells
INTERNEURONS of the vertebrate RETINA containing two processes. They receive inputs from the RETINAL PHOTORECEPTOR CELLS and send outputs to the RETINAL GANGLION CELLS. The bipolar cells also make lateral connections in the retina with the RETINAL HORIZONTAL CELLS and with the AMACRINE CELLS.
