Human Chorionic Gonadotropin Hcg rDNA - Biotech, Pharma and Life Science Channel

04:47 EDT 23rd May 2015 | BioPortfolio

PubMed Articles [11119 Associated PubMed Articles listed on BioPortfolio]

Corrigendum.

A simple and sensitive electrochemical immunosensor based on thiol aromatic aldehyde as a substrate for the antibody immobilization.

In this work, a novel sulfur-containing compound with aldehyde groups was synthesized, which was used to immobilize antibodies through the covalent bonding of the aldehyde groups with amino groups, in...

Label-free and homogeneous aptamer proximity binding assay for fluorescent detection of protein biomarkers in human serum.

By using the aptamer proximity binding assay strategy, the development of a label-free and homogeneous approach for fluorescent detection of human platelet-derived growth factor BB (PDGF-BB) is descri...

Sandwich-format electrochemiluminescence assay for PDGF-BB using quantum dots-dendrimer nanocomposites as probe.

This work describes a novel electrochemiluminescence aptasensor for highly sensitive detection of platelet-derived growth factor BB (PDGF-BB) using aptamer functionalized CdS quantum dots-polyamidoami...

One-pot synthesis of fluorescent DHLA-stabilized Cu nanoclusters for the determination of H2O2.

A facile one-pot approach has been developed to prepare orange-emitting Cu nanoclusters (NCs) using tetrakis(hydroxymethyl)phosphonium chloride as a reducing agent and lipoic acid as a capping agent u...

Sexual Orientation Identity Disparities in Awareness and Initiation of the Human Papillomavirus Vaccine Among U.S. Women and Girls: A National Survey.

Lesbians and bisexual women are at risk for human papillomavirus (HPV) infection from female and male sexual partners.

Human urine-derived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt/β-catenin signaling pathway.

Human urine-derived stem cells (USCs) have great application potential for cytotherapy as they can be obtained by non-invasive and simple methods. Silicate bioceramics, including calcium silicate (CS)...

The transducible TAT-RIZ1-PR protein exerts histone methyltransferase activity and tumor-suppressive functions in human malignant meningiomas.

Malignant meningiomas are a rare meningioma subtype and tend to have post-surgical recurrence. Significant endeavors have been taken to identify functional therapeutic targets to halt the growth of th...

Cancer of the Oropharynx.

The oropharynx has a crucial role in swallowing because of the surrounding constrictor musculature, need for mobility and pliability, and proximity of the base of tongue to the larynx. Human papilloma...

Molecular Biology and Immunology of Head and Neck Cancer.

In recent years, our knowledge and understanding of head and neck squamous cell carcinoma (HNSCC) has expanded dramatically. New high-throughput sequencing technologies have accelerated these discover...

News Articles [4239 Associated News Articles listed on BioPortfolio]

Perforin and granzymes: function, dysfunction and human pathology

Cytotoxic lymphocytes recognize virus-infected and transformed cells and kill them by apoptosis. Recent studies on the structural and cellular biology of the key mediators of this cytotoxicity — per...

COLUMN-Surgery so simple a gardener can do it - but he probably shouldn't

It needs to be a basic human right. Because millions of people around the globe die each year or suffer lifelong disability from easily correctible conditions like obstructed labor or appendicitis. ...

How the Bird Flu Sweeping Through US Flocks Is Different Than Past Outbreaks

An now, Minnesota has canceled its poultry shows at the state fair to protect its prize fowl. But this outbreak is different from previous outbreaks, some of which have led to human infections in othe...

New Biotechnology for High Efficiency Purification of Life Human Cells

(Physorg) – Cell therapies require a purification step that isolates the desired cell types from contaminating cells. Normally cell surface receptors are used as markers to distinguish cell type...

T. Rex Autopsy Coming to the Small Screen

The deceased waits on the slab, under the glare of lights. But the corpse is 46 feet long, has a heart 100 times larger than a human’s and sharpened teeth up to a foot long. The cameras roll, as the...

Regeneron/Sanofi's sarilumab heading for regulators for RA

Sarilumab inhibits the interleukin-6 receptor, like Roche's marketed arthritis treatment Actemra (tocilizumab). While Actemra is a recombinant humanized monoclonal antibody, Sanofi/Regeneron's is a fu...

Seeking Deeper Understanding of How the Brain Works

How is the mind formed, and what does it mean to be human? These are the questions that intrigue Edward Boyden, an associate professor of biological engineering and brain and cognitive sciences at MIT...

US scientists vow to answer CRISPR’s sticky moral questions

Top science academics have launched an initiative to consider emerging human gene-editing tools such as CRISPR-Cas9.

Merck Gets Positive CHMP Opinion For Skin Cancer Therapy Keytruda

WHITEHOUSE STATION (dpa-AFX) - Merck & Co. Inc. (MRK), known as MSD outside the United States and Canada, Friday announced a positive opinion from the Committee for Medicinal Products for Human Us...

Amgen Gets Positive CHMP Opinion For Repatha

THOUSAND OAKS (dpa-AFX) - Amgen, Inc. (AMGN) said that the Committee for Medicinal Products for Human Use or CHMP of the European Medicines Agency has adopted a positive opinion for the marketing ...

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Companies [279 Associated Companies listed on BioPortfolio]

Emulate, Inc.

Emulate, Inc. is a private company focused on commercializing Organs-on-Chips as an automated human bioemulation platform that achieves a new standard for mimicking true human phy...

Otsuka Pharmaceutical Development & Commercialization, Inc.

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Medolac Laboratories

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Xytex Corporation

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Tractica

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Replicor Inc.

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aTyr Pharma, Inc.

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Nuix

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Proteo Biotech AG

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Clinical Trials [1407 Associated Clinical Trials listed on BioPortfolio]

Safety and Pharmacokinetic Study of PF-06651600 in Healthy Volunteers

This study is a first in human study of PF-06651600. PF-06651600 is being developed for treatment of inflammatory bowel disease. This study will test single and multiple doses of PF-06651...

An Open-Label Extension Study of GA-GCB ERT in Patients With Type 1 Gaucher Disease

The purpose of this study is to evaluate the long-term safety of every other week dosing of Gene-Activated® human glucocerebrosidase (GA-GCB, velaglucerase alfa) intravenously in patients...

Safety of a Live Attenuated Human Parainfluenza Virus Type 2 (HPIV2) Vaccine for Adults, Children, and Infants

Human parainfluenza virus type 2 (HPIV2) can result in severe respiratory illness in infants and young children. This study will test the safety of and immune response to an HPIV2 vaccine ...

Longitudinal Study of the Porphyrias

The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the human porphyrias including the natural history, morbidity, pregnancy outcomes, and mortal...

Safety and Dose-finding Study of DC-TAB in Healthy Subjects

The purpose of this study is to determine safety and appropriate dose of DC-TAB for selective immune tolerance induction in humans.

HRT Versus MOS for Endometrial Preparation Prior to FET in Non PCOS Patients

Evaluation of endometrial preparation using either hormonal therapy or ovarian stimulation prior to frozen-thawed embryo transfer (FET) in patients without polycystic ovarian syndrome (PCO...

Effects of Brassica on Human Gut Lactobacilli

Brassica vegetables are an important part of the investigators normal diet and are associated with a reduced risk of many chronic diseases. The protective effect may be as a result of the ...

Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses

Ublituximab (also known as LFB-R603) is a monoclonal antibody that specifically binds to the trans-membrane antigen CD20. The binding induces immune response that causes lysis of B cells. ...

Patient Compliance to Self-collection for Detection of HPV-DNA

A study to investigate the compliance of unassisted women to self-collection of specimens for Hybrid Capture (HC) for detection of Human Papilloma Virus (HPV) DNA compared to Pap smear col...

Does DNA Sperm Fragmentation Affects Embryo Morphokinetic?

The embryokinetics may be a new prognostic factor for choosing the human embryos with the highest implantation potential. In order to identify the factors that may affect the rate of embry...

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Medical and Biotech [MESH] Definitions

A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).

The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.

Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.

The beta subunit of luteinizing hormone. It is a 15-kDa glycopolypeptide with structure similar to the beta subunit of the placental chorionic gonadatropin (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN) except for the additional 31 amino acids at the C-terminal of CG-beta. Full biological activity of LH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the LHB gene causes HYPOGONADISM and infertility.

A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).

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