Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

01:21 EST 29th January 2015 | BioPortfolio

PubMed Articles [4694 Associated PubMed Articles listed on BioPortfolio]

The Impact of Conflict of Interest in Abdominal Wall Reconstruction With Acellular Dermal Matrix.

Conflict of interest (COI) and disclosure of financial relationships have received increased attention recently owing in part to the passage of the Physician Payments Sunshine Act, which requires manu...

Nanostructured lipid carriers loaded with tributyrin as an alternative to improve anticancer activity of all-trans retinoic acid.

Objectives: All-trans retinoic acid (ATRA) is one of the most successful examples of differentiation agents and histone deacetylase inhibitors, such as tributyrin (TB), are known for their antitumor a...

Optimizing Distribution of Pandemic Influenza Antiviral Drugs.

We provide a data-driven method for optimizing pharmacy-based distribution of antiviral drugs during an influenza pandemic in terms of overall access for a target population and apply it to the state ...

Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells.

Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer ...

Implementation of modern therapy approaches and research for non-small cell lung cancer in Japan.

The genetic backgrounds of the Japanese (or Asians) are, at least in part, different from those of Caucasians. It is necessary to recognize this difference to develop medicine that is both optimized a...

Effects of testosterone replacement in men with opioid-induced androgen deficiency: a randomized controlled trial.

Symptomatic androgen deficiency is common in patients taking opioid analgesics, as these drugs potently suppress the hypothalamic-pituitary-gonadal axis. However, the efficacy of testosterone replacem...

New thermosensitive nanoparticles prepared by biocompatible pegylated aliphatic polyester block copolymers for local cancer treatment.

New pegylated thermosensitive polymers were developed to study them as drug vehicles in targeting release nanoparticulate systems of anticancer drugs.

Illegal Drugs Laws: Clearing a 50-Year-Old Obstacle to Research.

The United Nations drug control conventions of 1960 and 1971 and later additions have inadvertently resulted in perhaps the greatest restrictions of medical and life sciences research. These conventio...

Epigallocatechin-3-gallate, a promising molecule for Parkinson's disease?

Parkinson's disease is the second most common neurodegenerative disease and it is characterized by the loss of the neurotransmitter dopamine and neuronal degeneration in the substantia nigra pars comp...

Therapeutic choices in convulsive status epilepticus.

Introduction: Convulsive status epilepticus (SE) is one of the most frequent and severe neurological emergencies in both adults and children. A timely administration of appropriate antiepileptic drugs...

News Articles [5237 Associated News Articles listed on BioPortfolio]

Personalized Medicine May Necessitate Increased Focus On Drug Quality

FDA Office of Biotechnology Products Director says promise of personalized medicine may place greater burden on pharma to ensure drugs work as intended in target populations.

Amgen Cites Strength From Being Both Innovator And Developer In Biosimilars Space

Struggling to both contain costs and put extra muscle behind its new products and late-stage candidates, Amgen also finds itself torn between roles as an innovator and a firm pursuing biosimilar appro...

Statins may benefit women as much as men

(Reuters Health) – A large international analysis finds that statin drugs reduce heart risk factors like high cholesterol as effectively in women as they do in men.

EMA Acts To Freeze GVK Drugs, Guard Against Shortages

The EMA has recommended suspension of some 700 drug formations linked with Indian clinical trials company GVK Biosciences, but assures national agencies that this won’t result in shortages or safety...

Onxeo S.A.: Publication of a Shareholders Letter

Regulatory News: OnxeoS.A. (Paris:ONXEO) (NASDAQ OMX:ONXEO) (Euronext Paris, NASDAQ OMX Copenhagen: ONXEO), an innovative company specializing in the development of orphan oncology drugs, today an...

Cancer diagnosis makes diabetes patients less adherent to their prescribed diabetes drugs

Diabetes patients become less adherent to their diabetes medications following a diagnosis of cancer, concludes a new study published in Diabetologia. The research is led by Marjolein Zanders, Netherl...

Health insurers using drug coverage to discriminate

Some insurers offering health plans through the new federal marketplace may be using drug coverage decisions to discourage people with HIV from selecting their plans, according to a new study from Har...

Study finds unfair HIV-drug pricing in US health plans

Some US health insurance plans are discriminating against people with HIV by placing antiretroviral

Russia may face shortage of anti-AIDS drugs in 2015

Russia may face with a shortage of anti-AIDS drugs in 2015 due to the current complex situation in the national economy and devaluation of the rouble, according to recent statements of Vadim Pokrovsky...

Many Commonly Used Drugs Tied to Weight Change

Several commonly used drugs are associated with weight changes of varying magnitude - and the consequences are worth considering, say the authors of a new paper. Reuters Health Information

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Companies [238 Associated Companies listed on BioPortfolio]

Prometheon Pharma

Prometheon Pharma is a biotechnology company housed in the globally #1-ranked Sid Martin Biotech Incubator at the University of Florida. Prometheon is dedicated to increasing pati...

ProteoTech Inc.

ProteoTech is a privately-held, drug development company that utilizes its amyloid expertise to discover and develop new drugs for treating misfolded protein disorders and amyloid...

Incyte and Agenus

Incyte Corporation is a Wilmington, Delaware-based biopharmaceutical company focused on the discovery, development and commercialization of proprietary small molecule drugs, prima...

Bartell Drugs

Founded in Seattle in 1890, Bartell Drugs owns and operates 62 locations in King, Snohomish and Pierce counties. Family owned and operated, it is the nation's oldest drugstore cha...

Hydra Biosciences, Inc

Hydra Biosciences is a biopharmaceutical company developing molecular regeneration medicines, novel cardiovascular therapies and drugs targeting novel ion channels. Tapping the unharnessed power of th...

Proteo Biotech AG

The company researches, develops and markets compounds for biological and medical research as well as for use as pharmaceuticals. The main focus is on anti-inflammatory drugs, in ...

RaNA Therapeutics, Inc.

RaNA Therapeutics is pioneering the discovery of a new class of medicines that target RNA to selectively activate protein expression within the body’s own cells. RaNA’s ...

PharmaEngine, Inc.

PharmaEngine, Inc. is a biopharmaceutical company established in Taipei, Taiwan in 2003. The company focuses on the development of new drugs to treat cancer and Asian prevalent di...

ScripsAmerica, Inc.

ScripsAmerica, Inc. is a supplier of prescription, OTC and nutraceutical drugs, delivering pharmaceutical products to a wide range of end users across the health care industry. En...

NEMUS Bioscience, Inc.

The Company is a biopharmaceutical company, headquartered in Costa Mesa, California, focused on the discovery, development, and commercialization of cannabis-based therapeutics fo...

Clinical Trials [164 Associated Clinical Trials listed on BioPortfolio]

The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea

The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.

When to Start Anti-HIV Drugs in Patients With Opportunistic Infections

The purpose of this study is to evaluate the effect of starting anti-HIV drugs in HIV infected patients who are being treated for opportunistic infections (OIs). This study will follow tw...

An Observational Study of Induction Therapy With Fuzeon (Enfuvirtide) in Combination With Antiretroviral Drugs in Patients With HIV-1 Infection

This multicenter, retrospective, observational study will evaluate the therapeut ic effectiveness of a strategy of induction with Fuzeon (enfuvirtide) within an optimized regimen of antire...

A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)

The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.

Re-examination Study For Varivax (V210-059 AM2)

This survey is conducted for preparing application materials for re-examination under the Korean Pharmaceutical Affairs Laws and its Enforcement Regulation; its aim is to reconfirm the cli...

Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

The purpose of this study is to evaluate the pharmacokinetics (PKs) of antiretroviral (ARV) and tuberculosis (TB) medications in pregnant women and their infants. (Pharmacokinetics are the...

A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood

The purpose of this study is to find out whether taking protease inhibitors (anti-HIV drugs) together with lipid-lowering drugs (drugs which lower the amount of fat in the blood) has an ef...

A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

The purpose of this study is to see if it is safe and effective to give efavirenz plus stavudine plus lamivudine to patients who have never taken anti-HIV drugs.

A Study of Timunox (Thymopentin) in HIV-Infected Patients Receiving Other Anti-HIV Drugs

To evaluate the mechanism whereby thymopentin appears to retard the progressive immune suppression attributable to HIV infection.

A Study of Stavudine in HIV-Infected Patients Who Have Not Had Success With Other Anti-HIV Drugs

To make stavudine (d4T) available to patients with advanced HIV disease for whom no alternative antiretroviral is satisfactory. To study the safety and efficacy of two dose levels in a twi...

Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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