Creatinine clearance - Biotech, Pharma and Life Science Channel
PubMed Articles
Helicobacter pylori Infection Inhibits Phagocyte Clearance of Apoptotic Gastric Epithelial Cells.
Increased apoptotic death of gastric epithelial cells is a hallmark of Helicobacter pylori infection, and altered epithelial cell turnover is an important contributor to gastric carcinogenesis. To add...
An essential role of antibodies in the control of chikungunya virus infection.
In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both human...
1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library technology. The triazine heterocycle proved t...
Although it is clear that the loss of CD4(+) T cells is a predisposing factor for the development of Pneumocystis pneumonia, specific Th mechanisms mediating protection are not well understood. Th1, T...
The impact of radioactive steel recycling on the public and professionals.
The decommissioning of nuclear power plants represents a complex process resulting in the generation of large amounts of waste materials, e.g. steel scrap containing various concentrations of radionuc...
Viral infections can exacerbate multiple sclerosis (MS) through poorly defined mechanisms. We developed an experimental system whereby infection with an asymptomatic neurotropic alphavirus caused a tr...
This study was designed to understand the impact of self-antigen load on manifestation of organ specific autoimmunity. Using a transgenic mouse model characterized by CNS hypermyelination, we show tha...
Infection with Neisseria gonorrhoeae triggers an intense inflammatory response characterized by an influx of neutrophils in the genital tract, yet natural gonococcal infection does not induce a state...
Chronic Kidney Disease in an Adult with Propionic Acidemia.
We report an adult male with classic propionic acidemia (PA) who developed chronic kidney disease in the third decade of his life. This diagnosis was recognized by an increasing serum creatinine and c...
Impairment in the elimination of misfolded proteins generates cellular toxicity and leads to various late-onset neurodegenerative diseases. However, the mechanisms by which cells recognize abnormal ce...
News Articles
Japan first to approve Avastin in first-line glioblastoma
The regulatory clearance marks the first time worldwide for the VEGF-targeting monoclonal antibody to be approved specifically for first-line use in glioblastoma, the most aggressive form of malignant...
Equip Your Healthcare Center with the Most Innovative Medical Equipments from Zone Medical
Ormeau, Australia, June 19, 2013 --(PR.com)-- For all kinds of medical centers and healthcare establishments in Australia, it is the best time to buy medical equipments and all other kinds of consuma...
High-Fat Diet Could Interrupt Amyloid Clearance
Study uncovers possible mechanism by which a diet high in saturated fat might disrupt the key process that clears amyloid from the brain, thereby raising risk for Alzheimer's disease. Medscape Medic...
OrthoSensor(TM) Receives FDA Clearance for VERASENSE(TM) Knee System with Limb Alignment
SUNRISE, FL -- (Marketwired) -- 06/18/13 -- OrthoSensor, Inc., the leader in intelligent orthopedics, today announced that the Company has received 510(k) clearance from the U.S. Food and Drug Admi...
EDAP Granted European Market Clearance for Focal.One(R)
LYON, France, June 18, 2013 (GLOBE NEWSWIRE) -- EDAP TMS SA (Nasdaq:EDAP), the global leader in therapeutic ultrasound, announced today that it received CE Mark (European regulatory approval) for Foc...
Mendor receives CE Mark clearance for its diabetes management platform
Mendor, a Finland-based diabetes technology firm, has received CE Mark clearance for its diabetes management cloud-based platform, Mendor Balance.
US FDA accepts TherapeuticsMD's IND application for vaginal estradiol suppository
Specialty pharmaceutical company TherapeuticsMD has obtained investigational new drug (IND) application clearance from the US Food and Drug Administration (FDA) for vaginal estradiol suppository, TX12...
Codman Neuro receives CE Mark clearance for enhanced Revive Se clot removal device
Codman Neuro, a part of DePuy Synthes Companies of Johnson & Johnson, has received CE Mark clearance for its Revive Se, the next generation self-expanding clot removal device for use in treating acute...
Omeros secures clearance for Phase I clinical trial to evaluate OMS721 antibody
US-based Omeros has received regulatory approval to commence a Phase I clinical trial of OMS721, the firm's lead human monoclonal antibody from its mannan-binding lectin-associated serine protease-2 (...
Mentor receives FDA clearance for MemoryShape breast implants
US-based aesthetic medical products maker Mentor Worldwide has secured approval from the US Food and Drug Administration (FDA) for its MemoryShape breast implants.
Events
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Companies
MiMedx® delivers innovative bioactive healing products for tissue regeneration MiMedx® is the global premier processor, marketer, and distributor of human amniotic tissue. MiMedx® has...
Tissue Regeneration Technologies, LLC
TRT is an international medical device company established to develop, manufacture and sell SoftWaveTM acoustical pressure pulse devices to treat various conditions poorly served...
NovaSom, Inc. is a privately held diagnostic-service provider for home testing and evaluation of sleep-disordered breathing, which includes the diagnosis of obstructive sleep apne...
Electromed, Inc., founded in 1992 and headquartered in New Prague, Minnesota, manufactures, markets and sells products that provide airway clearance therapy, including the SmartVe...
Clear Catheter Systems is a Bend, Oregon based medical device company developing an anti-clogging platform of surgical drainage devices. Its lead product is the PleuraFlow Cathete...
Ivivi Health Sciences is an emerging leader in the field of inductive electrotherapy. Its lead product, the Ivivi Torino II, has a demonstrated mechanism of action and proven clin...
PâCure develops advanced solutions that help bring proton therapy to routine clinical practice. The P-Cure system provides an integrated solution with volumetric imaging, pat...
Proteostasis Therapeutics and Elan Corporation
Proteostasis Therapeutics is developing âProteostasis Regulatorsâ (PRs), small molecule drugs that restore proper protein function or remove misfolded and aggregated pro...
We are a medical technology company focused on developing and commercializing products utilizing our proprietary controlled-cooling technology platform. Our first commercial produ...
Boston Biomedical Associates has extensive expertise in guiding companies through the regulatory approval process, as well as post market activities (e.g. MDR, vigilance reporting...
Clinical Trials
Tc-99m Renography and Cisplatin-Induced Nephrotoxicity
Cisplatin is a heavy-metal complex widely used in the treatment of a variety of malignancies, including small cell and non-small cell lung cancer, ovarian, bladder, head and neck, esophage...
Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Computed Tomography
It is well known that X-ray contrast media can affect kidney function in some patients, especially when administered intra-arterially, and patients who already suffer from reduced kidney f...
Lactate Metabolism Study in HIV Infected Persons
Lactic acidosis is a potentially life-threatening disease associated with the treatment of chronic HIV infection. Although acidosis is rare, hyperlactatemia is common and may have long ter...
The purpose of the study is to compare the effectiveness of two treatment regimens in clearing the Hepatitis C Virus in patients infected with Hepatitis C genotype 1. The study aims to de...
N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery
Cardiac surgery improves the survival and quality of life of people with heart disease. Nonetheless, several complications continue to adversely affect outcomes following cardiac surgery....
Phase 2 Study Of Neoadjuvant Iressa Treatment In Stage 1 NSCLC
ELIGIBILITY - Non-small cell lung cancer Clinical Stage 1A (T1N0M0 a tumor that is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchosc...
Early Allogeneic Blood Stem Cell Transplantation in High-Risk Acute Myeloid Leukemia (AML)
Karyotype is a major prognostic risk factor in patients with acute myeloid leukemia (AML) translating into unfavourable outcome in case of poor-risk cytogenetic aberrations. Several studie...
Blood clots in the leg veins, known as deep vein thrombosis, are important because they may travel to the lung (known as pulmonary embolism) and cause death. Blood clots are treated with...
"PTHrP(1-36) IV Dose Escalation Study"
This is a single-blinded, one-treatment, combination dose escalation and pharmacokinetic study done in healthy volunteers. The investigators want to determine whether PTHrP(1-36) shares a...
Control Strategies of the Locomotor System During Obstacle-Crossing in Stroke Patients
Tripping over obstacles is one of the common movements in daily life and is the most frequently mentioned cause of falls in the elderly. Indeed, crossing obstacles is a more complex motor...
Videos
Renal Fungtion.wmv
http://renaltreatment.net - Renal function, in nephrology, is an indication of the state of the kidney and its role in renal physiology. Glomerular filtratio...
Medical and Biotech [MESH] Definitions
Hyperuricemia
Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
Collectins
A class of C-type lectins that target the carbohydrate structures found on invading pathogens. Binding of collectins to microorganisms results in their agglutination and enhanced clearance. Collectins form trimers that may assemble into larger oligomers. Each collectin polypeptide chain consists of four regions: a relatively short N-terminal region, a collagen-like region, an alpha-helical coiled-coil region, and carbohydrate-binding region.
Azotemia
A biochemical abnormality referring to an elevation of BLOOD UREA NITROGEN and CREATININE. Azotemia can be produced by KIDNEY DISEASES or other extrarenal disorders. When azotemia becomes associated with a constellation of clinical signs, it is termed UREMIA.
Apolipoprotein C-i
A 6.6-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS; INTERMEDIATE-DENSITY LIPOPROTEINS; and HIGH-DENSITY LIPOPROTEINS. Apo C-I displaces APO E from lipoproteins, modulate their binding to receptors (RECEPTORS, LDL), and thereby decrease their clearance from plasma. Elevated Apo C-I levels are associated with HYPERLIPOPROTEINEMIA and ATHEROSCLEROSIS.
Proteostasis Deficiencies
Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.
