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Creatinine clearance - Biotech, Pharma and Life Science Channel

00:14 EDT 16th April 2014 | BioPortfolio

PubMed Articles [842 Associated PubMed Articles listed on BioPortfolio]

Structural characteristics that determine the inhibitory role of phenolic compounds on 2-amino-1-methyl-6-phenylimidazo4,5-bpyridine (PhIP) formation.

In an attempt to understand the structural characteristics of phenolic compounds that favour the inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation, this study analyzes the...

Sub-10-nm Pd Nanosheets with Renal Clearance for Efficient Near-Infrared Photothermal Cancer Therapy.

Efficient renal clearance is of fundamentally important property of nanoparticles for their in vivo biomedical applications. In this work, we report the successful synthesis of ultra-small Pd nanoshee...

Insights into the molecular interactions between aminopeptidase and amyloid beta peptide using molecular modeling techniques.

Amyloid beta (Aβ) peptides play a central role in the pathogenesis of Alzheimer's disease. The accumulation of Aβ peptides in AD brain was caused due to overproduction or insufficient clearance and...

CTLA-4 (CD152) enhances the Tc17 differentiation program.

Although CD8(+) T cells that produce IL-17 (Tc17 cells) have been linked to host defense, Tc17 cells show reduced cytotoxic activity, which is the characteristic function of CD8(+) T cells. Here, we s...

The genetics of spontaneous clearance of hepatitis C virus infection: A complex topic with much to learn.

Low Creatinine Clearance is a Risk Factor for D2 Gastrectomy after Neoadjuvant Chemotherapy.

The feasibility and safety of D2 surgery following neoadjuvant chemotherapy (NAC) has not been fully evaluated in patients with gastric cancer. Moreover, risk factor for surgical complications after D...

Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein.

Haploidentical natural killer (NK) cell infusions can induce remissions in some patients with AML but regulatory T-cell (Treg) suppression may reduce efficacy. We treated 57 refractory AML patients wi...

Hepatic scavenger receptor BI protects against polymicrobial-induced sepsis through promoting LPS clearance in mice.

Recent studies revealed that scavenger receptor BI (SR-BI or Scarb1) plays a critical protective role in sepsis. However, the mechanisms underlying this protection remain largely unknown. In this stud...

Modulation of TLR3, TLR4 and TLR7 mediated IFN-β, Rantes and TNFα production by HIVEP1.

Upon activation of Toll-like receptors (TLRs), recruitment of the adaptor proteins, MyD88, Mal, TRIF and TRAM is facilitated which then elicits downstream signaling cascades leading to the production...

The comparability of oxalate excretion and oxalate:creatinine ratio in the investigation of primary hyperoxaluria: review of data from a referral centre.

Urine oxalate measurement is an important investigation in the evaluation of renal stone disease. Primary hyperoxaluria (PH) is a rare inherited metabolic disease characterised by persistently elevate...

News Articles [590 Associated News Articles listed on BioPortfolio]

FDA OKs Trials for Vivolux First-in-Class Cancer Drug

Vivolux AB, a drug discovery company specialized in cancer treatment, announced that the FDA has granted clearance to proceed with VLX600 into clinical Phase 1/2 trials.

RPS® Expands Eye Care Organization in Response to InflammaDry® Regulatory Clearance and Growing Demand

Rapid Pathogen Screening, Inc. (RPS®) today announced the expansion of its eye care organization in order to meet growing demand for InflammaDry® – a rapid, disposable, in-office test to a...

Collagen Matrix, Inc. Receives FDA 510(k) Clearance of a Flexible Collagen Nerve Conduit for Reduction of Painful Neuroma Formation

OAKLAND, N.J., April 15, 2014 /PRNewswire/ -- Collagen Matrix, Inc. announced today that it has received FDA's 510(k) clearance of its Flexible Collagen Nerve Conduit for management of peripheral...

CryoLife Announces Release Date and Teleconference Call Details for 2014 First Quarter Financial Results

ATLANTA, April 15, 2014 /PRNewswire/ -- CryoLife, Inc. (NYSE: CRY), a leading medical device and tissue processing company focused on cardiac and vascular surgery, announced today that 2014 first...

Paid Gout Clinical Trial Now Enrolling at Achieve Clinical Research Near Birmingham, Alabama; Accepting M/F Patients with Gout Age 18 - 75

Achieve is conducting a randomized, active and placebo-controlled study to evaluate the efficacy and safety of an experimental drug for preventing flares and reducing serum uric acid in patients with...

FDA Gives Clearance to Proceed with Clinical Study - New Drug Candidate from Vivolux Starves Cancer Cells

Vivolux AB, a drug discovery company specialized in cancer treatment, announced today that the FDA has granted clearance to proceed with VLX600 into the clinical phase I/II. VLX60...

Vivolux receives FDA clearance to proceed with phase I/II clinical trial of VLX600

Vivolux AB, a drug discovery company specialized in cancer treatment, announced today that the FDA has granted clearance to proceed with VLX600 into the clinical phase I/II. VLX600 is one of the compa...

Zohydro v. Massachusetts = Wyeth v. Levine? State Asserts Power To Seek Label Change

Arguing for its right to ban Zogenix Inc.’s opioid, Massachusetts contends that FDA clearance of a drug for marketing is a “gateway approval” that does not preempt states from imposing stricter...

GE Healthcare Announces FDA Clearance Of Revolution CT

FAIRFIELD (dpa-AFX) - GE Healthcare, a unit of General Electric Co (GE), Monday announced U.S. FDA 510(k) clearance of its Revolution CT, which will enable physicians to diagnose even the most cha...

Abbott Gets FDA Clearance For ARCHITECT Clinical Chemistry Hemoglobin A1c Test

NORTH CHICAGO (dpa-AFX) - Healthcare company Abbott Laboratories (ABT) said its new ARCHITECT Clinical Chemistry Hemoglobin A1c or HbA1c test, that can help physicians in diagnosing and monitoring...

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Companies [41 Associated Companies listed on BioPortfolio]

ClearFlow, Inc.

ClearFlow, Inc. is an Anaheim, CA based medical device company developing proprietary active wound evacuation systems to speed recovery, reduce complications and lower healthcare...

Nexstim Oy

Founded in 2000, Finland-based Nexstim Oy is the world leader in image-guided transcranial magnetic stimulation (TMS). Nexstim has pioneered the technology for brain diagnostics a...

Clear Catheter Systems, Inc.

Clear Catheter Systems is a Bend, Oregon based medical device company developing an anti-clogging platform of surgical drainage devices. Its lead product is the PleuraFlow Cathete...

iScreen Vision

iScreen Vision is a leading provider of pediatric vision screening equipment and services. iScreen Vision utilizes digital photoscreening technology. Its system includes cloud-bas...

diaDexus, Inc.

Founded in 1997 by SmithKline Beecham (now GlaxoSmithKline) and Incyte, diaDexus, Inc. is a privately held biotechnology company focused on discovering, developing, and commercializing novel, patent-p...

Copyright Clearance Center, Inc.

Copyright Clearance Center (CCC), the rights licensing experts, is a global rights broker for the world’s most sought after materials, including in- and out-of-print books, j...

CorMatrix Cardiovascular, Inc.

CorMatrix Cardiovascular holds an exclusive license from Purdue University to research, develop, manufacture and market naturally occurring ECM products for cardiovascular applications. The company cu...

ZELTIQ Aesthetics, Inc.

We are a medical technology company focused on developing and commercializing products utilizing our proprietary controlled-cooling technology platform. Our first commercial produ...

ApniCure, Inc.

ApniCure is a private Redwood City, Calif.-based medical device company focused on developing and commercializing novel home-use devices incorporating a proprietary platform techn...

NovaSom, Inc.

NovaSom, Inc. is a privately held diagnostic-service provider for home testing and evaluation of sleep-disordered breathing, which includes the diagnosis of obstructive sleep apne...

Clinical Trials [364 Associated Clinical Trials listed on BioPortfolio]

Treosulfan Pharmacokinetics in Children Undergoing Allogeneic HSCT

Every year around 70 children affected by cancer or life-threatening genetic diseases undergo haematopoietic cell transplantation (HCT) within the Blood and Marrow Transplant (BMT) unit at...

Vitamin D3 Substitution in Vitamin D Deficient Kidney Transplant Recipients

The purpose of the study is to evaluate the effects of Cholecalciferol (Vitamin D3) substitution on the posttransplant outcome (glomerular filtration rate as well as serum creatinine level...

Tc-99m Renography and Cisplatin-Induced Nephrotoxicity

Cisplatin is a heavy-metal complex widely used in the treatment of a variety of malignancies, including small cell and non-small cell lung cancer, ovarian, bladder, head and neck, esophage...

Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Computed Tomography

It is well known that X-ray contrast media can affect kidney function in some patients, especially when administered intra-arterially, and patients who already suffer from reduced kidney f...

Lactate Metabolism Study in HIV Infected Persons

Lactic acidosis is a potentially life-threatening disease associated with the treatment of chronic HIV infection. Although acidosis is rare, hyperlactatemia is common and may have long ter...

Induction Dosing With Pegylated Interferon Alfa 2a and Ribavirin in Patients With Chronic Hepatitis C Genotype 1

The purpose of the study is to compare the effectiveness of two treatment regimens in clearing the Hepatitis C Virus in patients infected with Hepatitis C genotype 1. The study aims to de...

N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery

Cardiac surgery improves the survival and quality of life of people with heart disease. Nonetheless, several complications continue to adversely affect outcomes following cardiac surgery....

Phase 2 Study Of Neoadjuvant Iressa Treatment In Stage 1 NSCLC

ELIGIBILITY - Non-small cell lung cancer Clinical Stage 1A (T1N0M0 a tumor that is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchosc...

Early Allogeneic Blood Stem Cell Transplantation in High-Risk Acute Myeloid Leukemia (AML)

Karyotype is a major prognostic risk factor in patients with acute myeloid leukemia (AML) translating into unfavourable outcome in case of poor-risk cytogenetic aberrations. Several studie...

Use of Low Molecular Weight Heparin (Tinzaparin) to Treat Blood Clots in Patients With Kidney Failure

Blood clots in the leg veins, known as deep vein thrombosis, are important because they may travel to the lung (known as pulmonary embolism) and cause death. Blood clots are treated with...

Medical and Biotech [MESH] Definitions

A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.

Abrupt reduction in kidney function defined as an absolute increase in serum CREATININE of more than or equal to 0.3. mg/dl, a percentage increase in serum creatinine of more than or equal to 50%, or a reduction in urine output. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.

A severe stage of acute renal insufficiency, characterized by the sudden decrease in GLOMERULAR FILTRATION RATE to less than 15 ml per min, sometime to less than 1 to 2 ml per min. It is usually associated with OLIGURIA; EDEMA; and increase in BLOOD UREA NITROGEN and serum CREATININE concentrations.

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