Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

16:38 EST 6th March 2015 | BioPortfolio

PubMed Articles [4752 Associated PubMed Articles listed on BioPortfolio]

The relevance of epigenetics to occlusive cerebral and peripheral arterial disease.

Athero-thrombosis of the arteries supplying the brain and lower limb are the main causes of stroke and limb loss. New therapies are needed to improve the outcomes of athero-thrombosis. Recent evidence...

New Drugs 2015 Part 1.

Alginate core-shell beads for simplified three-dimensional tumor spheroid culture and drug screening.

We demonstrate that when using cell-laden core-shell hydrogel beads to support the generation of tumor spheroids, the shell structure reduces the out-of-bead and monolayer cell proliferation that occu...

Complications of mammalian target of rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life-threatening.

The aim of this study was to evaluate the most common adverse events (AEs) linked to everolimus therapy, a mammalian target of rapamycin (mTOR) inhibitor, in children and adolescents with tuberous scl...

The evolving HIV epidemic among people who inject drugs in India and the need for a heightened response.

High HIV burden among people who inject drugs in 15 Indian cities.

Injecting drug use has historically been the principal driver of the HIV epidemic in the northeast states of India. However, recent data indicate growing numbers of people who inject drugs (PWIDs) in ...

Dopaminergic Control of the Globus Pallidus through Activation of D2 Receptors and Its Impact on the Electrical Activity of Subthalamic Nucleus and Substantia Nigra Reticulata Neurons.

The globus pallidus (GP) receives dopaminergic afferents from the pars compacta of substantia nigra and several studies suggested that dopamine exerts its action in the GP through presynaptic D2 recep...

Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells.

In recent years, mesoporous silica nanoparticles (MSN) have been used as effective supports for the development of controlled release nanodevices able to act as a multifunctional delivery platform for...

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity.

Metformin is the mainstay therapy for type 2 diabetes (T2D), and many patients also take salicylate-based drugs (i.e. Aspirin; ASA) for cardioprotection. Metformin and salicylate both increase AMP-act...

Anemia: progress in molecular mechanisms and therapies.

Anemia is a major source of morbidity and mortality worldwide. Here we review recent insights into how red blood cells (RBCs) are produced, the pathogenic mechanisms underlying various forms of anemia...

News Articles [4716 Associated News Articles listed on BioPortfolio]

Novartis-Biosimilar Zarxio erhält Zulassung

das erste in den USA registrierte Biosimilar, teilt die FDA am Freitag mit. Anfang Januar dieses Jahres hatte die Expertenkomitee der Gesundheitsbehörde (Oncologic Drugs Advisory Committee) bereits.....

Regeneron Jumps Ahead In $10 Billion Race For Next Generation Cardio Drugs

New Approaches Required to Lower Cholesterol

Patients whose low-density lipoprotein (LDL) (or bad) cholesterol levels do not respond to cholesterol-lowering statin drugs may have more artery blockages than those whose cholesterol levels drop wit...

Learn about doping in sports

‘Drugs in sport’, edited by David R. Mottram and Neil Chester.

The Fcp1-Wee1-Cdk1 axis affects spindle assembly checkpoint robustness and sensitivity to antimicrotubule cancer drugs

Medical nanoparticles transport drugs for local treatment of lung cancer

Nanoparticles can function as carriers for medicines to combat lung cancer, according to the latest research from Germany. Working in a joint project, scientists from the Helmholtz Zentrum München ...

Prime Therapeutics welcomes FDA's approval of first biosimilar in U.S., but says more clarity is needed

ST. PAUL, Minn., March 6, 2015 /PRNewswire/ -- Prime Therapeutics LLC (Prime), a non-profit pharmacy benefit manager serving more than 26 million members, today released the following statement r...

Researchers develop first validated method of detecting drugs of abuse in exhaled breath

Drug testing is most commonly performed using urine samples. The methodology and regulations for reliable urine testing are well developed and can be considered the current gold standard for drug test...

Merck and Eisai partner on cancer therapy trial

Merck and Takeda are teaming up for collaborative trials to test the effects of using combinations of each company’s oncology drugs. They are to test Merck’s anti-PD1 cancer treatment Keytruda (pe...

First validated method of detecting drugs of abuse in exhaled breath

Drug testing is most commonly performed using urine samples. The methodology and regulations for reliable urine testing are well developed and can be considered the current gold standard for drug test...

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Companies [241 Associated Companies listed on BioPortfolio]

MedDay

MedDay is a privately held biotechnology company developing new drugs for nervous system disorders. The company was founded in 2011 by Frédéric Sedel, MD, PhD (Chief Executi...

Cerecor Inc.

Driven by an innovative team of industry experts and leading scientists, Cerecor aspires to develop neuroscience drugs that will make a difference. We are committed to improving t...

MediVector, Inc.

MediVector, Inc. is a Boston-based drug development company specializing in decreasing the time and cost of bringing drugs to market. The company complements its team’s clini...

Akaal Pharma Pty Ltd.

Akaal Pharma Pty Ltd (Akaal Pharma) is a clinical-stage drug discovery and development company focused on the development of novel small molecule drugs for the treatment of inflam...

Hydra Biosciences, Inc

Hydra Biosciences is a biopharmaceutical company developing molecular regeneration medicines, novel cardiovascular therapies and drugs targeting novel ion channels. Tapping the unharnessed power of th...

Voisin Consulting Life Sciences

Voisin Consulting assists biotechnology, pharmaceutical and biomedical companies in the design and implementation of innovative regulatory strategies to expedite product development programs such as d...

Prometheon Pharma

Prometheon Pharma is a biotechnology company housed in the globally #1-ranked Sid Martin Biotech Incubator at the University of Florida. Prometheon is dedicated to increasing pati...

ProteoTech Inc.

ProteoTech is a privately-held, drug development company that utilizes its amyloid expertise to discover and develop new drugs for treating misfolded protein disorders and amyloid...

Incyte and Agenus

Incyte Corporation is a Wilmington, Delaware-based biopharmaceutical company focused on the discovery, development and commercialization of proprietary small molecule drugs, prima...

Bartell Drugs

Founded in Seattle in 1890, Bartell Drugs owns and operates 62 locations in King, Snohomish and Pierce counties. Family owned and operated, it is the nation's oldest drugstore cha...

Clinical Trials [172 Associated Clinical Trials listed on BioPortfolio]

Clinical Trial of MK0683 in Combination With FDA Approved Cancer Drugs in Patients With Advanced NSCLC (MK0683-058)

This is a clinical trial to determine the safety and tolerability of MK0683 in combination with gemcitabine and cisplatin and/or carboplatin.

Vytorin Reexamination Study (0653A-174)

This survey is conducted for preparing application material for re-examination under the Pharmaceutical Affairs Laws and its Enforcement Regulation, its aim is to reconfirm the clinical us...

Cozaar XQ Re-examination Study (MK-0954-349)

This survey is conducted for preparing application material for re-examination under the Pharmaceutical Affairs Law and its Enforcement Regulation; its aim is to reconfirm the clinical use...

The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea

The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.

When to Start Anti-HIV Drugs in Patients With Opportunistic Infections

The purpose of this study is to evaluate the effect of starting anti-HIV drugs in HIV infected patients who are being treated for opportunistic infections (OIs). This study will follow tw...

An Observational Study of Induction Therapy With Fuzeon (Enfuvirtide) in Combination With Antiretroviral Drugs in Patients With HIV-1 Infection

This multicenter, retrospective, observational study will evaluate the therapeut ic effectiveness of a strategy of induction with Fuzeon (enfuvirtide) within an optimized regimen of antire...

A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)

The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.

Investigation of Potential Drug-drug Interactions Between Faldaprevir and the Immunosuppressant Drugs Cyclosporine or Tacrolimus

The primary objective of this trial is to investigate the effect of multiple-dose faldaprevir (FDV) on the single-dose pharmacokinetics of cyclosporine or tacrolimus

Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects

The aim of the ADDUCE project is to investigate any adverse effects of methylphenidate (trade name ritalin) on growth, neurological system, psychiatric states and cardiovascular system ove...

Re-examination Study For Varivax (V210-059 AM2)

This survey is conducted for preparing application materials for re-examination under the Korean Pharmaceutical Affairs Laws and its Enforcement Regulation; its aim is to reconfirm the cli...

Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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