Diseasemodifying drugs - Biotech, Pharma and Life Science Channel
PubMed Articles
Timely formulary management for preventing errors related to antiretroviral drugs.
Here, we describe the development and application of a liquid chromatography-tandem mass spectrometry method with positive electrospray ionisation and scheduled multiple reaction monitoring algorithm...
Therapeutic drug monitoring (TDM) may be very useful in the clinical management of antiepileptic drug therapy for multiple reasons, such as individual variability, metabolism, genetic factors or drug-...
This study was conducted in two experiments, to identify non-steroidal anti-inflammatory drugs (NSAIDs) with high endocrine disruption potentials, and to understand consequences of exposure to such NS...
Refractory epilepsy is reportedly associated with an overexpression of ATP-binding cassette transporters such as P-glycoprotein (Pgp) and breast cancer resistance protein (Bcrp). In this study, we exa...
Sorption characteristics of eight drugs related to recreational and clandestine activity-amphetamine, cocaine, heroin, N-formyl amphetamine, N-formyl methamphetamine, methamphetamine, 3, 4-methylenedi...
Peptide-based hydrogel nanoparticles as effective drug delivery agents.
Peptide-based hydrogel nanoparticles represent a promising alternative to current drug delivery approaches. We have previously demonstrated that the Fmoc-FF aromatic dipeptide building block can self-...
The present study analyzed the potential antinociceptive effect of the antimigraine drugs sumatriptan, dihydroergotamine or methysergide in rats submitted to the formalin test. Moreover, by using sele...
Polypharmacy, defined as the concomitant use of two or more psychotropic drugs, has become increasingly common in the paediatric and adolescent population over the past two decades. Combining psychotr...
The prevalence of attention-deficit hyperactivity disorder (ADHD) in the USA is estimated at approximately 4-9 % in children and 4 % in adults. It is estimated that prescriptions for ADHD medication...
News Articles
Express Diagnostics Int’l today announced that it has received Health Canada Class III approval to market and sell its DrugCheck® NxStep Onsite Drug Screen Cup in Canada. The urinalysis screeni...
Resistance to combination drugs threatens efforts to eradicate malaria
With 300-500 million people falling ill to malaria each year, this debilitating tropical disease remains a global problem. Current combination drug therapy is still generally effective, but recent sig...
Study says wiser medication use could cut health costs
If doctors and patients used prescription drugs more wisely, they could save the U.S. health care system at least $213 billion a year, a study concludes.
Procurement lag-led stock-outs threaten India's TB program
A stock-out of critical antituberculosis drugs largely on account of a procurement lag is threatening to stymie progress under India's TB control program and to affect patient treatment regimens in a...
Aspen Bids To Buy Thrombosis Drugs, Production Plant From GSK
Aspen Pharmacare has made a bid to acquire GlaxoSmithKline's line of thrombosis drugs as well as their production plant that could add more than $400 million a year to revenues.
Roche Experimenting With New Pricing Models In Oncology
Cancer drug prices are unsustainable and creative approaches are needed, Roche’s COO Daniel O’Day says. The firm’s moves into emerging markets are a lab for new methods, though the real test wil...
Shanxi Province Sets Prices For 42 Narcotic, Psychotic Drugs
Shanxi has announced state-determined retail prices for 42 drugs including anesthetic and Class I psychotics, effective until 2014, yet subject to any subsequent revision.
June 2013 Focus.pdf Inside this issue: From the President Boettcher Investigators ‘Breakthrough’ drug...
Conventional triple therapy as good as etanercept for uncontrolled rheumatoid arthritis
N Engl J Med2013; doi:10.1056/NEJMoa1303006bmj;346/jun18_8/f3846/FIG1F1fig1When methotrexate fails to control rheumatoid arthritis, patients can add other disease modifying drugs or opt for more......
DNDi receives the BBVA Foundation Frontiers of Knowledge Award in Development Cooperation
(Drugs for Neglected Diseases Initiative) Coinciding with its tenth anniversary year, the Drugs for Neglected Diseases initiative (DNDi) has been granted the BBVA Foundation Frontiers of Knowledge Awa...
Events
Recent years have seen huge growth in orphan drug development, but also a time of increased pressure as many leading blockbuster drugs soon come off patent.
Companies
Verastem, Inc. (NASDAQ: VSTM) is a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells. Cancer stem cell...
Concert Pharmaceuticals is a clinical stage biotechnology company with a broad development pipeline targeting renal disease, CNS disorders, inflammation and hematologic disorders....
PhaseBio Pharmaceuticals, Inc.
PhaseBio Pharmaceuticals, Inc. (PhaseBio), located in Research Triangle Park, NC, is a development stage, privately held protein engineering company focused on developing the next...
Kineta is a Seattle-based privately held biotechnology company specializing in clinical advancement of novel drug candidates derived from leading edge scientific research. Our wor...
BioInvent International is a unique company dedicated to working with clients to ensure their success in the discovery, development and manufacture of antibody drugs. The discovery of new drug targets...
Perosphere is a specialty pharmaceutical company that identifies and develops new chemical entities and other therapeutics that can be used as ârescueâ drugs. For more i...
Aradigm Corporation and Grifols S.A.
Aradigm is an emerging specialty pharmaceutical company focused on the development and commercialization of drugs delivered by inhalation for the prevention and treatment of sever...
Monarch Medical Technologies is a privately held medical technology company founded by clinicians with a vision of dramatically improving hospital-based glucose management by repl...
R-Tech Ueno is a bio-venture company established in September 1989 for the purpose of marketing and R&D of drugs. Under leadership of the president, also a medical doctor, the company is developing ne...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
Clinical Trials
Pyroxamide in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of pyroxamide in...
A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-181)(COMPLETED)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as goserelin, may stop the adrenal glands from making androgens. Drugs used in chemotherapy, such as docetax...
Pixantrone or Other Chemotherapy Drugs in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It is not yet known whether...
RATIONALE: Drugs used in chemotherapy, such as eflornithine, work in different ways to stop tumor cells from dividing so they stop growing or die. Androgens can stimulate the growth of pro...
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as goserelin and leuprolide may fight prostate cancer by stopping the adrenal glands from producing andro...
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Drugs used in immunotherapy such as rituximab can locate cancer cel...
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as nilutamide, bicalutamide, flutamide, or cyproterone may stop the adrenal glands from producing androge...
This is a 48-week study to collect additional information on the safety, tolerability, pharmacokinetics, and antiviral activity of an investigational regimen (course of therapy) including...
Ketoconazole and Docetaxel in Treating Patients With Metastatic Prostate Cancer
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as ketoconazole may stop the adrenal glands from producing androgens. Drugs used in chemotherapy use diff...
Videos
Why should I consider taking disease modifying drugs? Q1
The MS Trust has asked Professor David Bates, Consultant Neurologist at University of Newcastle-upon-Tyne NHS Hospitals Foundation Trust to answer some of th...
Medical and Biotech [MESH] Definitions
Cinnamomum Aromaticum
A plant species of the genus CINNAMOMUM that contains CINNAMATES and has been used in traditional Chinese medicine (DRUGS, CHINESE HERBAL).
Epimedium
A plant genus of the family BERBERIDACEAE which is used in DRUGS, CHINESE HERBAL. Members contain flavonol glycosides including epimedins, icariin and noricariin.
Cuscuta
A plant genus of the family Cuscutaceae. It is a threadlike climbing parasitic plant that is used in DRUGS, CHINESE HERBAL.
Histamine H1 Antagonists, Non-sedating
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Herb-drug Interactions
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
