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Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

02:22 EDT 28th March 2017 | BioPortfolio

PubMed Articles [4646 Associated PubMed Articles listed on BioPortfolio]

Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain.

With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thios...

Nanocarriers as treatment modalities for hypertension.

Hypertension, a worldwide epidemic at present, is not a disease in itself rather it is an important risk factor for serious cardiovascular disorders including myocardial infarction, stroke, heart fail...

In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration.

Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal...

Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (risperidone) using liquisolid technique.

BCS class II drugs usually suffer inadequate bioavailability as dissolution step is the absorption rate limiting step. In this work, the effect of solubility increase at the main absorption site for t...

Effective improvement of the neuroprotective activity after spinal cord injury by synergistic effect of glucocorticoid with biodegradable amphipathic nanomicelles.

Dexamethasone acetate (DA) produces neuroprotective effects by inhibiting lipid peroxidation and inflammation by reducing cytokine release and expression. However, its clinical application is limited ...

Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix.

In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphatidylethanolamine-poly(ethylene glycol)2000 (DSPE-PEG) as absorption enhancer and hydroxy propyl meth...

Hydrophobic kenaf nanocrystalline cellulose for the binding of curcumin.

Nanocrystalline cellulose (NCC) extracted from lignocellulosic materials has been actively investigated as a drug delivery excipients due to its large surface area, high aspect ratio, and biodegradabi...

A new unsaturated derivative of hyaluronic acid - Synthesis, analysis and applications.

Hyaluronic acid (HA) containing CC double bond in positions 4 and 5 of N-acetyl-glucosamine ring (ΔHA) is an unique material, which could be used for biomedical applications and cosmetics. The main a...

Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs.

Targeted delivery and retention of drug formulations in the olfactory mucosa, the target site for nose-to-brain drug absorption is a major challenge due to the geometrical complexity of the nose and n...

Docking-based virtual screening of Brazilian natural compounds using the OOMT as the pharmacological target database.

The demand for new therapies has encouraged the development of faster and cheaper methods of drug design. Considering the number of potential biological targets for new drugs, the docking-based virtua...

News Articles [5131 Associated News Articles listed on BioPortfolio]

Simponi® is Sixth Drug in InformTx™ Therapeutic Drug Monitoring Service from Miraca Life Sciences

Miraca Life Sciences, the largest U.S. independent anatomic pathology laboratory, continues to expand its InformTx™ therapeutic drug monitoring (TDM) capabilities, now testing f...

TaiGen Sells 9% of China JV to HEC ChangJiang for $20 Million

South Korea's TaiGen Biotech will be paid $20 million for a 9% interest in a China JV by its partner YiChang HEC ChangJiang Pharma. The JV, formed six months ago, is developing two direct acting anti-...

Hunan Zhaotai Forms New Zealand JV for Cancer Drug Development

Hunan Zhaotai Medical Group has formed a cancer treatment JV with New Zealand's Malaghan Institute, which will conduct clinical trials on Zhaotai's CAR-T cancer drug portfolio in New Zealand. Zhaotai ...

Research findings offer potential explanation for opioid-induced itching

Opioids have long been an important tool in the world of pain management, but the side effects of these drugs - from addiction and respiratory failure to severe itching and dizziness, can be overwhelm...

Top heart doctors warn proposed NIH cuts would be catastrophic

(Reuters) - Top heart doctors and researchers have a simple reaction to President Donald Trump's proposed 20 percent cut to the budget of the U.S. National Institutes of Health: fear that research tha...

Enanta Pharmaceuticals to Present at the H.C. Wainwright 1st Annual NASH Investor Conference

Presentation to be Webcast on April 3 at 4:00 pm ET Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a research and development-focused biotechnology company dedicated to creating ...

STAT Plus: Gilead faces a fresh challenge to a key hepatitis C patent in Europe

This is the latest challenge by groups arguing Gilead filed patents that unfairly allowed it to monopolize hepatitis c drugs in various countries.

EMA backs three orphan drugs

Couples Substance Abuse Treatment Resource Center Enters Into Marketing Agreement With Addiction Marketing SEO Firm

CouplesRehab.org recently announced a new marketing contract was inked out between the couples addiction treatment site and Knack Media. The marketing firm is known for generating drug rehab leads and...

Internists issue recommendations for preventing and treating substance use disorders

The American College of Physicians (ACP) today released a paper with a comprehensive set of public policy recommendations for the prevention and treatment of substance use disorders involving illicit ...

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Companies [255 Associated Companies listed on BioPortfolio]

H.I.G. BioHealth Partners

H.I.G. BioHealth Partners is the dedicated life-science investment affiliate of H.I.G. Capital. H.I.G. BioHealth Partners invests in a broad range of healthcare opportunities acro...

Impel NeuroPharma, Inc.

Impel NeuroPharma, Inc. is a Seattle-based company developing intranasal drug treatments for central nervous system (CNS) disorders. Impel NeuroPharma has developed a novel drug d...

Chi-Med

Chi-Med is a China-based, globally-focused healthcare group which researches, develops, manufactures and sells pharmaceuticals and health-related consumer products. Its Innovation...

Discuva

Discuva aims to revolutionise the treatment of disease caused by bacterial infection by discovering and developing new antibiotics against highly drug-resistant pathogens. The com...

Cook Medical Australia

A global pioneer in medical breakthroughs, Cook Medical is committed to creating effective solutions that benefit millions of patients worldwide. Today, we combine medical devices...

Abilita Bio Inc.

Founded in 2014, Abilita Bio is an innovation-driven biotechnology company focused on enabling the discovery and development of drugs targeting challenging human membrane proteins...

Decibel Therapeutics

By combining recent innovations in hearing science with leading diagnostic tools, biological insights, modeling and therapeutic delivery techniques, Decibel is pioneering a compre...

Neurotechnology Industry Organization

The Neurotechnology Industry Organization is the trade association that represents companies involved in neuroscience including software, drugs, devices, and diagnostics, brain re...

Reset Therapeutics, Inc.

Reset, a discovery-stage biopharma company co-founded by leaders in the field of circadian biology and Bay City Capital, is developing first-in-class approaches to treating diseas...

SciFluor Life Sciences, Inc.

SciFluor Life Sciences is a drug discovery company developing a best-in-class portfolio of partnership-ready therapeutic drugs strategically capitalizing on the transformational p...

Clinical Trials [892 Associated Clinical Trials listed on BioPortfolio]

Microbiome Shift in Peri-mucositis by Anti-inflammatory Drugs

Dental implants are often used to replace missing teeth. In fact, in the US over 700,000 implants are places every year and over 2 million implants are places world wide. Peri-implant muco...

Z-Drugs for Sleep Disorders in Alzheimer's Disease

The purpose of this study is to determine whether Zolpidem and Zoplicone are efective in the treatment of sleep disorders in Alzheimer's disease (AD)

Phase 1 Study of the Effects of Combining Topical FDA-approved Drugs on Age-related Pathways on the Skin of Healthy Volunteers

This is a phase 1 study in healthy adult volunteers to examine the effects of 3 FDA approved medications on skin aging when applied in topical form. This is an open label, placebo controll...

Precise Local Injection of Anti-cancer Drugs Using Presage's CIVO™ Device in Soft Tissue Sarcoma

This is a feasibility study in patients with localized or metastatic soft tissue sarcoma undergoing surgery to determine how sarcoma in situ responds to injected microdoses of anti-cancer ...

The Exploratory Study of Electroacupuncture in the Treatment of Peripheral Neuropathy Induced by Platinum Based Chemotherapy Drugs

Through the research to confirm the effectiveness and safety of using electroacupuncture in the treatment of chemotherapy-induced peripheral neuropathy.

Efficacy Study to Evaluate the Effect of New Antiviral Drugs on HCV Infection.

The purpose of this study is to determinate the AMH levels before and after antiviral therapy with Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir in comparison with age-matched HCV-positi...

Integrated Treatment and Prevention for People Who Inject Drugs

The purpose of this study is to determine the feasibility of a future trial that will assess whether an integrated intervention combining psychosocial counseling and supported referrals fo...

EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION

The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Ext...

Comparison of Recurrence of Atrial Fibrillation 90 Days Post Cryoballoon Ablation With and Without Anti-Arrhythmic Drugs

This study is being done to find out if patients taking Anti Arrhythmia Drugs (AAD's) after cryoballoon ablation for atrial fibrillation, compared to patients who do not take Anti- Arrhyth...

Drug Observance and Side Effects of Cytoreductive Drugs in PV and ET Patients

Patients treated with oral or sub-cutaneous drugs for polycythemia vera or essential thrombocythemia completed an unique paper questionnaire in order to describe their observance, the side...

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Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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