Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

22:23 EDT 22nd October 2014 | BioPortfolio

PubMed Articles [4621 Associated PubMed Articles listed on BioPortfolio]

Simple SPE-HPLC determination of some common drugs and herbicides of environmental concern by pulsed amperometry.

In this work the electrochemical behavior of substances of environmental concern [bentazone, atrazine, carbamazepine, phenytoin and its metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin, HPPH] on a gla...

Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry.

Benign prostatic hyperplasia and prostate cancer can be treated with the 5α-reductase inhibitors, finasteride and dutasteride, when pharmacodynamic biomarkers are useful in assessing response. A nove...

Fast determination of 40 drugs in water using large volume direct injection liquid chromatography-tandem mass spectrometry.

This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals a...

Sequential hollow-fiber liquid phase microextraction for the determination of rosiglitazone and metformin hydrochloride (anti-diabetic drugs) in biological fluids.

A new analytical method for the simultaneous determination of the antidiabetic drugs rosiglitazone (ROS) and metformin hydrochloride (MH) with marked differences in their affinity towards organic solv...

Combination of poly(diallyldimethylammonium chloride) and hydroxypropyl-γ-cyclodextrin for high-speed enantioseparation of phenothiazines by capillary electrophoresis.

High-speed capillary electrophoresis (CE) enables the simple, rapid, and inexpensive analysis of large sets of chiral samples in the pharmaceutical industry. Hence, we developed a novel method for sep...

Murine models in the evaluation of heparan sulfate-based anticoagulants.

Evaluating anticoagulants in animal thrombosis models is a standard component of preclinical drug testing. Mice are frequently used for these initial evaluations because a variety of thrombosis models...

Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticals.

Capillary electrophoresis is a separation technique with high resolving power and sensitivity with applications in glycosaminoglycan analysis. In this chapter, we present validated protocols for deter...

Screening of six UGT enzyme activities in human liver microsomes using liquid chromatography/triple quadrupole mass spectrometry.

Uridine 5'-diphosphoglucuronosyltransferase (UGT) enzymes are essential for the clearance of many drugs; however, altered UGT activity is a potential cause of adverse drug-drug interactions (DDI). The...

Complementary and alternative treatments for primary dysmenorrhea in adolescents.

: Primary dysmenorrhea is the most common gynecologic complaint among adolescents. Conventional treatments include nonsteroidal anti-inflammatory drugs and hormonal contraceptives, but complementary a...

In brief: Khedzela - a new brand of desvenlafaxine.

News Articles [5306 Associated News Articles listed on BioPortfolio]

Toxic influence

Europe must act to stop livestock drugs from wiping out its vulture populations.

[Comment] Blood pressure in acute stroke: which questions remain?

In ENOS, one of the largest randomised trials of blood pressure-lowering in acute stroke now published in The Lancet, Philip Bath and colleagues assessed whether blood pressure could be safely lowered...

[Articles] Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

In patients with acute stroke and high blood pressure, transdermal glyceryl trinitrate lowered blood pressure and had acceptable safety but did not improve functional outcome. We show no evidence to s...

Lakeview Health Addiction Expert Deborah Graves Feigel Commends #14days Series for Building Public Awareness of the Power of Recovery

Addiction expert weighs in on the positives of the latest cbsnews.com #14days national campaign to build awareness and support for those in recovery, as well as important considerations for those look...

EU earmarks $250 million to help develop Ebola vaccines: sources

LONDON (Reuters) - Europe is to plow 200 million euros ($250 million) into the development of Ebola vaccines, as well as drugs and diagnostic tests, according to two people with direct knowledge of th...

Researchers uncover powerful new class of weapons in the war on cancer

An interdisciplinary team of researchers from the University of Texas Medical Branch, and Winship Cancer Institute of Emory University have identified small molecules that can represent a new class of...

UPDATE 2-GSK eyes prime FTSE 100 slot for standalone HIV drugs business

* Company going through "painful" period as Advair slides

GSK eyes top slot in FTSE 100 index for standalone HIV drugs unit

LONDON (Reuters) - GlaxoSmithKline , battered by weak U.S. drug sales and a bribery scandal in China, set out a bold recovery plan on Wednesday, including an initial public offering of part of its fas...

UPDATE 1-GSK eyes top slot in FTSE 100 index for standalone HIV drugs unit

* Company going through "painful" period as Advair slides

New Drugs for Obesity and Diabetes

In the last few weeks, a number of new agents have taken strides toward launch onto the diabetes and obesity markets, which both represent large and commercially lucrative market sectors. Diabetes aff...

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Companies [230 Associated Companies listed on BioPortfolio]

BBB Therapeutics

BBB Therapeutics is pioneering innovative therapeutics to treat severe brain disorders for which there are currently limited treatment options. We are advancing a clinical pipelin...

Cosmederm Bioscience

Cosmederm Bioscience is a specialty pharmaceutical company focused on dermatology and pain management. The Company currently operates in the areas of aesthetic medicine with its R...

Cerecor Inc.

Driven by an innovative team of industry experts and leading scientists, Cerecor aspires to develop neuroscience drugs that will make a difference. We are committed to improving t...

AMATSIGROUP

AMATSIGROUP, as a CDMO (Contract Development and Manufacturing Organisation), provides services throughout both preclinical and clinical phases in veterinary and human drugs. AMAT...

PharmaEngine, Inc.

PharmaEngine, Inc. is a biopharmaceutical company established in Taipei, Taiwan in 2003. The company focuses on the development of new drugs to treat cancer and Asian prevalent di...

Retina Associates of Florida

Retina Associates is a state-of-the art diagnostic and treatment center as well as a leading clinical research center for macular degeneration and other retinal diseases. Its phys...

BioFilm, Ltd.

Founded in 2003 as a subsidiary of Devro plc., BioFilm is the largest Thin Dissolving Film (TDF) producer in Europe, with their GMP certified manufacturing and packaging facility ...

Catalent, Inc.

Catalent, Inc. is the leading global provider of advanced delivery technologies and development solutions for drugs, biologics and consumer health products. With over 80 years ser...

Biosceptre

Biosceptre has identified a pan-cancer target, present in many cancer types, and importantly not found in healthy tissue. Early research and initial evidence suggest that drugs di...

Therapeutic Proteins International

Therapeutic Proteins International, LLC (TPI) is a fully integrated manufacturer of biosimilar recombinant protein products. TPI’s vision is to produce high quality, life-alt...

Clinical Trials [142 Associated Clinical Trials listed on BioPortfolio]

A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)

The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.

Re-examination Study For Varivax (V210-059 AM2)

This survey is conducted for preparing application materials for re-examination under the Korean Pharmaceutical Affairs Laws and its Enforcement Regulation; its aim is to reconfirm the cli...

Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

The purpose of this study is to evaluate the pharmacokinetics (PKs) of antiretroviral (ARV) and tuberculosis (TB) medications in pregnant women and their infants. (Pharmacokinetics are the...

A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood

The purpose of this study is to find out whether taking protease inhibitors (anti-HIV drugs) together with lipid-lowering drugs (drugs which lower the amount of fat in the blood) has an ef...

A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

The purpose of this study is to see if it is safe and effective to give efavirenz plus stavudine plus lamivudine to patients who have never taken anti-HIV drugs.

A Study of Timunox (Thymopentin) in HIV-Infected Patients Receiving Other Anti-HIV Drugs

To evaluate the mechanism whereby thymopentin appears to retard the progressive immune suppression attributable to HIV infection.

A Study of Stavudine in HIV-Infected Patients Who Have Not Had Success With Other Anti-HIV Drugs

To make stavudine (d4T) available to patients with advanced HIV disease for whom no alternative antiretroviral is satisfactory. To study the safety and efficacy of two dose levels in a twi...

The Safety and Effectiveness of Nevirapine Plus Lamivudine Plus Other Anti-HIV Drugs

To evaluate the tolerance, safety, and effectiveness of Viramune in preventing clinical AIDS progression events or death when used in combination with Lamivudine and background nucleoside ...

A Study of MKC-442 in Combination With Other Anti-HIV Drugs

The purpose of this study is to see if it is safe and effective to give MKC-442 plus stavudine (d4T) plus didanosine (ddI) plus hydroxyurea.

A Comparison of Two Triple-Drug Combinations in Patients Who Have Never Been Treated With Anti-HIV Drugs

The purpose of this study is to compare the safety of didanosine plus stavudine plus nelfinavir (NLF) with that of zidovudine plus lamivudine plus NLF. This study also examines how long th...

Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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