Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

08:13 EDT 22nd September 2014 | BioPortfolio

PubMed Articles [4690 Associated PubMed Articles listed on BioPortfolio]

In brief: Khedzela - a new brand of desvenlafaxine.

New oral anticogulants for acute venous thromboembolism.

Simeprevir (Olysio) for chronic hepatitis c.

How to Treat Erectile Dysfunction in Men with Diabetes: from Pathophysiology to Treatment.

Erectile dysfunction (ED) is highly prevalent affecting at least 50 % of men with diabetes mellitus (DM). DM may cause ED through a number of pathophysiological pathways. These include neuropathy, en...

Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry: Potential application to quantitative analysis.

Veterinarian and human pharmaceuticals may be intentionally added to animal feed to enhance animal production. Monitoring these substances is necessary for protecting the consumers. In this work, a sc...


Angiogenesis occurs during tumor development and plays a critical role in the progression of clear cell renal cell carcinoma (CCRCC). Tyrosine kinase inhibitors (TKIs) are multi-target inhibitors of T...


In the past decade, we have observed tremendous advance in the treatment for NSCLC. The discovery of sensitizing EGFR mutations as the basis of clinical response to tyrosine kinase inhibitors (TKIs) h...

Pulmonary Pathology: LC22-1 PULMONARY HYPERTENSION.

Pulmonary hypertension is a disease that is characterized by an increased pulmonary artery pressure and often results in right ventricular failure. Patients of any age might present with exertional dy...


The MYCN oncogene is the single most powerful biologic prognostic factor yet identified in childhood neuroblastoma. Children whose tumours display MYCN amplification have a particular poor prognosis, ...


Mucormycosis is a rare and often fatal infection caused by fungi of the Mucorales order, commonly affecting immunocompromised patients and adults with diabetic ketoacidosis. Infants are infected throu...

News Articles [5334 Associated News Articles listed on BioPortfolio]

Merck KGaA to buy Sigma-Aldrich for $17 billion

FRANKFURT (Reuters) - German drugs and chemicals maker Merck KGaA said on Monday it agreed to acquire Sigma-Aldrich for $17 billion in cash to boost its life science business.

Merck KGaA to buy Sigma-Aldrich for $17 bln

FRANKFURT, Sept 22 (Reuters) - German drugs and chemicals maker Merck KGaA said on Monday it agreed to acquire Sigma-Aldrich for $17 billion in cash to boost its life science business.

Singapore Doctors Develop New Drug to Combat Superbugs

A team from Singpore has discovered new ways to enhance the efficacy of drugs used to treat respiratory system infections and antibiotic-resistant superbugs.

China Remains Pie In Sky For Indian Drug Makers

As Chinese president Xi Jinping wraps up his first visit to India, Indian drug makers in China see hopes of a wider opening for their quality generics, instead of a haven for cheap counterfeit cancer ...

Brand Name Pharmaceutical Manufacturing in Canada Industry Market Research Report Now Available from IBISWorld

The expansion of Canadian's access to primary healthcare services will bolster demand for pharmaceuticals. For these reasons, industry research firm IBISWorld has added a report on the Brand Name ...

Incontinence Maybe Be Caused by Drugs for Pain, Depression, BPH Says New Article While Dr. Allen’s Devices Treat Underlying Problems Naturally, States Fine Treatment

There are four groups of medications doctors commonly recommend that can cause or increase incontinence, such as alpha blockers, antidepressants and narcotic pain relievers, states a recent article fr...

CSPC Pharma to Support Drug Discovery Work at Columbia University

CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) will collaborate with Columbia University of New York City to develop drugs that inhibit aldose reductase, an enzyme that causes eye and nerve dam...

PCMA: New OIG Report Cites Drug Manufacturer“Copay Coupon” Use in Medicare Part D

Suppliers are Prohibited From Using “Kickbacks” to Increase Sales in Federal Programs (Washington, DC) (PRWEB) September 19, 2014 “Copay coupons,” a drug manufacturer marketing tactic often u...

Xarelto Makers Seek Dismissal of Cases Brought in Philadelphia, Notes Rottenstein Law Group LLP

Defendant Xarelto manufacturers want several lawsuits dismissed from Pennsylvania state court, arguing that there is no connection with the state. Rockville Centre, NY (PRWEB) September 19, 2014 Acco...

Risky Drugs for Headache and Anxiety which as NCHS Reports that Can Lead to Death Are Able to Avoid with Dr. Allen’s Device for Head and Brain, Says Fine Treatment

By treating headache, depression and anxiety with New Dr. Allen’s Device for Head and Brain people can avoid serious side effects from opioid analgesics which, as a recent National Center for Health...

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Companies [226 Associated Companies listed on BioPortfolio]

Retina Associates of Florida

Retina Associates is a state-of-the art diagnostic and treatment center as well as a leading clinical research center for macular degeneration and other retinal diseases. Its phys...

BioFilm, Ltd.

Founded in 2003 as a subsidiary of Devro plc., BioFilm is the largest Thin Dissolving Film (TDF) producer in Europe, with their GMP certified manufacturing and packaging facility ...

Catalent, Inc.

Catalent, Inc. is the leading global provider of advanced delivery technologies and development solutions for drugs, biologics and consumer health products. With over 80 years ser...


Biosceptre has identified a pan-cancer target, present in many cancer types, and importantly not found in healthy tissue. Early research and initial evidence suggest that drugs di...

Therapeutic Proteins International

Therapeutic Proteins International, LLC (TPI) is a fully integrated manufacturer of biosimilar recombinant protein products. TPI’s vision is to produce high quality, life-alt...

Sephos Biotherapeutics

Sephos Biotherapeutics is a privately owned company focused on designing drugs for the treatment of cancer stem cells where the structure and biological activity of the drugs have...


Based in St. Petersburg, Russia, joint-stock company BIOCAD is a leading Russian private biopharmaceutical company, specializing in the research, development and manufacture of ge...

DesignMedix, Inc.

DesignMedix, Inc. was founded in 2008 to develop drugs to overcome drug resistance. The company’s initial focus is on oral drugs to treat malaria, which kills over 600,000 pe...

Zarbee’s Naturals

Founded in 2008 by pediatrician Dr. Zak Zarbock, Zarbee’s Naturals manufactures the nation’s #1 natural cough syrup and a complete line of “family-safe” health...

Ichor Medical Systems, Inc.

Ichor Medical Systems’ TriGrid™ Delivery System (TriGrid) is the first integrated and fully automated device for electroporation-mediated DNA administration in humans. I...

Clinical Trials [140 Associated Clinical Trials listed on BioPortfolio]

Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

The purpose of this study is to evaluate the pharmacokinetics (PKs) of antiretroviral (ARV) and tuberculosis (TB) medications in pregnant women and their infants. (Pharmacokinetics are the...

A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood

The purpose of this study is to find out whether taking protease inhibitors (anti-HIV drugs) together with lipid-lowering drugs (drugs which lower the amount of fat in the blood) has an ef...

A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

The purpose of this study is to see if it is safe and effective to give efavirenz plus stavudine plus lamivudine to patients who have never taken anti-HIV drugs.

A Study of Timunox (Thymopentin) in HIV-Infected Patients Receiving Other Anti-HIV Drugs

To evaluate the mechanism whereby thymopentin appears to retard the progressive immune suppression attributable to HIV infection.

A Study of Stavudine in HIV-Infected Patients Who Have Not Had Success With Other Anti-HIV Drugs

To make stavudine (d4T) available to patients with advanced HIV disease for whom no alternative antiretroviral is satisfactory. To study the safety and efficacy of two dose levels in a twi...

The Safety and Effectiveness of Nevirapine Plus Lamivudine Plus Other Anti-HIV Drugs

To evaluate the tolerance, safety, and effectiveness of Viramune in preventing clinical AIDS progression events or death when used in combination with Lamivudine and background nucleoside ...

A Study of MKC-442 in Combination With Other Anti-HIV Drugs

The purpose of this study is to see if it is safe and effective to give MKC-442 plus stavudine (d4T) plus didanosine (ddI) plus hydroxyurea.

A Study of Three Drug Combination Therapies in HIV-Infected Patients Who Have Never Been Treated With Anti-HIV Drugs

The purpose of this study is to see if it is safe and effective to give one of three different triple-drug combinations to HIV-infected patients who have never been treated with anti-HIV d...

A Comparison of Epivir Plus Crixivan Combined With Zerit or Retrovir in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

To evaluate the tolerance, and comparative virologic and immunologic effects of the two combination regimens.

Safety and Effectiveness of Tenofovir Disoproxil Fumarate (Tenofovir DF) Plus Other Anti-HIV Drugs in HIV-Infected Patients

The purpose of this study is to see if giving tenofovir DF plus a combination of other anti-HIV drugs is safe and effective.

Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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