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Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

09:43 EST 14th February 2016 | BioPortfolio

PubMed Articles [4710 Associated PubMed Articles listed on BioPortfolio]

(177)Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment.

Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvio...

ADVANCES IN ANIMAL WELFARE FOR FREE-LIVING ANIMALS.

Over several decades, animal welfare has grown into its own free-standing field of scientific study, from its early beginnings in laboratory animal research to eventually include exhibited animals and...

New progress and prospects: The application of nanogel in drug delivery.

Nanogel has attracted considerable attention as one of the most versatile drug delivery systems especially for site-specific and/or time-controlled delivery of bioactive agents owing to their combinin...

Targeted delivery of 5-fluorouracil to cholangiocarcinoma cells using folic acid as a targeting agent.

There are limits to the standard treatment for cholangiocarcinoma (CCA) including drug resistance and side effects. The objective of this study was to develop a new technique for carrying drugs by con...

Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application.

The present work reports the synthesis of biocompatible zirconium phosphate (ZP) nanoparticles as nanocarrier for drug delivery application. The ZP nanoparticles were synthesized via a simple sonochem...

Dispersive micro-solid phase extraction using magnetic nanoparticle modified multi-walled carbon nanotubes coupled with surfactant-enhanced spectrofluorimetry for sensitive determination of lomefloxacin and ofloxacin from biological samples.

A dispersive micro-solid-phase extraction (D-μ-SPE) procedure coupled with surfactant-enhanced spectrofluorimetric detection was developed for determination of ofloxacin and lomefloxacin from biologi...

Sulfite Oxidase Activity of Cytochrome c: Role of Hydrogen Peroxide.

In humans, sulfite is generated endogenously by the metabolism of sulfur containing amino acids such as methionine and cysteine. Sulfite is also formed from exposure to sulfur dioxide, one of the majo...

Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction.

Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden card...

Recent advances in solid dispersions and the formulation of poorly absorbed drugs.

Gold(III) compounds-mediated inhibition of lung cancer cell proliferation.

Research on chemotherapeutics for lung cancer is crucial for designing a new therapeutic strategy against malignant lung tumors. Although radiotherapy and chemotherapy, which are not selective for can...

News Articles [4854 Associated News Articles listed on BioPortfolio]

The Real Miracle Of Drug Development: Immunity From Inflation!

They say there are two certainties in life: death and taxes. If we were to add a third certainty to that list, it might be that we generally have inflation as well. But if rising prices on consumer go...

Kathy Giusti: the businesswoman who took on her own cancer

There are now 10 drugs available for treating multiple myeloma, in large part thanks to the cofounder of the Multiple Myeloma Research Foundation.

One Hospital's Unusual Freebie For Newborns: Genetic Testing To See How Well They Metabolize Drugs

At most hospitals, new parents receive swag along the lines of diaper bags, rectal thermometers and those little blue bulb syringes used tosuctionout mucus from a baby's nose. The brand-new Inova Wome...

[Public Health] Averting a malaria disaster: will insecticide resistance derail malaria control?

World Malaria Day 2015 highlighted the progress made in the development of new methods of prevention (vaccines and insecticides) and treatment (single dose drugs) of the disease. However, increasing d...

Obsessed Athletes More Likely to Approve of Performance-Enhancing Drugs: Study

SATURDAY, Feb. 13, 2016 -- The more obsessed that college athletes are with their sport, the more likely they are to approve of using performance-enhancing drugs, a new Canadian study finds. Two types...

Coronaviruses — drug discovery and therapeutic options

Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), which are caused by coronaviruses, have attracted substantial attention owing to their high mortality rates and po...

Express Scripts sees slow 2016 sales for new cholesterol drugs

NEW YORK (Reuters) - A surge in sales of pricey new cholesterol treatments is unlikely to materialize this year, contrary to the previous expectations of Express Scripts Holding, an executive from the...

Embracing Pharmacy Care Management for High-Value Care Delivery

Laureen BiczakIndustry groups are increasingly recognizing the role of effective medication management in achieving clinical benefits and improved costs — particularly medication adherence and t...

Merck, Sun Pharma winding down JV

Indian pharmaceutical company Sun Pharmaceutical Industries Ltd. (BSE:524715; NSE:SUNPHARMA) said it will wind down operations of its JV with Merck & Co. Inc. (NYSE:MRK) due to "changes in the strateg...

Drug Discovery Spotlight: First HIV-Positive Organ Transplants; Drug Industry Ad Campaign; Depression Drugs

Welcome to Drug Discovery Spotlight, where we’ve rounded up this week’s top news, trending headlines, and all-around interesting reads. John Hopkins to Perform First HIV-Positive Organ Transplant...

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Companies [266 Associated Companies listed on BioPortfolio]

Verseon

Verseon is a technology-based pharmaceutical company that employs its proprietary computational drug discovery platform to develop novel therapeutics for today’s challenging ...

Enable Injections

Founded February 2010 by medical device industry veterans, Cincinnati, OH-based Enable Injections develops and manufactures devices that allow easy, comfortable patient self-admin...

Icagen, Inc.

Icagen, Inc. is a biopharmaceutical company based in Research Triangle Park, North Carolina, focused on the discovery, development and commercialization of novel orally-administered small molecule...

CureDuchenne Ventures LLC

CureDuchenne Ventures LLC collaborates with pharmaceutical and biotechnology companies to facilitate the development of drugs to treat Duchenne muscular dystrophy. CureDuchenne Ve...

XL-protein GmbH

XL-protein is a privately owned biopharmaceutical company based in Freising, Germany, which exploits its proprietary PASylation® technology to develop biologics with extended p...

Decibel Therapeutics

By combining recent innovations in hearing science with leading diagnostic tools, biological insights, modeling and therapeutic delivery techniques, Decibel is pioneering a compre...

Tanner Pharma Group

For over 15 years, Tanner Pharma Group has provided highly specialized pharmaceutical services to its partners around the world. Leading pharmaceutical and biotech companies partn...

OncoRx Pharmaceuticals Inc.

OncoRx Pharmaceuticals (www.oncorxpharmaceuticals.com) is an early-stage pharmaceutical company dedicated to the discovery and development of novel drugs that control tumor metast...

HealthWarehouse.com, Inc.

HealthWarehouse.com, Inc. (OTC Bulletin Board: HEWA) is a trusted, VIPPS accredited pharmacy based in Cincinnati, Ohio. HealthWarehouse.com offers 300 prescription drugs for $3.50 with 100% FREE ship...

DeuteRx LLC

DeuteRx is pioneering ‘deuterium-enabled chiral switching’ (DECS), a revolutionary approach to improve racemic (a mixture of two mirror-image compounds or enantiomers) s...

Clinical Trials [433 Associated Clinical Trials listed on BioPortfolio]

Peripheral Blood Biomarkers Associated With CIPN

The investigators are doing a research study that will teach us about the tingly pain that people develop when they get chemotherapy.

Triumeq As an Integrase Single Tablet Regimen in People With HIV Who Inject Drugs

The purpose of this study is to assess the tolerability, adherence and efficacy of single tablet dolutegravir/abacavir/lamivudine antiretroviral therapy in people living with HIV with a hi...

Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion

The study is to investigate the anticancer effect and the related immunological mechanism of MTX-ATMPs in the treatment of malignant pleural effusion.

EMBRACE-SC: Observational Study of Subcutaneous (SC) Tocilizumab Alone or in Combination With Conventional Disease-Modifying Antirheumatic Drugs (cDMARDs) in Rheumatoid Arthritis

The purpose of this study is to evaluate the percentage of participants treated with subcutaneous (SC) Tocilizumab who are still on treatment after 52 weeks and the factors that play a maj...

Study of the Effects of ITCA 650 on Gastric Emptying and Interaction of ITCA 650 on 4 Commonly Studied Drugs

A Phase 1, Fixed-Sequence, Open-label Study in Healthy Subjects to Estimate the Effects of ITCA 650 on Gastric Emptying and on the Absorption Pharmacokinetics of Each of 4 Commonly Studied...

Use of Well Known Drugs for New Destination - RA Improvement (RANT)

The purpose of this interventional study is to determine whether tetracyclines, statins, antiviral and Vitamin D3 in single subministration are effective in improvement of life and health ...

Use on Human Beings of Mix of Known Drugs for New Destination - MS Treatment

The purpose of this interventional study was to evaluate the use on human being of a mix between very well known drugs, tested upon registered trial n° NCT02606929, to consider effectiven...

Oncologists Satisfaction With Outcomes of Some Cytotoxic Agents

The study measures the degree of oncology physician satisfaction with the outcomes of some cytotoxic agents.

Analgesic Effects of Midazolam in Human Volunteers

This study evaluates analgesic properties of midazolam compared to placebo and fentanyl. Each participant will receive all three drugs (midazolam, fentanyl, placebo) on three different occ...

Use of Well Known Drugs for New Destination - MS Improvement (MSNT)

The purpose of this expanded access retrospective study is to determine whether tetracyclines, statins and antimycotics are effective in improvement of life and health condition in the tre...

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Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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