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Human Chorionic Gonadotropin Hcg rDNA - Biotech, Pharma and Life Science Channel

14:44 EST 22nd February 2017 | BioPortfolio

PubMed Articles [11662 Associated PubMed Articles listed on BioPortfolio]

Carbonic anhydrase inhibitory properties of some uracil derivatives.

Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4-12) to inhibit...

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors.

Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are invo...

Priming increases the anti-tumor effect and therapeutic window of (177)Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1.

(177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rar...

Advance of autophagy in chronic kidney diseases.

Autophagy, a highly conserved mechanism for cell survival, emerges as an important pathway in many biological processes and diseases conditions. Studies of cultured renal cells, human kidney tissues a...

Intraoperative intrinsic optical imaging of human somatosensory cortex during neurosurgical operations.

Intrinsic optical imaging as developed by Grinvald et al. is a powerful technique for monitoring neural function in the in vivo central nervous system. The advent of this dye-free imaging has also en...

Moderate hyperoxia induces inflammation, apoptosis and necrosis in human umbilical vein endothelial cells: An in-vitro study.

Perioperative oxygen (O2) therapy can cause hyperoxia. Extreme hyperoxia can injure the cardiovascular system and remote organs.

One Gene, Several Diseases: The Characteristics of Pleiotropic Proteins.

Theoretical and experimental study of polycyclic aromatic compounds as β-tubulin inhibitors.

In this work, through a docking analysis of compounds from the ZINC chemical library on human β-tubulin using high performance computer cluster, we report new polycyclic aromatic compounds that bind ...

Morphological and molecular characterization of Cucullanus bourdini Petter et Le Bel, 1992 (Ascaridida: Cucullanidae) from the yellowback fusilier Caesio xanthonota Bleeker (Perciformes: Caesionidae).

The detailed morphology of Cucullanus bourdini Petter et Le Bel, 1992 was further studied using both light and scanning electron microscopy, based on specimens collected from the yellowback fusilier C...

Molecular diagnosis of Entamoeba spp. versus microscopy in the Great Cairo.

Amoebiasis is a human disease produced by Entamoeba histolytica which causes widespread mortality and morbidity worldwide through diarrheal disease and abscess establishment in parenchymal tissues suc...

News Articles [5188 Associated News Articles listed on BioPortfolio]

Meso Scale Discovery Launches New V-PLEX Assays for Th17 Research

Meso Scale Discovery, a division of Meso Scale Diagnostics, LLC. (MSD), today launched V-PLEX® immunoassays validated for the detection of the biomarkers IL-17A, IL-21, IL...

Prolacta Bioscience(R) to Present at the Cowen and Company 37th Annual Health Care Conference ...

DUARTE, CA--(Marketwired - Feb 22, 2017) - Prolacta Bioscience ®-- the nation's leading provider of human milk-based neonatal nutritional products, announced today that Read more...

Atreca, Inc. Presents New Preclinical Findings for Novel Cancer Immunotherapy Platform at Molecular Medicine Tri-Conference 2017

Atreca’s Immune Repertoire Capture® Platform Generates Potent Antibodies Targeting Multiple Tumor Types Atreca Antibody Eliminates Tumor in In Vivo Pr...

Transplanting good bacteria to kill Staph

Healthy human skin is alive with bacteria. In fact, there are more microorganisms living in and on the human body than there are human cells. Most can live on the human skin without harming the host, ...

Evolution debate: Are humans continuing to evolve?

Is natural selection still a major force in human evolution? Or have medical advancements effectively muted nature's power to reshape humanity? The post

Nature Study Suggests New Therapy for Gaucher Disease

CINCINNATI, Feb. 22, 2017 /PRNewswire-USNewswire/ -- Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher and maybe other lysosomal storage diseas...

What role should society play in decisions about gene editing of human germline?

The National Academies of Sciences and National Academy of Medicine [published a report that] suggests limitations on genetic engineering to the heritable “germline

New frontier in fight against Alzheimer’s, epilepsy opens with discovery of learning mechanism

Researchers have discovered a brand new mechanism that controls the way nerve cells in our brain communicate with each other to regulate learning and long-term memory. The fact that a new brain mecha...

Certara Strategic Consulting Awarded Good Laboratory Practices (GLP) Compliant Toxicokinetic Test Site Certification

CSC’s pre-clinical toxicology and pharmacokinetics modeling and simulation are used to inform first-in-human dosing in Phase 1 trials Certara®, the leading provider of deci...

COGNITION PERSÉVÉRANTE : Pourquoi il ne faut pas rapporter ses problèmes de travail à la maison - Frontiers in Human Neuroscience

Tout est question de stress et prolonger le stress de la journée de travail, en ramenant ses problèmes de travail à la maison peut avoir un lourd impact sur la santé physiq...

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Companies [311 Associated Companies listed on BioPortfolio]

Chan Zuckerberg Biohub

The CZ Biohub is an independent non-profit medical research organization collaborating with the University of California, Berkeley, Stanford University and the University of Calif...

Abilita Bio Inc.

Founded in 2014, Abilita Bio is an innovation-driven biotechnology company focused on enabling the discovery and development of drugs targeting challenging human membrane proteins...

Axial Biotherapeutics

Axial Biotherapeutics is a biopharmaceutical company harnessing the link between the human gut microbiome and the central nervous system to develop a new class of biotherapeutics ...

Eastpointe Human Services

Eccovia Solutions

Eccovia Solutions is a trusted provider of industry-leading software and services for health and human service organizations. As an innovator in cloud-based technology, we are at ...

Effective Health Systems, LLC

Effective Health Systems (www.effectivehealthsystems.com) was launched in 2007. Effective Health Systems is a human capital management firm whose focus is on delivering technologi...

Biomoda

Biomoda, Inc. is a developmental stage company engaged in the business of developing biopharmaceutical technology to diagnose and treat human diseases. The Company currently licenses two patents in th...

The International WELL Building Institute

The International WELL Building Institute (IWBI) is a for-benefit organization (B-Corp) whose mission is to improve human health and wellbeing through the built environment. IWBI ...

Octapharma Group

Headquartered in Lachen, Switzerland, Octapharma is one of the largest human protein manufacturers in the world, developing and producing human proteins from human plasma and huma...

Unite US

Unite US is a technology platform reinventing the delivery of health, employment, and human services. The company is disrupting the fragmented health and human services industry b...

Clinical Trials [2043 Associated Clinical Trials listed on BioPortfolio]

A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA

Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tis...

HPV IIS Reminder/Recall- New York State

The overarching goal of this study is to evaluate the effectiveness, cost-effectiveness and sustainability of utilizing statewide Immunization Information Systems (IIS) to conduct centrali...

Atomic Magnetometer for Fetal Biomagnetism

The goal of this study is the evaluation of an atomic magnetometer that is practical for human biomagnetism studies. We have built a device that has the necessary sensitivity, and will be ...

A Safety and Efficacy Study of TALEN and CRISPR/Cas9 in the Treatment of HPV-related Cervical Intraepithelial NeoplasiaⅠ

This is an open-label and triple cohort study of the safety and efficacy of TALEN and CRISPR/Cas9 to possibly treat HPV Persistency and human cervical intraepithelial neoplasiaⅠwithout i...

Biomarkers in Dyspnea

To explore biological mechanisms in human model of induced dyspnea, in order to remove the source of dyspnoea, to modify cerebral impact and to allow the development of targeted therapies.

First-in-Human Dose Escalation Study of M201-A in Healthy Japanese Subjects

This Phase I first-in-human is designed to evaluate the safety, tolerability and pharmacokinetics of single ascending doses of M201-A administered by single continuous intravenous injectio...

First in Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and to Explore Pharmacodynamics of BAY1834845

This study is a first in human study that will investigate the safety, tolerability and pharmacokinetics and explore the pharmacodynamics of ascending single doses of BAY1834845 using a pl...

Facilitated Immunoglobulin Administration Registry and Outcomes Study (FIGARO)

Long-term observational study on the utilisation and outcomes of HyQvia (a product consisting of recombinant human hyaluronidase and a human normal immunoglobulin 10% solution) under every...

First-in-Human Study of KO-947 in Non-Hematological Malignancies

This phase 1 first-in-human (FIH) dose escalation study will determine the maximum tolerated dose (MTD) of KO-947 in subjects with locally advanced unresectable or metastatic, relapsed and...

HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions

This randomized phase IV trial studies how well human papillomavirus (HPV) vaccine therapy works in interrupting progression in patients with high-grade vulvar or anal lesions. Vaccines ma...

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Medical and Biotech [MESH] Definitions

A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).

The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.

Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.

The beta subunit of luteinizing hormone. It is a 15-kDa glycopolypeptide with structure similar to the beta subunit of the placental chorionic gonadatropin (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN) except for the additional 31 amino acids at the C-terminal of CG-beta. Full biological activity of LH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the LHB gene causes HYPOGONADISM and infertility.

A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).

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