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Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

12:13 EDT 24th April 2014 | BioPortfolio

PubMed Articles [3323 Associated PubMed Articles listed on BioPortfolio]

In brief: Khedzela - a new brand of desvenlafaxine.

New oral anticogulants for acute venous thromboembolism.

Simeprevir (Olysio) for chronic hepatitis c.

Aspirin Desensitization: Useful Treatment for Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in Aspirin-Exacerbated Respiratory Disease (AERD)?

Aspirin intolerance syndrome is due to disturbances in the arachidonic acid metabolism implicating both the lipoxygenase and cyclooxygenase pathways. This results in imbalances of eicosanoid, leukotri...

An integrated approach for detection and characterization of the trace impurities in levofloxacin using liquid chromatography-tandem mass spectrometry.

Impurity analysis plays an important role to guarantee the quality and safety of pharmaceuticals. However, identification of impurities remains challenging, especially for those unknown or at trace le...

Induction Therapy with Combination TNF Inhibitor and Methotrexate in Early Rheumatoid Arthritis.

With the introduction of more objective disease activity measures and the development of biological therapies, there were dramatic changes in the treatment of rheumatoid arthritis (RA). The combinatio...

Platelet function testing in contemporary clinical and interventional practice.

Dual antiplatelet therapy with a combination of aspirin and an inhibitor of the ADP P2Y12 receptor is the recommended treatment for patients with acute coronary syndrome or who are undergoing percutan...

Management of hyponatremia in clinical hepatology practice.

The burden of liver disease continues to increase in the United States, with the epidemics of hepatitis C, alcoholic liver disease, and the coming wave of nonalcoholic fatty liver disease patients all...

Pharmacogenetics of antiplatelet therapy.

There has been substantial progress toward understanding and investigating the specific genetic factors that influence interindividual variations in platelet-directed therapy. There has also been subs...

Anti-epileptic drugs and hormonal treatments.

Epilepsy and the medications used in its treatment are known to affect the menstrual cycle, aspects of contraception, and bone health in women. Adolescence is an important time to review the diagnosis...

News Articles [5264 Associated News Articles listed on BioPortfolio]

The safety of incretin based drugs

Important concerns have been raised about the impact of incretin based drugs on the risk of acute pancreatitis in patients with type 2 diabetes. Two linked papers by Li and colleagues...

Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study

Objectives To determine whether the use of incretin based drugs, compared with sulfonylureas, is associated with an increased risk of acute pancreatitis.Design Population based cohort study.Setting......

Lilly's disappointing sales put focus on drug pipeline

(Reuters) - Eli Lilly and Co reported lower-than-expected quarterly revenue on Thursday, hurt by disappointing sales of its cancer and diabetes drugs, and its shares fell more than 3 percent.

UPDATE 3-AstraZeneca plans spin-offs as cancer progress fuels bid talk

* Anti-PD-L1 product and three other drugs into Phase III

Eli Lilly 1Q profit tumbles 53 percent on patents

Eli Lilly's first-quarter earnings plunged 53 percent after the expiration of a key patent protecting its top-selling antidepressant cut into the drugmaker's revenue.The Indianapolis company lost U.S....

Skin layer grown from human stem cells could replace animals in drug and cosmetics testing

An international team led by King's College London and the San Francisco Veteran Affairs Medical Center (SFVAMC) has developed the first lab-grown epidermis – the outermost skin layer - with a funct...

UPDATE 1-Lilly posts sales below estimates, trims profit forecast

April 24 (Reuters) - U.S. drugmaker Eli Lilly and Co reported lower-than-expected quarterly revenue on Thursday, hurt by disappointing sales of its cancer and diabetes drugs, and trimmed its 2014 prof...

National Drug Take-Back Day: In the Shadow of Opioid Abuse Crisis, Now More Important Than Ever

By: Douglas C. Throckmorton There were more than 22,000 deaths in the United States relating to prescription drug overdose in 2010, many of which were due to intentional misuse and abuse. More than ha...

Marken Ready for Orphan Drug Distribution

RESEARCH TRIANGLE PARK, N.C., April 24, 2014 /PRNewswire/ -- Marken announced today the release of a new white paper which identifies supp...

Shipping With Active Packaging Containers: Three Pre-Flight Decisions That Impact The Success of High-Value Global Shipments

It is the dead of winter in the northern hemisphere and the height of summer in the southern, with external temperature fluctuations exceeding 50 degrees. Flight delays have added precious days to the...

Events [0 Results]

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Companies [214 Associated Companies listed on BioPortfolio]

Hydra Biosciences, Inc.

Hydra Biosciences is a privately-held biopharmaceutical company based in Cambridge, Massachusetts, and develops drugs to treat pain, inflammation, anxiety and other diseases using...

Catalyst Pharmaceutical Partners, Inc.

Catalyst Pharmaceutical Partners, Inc. is a specialty pharmaceutical company focused on the development and commercialization of prescription drugs targeting rare (orphan) neuromu...

Kineta, Inc.

Kineta, Inc. is a Seattle-based privately held biotechnology company specializing in clinical advancement of novel drug candidates derived from leading-edge scientific research. O...

DesignMedix, Inc.

DesignMedix, Inc. was founded in 2008 to develop drugs to overcome drug resistance. The company’s initial focus is on oral drugs to treat malaria, which kills over 600,000 pe...

CogState Ltd

CogState Ltd specializes in the development and commercialization of rapid, computerized tests of cognition (brain function). The tests are sold to pharmaceutical, biotechnology, nutraceutical and...

Cytox Limited

Cytox is a UK company developing products and services for neurodegenerative disorders. The company provides biomarker services to pharmaceutical industry clients conducting clinical trials with drugs...

NeuroVive Pharmaceutical AB

NeuroVive Pharmaceutical AB (www.neurovive.com) is a Swedish drug development company whose primary mission is to develop drugs for the treatment of acute brain injury, reperfusion injury in myocard...

Synthon Chiragenics Corporation

Synthon Chiragenics Corporation is a world-leader in carbohydrate-based chiral technology for pharmaceuticals. Unlike proteins and amino acids that have been the target of biomedical research for deca...

Zarbee’s Naturals

Founded in 2008 by pediatrician Dr. Zak Zarbock, Zarbee’s Naturals manufactures the nation’s #1 natural cough syrup and a complete line of “family-safe” health...

Susavion Biosciences, Inc.

The founders of Susavion Biosciences, Dr. Laura L. Eggink and Dr. J. Kenneth Hoober, developed a platform of novel peptide drugs, which have the potential to provide a breakthroug...

Clinical Trials [137 Associated Clinical Trials listed on BioPortfolio]

Pyroxamide in Treating Patients With Advanced Cancer

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of pyroxamide in...

A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-181)(COMPLETED)

The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.

Hormone Therapy and Docetaxel or Hormone Therapy Alone in Treating Patients With Metastatic Prostate Cancer

RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as goserelin, may stop the adrenal glands from making androgens. Drugs used in chemotherapy, such as docetax...

Pixantrone or Other Chemotherapy Drugs in Treating Patients With Relapsed Non-Hodgkin's Lymphoma

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It is not yet known whether...

Neoadjuvant Eflornithine and Bicalutamide Compared With Eflornithine Alone, Bicalutamide Alone, and No Neoadjuvant Therapy in Treating Patients With Localized Prostate Cancer Undergoing Brachytherapy or Radical Prostatectomy

RATIONALE: Drugs used in chemotherapy, such as eflornithine, work in different ways to stop tumor cells from dividing so they stop growing or die. Androgens can stimulate the growth of pro...

Hormone Ablation Therapy, Doxorubicin, and Zoledronate With or Without Strontium 89 in Treating Patients With Androgen-Dependent Prostate Cancer and Bone Metastases

RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as goserelin and leuprolide may fight prostate cancer by stopping the adrenal glands from producing andro...

Immunotherapy Combined With Chemotherapy Followed by Radiation Therapy and Chemotherapy in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Drugs used in immunotherapy such as rituximab can locate cancer cel...

Hormone Therapy With or Without Docetaxel And Estramustine in Treating Patients With Prostate Cancer That is Locally Advanced or At High Risk of Relapse

RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as nilutamide, bicalutamide, flutamide, or cyproterone may stop the adrenal glands from producing androge...

A Clinical Study Of An Investigational Regimen Including Marketed HIV Drugs In HIV-1 Pediatric Subjects Ages 2-18 Years

This is a 48-week study to collect additional information on the safety, tolerability, pharmacokinetics, and antiviral activity of an investigational regimen (course of therapy) including...

Ketoconazole and Docetaxel in Treating Patients With Metastatic Prostate Cancer

RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as ketoconazole may stop the adrenal glands from producing androgens. Drugs used in chemotherapy use diff...

Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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