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Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

08:35 EDT 26th May 2016 | BioPortfolio

PubMed Articles [4739 Associated PubMed Articles listed on BioPortfolio]

(177)Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment.

Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvio...

Formation of nanoporous aerogels from wheat starch.

Biodegradable nanoporous aerogels were obtained from wheat starch using a simple and green method based on supercritical carbon dioxide (SC-CO2) drying. Effects of processing parameters (temperature, ...

Gums' based delivery systems: Review on cashew gum and its derivatives.

The development of delivery systems using natural polymers such as gums offers distinct advantages, such as, biocompatibility, biodegradability, and cost effectiveness. Cashew gum (CG) has rheological...

Syntheses and characterization of amphiphilic quaternary ammonium chitosan derivatives.

Amphiphilic chitosan derivatives possess improved physico-chemical properties and could be used as carriers in drug delivery systems. The aim of this study was to investigate the behaviour of an amphi...

Simultaneous determination of ethionamide and pyrazinamide using poly(l-cysteine) film-modified glassy carbon electrode.

A selective, simple and rapid square wave voltammetry method, based on electropolymerization of l-cysteine (poly(l-Cys)) on a glassy carbon electrode (GCE), was developed in this study for simultaneou...

Gas-phase ion-molecule reactions for the identification of the sulfone functionality in protonated analytes in a linear quadrupole ion trap mass spectrometer.

The oxidation of sulfur atoms is an important biotransformation pathway for many sulfur-containing drugs. In order to rapidly identify the sulfone functionality in drug metabolites, a tandem mass spec...

Trials and tribulations of conducting bio-behavioral surveys in prisons: implementation science and lessons from Ukraine.

Purpose - Ukraine is home to Europe's worst HIV epidemic, overwhelmingly fueled by people who inject drugs who face harsh prison sentences. In Ukraine, HIV and other infectious diseases are concentrat...

Two-step voltage dual electromembrane extraction: A new approach to simultaneous extraction of acidic and basic drugs.

In the present work, acidic and basic drugs were simultaneously extracted by a novel method of high efficiency herein referred to as two-step voltage dual electromembrane extraction (TSV-DEME). Optimi...

Use and abuse of anti-angiogenic drugs for Retinopathy of Prematurity treatment in Argentina, 2015.

Anticoagulant and vasodilator therapy for Nicolau syndrome following intramuscular benzathine penicillin injection in a 4 year old boy.

Nicolau syndrome (NS) is a rare complication of intramuscular, intraarticular or subcutaneous injection of particular drugs leading to ischemic necrosis of the surrounding skin, soft tissue and muscul...

News Articles [5431 Associated News Articles listed on BioPortfolio]

Microbiology: Enzymes bust bacterial biofilms

Enzymes that break down tough films of disease-causing bacteria could one day be used as drugs.Biofilms protect bacteria from antibiotics and are difficult to eradicate. To look for biofilm-fighting m...

Society must seize control of the antibiotics crisis

Pressure from the public could force firms to develop new drugs that treat resistant infections, says Carlos Amábile-Cuevas.

The Hepatitis C Trust considers legal action over cap on NHS patients allowed to seek treatment

NHS England is limiting treatment with new drugs for hepatitis C to 10,000 of the most in-need patients, prompting The Hepatitis C Trust to consider seeking a judicial review of the decision.

Vizient, Inc. Teams up with NQF and CDC to Issue Critical Guidance to Help Hospitals Better Manage Use of Antibiotics

IRVING, Texas–(BUSINESS WIRE)–Decades of overprescribing and misuse of antibiotics have resulted in bacteria that are increasingly resistant to current drugs, creating a growing threat of ...

Inventing A Machine That Spits Out Drugs In A Whole New Way

A refrigerator-sized machine could someday make lifesaving drugs on site when outbreaks occur or where medicine is in short supply, like on the battlefield.

Nice does not recommend Eli Lilly’s lung cancer drug in draft guidance

The National Institute of Care and Excellence (Nice) did not recommend US drugmaker Eli Lilly’s (NYSE: LLY) Portrazza to treat lung cancer saying the therapy cost too much compared to combination ch...

FDA advisory panel backs Sanofi’s IGlarLixi for approval

The US Food and Drug Administration’s Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC)…

Panel Embraces Sanofi Diabetes Combo, Shuns 'Pen' Devices

While the FDA's Endocrinologic and Metabolic Drugs Advisory Committee backed approval of Sanofi SA's fixed-ratio combination type 2 diabetes medicine...  

Korean Regulatory Overhaul To Cut R&D, Approval Periods

In its latest series of broad support measures for the biopharma sector, South Korea is to ease selected regulatory rules to shorten R&D and approval periods, and ensure the prompt and stable supp...

FDA Panel Recommends Approval Of Sanofi Treatment For Adults With Type2 Diabetes

PARIS (dpa-AFX) - Sanofi (SNYNF, SNY) announced that the Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) of the U.S. Food and Drug Administration (FDA) recommended the approval of th...

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Companies [270 Associated Companies listed on BioPortfolio]

Reset Therapeutics, Inc.

Reset, a discovery-stage biopharma company co-founded by leaders in the field of circadian biology and Bay City Capital, is developing first-in-class approaches to treating diseas...

SciFluor Life Sciences, Inc.

SciFluor Life Sciences is a drug discovery company developing a best-in-class portfolio of partnership-ready therapeutic drugs strategically capitalizing on the transformational p...

Altan Pharma Limited

Altan Pharma Ltd. is a privately held, specialty pharmaceutical company that develops, manufactures and commercialises injectable drugs for the hospital and other provider segm...

Ensemble Therapeutics

EnsemblinsTM are a new class of synthetic macrocycles developed by Ensemble using its proprietary chemistry platforms, including DNA-Programmed ChemistryTM. Macrocyc...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Verseon

Verseon is a technology-based pharmaceutical company that employs its proprietary computational drug discovery platform to develop novel therapeutics for today’s challenging ...

Enable Injections

Founded February 2010 by medical device industry veterans, Cincinnati, OH-based Enable Injections develops and manufactures devices that allow easy, comfortable patient self-admin...

Icagen, Inc.

Icagen, Inc. is a biopharmaceutical company based in Research Triangle Park, North Carolina, focused on the discovery, development and commercialization of novel orally-administered small molecule...

CureDuchenne Ventures LLC

CureDuchenne Ventures LLC collaborates with pharmaceutical and biotechnology companies to facilitate the development of drugs to treat Duchenne muscular dystrophy. CureDuchenne Ve...

XL-protein GmbH

XL-protein is a privately owned biopharmaceutical company based in Freising, Germany, which exploits its proprietary PASylation® technology to develop biologics with extended p...

Clinical Trials [534 Associated Clinical Trials listed on BioPortfolio]

This Study Tests the Effect of BI 655066 on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis

To assess the influence of BI 655066 onkinetics of cytochrome P450 (CYP) probe drugs as a means of predicting drug-drug interactions

Evaluating Newly Approved Drugs for Multidrug-resistant TB

endTB Clinical Trial a Phase III, randomized, controlled, open-label, non-inferiority, multi-country trial evaluating the efficacy and safety of five new, all-oral, shortened regimens for ...

"Drugs in Lactation" Analysis Consortium

Some medications taken by the breastfeeding women are excreted into milk, posing a potential risk of toxicity to the infant. The first line of evidence required for toxicity risk assessmen...

Application of Two Anti-angiogenesis Drugs Combined With Chemotherapy in Advanced Colorectal Cancer Under the Background of Precision Medical

The purpose of this study is to determine whether Endostar pumping into vein with Thalidomide are more effective in the treatment of Advanced Colorectal Cancer (ACRC).

Low-dose Combination of Three Antihypertensive Drugs

The aim of the study is to compare the efficacy and safety of low-dose combination of three antihypertensive drugs versus fixed high-dose combination of two antihypertensive drugs in arter...

Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a dru...

Incretin-mimetic Hypoglycemic Drugs and Severe Retinopathy

Experimental data suggest that GLP-1 promote endothelial cell growth and angiogenesis which may have beneficial effects on the cardiovascular system but harmful effects on the retina . Thi...

Peripheral Blood Biomarkers Associated With CIPN

The investigators are doing a research study that will teach us about the tingly pain that people develop when they get chemotherapy.

Triumeq As an Integrase Single Tablet Regimen in People With HIV Who Inject Drugs

The purpose of this study is to assess the tolerability, adherence and efficacy of single tablet dolutegravir/abacavir/lamivudine antiretroviral therapy in people living with HIV with a hi...

Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion

The study is to investigate the anticancer effect and the related immunological mechanism of MTX-ATMPs in the treatment of malignant pleural effusion.

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Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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