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Creatinine clearance - Biotech, Pharma and Life Science Channel

15:40 EDT 23rd April 2014 | BioPortfolio

PubMed Articles [889 Associated PubMed Articles listed on BioPortfolio]

Structural characteristics that determine the inhibitory role of phenolic compounds on 2-amino-1-methyl-6-phenylimidazo4,5-bpyridine (PhIP) formation.

In an attempt to understand the structural characteristics of phenolic compounds that favour the inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation, this study analyzes the...

Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization.

EAAT2 is a predominantly astroglial glutamate transporter responsible for the majority of synaptic glutamate clearance in the mammalian central nervous system (CNS). Its dysfunction has been linked wi...

Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints.

Intra-articular (i.a.) drug delivery for local treatment of osteoarthritis remains inadequate due to rapid clearance by the vasculature or lymphatics. Local therapy targeting articular cartilage is fu...

Outcome evaluation of an intervention to improve the effective and safe use of meropenem.

Background Pharmacists have been involved in promoting the proper and safe use of antimicrobial drugs in our institution since 2010. Setting Kochi Medical School Hospital, Japan. Objective To design a...

Negative-Pressure Wound Therapy Enhances Local Inflammatory Responses in Acute Infected Soft-Tissue Wound.

Clinical studies found that negative-pressure wound therapy (NPWT) displayed significant clinical benefits in the healing of infected wounds. However, the effect of NPWT on local inflammatory response...

Myocardial Dysfunction in Early Diabetes Patients with Microalbuminuria: A 2-Dimensional Speckle Tracking Strain Study.

The aim of this study was to assess myocardial dysfunction in primary diabetes patients with microalbuminuria by 2-dimensional speckle tracking strain. Sixty-two patients with diabetes with or without...

Neutralization of pathogenic beta1-receptor autoantibodies by aptamers in vivo: the first successful proof of principle in spontaneously hypertensive rats.

Autoantibodies (AABs) against the second extracellular loop of the beta1-receptor (beta1(II)-AABs) are found as a pathogenic driver in patients with idiopathic dilated cardiomyopathy, Chagas cardiomyo...

CD8 T Cells Use IFN-γ To Protect against the Lethal Effects of a Respiratory Poxvirus Infection.

CD8 T cells are a key component of immunity to many viral infections. They achieve this through using an array of effector mechanisms, but precisely which component/s are required for protection again...

Glycine aggravates ischemia reperfusion-induced acute kidney injury through N-Methyl-D-Aspartate receptor activation in rats.

The present study was designed to investigate the role of glycine in ischemia reperfusion-induced acute kidney injury (AKI) in rats. The AKI was induced in rats by occluding renal pedicles for 40 min...

Dietary Intake of Advanced Glycation End Products Did Not Affect Endothelial Function and Inflammation in Healthy Adults in a Randomized Controlled Trial.

When food is heated to high temperatures, the characteristic "browning" generates advanced glycation end products (AGEs). AGEs are associated with an increased risk of cardiovascular disease, diabetes...

News Articles [613 Associated News Articles listed on BioPortfolio]

Kidney injuries 'killing thousands,' study claims

“Failures in basic hospital care are resulting in more than 1,000 deaths a month from … acute kidney injury,” The Independent reports. A study commissioned by the NHS estimates that up to 40,000...

Court Finds in Favor of Ivera Medical; Excelsior Medical Request Denied

SAN DIEGO, CA -- (Marketwired) -- 04/23/14 -- Ivera Medical, headquartered in San Diego, CA, announced that on April 16th, 2014 the US Patent and Trade Office (USPTO) denied a request by Excelsior Me...

Fate Therapeutics Announces FDA Clearance of IND Amendment for Clinical Development of PROHEMA(R) in Pediatric Patients

SAN DIEGO, April 23, 2014 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (Nasdaq:FATE), a biopharmaceutical company engaged in the discovery and development of adult stem cell modulators to treat orphan...

Intuitive Surgical’s da Vinci Sp System Earns FDA Clearance

Intuitive Surgical, Inc., the global leader in robotic-assisted minimally invasive surgery, has announced it has received FDA 510(k) clearance for the da Vinci Sp Surgical System, which is designed to...

FDA Clears Erchonia’s New Allay Laser for Chronic Heel Pain from Plantar Fasciitis

Erchonia today announces the U.S. Food and Drug Administration (FDA) has granted the company 510 (k) clearance to market Allay, its new low level laser for the relief of chronic heel pain from plantar...

Merck KGaA Again Extends Offer for AZ Electronic Materials

Germany's Merck KGaA has once again extended its offer for AZ Electronic Materials. The new completion date is May 2, pending antitrust clearance by China's ministry of commerce (MOFCOM). Merck said d...

GSK and Genmab obtain FDA clearance for Arzerra as first-line treatment for CLL

GlaxoSmithKline (GSK) and Genmab have obtained US Food and Drug Administration (FDA) approval for Arzerra (ofatumumab) as first-line treatment in combination with chlorambucil for patients with chroni...

Spine medical center at Meijo Hospital in Nagoya installs EOS imaging system

EOS imaging, the pioneer in 2D/3D orthopaedic medical imaging, today announced the installation of the EOS imaging system in Japan's leading spine medical center at Meijo Hospital in Nagoya. The insta...

Intuitive Surgical Announces FDA Clearance of da Vinci(R) Sp(TM) Surgical System

SUNNYVALE, Calif., April 22, 2014 (GLOBE NEWSWIRE) -- Intuitive Surgical, Inc. (Nasdaq:ISRG), the global leader in robotic-assisted minimally invasive surgery, today announced it has received FDA 510...

Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia

Heymut Omran and colleagues show that biallelic mutations in CCNO cause a chronic destructive lung disease resulting from loss of multiple motile cilia from the surface of respiratory epithelial cells...

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Companies [41 Associated Companies listed on BioPortfolio]

ClearFlow, Inc.

ClearFlow, Inc. is an Anaheim, CA based medical device company developing proprietary active wound evacuation systems to speed recovery, reduce complications and lower healthcare...

Nexstim Oy

Founded in 2000, Finland-based Nexstim Oy is the world leader in image-guided transcranial magnetic stimulation (TMS). Nexstim has pioneered the technology for brain diagnostics a...

Clear Catheter Systems, Inc.

Clear Catheter Systems is a Bend, Oregon based medical device company developing an anti-clogging platform of surgical drainage devices. Its lead product is the PleuraFlow Cathete...

iScreen Vision

iScreen Vision is a leading provider of pediatric vision screening equipment and services. iScreen Vision utilizes digital photoscreening technology. Its system includes cloud-bas...

diaDexus, Inc.

Founded in 1997 by SmithKline Beecham (now GlaxoSmithKline) and Incyte, diaDexus, Inc. is a privately held biotechnology company focused on discovering, developing, and commercializing novel, patent-p...

Copyright Clearance Center, Inc.

Copyright Clearance Center (CCC), the rights licensing experts, is a global rights broker for the world’s most sought after materials, including in- and out-of-print books, j...

CorMatrix Cardiovascular, Inc.

CorMatrix Cardiovascular holds an exclusive license from Purdue University to research, develop, manufacture and market naturally occurring ECM products for cardiovascular applications. The company cu...

ZELTIQ Aesthetics, Inc.

We are a medical technology company focused on developing and commercializing products utilizing our proprietary controlled-cooling technology platform. Our first commercial produ...

ApniCure, Inc.

ApniCure is a private Redwood City, Calif.-based medical device company focused on developing and commercializing novel home-use devices incorporating a proprietary platform techn...

NovaSom, Inc.

NovaSom, Inc. is a privately held diagnostic-service provider for home testing and evaluation of sleep-disordered breathing, which includes the diagnosis of obstructive sleep apne...

Clinical Trials [364 Associated Clinical Trials listed on BioPortfolio]

Treosulfan Pharmacokinetics in Children Undergoing Allogeneic HSCT

Every year around 70 children affected by cancer or life-threatening genetic diseases undergo haematopoietic cell transplantation (HCT) within the Blood and Marrow Transplant (BMT) unit at...

Vitamin D3 Substitution in Vitamin D Deficient Kidney Transplant Recipients

The purpose of the study is to evaluate the effects of Cholecalciferol (Vitamin D3) substitution on the posttransplant outcome (glomerular filtration rate as well as serum creatinine level...

Tc-99m Renography and Cisplatin-Induced Nephrotoxicity

Cisplatin is a heavy-metal complex widely used in the treatment of a variety of malignancies, including small cell and non-small cell lung cancer, ovarian, bladder, head and neck, esophage...

Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Computed Tomography

It is well known that X-ray contrast media can affect kidney function in some patients, especially when administered intra-arterially, and patients who already suffer from reduced kidney f...

Lactate Metabolism Study in HIV Infected Persons

Lactic acidosis is a potentially life-threatening disease associated with the treatment of chronic HIV infection. Although acidosis is rare, hyperlactatemia is common and may have long ter...

Induction Dosing With Pegylated Interferon Alfa 2a and Ribavirin in Patients With Chronic Hepatitis C Genotype 1

The purpose of the study is to compare the effectiveness of two treatment regimens in clearing the Hepatitis C Virus in patients infected with Hepatitis C genotype 1. The study aims to de...

N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery

Cardiac surgery improves the survival and quality of life of people with heart disease. Nonetheless, several complications continue to adversely affect outcomes following cardiac surgery....

Phase 2 Study Of Neoadjuvant Iressa Treatment In Stage 1 NSCLC

ELIGIBILITY - Non-small cell lung cancer Clinical Stage 1A (T1N0M0 a tumor that is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchosc...

Early Allogeneic Blood Stem Cell Transplantation in High-Risk Acute Myeloid Leukemia (AML)

Karyotype is a major prognostic risk factor in patients with acute myeloid leukemia (AML) translating into unfavourable outcome in case of poor-risk cytogenetic aberrations. Several studie...

Use of Low Molecular Weight Heparin (Tinzaparin) to Treat Blood Clots in Patients With Kidney Failure

Blood clots in the leg veins, known as deep vein thrombosis, are important because they may travel to the lung (known as pulmonary embolism) and cause death. Blood clots are treated with...

Medical and Biotech [MESH] Definitions

A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.

Abrupt reduction in kidney function defined as an absolute increase in serum CREATININE of more than or equal to 0.3. mg/dl, a percentage increase in serum creatinine of more than or equal to 50%, or a reduction in urine output. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.

A severe stage of acute renal insufficiency, characterized by the sudden decrease in GLOMERULAR FILTRATION RATE to less than 15 ml per min, sometime to less than 1 to 2 ml per min. It is usually associated with OLIGURIA; EDEMA; and increase in BLOOD UREA NITROGEN and serum CREATININE concentrations.

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