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Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

05:58 EST 17th January 2017 | BioPortfolio

PubMed Articles [4615 Associated PubMed Articles listed on BioPortfolio]

Delivering on Antimicrobial Resistance Agenda Not Possible without Improving Fungal Diagnostic Capabilities.

Antimicrobial resistance, a major public health concern, largely arises from excess use of antibacterial and antifungal drugs. Lack of routine diagnostic testing for fungal diseases exacerbates the pr...

Baseline General Characteristics of the Korean Chronic Kidney Disease: Report from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD).

The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) was developed to investigate various clinical courses and risk factors for progression of Korean chronic kidney ...

Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs.

Glioblastoma, the most common brain tumor, is characterized by high proliferation rate, invasion, angiogenesis, and chemo- and radio-resistance. One of most remarkable feature of glioblastoma is the s...

Spiro-oxindoles as a Promising Class of Small Molecule Inhibitors of p53-MDM2 Interaction Useful in Targeted Cancer Therapy.

As a result of the toxicity of currently available anticancer drugs and the inefficiency of chemotherapeutic treatments, the design and discovery of effective and selective antitumor agents continues ...

Exposure to Anticholinergic and Sedative Drugs, Risk of Falls, and Mortality: An Elderly Inpatient, Multicenter Cohort: Erratum.

The Social Value of Knowledge and the Responsiveness Requirement for International Research.

Ethicists have long recognized that two necessary features of ethical research are scientific validity and social value. Yet despite a significant literature surrounding the validity component of this...

Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy.

Diabetic cardiomyopathy (DCM) is described as impaired cardiac diastolic and systolic functions. Diabetes mellitus (DM), a related cardiovascular disease, has become one of the major causes of death i...

A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation.

Drugs that exhibit close margins between therapeutic and toxic blood concentrations are considered to have a narrow therapeutic index (NTI). The Food and Drug Administration has proposed that NTI drug...

Persistent pain after motor vehicle collision: comparative effectiveness of opioids vs nonsteroidal antiinflammatory drugs prescribed from the emergency department-a propensity matched analysis.

Each year millions of Americans present to the emergency department (ED) for care after a motor vehicle collision (MVC); the majority (>90%) are discharged to home after evaluation. Acute musculoskele...

EEG Monitoring Technique Influences the Management of Hypoxic-Ischemic Seizures in Neonates Undergoing Therapeutic Hypothermia.

Electroencephalogram (EEG) monitoring techniques for neonatal hypoxia-ischemia (HI) are evolving over time, and the specific type of EEG utilized could influence seizure diagnosis and management. We e...

News Articles [5467 Associated News Articles listed on BioPortfolio]

A ‘civil war’ over painkillers rips apart the medical community — and leaves patients in fear

As doctors and regulators restrict access to opioid treatments, many patients who genuinely need drugs to manage their pain say they are being left behind.

Ergomed predicts more to come as revenues surge

Ergomed Plc (LON:ERGO)  has reported another year of strong growth at its services division while it waits for trial results from a raft of drugs under development. The company is a hybrid, a p...

Excelera® Specialty Pharmacy Network Welcomes Billings Clinic

ExceleraRx Corp. announced that Billings Clinic has joined the Excelera national specialty pharmacy network. Minneapolis, MN (PRWEB) January 17, 2017 The Excelera network consists of point-of-care sp...

Woman dies after infection with bacteria resistant to all antibiotics available in US

A woman in the US died of septic shock last year after becoming infected with carbapenem resistant Enterobacteriaceae (CRE) that were resistant to all antimicrobial drugs available in the US.The... ...

A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers

Bacteria have to overcome many obstacles to invade the meninges from the bloodstream. This Review considers how extracellular pathogens such as Neisseria meningitides and Streptococcus pneumoniae bypa...

Better fungal disease diagnostics could be critical to fight against antimicrobial resistance

Poor diagnosis worldwide of fungal disease causes doctors to overprescribe antibiotics, increasing harmful resistance to antimicrobial drugs, according to a paper published today in Emerging Infectiou...

VIDEO: Compounded drops in cataract surgery an option over branded, generic drops

KOLOA, Hawaii ― At Hawaiian Eye 2017, Richard L. Lindstrom, MD, discusses the value of compounded drops with multiple drugs in cataract surgery for cost savings and patient compliance.

Better diagnosis of fungal infections key to reducing antibiotic resistance

(Rutgers University) Poor diagnosis worldwide of fungal disease causes doctors to overprescribe antibiotics, increasing harmful resistance to antimicrobial drugs, according to a paper published today ...

NY proposal aimed at prescription drug prices

Governor Andrew M. Cuomo has announced a new proposal to protect New Yorkers from the soaring prices of prescription drugs in New York State.  The Governor’s plan consists of a three-pronged ap...

Can HIV Drugs Boost Syphilis Risk?

MONDAY, Jan. 16, 2017 -- Gay and bisexual men taking antiretroviral drugs to treat HIV infection may be at increased risk for syphilis, new research contends. Based on a review of available evidence, ...

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Companies [271 Associated Companies listed on BioPortfolio]

Neurotechnology Industry Organization

The Neurotechnology Industry Organization is the trade association that represents companies involved in neuroscience including software, drugs, devices, and diagnostics, brain re...

Reset Therapeutics, Inc.

Reset, a discovery-stage biopharma company co-founded by leaders in the field of circadian biology and Bay City Capital, is developing first-in-class approaches to treating diseas...

SciFluor Life Sciences, Inc.

SciFluor Life Sciences is a drug discovery company developing a best-in-class portfolio of partnership-ready therapeutic drugs strategically capitalizing on the transformational p...

Altan Pharma Limited

Altan Pharma Ltd. is a privately held, specialty pharmaceutical company that develops, manufactures and commercialises injectable drugs for the hospital and other provider segm...

Ensemble Therapeutics

EnsemblinsTM are a new class of synthetic macrocycles developed by Ensemble using its proprietary chemistry platforms, including DNA-Programmed ChemistryTM. Macrocyc...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Verseon

Verseon is a technology-based pharmaceutical company that employs its proprietary computational drug discovery platform to develop novel therapeutics for today’s challenging ...

Enable Injections

Founded February 2010 by medical device industry veterans, Cincinnati, OH-based Enable Injections develops and manufactures devices that allow easy, comfortable patient self-admin...

Icagen, Inc.

Icagen, Inc. is a biopharmaceutical company based in Research Triangle Park, North Carolina, focused on the discovery, development and commercialization of novel orally-administered small molecule...

CureDuchenne Ventures LLC

CureDuchenne Ventures LLC collaborates with pharmaceutical and biotechnology companies to facilitate the development of drugs to treat Duchenne muscular dystrophy. CureDuchenne Ve...

Clinical Trials [813 Associated Clinical Trials listed on BioPortfolio]

Efficacy Study to Evaluate the Effect of New Antiviral Drugs on HCV Infection.

The purpose of this study is to determinate the AMH levels before and after antiviral therapy with Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir in comparison with age-matched HCV-positi...

Integrated Treatment and Prevention for People Who Inject Drugs

The purpose of this study is to determine the feasibility of a future trial that will assess whether an integrated intervention combining psychosocial counseling and supported referrals fo...

EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION

The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Ext...

Comparison of Recurrence of Atrial Fibrillation 90 Days Post Cryoballoon Ablation With and Without Anti-Arrhythmic Drugs

This study is being done to find out if patients taking Anti Arrhythmia Drugs (AAD's) after cryoballoon ablation for atrial fibrillation, compared to patients who do not take Anti- Arrhyth...

Drug Observance and Side Effects of Cytoreductive Drugs in PV and ET Patients

Patients treated with oral or sub-cutaneous drugs for polycythemia vera or essential thrombocythemia completed an unique paper questionnaire in order to describe their observance, the side...

The Effects of add-on Anti-diabetic Drugs in Type 2 Diabetic Patients

Recently, there are some new classes of anti-diabetic drugs availible in Taiwan. In this study, we will observe the change in inflammation and energy homeostasis in type 2 diabetic outpati...

Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis

An open-label,prospective, randomized pilot study to evaluate the efficacy, safety and tolerability of paeoniflorin, for the treatment of autoimmune hepatitis (AIH) with mild necroinflamma...

Evaluation of Changes in Consumption of Drugs and Substances After Incarceration

To improve the management and risk reduction, it is essential to understand the evolution of the consumption of psychoactive substances, medicated or not in detention; it does not have at ...

Evaluation of Aerosolized Drugs Deposition During Mechanical Ventilation

Aerosol delivery through a ventilator is influenced by numerous factors from ventilator-related, circuit-related to device-related factors. Aerosolized drug delivery through a ventilator s...

The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial

For the past 130 years, appendectomy has been the standard treatment for appendicitis. Recent studies from Europe have challenged the notion that surgery is the best option, showing that a...

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Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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