Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

03:21 EST 28th November 2014 | BioPortfolio

PubMed Articles [4687 Associated PubMed Articles listed on BioPortfolio]

Simple SPE-HPLC determination of some common drugs and herbicides of environmental concern by pulsed amperometry.

In this work the electrochemical behavior of substances of environmental concern [bentazone, atrazine, carbamazepine, phenytoin and its metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin, HPPH] on a gla...

Nanostructure imaging mass spectrometry: the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity.

Nanostructure imaging mass spectrometry (NIMS) has become an effective technology for generating ions in the gas phase, providing high sensitivity and imaging capabilities for small molecules, metabol...

Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry.

Benign prostatic hyperplasia and prostate cancer can be treated with the 5α-reductase inhibitors, finasteride and dutasteride, when pharmacodynamic biomarkers are useful in assessing response. A nove...

Fast determination of 40 drugs in water using large volume direct injection liquid chromatography-tandem mass spectrometry.

This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals a...

Sequential hollow-fiber liquid phase microextraction for the determination of rosiglitazone and metformin hydrochloride (anti-diabetic drugs) in biological fluids.

A new analytical method for the simultaneous determination of the antidiabetic drugs rosiglitazone (ROS) and metformin hydrochloride (MH) with marked differences in their affinity towards organic solv...

Combination of poly(diallyldimethylammonium chloride) and hydroxypropyl-γ-cyclodextrin for high-speed enantioseparation of phenothiazines by capillary electrophoresis.

High-speed capillary electrophoresis (CE) enables the simple, rapid, and inexpensive analysis of large sets of chiral samples in the pharmaceutical industry. Hence, we developed a novel method for sep...

Murine models in the evaluation of heparan sulfate-based anticoagulants.

Evaluating anticoagulants in animal thrombosis models is a standard component of preclinical drug testing. Mice are frequently used for these initial evaluations because a variety of thrombosis models...

Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticals.

Capillary electrophoresis is a separation technique with high resolving power and sensitivity with applications in glycosaminoglycan analysis. In this chapter, we present validated protocols for deter...

Current role of chemotherapy and bone marrow transplantation in multiple sclerosis.

The range of available treatment options for patients with multiple sclerosis (MS) has expanded tremendously in recent years, adding further complexity to the therapeutic decision-making process. The ...

Mass spectrometry studies of lycodine-type Lycopodium alkaloids: sauroxine and N-demethylsauroxine.

Sauroxine and N-demethylsauroxine are lycodine-type Lycopodium alkaloids. In recent years, Lycopodium alkaloids have gained significant interest due to their unique skeletal characteristics as well as...

News Articles [5176 Associated News Articles listed on BioPortfolio]

Connecticut Consumers Pay More for Physician-Dispensed Drugs, WCRI Reports

According to a media release by the Workers Compensation Research Institute (WCRI), physician-dispensed drug prices in Connecticut are 30-60 percent higher than pharmacy prices. Connecticut medical ma...

Could Phaxan™ become the new drug of choice for intravenous anaesthesia, procedural and intensive care sedation.

The anaesthesia drugs market in the US is forecast to reach $7 billion by 2015. The need for a for a new anaesthetic that is both safe and effective continues to grow significantly, with more than 80 ...

Chronic Prostatitis Can Lead to Prostate Cancer, Says Recent Article, and Medications May Worsen Situation, While Dr. Allen’s Device Treats Prostate Naturally

Dr. Allen’s Device relieves symptoms of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) by improving a prostate condition naturally that is important as a recent article states that some ...

Oral Oncolytics Series: Leukemia, 2014 - 2024

LONDON, Nov. 27, 2014 /PRNewswire/ -- INTRODUCTIONTargeted therapeutics is fast emerging as the key focus area in biopharmaceutical industry. Oral targeted therapeutics has attracted many drug develop...

NICE's Soliris yes proves expensive drugs can make it

Soliris has been recommended in final draft guidance to treat atypical hemolytic uremic syndrome (aHUS), a condition affecting just 200 people in the UK. Despite the small patient population, NICE est...

Chimerix, Toyama Drugs, Whole Blood and Plasma in First Ebola Clinical Trials

The first clinical trials of experimental Ebola treatments in patients in Africa are poised to get under way at three treatment centers run by Médecins Sans Frontières (MSF) in Guinea and Liberia. T...

Russia tightens procedure for accelerated registration of drugs

Only the first three generics, along with generics intended for minors, as well as orphan drugs, will become subject of accelerated procedures for state registration in Russia, according to new amendm...

Hovione Files its First Investigational New Drug Application With the FDA

CORK, Ireland, November 27, 2014 /PRNewswire/ -- Hovione announced today it has filed its first Investigational New Drug (IND) Application with the U.S. Food and Drug Administration (FDA). This event...

HIV infections double in Russia, ex-Soviet states

HIV infections have doubled in ten years in Russia and former Soviet states, due mainly to unprotected sex and injecting drugs, a report said Thursday.

Spartan Bioscience Receives Korean Regulatory Approval for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs

Non-invasive test detects CYP2C19 mutations affecting drugs such as Plavix®, Inderal®, Celexa®, Vfend®, and Losec® Ottawa, Ontario (PRWEB) November 27, 2014 Spartan Bioscienc...

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Companies [233 Associated Companies listed on BioPortfolio]

PharmaEngine, Inc.

PharmaEngine, Inc. is a biopharmaceutical company established in Taipei, Taiwan in 2003. The company focuses on the development of new drugs to treat cancer and Asian prevalent di...

ScripsAmerica, Inc.

ScripsAmerica, Inc. is a supplier of prescription, OTC and nutraceutical drugs, delivering pharmaceutical products to a wide range of end users across the health care industry. En...

NEMUS Bioscience, Inc.

The Company is a biopharmaceutical company, headquartered in Costa Mesa, California, focused on the discovery, development, and commercialization of cannabis-based therapeutics fo...

RetroSense Therapeutics, LLC

RetroSense Therapeutics is a privately-held biotechnology company developing life-enhancing gene therapies designed to restore vision in patients suffering from blindness due to r...

Synta Pharmaceuticals

Synta Pharmaceuticals is a biopharmaceutical company focused on discovering, developing, and commercializing products for extending and enhancing the lives of patients with severe medical conditions. ...

BBB Therapeutics

BBB Therapeutics is pioneering innovative therapeutics to treat severe brain disorders for which there are currently limited treatment options. We are advancing a clinical pipelin...

Cosmederm Bioscience

Cosmederm Bioscience is a specialty pharmaceutical company focused on dermatology and pain management. The Company currently operates in the areas of aesthetic medicine with its R...

Cerecor Inc.

Driven by an innovative team of industry experts and leading scientists, Cerecor aspires to develop neuroscience drugs that will make a difference. We are committed to improving t...

AMATSIGROUP

AMATSIGROUP, as a CDMO (Contract Development and Manufacturing Organisation), provides services throughout both preclinical and clinical phases in veterinary and human drugs. AMAT...

Retina Associates of Florida

Retina Associates is a state-of-the art diagnostic and treatment center as well as a leading clinical research center for macular degeneration and other retinal diseases. Its phys...

Clinical Trials [154 Associated Clinical Trials listed on BioPortfolio]

The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea

The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.

When to Start Anti-HIV Drugs in Patients With Opportunistic Infections

The purpose of this study is to evaluate the effect of starting anti-HIV drugs in HIV infected patients who are being treated for opportunistic infections (OIs). This study will follow tw...

An Observational Study of Induction Therapy With Fuzeon (Enfuvirtide) in Combination With Antiretroviral Drugs in Patients With HIV-1 Infection

This multicenter, retrospective, observational study will evaluate the therapeut ic effectiveness of a strategy of induction with Fuzeon (enfuvirtide) within an optimized regimen of antire...

A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)

The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.

Re-examination Study For Varivax (V210-059 AM2)

This survey is conducted for preparing application materials for re-examination under the Korean Pharmaceutical Affairs Laws and its Enforcement Regulation; its aim is to reconfirm the cli...

Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

The purpose of this study is to evaluate the pharmacokinetics (PKs) of antiretroviral (ARV) and tuberculosis (TB) medications in pregnant women and their infants. (Pharmacokinetics are the...

A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood

The purpose of this study is to find out whether taking protease inhibitors (anti-HIV drugs) together with lipid-lowering drugs (drugs which lower the amount of fat in the blood) has an ef...

A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

The purpose of this study is to see if it is safe and effective to give efavirenz plus stavudine plus lamivudine to patients who have never taken anti-HIV drugs.

A Study of Timunox (Thymopentin) in HIV-Infected Patients Receiving Other Anti-HIV Drugs

To evaluate the mechanism whereby thymopentin appears to retard the progressive immune suppression attributable to HIV infection.

A Study of Stavudine in HIV-Infected Patients Who Have Not Had Success With Other Anti-HIV Drugs

To make stavudine (d4T) available to patients with advanced HIV disease for whom no alternative antiretroviral is satisfactory. To study the safety and efficacy of two dose levels in a twi...

Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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