Human Chorionic Gonadotropin Hcg rDNA - Biotech, Pharma and Life Science Channel

04:26 EDT 28th July 2015 | BioPortfolio

PubMed Articles [11559 Associated PubMed Articles listed on BioPortfolio]

Corrigendum.

Human Chromosome Y and Haplogroups; introducing YDHS Database.

As the high throughput sequencing efforts generate more biological information, scientists from different disciplines are interpreting the polymorphisms that make us unique. In addition, there is an i...

A nerve guidance conduit with topographical and biochemical cues: potential application using human neural stem cells.

Despite major advances in the pathophysiological understanding of peripheral nerve damage, the treatment of nerve injuries still remains an unmet medical need. Nerve guidance conduits present a promis...

Curcumin-reduced graphene oxide sheets and their effects on human breast cancer cells.

Curcumin (as a natural reductant material) was utilized for green reduction and functionalization of chemically exfoliated graphene oxide (GO) sheets. The π-π attachment of the curcumin molecules on...

Silver nanoparticles with antimicrobial activities against Streptococcus mutans and their cytotoxic effect.

Microbial resistance represents a challenge for the scientific community to develop new bioactive compounds. The goal of this research was to evaluate the antimicrobial activity of silver nanoparticle...

Effect of discarded keratin-based biocomposite hydrogels on the wound healing process in vivo.

Biocompatible keratin-based hydrogels prepared by electron beam irradiation (EBI) were examined in wound healing. As the EBI dose increased to 60kGy, the tensile strength of the hydrogels increased, w...

A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium.

In the intestine, a single layer of epithelial cells sealed together at their apical surfaces by tight junctions helps to prevent the luminal commensal and pathogenic micro-organisms and their toxins ...

Evaluation of microbial quality and yeast diversity in fresh-cut apple.

The present work's aim was to study the microbial quality of minimally processed apples commercialized in Portugal. Sixty eight samples of fresh-cut apple were analyzed before their best-before date i...

Real-time PCR detection of Campylobacter spp.: A comparison to classic culturing and enrichment.

The major disadvantage of the current gold standard for detection of the food pathogen Campylobacter, i.e. culturing, is the lengthy procedure. In this study we assessed the use of real-time PCR for d...

Methicillin-resistant Staphylococcus aureus (MRSA) in slaughtered pigs and abattoir workers in Italy.

Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen present in the hospital environment (HA-MRSA), in the community (CA-MRSA) and in livestock, including pigs (LA-MRSA). MRSA may enter th...

News Articles [4227 Associated News Articles listed on BioPortfolio]

Optibiotix completes study on cholesterol reducing capsule

Life sciences group Optibiotix (LON:OPTI) has completed clinical studies for its cholesterol reducing capsules with no safety concerns arising. Human testing, which began in January, has been carrie...

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

Plasmepsin V is an aspartyl protease essential for export of effector proteins to Plasmodium-infected erythrocytes. A new inhibitor blocks plasmepsin V and inhibits parasite growth; it has also allowe...

Phenolyzer: phenotype-based prioritization of candidate genes for human diseases

The Phenolyzer software provides prioritized candidate gene lists based on disease and phenotype terms that are entered by users as free text.

Improved DNA analysis of human hair

University of Adelaide researchers have developed a simple, low-cost method for the DNA profiling of human hairs. By modifying existing laboratory methods, the team was able to produce accurate DNA pr...

Northern Ireland Abortion Ban Endangers Women’s Lives, Says UN

(The Guardian) – The United Nations has denounced Northern Ireland’s ban on most abortions. In a critical report on the province’s abortion policy released on Friday, the UN’s human rights...

Amgen Announces Webcast of 2015 Second Quarter Financial Results

THOUSAND OAKS, Calif., July 27, 2015 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that it will report its second quarter financial results on Thursday, July 30, 2015, after the close o...

In CRISPR advance, scientists successfully edit human T cells

In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9. Because th...

Scientists Win $1.5 Million to Study New Strategies for Parkinson’s Disease and Other Disorders

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded nearly $1.5 million from the National Institute of General Medical Sciences of the National Institutes of ...

Pennsylvania Department of Human Services Celebrates the 25th Anniversary of the Americans with Disabilities Act

HARRISBURG, Pa., July 27, 2015 /PRNewswire-USNewswire/ -- Twenty-five years ago the Americans with Disabilities Act (ADA) ushered in a new era of increased protections and opportunities for indiv...

Burwell Announces $133M In Funding For Substance Abuse Treatment

The announcement by Health and Human Services Secretary Sylvia Burwell came during the National Governors Association meeting. Meanwhile, a pair of Washington Post articles detail how long waiting lis...

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Companies [290 Associated Companies listed on BioPortfolio]

CivicHealth

CivicHealth’s comprehensive technology solutions are used to coordinate care pathways across multiple organizations, including human services. CivicHealth’s robust platf...

Rapamycin Holdings, Inc.

Rapamycin Holdings holds the exclusive licenses for Rapamycin-related research discoveries made at the University of Texas Health Science Center San Antonio. The company is levera...

Axiogenesis AG

The business objective of Axiogenesis lies in the area of clinical (red) biotechnology, specifically in the production of stem cell-based assays that enable drug development. These innovative and pr...

Cardinal Innovations Healthcare

Amy Kendall, J.D., Ph.D., was appointed Chief Administrative Officer effective May 16, 2015. In her role, Kendall will oversee the Human Resource, Community Partners, Cultural Com...

National Verruca Foundation

The National Verruca Foundation was established to provide accurate information and increase awareness of non-genital warts. Through education and advocacy, we hope to improve the...

Texas Health and Human Services Commission

Ritter Pharmaceuticals, Inc.

Ritter Pharmaceuticals, Inc. develops novel therapeutic products that modulate the human gut microbiome to treat inflammatory, gastrointestinal and metabolic diseases. Ritter i...

Paycom Software, Inc.

As a leader in payroll and HR technology, Oklahoma City-based Paycom redefines the human capital management industry by allowing companies to effectively navigate a rapidly changi...

Square Roots

Square Roots is a life sciences company focused on integrating new technology and scientific findings to examine, improve and optimize the state of maternal and infant care. We ar...

Arcadia Biosciences, Inc.

Based in Davis, Calif., with additional facilities in Seattle, Wash. and Phoenix, Ariz., Arcadia Biosciences is an agricultural technology company focused on developing technologi...

Clinical Trials [1455 Associated Clinical Trials listed on BioPortfolio]

Influence of Gravity on the Size-mass Illusion

Parabolic flight is the only ground-based condition in which free-fall (0G) can be created long enough for safely testing changes in human perception and behavior. In addition to the 0G pe...

A Safety and Pharmacokinetic Study of TRX-818 Administered Orally to Patients With Advanced Cancer

TRX-818 is a new small molecule chemical entity being developed as a potential anti-cancer therapeutic by TaiRx, Inc. TRX-818 is a potent anti-cancer agent in numerous human cancer cell li...

SPECTAmel: Screening Patients With Melanoma Tumors for Efficient Clinical Trial Access

SPECTAmel is a standardized, quality-assured molecular screening platform for tumor characterization and storage of human biological material (HBM) for the purpose of integrating new bioma...

Preoperative Olaparib Endometrial Carcinoma Study (POLEN)

The primary objective of this study is to identify, in human tumour samples, biomarker changes associated to short exposure to AZD2281 as potential predictors of activity in Endometrial Ca...

Selenium and Ischemic Stroke Outcome

Selenium is a trace element essential to human health.Selenium protection against cellular damage by oxygen radicals is accomplished through selenoproteins. Ischemic stroke is associated w...

Understanding Substance Use and Incident HIV/STI Among Young Black MSM

The scientific purpose of this study is to look at how substance use may relate to human immunodeficiency virus (HIV) infection among young black men who have sex with men in Atlanta.

Bioequivalence Study of Clopidogrel 75 mg in Two Tablet Formulations Relative to Reference Tablet in Healthy Subjects

Clopidogrel is a potent anti-thrombotic drug that inhibits adenosine diphosphate (ADP)-induced platelet aggregation. This is an open-label, randomized, single dose, three-way cross over, s...

Safety, Tolerability and Activity of TNT009 in Healthy Volunteers and Patients With Complement Mediated Disorders

Prospective, double-blind, randomized, placebo-controlled First-In-Human study with three sub-parts: Part A, a single ascending dose study (SAD) in normal human volunteers (NHVs), Part B, ...

The Influence of Oxytocin on Pair-bonding and Emotion Regulation

The neuropeptide oxytocin (OXT) has been identified as a key modulator of human social behavior and it has been recently shown that OXT also contributes to pair-bonding in men. However, it...

A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male Subjects

This study will provide information regarding the metabolic pathway of GBT440, the need for evaluation of potential drug-drug interactions, and the need for studies in special populations....

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Medical and Biotech [MESH] Definitions

A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).

The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.

Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.

The beta subunit of luteinizing hormone. It is a 15-kDa glycopolypeptide with structure similar to the beta subunit of the placental chorionic gonadatropin (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN) except for the additional 31 amino acids at the C-terminal of CG-beta. Full biological activity of LH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the LHB gene causes HYPOGONADISM and infertility.

A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).


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