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Human Chorionic Gonadotropin Hcg rDNA - Biotech, Pharma and Life Science Channel

12:01 EDT 26th July 2016 | BioPortfolio

PubMed Articles [11347 Associated PubMed Articles listed on BioPortfolio]

Difficulties facing healthcare workers in the era of AIDS treatment in Lesotho.

Sub-Saharan Africa is most affected by the AIDS pandemic and Lesotho is no exception. In many countries, healthcare workers are at the forefront of the fight against AIDS. This study explores the diff...

Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors.

Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been documented in several human neoplasms such as breast, prostate, and ovarian cancer. There is growing interest in developing ra...

Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial.

We aimed at assessing the benefit-to-risk ratio of activated protein C (drotrecogin-alfa activated, DAA) and corticosteroids, given alone or in combination, in patients with septic shock.

Priming Endothelial Cells With a Melanoma-Derived Extracellular Matrix Triggers the Activation of αvβ3/VEGFR2 Axis.

The unique composition of tumor-produced extracellular matrix (ECM) can be a determining factor in changing the profile of endothelial cells in the tumor microenvironment. As the main receptor for ECM...

Modification biological activity of S and R forms of Proteus mirabilis and Burkholderia cepacia lipopolysaccharides by carrageenans.

The modification of biological features of S and R forms of Proteus mirabilis and Burkholderia cepacia LPS by kappa/iota and kappa/beta carrageenans was shown in Limulus activation test, ELISA, human ...

Possible Transmission of mcr-1-Harboring Escherichia coli between Companion Animals and Human.

Mutation in West Nile Virus Structural Protein prM during Human Infection.

A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient'...

Cover Image, Volume 117, Number 9, September 2016.

Cover: The cover image, by Noor Ahmad Shaik et al., is based on the Article A Computational Protein Phenotype Prediction Approach to Analyze the Deleterious Mutations of Human MED12 Gene, DOI: 10.1002...

Clinical calculators in hospital medicine: Availability, classification, and needs.

Clinical calculators are widely used in modern clinical practice, but are not generally applied to electronic health record (EHR) systems. Important barriers to the application of these clinical calcu...

Using meta-differential evolution to enhance a calculation of a continuous blood glucose level.

We developed a new model of glucose dynamics. The model calculates blood glucose level as a function of transcapillary glucose transport. In previous studies, we validated the model with animal experi...

News Articles [5412 Associated News Articles listed on BioPortfolio]

Scientists Test Nanoparticle Drug Delivery in Dogs

NewsAn engineer teamed up with a veterinarian to test a bone cancer drug delivery system in animals bigger than the standard animal model, the mouse. They chose dogs - mammals closer in size and biolo...

Researchers identify protein role in pathway required for Ebola replication

A newly identified requirement of a modified human protein in ebolavirus (EBOV) replication, may unlock the door for new approaches to treating Ebola.

CHMP nod for Allergan's IBS-D drug

Allergan has received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) for Truberzi (eluxadoline) for the treatment of irritable bowel syndrome with diarrhoe...

BRIEF-Fate Therapeutics receives patent for human induced pluripotent cells

* Fate Therapeutics announces issuance of U.S. Patent on compositions of human induced pluripotent cells

MetroStar a winner in the Department of Health and Human Services' Consumer Health Data Aggregator Challenge

RESTON, Va., July 26, 2016 /PRNewswire/ -- MetroStar Systems, an information technology services and consulting firm in Reston, VA, today announced that they were one of four winners in the Depar...

IBS-D treatment Truberzi receives positive opinion from CHMP

Global pharmaceutical company Allergan has announced that the Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency (EMA), has issued a posit...

Flex Pharma Completes Enrollment of Human Proof-of Concept Efficacy Study in Nocturnal Leg Cramps

-- Topline Results Expected Ahead of Plan, by Year End, for Single Molecule TRP Ion Channel Activator in Randomized, Blinded, Controlled, Cross-over Study -- Read more...

Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer

Human EHMT2/G9a activates p53 through methylation-independent mechanism

FOXM1 allows human keratinocytes to bypass the oncogene-induced differentiation checkpoint in response to gain of MYC or loss of p53

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Companies [316 Associated Companies listed on BioPortfolio]

Eccovia Solutions

Eccovia Solutions is a trusted provider of industry-leading software and services for health and human service organizations. As an innovator in cloud-based technology, we are at ...

Effective Health Systems, LLC

Effective Health Systems (www.effectivehealthsystems.com) was launched in 2007. Effective Health Systems is a human capital management firm whose focus is on delivering technologi...

Biomoda

Biomoda, Inc. is a developmental stage company engaged in the business of developing biopharmaceutical technology to diagnose and treat human diseases. The Company currently licenses two patents in th...

The International WELL Building Institute

The International WELL Building Institute (IWBI) is a for-benefit organization (B-Corp) whose mission is to improve human health and wellbeing through the built environment. IWBI ...

Mawi DNA Technologies

Mawi DNA Technologies was founded in 2013 and has developed and commercialized the iSWAB technology, an innovative system for collection of biosamples. The company’s flags...

Octapharma Group

Headquartered in Lachen, Switzerland, Octapharma is one of the largest human protein manufacturers in the world, developing and producing human proteins from human plasma and huma...

Unite US

Unite US is a technology platform reinventing the delivery of health, employment, and human services. The company is disrupting the fragmented health and human services industry b...

MOLOGEN AG

MOLOGEN is specializing in selected areas of Molecular Medicine. Our areas of competence are gene expression, gene therapy and bioinformatics. We are dedicated to the development of DNA expression and...

SAB Biotherapeutics, Inc.

SAB Biotherapeutics, Inc. (SAB), headquartered in Sioux Falls, S.D. is an established, biopharmaceutical company that is leading the science and manufacturing of immunoglobulin th...

Sandbox

Launched in 2016, Sandbox is an independent, full-service agency formed by four complementary entrepreneurial agencies united by a "play well together" ethos of collaboration. Hea...

Clinical Trials [1817 Associated Clinical Trials listed on BioPortfolio]

Enteric Nervous System in Alzheimer Disease

The close homology between the central and enteric nervous systems suggests that a disease process affecting the central nervous system could also involve its enteric counterpart. The inve...

Investigation Into the Infectivity Levels of Human Papilloma Virus (HPV) in Tonsillar Tissue

Human Papilloma Virus (HPV) has been shown to be a cause of Head & Neck Squamous Cell Carcinoma (HNSCC) and the majority of current studies focus on what is happening in patients with a HP...

Robots to Reduce Pain During IV Placement

Peripheral intravenous catheters (IVs) are utilized in the majority of hospitalized children. The placement of IVs requires significant staff time, contributes to health care costs, and ca...

Safety and Virologic Effect of a Human Monoclonal Antibody, VRC-HIVMAB080-00-AB (VRC01LS), With Broad HIV-1 Neutralizing Activity, Administered Intravenously to HIV-Infected Adults

Background: The human body uses antibodies as one way to help fight infection. VRC01LS is an antibody directed against the HIV virus. Researchers want to see if it is safe and well tolera...

Rapid Diagnostics for Traumatic Brain Injury (TBI)

Novel biomarkers of traumatic brain injury (TBI) have been discovered in laboratory animal models. The objective of this study is to find whether similar markers are detectable in the body...

Controlled Human Malaria Infection Model for Evaluation of Transmission‐Blocking Interventions - Study 1

This is a single-center, open label study. The primary aim of this project is to develop a controlled human malaria infection transmission model ("CHMI-trans") or "challenge model" to eval...

Safety, Tolerability, PK of Oral NYX-2925 in Healthy Volunteers

This is a first in human study of NYX-2925. It will evaluate single and multiple ascending doses of NYX-2925 in healthy volunteers.

Allogeneic Human Mesenchymal Stem Cells for Alzheimer's Disease

STUDY OBJECTIVES Primary: To assess the safety and tolerability of ischemia-tolerant allogeneic human mesenchymal stem cells (hMSCs) manufactured by Stemedica versus placebo admini...

In-vivo Efficacy of Patient Preoperative Prep

The objective of the study is to demonstrate the antimicrobial efficacy of the ZP Preoperative Prep on skin flora of the abdomen and inguinal regions of human subjects.

Clinical Evaluation of Patient Preoperative Prep

The objective of the study is to demonstrate the antimicrobial efficacy of the ZP Preoperative Prep on skin flora of the abdomen and inguinal regions of human subjects.

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Medical and Biotech [MESH] Definitions

A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).

The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.

Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.

The beta subunit of luteinizing hormone. It is a 15-kDa glycopolypeptide with structure similar to the beta subunit of the placental chorionic gonadatropin (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN) except for the additional 31 amino acids at the C-terminal of CG-beta. Full biological activity of LH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the LHB gene causes HYPOGONADISM and infertility.

A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).

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