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Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

11:18 EDT 27th July 2016 | BioPortfolio

PubMed Articles [4732 Associated PubMed Articles listed on BioPortfolio]

Sexual abstinence: What is the understanding and views of secondary school learners in a semi-rural area of North West Province, South Africa?

Among strategies to prevent HIV, other sexually transmitted infections (STIs) and unwanted pregnancies, are programs that promote sexual abstinence among adolescents. However, literature suggests that...

(177)Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment.

Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvio...

Biological evaluation of N-2-hydroxypropyl trimethyl ammonium chloride chitosan as a carrier for the delivery of live Newcastle disease vaccine.

Mucosal immune system plays a very important role in antiviral immune response. We prepared Newcastle disease viruses (NDV) encapsulated in N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-2-...

Preparation and evaluation of naringenin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for ocular drug delivery.

The aim of this study was to prepare and characterize the naringenin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles (Nag-CD/CS-NPs) and evaluate their potential for the topical ophthalm...

A phase I dose-escalation study of LY2875358, a bivalent MET antibody, given as monotherapy or in combination with erlotinib or gefitinib in Japanese patients with advanced malignancies.

Background MET is a tyrosine kinase receptor involved in the regulation of cell proliferation and migration. Reported here are the phase I dose-escalation results for LY2875358, a monoclonal antibody ...

Is Synovial Macrophage Activation the Inflammatory Link Between Obesity and Osteoarthritis?

Osteoarthritis (OA) is the most common musculoskeletal disease, affecting nearly 25 % of the world population (WHO reports), leading to pain and disability. There are as yet no clinically proven the...

Formation of nanoporous aerogels from wheat starch.

Biodegradable nanoporous aerogels were obtained from wheat starch using a simple and green method based on supercritical carbon dioxide (SC-CO2) drying. Effects of processing parameters (temperature, ...

Gums' based delivery systems: Review on cashew gum and its derivatives.

The development of delivery systems using natural polymers such as gums offers distinct advantages, such as, biocompatibility, biodegradability, and cost effectiveness. Cashew gum (CG) has rheological...

Syntheses and characterization of amphiphilic quaternary ammonium chitosan derivatives.

Amphiphilic chitosan derivatives possess improved physico-chemical properties and could be used as carriers in drug delivery systems. The aim of this study was to investigate the behaviour of an amphi...

Design Issues in Transgender Studies.

Transgender individuals constitute an important focus for HIV prevention, but studies in this population present some unique methodologic and operational challenges. We consider issues related to samp...

News Articles [5640 Associated News Articles listed on BioPortfolio]

Impact of FDCs ban on pharmaceutical industry

Fixed dose combinations (FDCs) refer to pharmaceutical preparations containing two or more drugs in a fixed ratio.

Hollow victories and hepatitis C

When Gilead Sciences introduced sofosbuvir based antivirals in 2014, the drugs were touted as a breakthrough for people with hepatitis C infection, promising high cure rates and fewer complications......

Shire and BMS secure NICE recommendations for oncology drugs

The National Institute for Health and Care Excellence (NICE) has issued final guidance recommending Shire’s Oncaspar (pegaspargase) and Bristol-Myers Squibb’s Opdivo (nivolumab) plus Yervoy (ipili...

GSK invests £275m in UK manufacturing

GSK has announced that it will invest £275 million into three of its manufacturing sites in the UK to boost production and support delivery of its respiratory and large molecule biological drugs.

Teens who misuse pain meds are more likely to abuse drugs as adults

A new University of Michigan study about substance abuse confirms why parents should properly dispose of leftover prescription opioids.

Can drugs that treat hypertension may also treat depression?

In the current issue of Psychotherapy and Psychosomatics, the relationship of drugs that are generally used for treating hypertension (angiotensin converting enzyme inhibitors) are examined in their e...

[Comment] Tribendimidine: great expectations

Parasitic infections inflict a disproportionate burden of disease in the tropics, where most of the world's vulnerable populations live. However, efforts to control neglected tropical diseases caused ...

UK drugs giant GSK invests £275m despite Brexit

Drugmaker GlaxoSmithKline on Wednesday revealed plans to invest £275 million into three of its British manufacturing sites, shrugging off Brexit worries.

UK drugs giant GSK invests £275m despite Brexit (Update)

Drugmaker GlaxoSmithKline on Wednesday revealed plans to invest £275 million into three of its British manufacturing sites, shrugging off Brexit worries.

UPDATE 2-GlaxoSmithKline invests $360 mln in UK despite Brexit vote

* Investment at sites making respiratory and biotech drugs (Adds government reaction, more on other post-Brexit investments)

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Companies [270 Associated Companies listed on BioPortfolio]

Reset Therapeutics, Inc.

Reset, a discovery-stage biopharma company co-founded by leaders in the field of circadian biology and Bay City Capital, is developing first-in-class approaches to treating diseas...

SciFluor Life Sciences, Inc.

SciFluor Life Sciences is a drug discovery company developing a best-in-class portfolio of partnership-ready therapeutic drugs strategically capitalizing on the transformational p...

Altan Pharma Limited

Altan Pharma Ltd. is a privately held, specialty pharmaceutical company that develops, manufactures and commercialises injectable drugs for the hospital and other provider segm...

Ensemble Therapeutics

EnsemblinsTM are a new class of synthetic macrocycles developed by Ensemble using its proprietary chemistry platforms, including DNA-Programmed ChemistryTM. Macrocyc...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Verseon

Verseon is a technology-based pharmaceutical company that employs its proprietary computational drug discovery platform to develop novel therapeutics for today’s challenging ...

Enable Injections

Founded February 2010 by medical device industry veterans, Cincinnati, OH-based Enable Injections develops and manufactures devices that allow easy, comfortable patient self-admin...

Icagen, Inc.

Icagen, Inc. is a biopharmaceutical company based in Research Triangle Park, North Carolina, focused on the discovery, development and commercialization of novel orally-administered small molecule...

CureDuchenne Ventures LLC

CureDuchenne Ventures LLC collaborates with pharmaceutical and biotechnology companies to facilitate the development of drugs to treat Duchenne muscular dystrophy. CureDuchenne Ve...

XL-protein GmbH

XL-protein is a privately owned biopharmaceutical company based in Freising, Germany, which exploits its proprietary PASylation® technology to develop biologics with extended p...

Clinical Trials [614 Associated Clinical Trials listed on BioPortfolio]

Evaluation of Aerosolized Drugs Deposition During Mechanical Ventilation

Aerosol delivery through a ventilator is influenced by numerous factors from ventilator-related, circuit-related to device-related factors. Aerosolized drug delivery through a ventilator s...

The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial

For the past 130 years, appendectomy has been the standard treatment for appendicitis. Recent studies from Europe have challenged the notion that surgery is the best option, showing that a...

Perioperative Antiplatelet Therapy in Patients With Drug-eluting Stent Undergoing Noncardiac Surgery

The purpose of this study is to evaluate the safety and effectiveness of perioperative antiplatelet therapy in patients with drug-eluting stent undergoing non-cardiac surgery.

Implementation of PPI Medication PGX Testing

USING GENETIC INFORMATION ABOUT THE INDIVIDUAL TO PICK THE RIGHT DRUG FOR THE RIGHT DISEASE AT THE RIGHT DOSE DEFINES PERSONALIZED MEDICINE. THIS PILOT STUDY SEEKS TO INSTITUTE PHARMACOGEN...

This Study Tests the Effect of BI 655066 on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis

To assess the influence of BI 655066 onkinetics of cytochrome P450 (CYP) probe drugs as a means of predicting drug-drug interactions

Evaluating Newly Approved Drugs for Multidrug-resistant TB

endTB Clinical Trial a Phase III, randomized, controlled, open-label, non-inferiority, multi-country trial evaluating the efficacy and safety of five new, all-oral, shortened regimens for ...

"Drugs in Lactation" Analysis Consortium

Some medications taken by the breastfeeding women are excreted into milk, posing a potential risk of toxicity to the infant. The first line of evidence required for toxicity risk assessmen...

Application of Two Anti-angiogenesis Drugs Combined With Chemotherapy in Advanced Colorectal Cancer Under the Background of Precision Medical

The purpose of this study is to determine whether Endostar pumping into vein with Thalidomide are more effective in the treatment of Advanced Colorectal Cancer (ACRC).

Low-dose Combination of Three Antihypertensive Drugs

The aim of the study is to compare the efficacy and safety of low-dose combination of three antihypertensive drugs versus fixed high-dose combination of two antihypertensive drugs in arter...

Once-daily Fixed Combination of Three Antihypertensive Drugs

Randomized comparison of once-daily fixed combiNation versus free-drug combination of three antihypertensive agents in arterial hypertension

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Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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