Luteinizing Hormone LH - Biotech, Pharma and Life Science Channel
Luteinizing hormone (LH), a gonadotropin, stimulates the gonads - in males, the testes, and in females, the ovaries. It is essential for reproduction, and secreted from cells in the anterior pituitary called gonadotrophs. In females, ovulation of mature follicles on the ovary is induced by a large burst of LH secretion known as the preovulatory LH surge. Residual cells within ovulated follicles proliferate to form corpora lutea, which secrete the steroid hormones progesterone and estradiol. Progesterone is necessary for maintenance of pregnancy, and, in most mammals, LH is required for continued development and function of corpora lutea. The name luteinizing hormone derives from this effect of inducing luteinization of ovarian follicles.
Uses of LH-related compounds;
* LH is being used as part of menotropin preparations together with FSH or alone if profound LH deficiency has been diagnosed.
*The first luteinizing hormone-releasing hormone (LHRH) agonists were synthesized in the 1970s and leuprolide acetate became available for the treatment of prostate cancer in the 1980s.
*Today there are several LHRH agonists commonly used in treatment of prostate cancer.
*The use of agonistic analogues of luteinizing hormone releasing hormone (LHRH) is an established therapy for hormone-dependent metastatic pre-menopausal breast cancer. In the treatment of post-menopausal metastatic breast cancer, LHRH agonists also have some effect, although minor. Experimental data and several pilot clinical trials suggest that in epithelial ovarian cancer and sex-cord-stromal tumours of the ovary, LHRH agonists might have antitumour activity through the suppression of gonadotrophin secretion (selective medical hypophysectomy). Phase III clinical trials, evaluating this hypothesis, are in progress. Since 50% of breast cancers and 80% of epithelial ovarian cancers and endometrial cancers have high affinity binding sites for LHRH, cytotoxic LHRH analogues might provide a targeted chemotherapy, which would be more efficacious and less toxic than conventional regimens.
Source; Hum Reprod. 2000 Sep;15(9):2059-61.
Add the LH News Channel to your RSS reader;
News Articles
BURLINGTON, Mass., May 21, 2013 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that the effect of an em...
Addex Therapeutics / Addex Validates Potential Efficacy Biomarker for Phase 1 Trial of its GABA-B Positive Allosteric modulator, ADX71441 . Processed and transmitted by Thomson Reuters ONE. The issu...
TherapeuticsMD Elects Jules A. Musing to Board of Directors
TherapeuticsMD, Inc. (NYSE MKT: TXMD), a women’s healthcare company focused on developing and commercializing products targeted exclusively for women, today announced the electi...
Celebrity Beauty Expert Dishes on Nonsurgical "Facelift" Secret
NEW YORK, May 16, 2013 /PRNewswire/ -- Many people turn to the popular media when they're looking for the latest "anti-aging" secrets. And lately it seems like the biggest names in the business have a...
Patients Honor Dr. Jean Allen for Compassion
LARGO, Fla., May 15, 2013 /PRNewswire-USNewswire/ -- Patients' Choice has announced that Dr. Jean Allen was one of a select few physicians honored with the prestigious 2012 Compassionate Doctor Certif...
TherapeuticsMD Reports First Quarter 2013 Financial Results
TherapeuticsMD, Inc. (NYSE MKT:TXMD), a women’s healthcare company focused on developing and commercializing products targeted exclusively for women, today announced financial r...
FEEL Golf Co., Inc. Signs EMR Software Development Agreement with ScheduleMorePatients LLC
FORT LAUDERDALE, Fla., May 8, 2013 /PRNewswire/ -- FEEL Golf Co., Inc. (OTCBB: FEEL), through its wholly owned Florida based subsidiary, Intelligent Living Inc. ("ILI"), announced today that the...
"Fountain of Youth" Pill SeroVital™-hgh Huge Draw at Annual Gynecology Meeting
NEW ORLEANS, May 8, 2013 /PRNewswire/ -- Despite the fact that human growth hormone (hGH) is highly controversial, an hGH boosting product called SeroVital™-hgh is causing a stir...
Aileron Therapeutics Successfully Completes First-Ever Stapled Peptide Clinical Trial
Safety and Pharmacokinetics of ALRN-5281, a Long-Acting Growth-Hormone-Releasing-Hormone Agonist, Established in Single-Ascending Dose Study Aileron Therapeutics...
Will "Anti-Aging" Industry Turn Growth Hormone into Billion-Dollar Business?
NEW YORK, May 7, 2013 /PRNewswire/ -- From SeroVital™-hgh, the oral compound that increases human growth hormone (hGH) naturally, to Prolor Biotech's experimental extended release hGH injec...
Events
None
Companies
TheAmerican Association of Clinical Endocrinologists (AACE)
The American Association of Clinical Endocrinologists (AACE) represents more than 6,500 endocrinologists in the United States and abroad. AACE is the largest association of clinic...
Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development, commercialization and manufacturing of no...
Hotze Pharmacy, a part of Hotze Enterprises, is leading a wellness revolution in bioidentical hormone replacement therapy by compounding the finest quality of biologically identic...
The American Association of Clinical Endocrinologists
The American Association of Clinical Endocrinologists (AACE) represents more than 6,500 endocrinologists in the United States and abroad. AACE is the largest association of clinic...
Antares Pharma, Inc. and Population Council
Antares Pharma focuses on self-injection delivery technologies and topical gel-based pharmaceutical products. The Companyâs subcutaneous injection technology platforms includ...
Neurogen Corporation & Ligand Pharmaceuticals
Ligand discovers and develops new drugs that address critical unmet medical needs of patients with muscle wasting, frailty, hormone-related diseases, osteoporosis, inflammatory di...
Neurotez Inc., founded in 2005, is a privately held Delaware corporation operating from New Jersey, formed to develop a Leptin product as a hormone replacement therapy for Alzheim...
GTx, Inc., headquartered in Memphis, Tenn., is a biopharmaceutical company dedicated to the discovery, development, and commercialization of small molecules that selectively targe...
Founded in 2003, BodyLogicMD physician-owned practices make up the nationâs largest and fastest growing network of the most highly trained physicians specializing in natural...
Neurotez Inc., founded in 2005, is a privately held Delaware corporation operating from New Jersey, formed to launch the clinical development of Leptin as a hormone replacement th...
Clinical Trials
Screening Evaluation for Women With Postpartum Depression
This study evaluates the relationship between mood changes and hormones in women with postpartum depression (PPD). This is an observational study; volunteers who participate will not rece...
Pamidronate to Treat Osteogenesis Imperfecta in Children
This study will evaluate the effect of pamidronate-a drug that decreases bone resorption (breakdown)-on osteogenesis imperfecta. This is a genetic disorder of collagen, the major protein...
RATIONALE: Aromatase inhibitors, such as letrozole, prevent the formation of estradiol, a female hormone. Giving letrozole together with goserelin, leuprolide, or surgery may be an effecti...
This study will evaluate the safety and effectiveness of insulin-like growth factor-1 (IGF-1) to treat patients with X-linked severe combined immunodeficiency (XSCID). Those who have XSCID...
This study will evaluate whether the drug mifepristone can improve the symptoms of Cushing's syndrome in people with ectopic adrenal corticotrophin hormone (ACTH) secretion. Cushing's synd...
First Human Dose Trial of NNC0195-0092 in Healthy Subjects
This trial is conducted in Europe. The aim of this trial is to assess safety, tolerability, pharmacokinetics (the exposure of the trial drug in the body) and pharmacodynamics (the effect o...
Mediators of Abnormal Reproductive Function in Obesity (MARO)
The study is seeking to understand how being overweight and obese makes women less fertile. The studies the investigators have done so far indicate that there is a hormone or other substan...
A Study of Epirubicin With Estramustine Phosphate and Celecoxib for the Treatment of Prostate Cancer
The purpose of this clinical trial is to find out the effect of epirubicin with estramustine phosphate and celecoxib on PSA and objective response in patients with hormone resistant prosta...
Goserelin and Anastrozole in Treating Men With Recurrent or Metastatic Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using goserelin and anastrozole may fight breast cancer by blocking the use of estrogen by the tumor cells....
Fulvestrant in Treating Patients With Recurrent Prostate Cancer
RATIONALE: Estrogen may cause the growth of prostate cancer cells. Hormone therapy using fulvestrant may fight prostate cancer by blocking the use of estrogen by the tumor cells. PURPOSE:...
PubMed Articles
Of marsupials and men: "Backdoor" dihydrotestosterone synthesis in male sexual differentiation.
Following development of the fetal bipotential gonad into a testis, male genital differentiation requires testicular androgens. Fetal Leydig cells produce testosterone that is converted to dihydrotest...
Pheochromocytoma is a rare but potentially lethal chromaffin cell tumor with currently no effective treatment. Peptide hormone receptors are frequently overexpressed on endocrine tumor cells and can b...
The glucocorticoid receptor (GR) and corticotropin-releasing hormone (CRH) are important molecular regulators of an individual's ability to respond to stressful stimuli in an adaptive manner. Impaired...
Luteinizing hormone (LH) activates ERK1/2, MAP kinases (MAPKs) necessary for its action on steroidogenesis and cell proliferation, and also induces MAPK phosphatase-1 (MKP-1), which rapidly dephosphor...
Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis.
Steroid biosynthesis is a multi-step process controlled by pituitary hormones, which, via cAMP-dependent signaling pathways, drive tissue-specific steroid formation. Steroidogenesis begins with the tr...
N-POMC1-28 increases cyclin D expression and inhibits P27(kip1) in the adrenal cortex.
The Adrenocorticotropic hormone (ACTH) and Pro-opimelanocortin (POMC) 1-28N-terminal peptide (N-POMC1-28) have been shown to act as an adrenal mitogen in vivo. A possible role for cyclin E in the zona...
The production of glucocorticoids and aldosterone in the adrenal cortex is regulated at multiple levels. Biosynthesis of these hormones is initiated when cholesterol, the substrate, enters the inner m...
Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds.
Diabetes mellitus, characterised by hyperglycemia and altered β-cell function, is an increasingly common disorder affecting millions of individuals world-wide. While therapeutic regimens exist to man...
Applying optimal model selection in principal stratification for causal inference.
Noncompliance to treatment allocation is a key source of complication for causal inference. Efficacy estimation is likely to be compounded by the presence of noncompliance in both treatment arms of cl...
Penetration of nanoparticles in flax (Linum usitatissimum L.) calli and regenerants.
We demonstrate a method for direct delivery of metal nanoparticles to flax calli and regenerant cells by vacuum deposition of metal nanolayers on powdered hormone followed by dispersal of the combined...
Videos
Ovulation test - Luteinizing hormone (LH)
This Ovulation Test kit from http://familyhealthtest.com/ovulation-test-1/ovulation-test.html detects the luteinizing hormone (LH) to predict the peak of a w...
Medical and Biotech [MESH] Definitions
Luteinization
Formation of CORPUS LUTEUM. This process includes capillary invasion of the ruptured OVARIAN FOLLICLE, hypertrophy of the GRANULOSA CELLS and the THECA CELLS, and the production of PROGESTERONE. Luteinization is regulated by LUTEINIZING HORMONE.
Thyroid Hormone Receptors Alpha
High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRA gene (also known as NR1A1, THRA1, ERBA or ERBA1 gene) as several isoforms produced by alternative splicing.
Thyroid Hormone Receptors Beta
High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRB gene (also known as NR1A2, THRB1, or ERBA2 gene) as several isoforms produced by alternative splicing. Mutations in the THRB gene cause THYROID HORMONE RESISTANCE SYNDROME.
Luteinizing Hormone, Beta Subunit
The beta subunit of luteinizing hormone. It is a 15-kDa glycopolypeptide with structure similar to the beta subunit of the placental chorionic gonadatropin (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN) except for the additional 31 amino acids at the C-terminal of CG-beta. Full biological activity of LH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the LHB gene causes HYPOGONADISM and infertility.
Follicle Stimulating Hormone, Beta Subunit
The beta subunit of follicle stimulating hormone. It is a 15-kDa glycopolypeptide. Full biological activity of FSH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the FSHB gene causes delayed puberty, or infertility.
