Host Response to Tumors - Biotech, Pharma and Life Science Channel
PubMed Articles
Evidence for predictive role of BRCA1 and bTUBIII in gastric cancer.
Sensitivity of gastric cancer (GC) to conventional cytotoxic therapy may be at least in part attributed to molecular features of the tumor cells. We analyzed all patients with metastatic GC treated in...
Recently, novel molecular targeted agents markedly changed the treatment of renal cell carcinoma (RCC), with promising results. However, there is little understanding of how these agents affect immune...
Hepatoma-derived growth factor (HDGF), a heparin-binding growth factor, has a wide range of biological functions, including mitogenic activity and vascular development. Recent studies demonstrated tha...
Phase-change materials are the alloys at the heart of an emerging class of next-generation, non-volatile digital memory technologies. However, the widely studied Ge-Sb-Te system possesses several unde...
In order to increase the usefulness of the alanine dosimeter as a tool for quality assurance measurements in radiotherapy using MV x-rays, the response with respect to the dose to water needs to be kn...
Sodium tungstate modulates ATM function upon DNA damage.
Both radiotherapy and most effective chemotherapeutic agents induce different types of DNA damage. Here we show that tungstate modulates cell response to DNA damaging agents. Cells treated with tungst...
Dynamic histone acetylation, catalyzed by lysine acetyltransferases and HDACs, is critical to IEG expression. Expression of IEGs, such as FOSL1, is induced by several signal transduction pathways resu...
IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages.
Chemokines, including MCP-1, are crucial to mounting an effective immune response due to their ability to recruit other immune cells. We show that sustained LPS or poly(I:C)-stimulated MCP-1 productio...
Himatanthus articulatus (Apocynaceae) is a plant native to the Amazon, popularly used to treat external ulcers, tumors, inflammations, cancer, syphilis and malaria.
Because of the lack of post-translational glycosylation, Escherichia coli is not a preferable host for immunoglobulin G (IgG) production. However, recent successes in the developments of aglycosylated...
News Articles
Roche, Bristol-Myers, Merck drugs aim at lung cancer
A new class of experimental drugs shown to shrink tumors by unleashing the immune system are beginning to attract notice for one of the greatest unmet needs in oncology: treatment of lung cancer. Ro...
Nab-paclitaxel was well tolerated in this population of patients with pretreated advanced urothelial cancer with an encouraging tumour response. These results warrant further study of nab-paclitaxel i...
CDC Offers Primer on Blast Injury Care
In the aftermath of bombings at the Boston marathon on April 15, the Centers for Disease Control and Prevention (CDC) has alerted health professionals that its website on mass casualty event preparedn...
Musculoskeletal ultrasonography in patients with rheumatoid arthritis
Musculoskeletal ultrasonography is widely used for evaluating patients with RA and these imaging techniques can also allow the comparison of therapeutic agents, as well as monitoring patient response...
Colorectal cancer: Is the new era of colorectal cancer classification finally here?
Colorectal cancer is a heterogeneous disease, with at least three well-known major, molecularly defined groups: the chromosomal instable, the microsatellite instable and the CpG island methylator phen...
Therapeutic Response in Feline Sandhoff Disease Despite Immunity to Intracranial Gene Therapy
Response to ‘Area-level deprivation and adiposity in children: is the relationship linear?’
Sunesis Pharmaceuticals, Inc. Presents at UBS Global Healthcare Conference, May-21-2013 12:30 PM
Sunesis Pharmaceuticals, Inc. (SNSS) May 21, 2013 12:30 pm ET Executives Eric H. Bjerkholt - Chief Financial Officer, Principal Accounting Officer, Executive Vice President of Corporate Developmen...
Dissecting the controversy about early psychological response to disasters and trauma
Right now in Oklahoma, first responders and volunteers are pulling out the stops to mobilize all the help they can, including psychological support. They'll be able to rely on people's great reserves...
Events
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Companies
From its establishment in 1977, simply as a Distributor of diagnostic products, IDS has become a globally-recognised innovator and marketeer in the IVD industry.The Company is particularly well-known...
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The companyâs lead drug candidate, TOK-001, is the first i...
OncoMed Pharmaceuticals is a clinical-stage company that discovers and develops novel therapeutics targeting cancer stem cells, the cells believed to be capable of driving tumor growth, recurrence and...
BioNova - The Nova Scotia Biotechnology and Life Sciences Industry Association
BioNova was incorporated in 1993 in response to rapid growth in Nova Scotia’s biotechnology and life sciences sector. Since that time, we have advanced alongside our members to offer advocacy and de...
BSD Medical Corporation develops, manufactures, markets and services systems to treat cancer and benign diseases using heat therapy delivered using focused radio frequency (RF) an...
Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development, commercialization and manufacturing of no...
OpenSpan provides technology and services that improves, accelerates and measures software- and data-driven work on the desktop, driving performance in front-office and back-offic...
Reliant Healthcare Professionals, Inc.
Based in Greenwood Village, Colorado, Reliant Healthcare Professionals, Inc. is a premier provider of rapid-response nurse staffing services, operating as FASTAFF Travel Nu...
DecImmune Therapeutics was founded by Michael Carroll PhD (The Immune Disease Institute, Harvard Medical School), and Francis Moore Jr. MD (Brigham and Womenâs Hospital, Harv...
Since its inception in 1963, Capitol Scientific has built a formidable enterprise by leveraging a vast portfolio of name brand products concentrated in high-purity & reagent chemi...
Clinical Trials
Vorinostat and Gemcitabine in Treating Patients With Metastatic or Unresectable Solid Tumors
This phase I trial is studying the side effects and best dose of vorinostat and gemcitabine in treating patients with metastatic or unresectable solid tumors. Drugs used in chemotherapy, s...
This randomized phase II trial is studying how well giving tacrolimus and mycophenolate mofetil (MMF) together with or without sirolimus works in preventing acute graft-versus-host disease...
Brentuximab Vedotin (SGN-35) as Salvage Treatment for CD30-positive Germ Cell Tumors
Complete responses with third-line or later salvage chemotherapy (CT) for germ cell tumors (GCT) range 0% to 10% and are usually short-lived and nearly all patients (pts) progressing after...
AFP464 in Treating Patients With Advanced Solid Tumors
This phase I trial is studying the side effects and best dose of AFP464 in treating patients with advanced solid tumors. Drugs used in chemotherapy, such as AFP464, work in different ways...
The purpose of this study is to assess the efficacy of a short course of therapy (24 weeks) versus standard 48 week treatment in previously untreated adult participants with chronic hepati...
Mesenchymal Stromal Cells (MSCs) for the Treatment of Graft Versus Host Disease (GVHD)
This is a bicentric, prospective, non randomized study. Pediatric and adult patients will be treated. Rationale: MSC have shown promising effects by reversal of severe therapy-resistant a...
Quetiapine in Melancholic Depression
In summary, the investigators propose to integrate fMRI assessments within a clinical trial of quetiapine XR in patients with melancholic depression in order to test the predictions that:...
Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients
The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are chronic conditions affecting approximately 1.4 million Americans. The burden of Clostridium dif...
RATIONALE: Drugs used in chemotherapy, such as vorinostat, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Vorinos...
Recent progress in treatment of recurrent/metastatic SCCHN has been made with the introduction of the taxanes. Docetaxel as a single agent has a response rate of 22-42% and 17% in patients...
Videos
Host Response May Be Key to Winning the War on Cancer
In this video blog, Dr. John Marshall speculates that understanding and manipulating the host response may yield even greater benefits than current efforts t...
Medical and Biotech [MESH] Definitions
Sporozoites
The product of meiotic division of zygotes in parasitic protozoa comprising haploid cells. These infective cells invade the host and undergo asexual reproduction producing MEROZOITES (or other forms) and ultimately gametocytes.
Integration Host Factors
Bacterial proteins that are used by BACTERIOPHAGES to incorporate their DNA into the DNA of the "host" bacteria. They are DNA-binding proteins that function in genetic recombination as well as in transcriptional and translational regulation.
Host Factor 1 Protein
An integration host factor that was originally identified as a bacterial protein required for the integration of bacteriophage Q beta (ALLOLEVIVIRUS). Its cellular function may be to regulate mRNA stability and processing in that it binds tightly to poly(A) RNA and interferes with ribosome binding.
Behavioral Research
Research that involves the application of the behavioral and social sciences to the study of the actions or reactions of persons or animals in response to external or internal stimuli. (from American Heritage Dictionary, 4th ed)
Receptor, Epha1
The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
