Oral Administration - Biotech, Pharma and Life Science Channel
PubMed Articles
INTRODUCTION: Nonunion of femoral neck fractures frequently occurs in elderly patients. In patients with rheumatoid arthritis, reoperation rates after internal fixation of a displaced femoral neck fra...
The neuroprotective mechanism of puerarin treatment of acute spinal cord injury in rats.
Puerarin extracted from radix puraeriae is shown to exert a variety of pharmacological effects including neuroprotective properties. However, its mechanisms of action are needed to further explore. Th...
The ventrolateral midbrain periaqueductal gray (PAG) neurons have been intensively studied because of their pivotal role in the descending pain modulation system. Activation of GABAB receptors, one ty...
The aims of the present work were to investigate the effects of the repeated administration of Parawixin2 (2-amino-5-ureidopentanamide; formerly FrPbAII), a novel GABA and glycine uptake inhibitor, in...
Negative impact of melatonin ingestion on the photopic electroretinogram of dogs.
Melatonin follows a circadian rhythm entrained by the light/dark cycle and plays a role in promoting light sensitivity at night. It has been suggested that melatonin and dopamine reciprocal inhibition...
Teriflunomide for treatment of multiple sclerosis.
Interferon beta and glatiramer acetate are still considered to be the first-line therapeutics for treatment of relapsing forms of multiple sclerosis (MS). The use of new compounds, such as natalizumab...
Flurbiprofen was formulated into nanoparticle suspension to improve its oral bioavailability. Hydroxypropyl-β-cyclodextrin inclusion-flurbiprofen complex (HP-β-CD-FP) was prepared, then incorporatin...
Fulminant viral myocarditis after rituximab therapy in pediatric nephrotic syndrome.
BACKGROUND: We report a 7-year-old boy with high-degree steroid-dependent idiopathic nephrotic syndrome (SDNS) who went into remission with rituximab (RTX) maintenance therapy. CASE-DIAGNOSIS/TREATMEN...
Photodynamic therapy (PDT) with photosensitizer is one of the promising modalities for cancer treatment. For clinical use of PDT, screening process should be preceded to enhance sensitivity to PDT. Th...
Abstract Carvedilol-loaded solid lipid nanoparticles (SLNs) were prepared using solubility parameter (δ) to select the lipid, and hot homogenization to fabricate SLNs. The effect of concentration of...
News Articles
New U.S. fears emerge over tainted compounded steroids
(Reuters) - The Food and Drug Administration said on Friday it has received seven reports of illnesses in patients who took steroid injections compounded by a pharmacy in Tennessee.
FDA warns of potentially tainted compounded steroids
(Reuters) - The Food and Drug Administration said on Friday it has received seven reports of illnesses in patients who took steroid injections compounded by a pharmacy in Tennessee.
UPDATE 2-U.S. FDA warns of potentially tainted compounded steroids
May 24 (Reuters) - The U.S. Food and Drug Administration said on Friday it has received seven reports of illnesses in patients who took steroid injections compounded by a pharmacy in Tennessee.
UPDATE 1-U.S. FDA warns of potentially tainted compounded steroids
May 24 (Reuters) - The U.S. Food and Drug Administration said on Friday it has received seven reports of negative reactions by patients who took steroid injections compounded by a pharmacy in Tennesse...
2-Year-Old Drug Takes Top Rx Slot from Warfarin
(MedPage Today) -- The oral anticoagulant rivaroxaban (Xarelto) -- first approved by the FDA in 2011 -- is now being prescribed by cardiologists more often than warfarin, according to the latest figur...
FDA panel backs Merck insomnia drug, but cites safety concerns
The US Food and Drug Administration’s Peripheral and Central Nervous System Drugs Advisory Committee has recommended Merck’s insomnia drug suvorexant when given in low dosages, [...]
The Patient Role in Stimulating Chronic Fatigue Syndrome Drug Development
The Food & Drug Administration convened a two-day meeting with CFS patients, advocates, clinicians and researchers in late April. One of the speakers invited by FDA was former Lilly corporate stra...
Plecanatide Eases Chronic Constipation
The novel agent belongs to a new class of oral therapies known as guanylate cyclase-C receptor agonists. Medscape Medical News
China State and Food Administration grants GMP certificate to Sinovac Beijing
The China State and Food Administration (CFDA) has granted the Certificate of Good Manufacturing Practices for Pharmaceutical Products (GMP Certificate) to Sinovac Beijing under the new GMP guidelines...
Astellas Pharma Inc. (TOKYO: 4503) and Medivation, Inc. (NASDAQ: MDVN) today announced that Astellas has submitted an application for marketing approval of enzalutamide (generic n...
Events
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Companies
LABS, Inc., founded in 1979 as Immunological Associates of Denver, was one of the first transplant laboratories established in the United States. Today, as a taxable, non-profit c...
ComPsych® Corporation is the world's largest provider of employee assistance programs (EAPs) and is the leading provider of fully integrated EAP, behavioral health, wellness, work-life, crisis interv...
KineMed, Inc. ("KineMed" or the "Company") is a drug discovery and development company employing its proprietary translational medicine technology (AquaTag™ and KineMarkerâÂ...
Izun Pharmaceuticals Corporation
Izun Pharmaceuticals is a US based pharmaceutical company with a wholly owned R&D center in Israel. Izun’s technology platform allows it to develop botanical drugs by optimiz...
AAIPharma Services Corp. is a leading provider of contract services that support all phases of drug development. The company’s wide array of capabilities includes analytical chemistry, formula...
Puma Biotechnology, Inc. is a development stage biopharmaceutical company that acquires and develops innovative products for the treatment of various forms of cancer. The Company...
WageWorks, Inc. is the leading provider of consumer-directed benefits solutions. Products include: flexible spending accounts (FSA), health reimbursement accounts (HRA), health savings accounts (HSA)...
Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development, commercialization and manufacturing of no...
Moda Health is a multifaceted organization that provides medical, dental, pharmacy, vision and professional liability insurance products, along with a variety of business services...
Merck and Cardiome Pharma Corp.
In April 2009, Cardiome and Merck announced a collaboration and license agreement for the development and commercialization of vernakalant. The agreement provides Merck, Sharp and...
Clinical Trials
This prospective randomised study comparing administration of a hypo-osmolar oral hydration solution with the classical hydration via IV (intravenous) infusion in premature infants of more...
Phase I study to evaluate the excretion of radioactivity, the metabolic profile, pharmacokinetics, safety and tolerability following a single oral administration of [14C] Prucalopride Succ...
Relative Bioavailability of Oral Suspension of Rivaroxaban Compared to Standard Tablet
Rivaroxaban is a substance developed for use in the treatment of blood coagulation disorders. Thrombosis (blood clots) can occur as a result of excessive coagulation activity in the blood...
1. To determine the safety and tolerability of oral Cellcept when used in combination with weekly intramuscular Avonex in early MS. 2. To document changes in exacerbation frequency...
This study investigates safety and pharmacokinetic comparison of DWJ1276, a combination drug of Rosuvastatin and Olmesartan (test formulation), and co-administration of Rosuvastatin and Ol...
Pharmacokinetic Drug Interaction Between Pregabalin and Thioctic Acid.
A randomized, open-label, six-sequence, three-period, three-treatment, multiple dosing clinical trial to investigate the pharmacokinetic drug interaction between Pregabalin and Thioctic ac...
Oral Dexamethasone for Treatment of Migraine
The aim of this project is to determine if a single dose of oral dexamethasone at the time of discharge from the ED [after successful treatment] prevents rebound headache. Hypothesis: Tha...
A Phase I Study of Oral Topotecan as a Radiosensitizing Agent in Patients With Rectal Carcinoma
This is an open-label, single center, phase I study designed to determine the MTD or oral topotecan as a radiosensitizing agent in the treatment of rectal cancer patients. Sequential cohor...
Tc-99m Renography and Cisplatin-Induced Nephrotoxicity
Cisplatin is a heavy-metal complex widely used in the treatment of a variety of malignancies, including small cell and non-small cell lung cancer, ovarian, bladder, head and neck, esophage...
Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Computed Tomography
It is well known that X-ray contrast media can affect kidney function in some patients, especially when administered intra-arterially, and patients who already suffer from reduced kidney f...
Videos
Oral Medication Administration Part 1
Preparation of oral medications for administration. This is the first part of a 2 part presentation.
Medical and Biotech [MESH] Definitions
Mass Vaccination
Administration of a vaccine to large populations in order to elicit IMMUNITY.
Infusions, Intralesional
The administration of medication or fluid directly into localized lesions, by means of gravity flow or INFUSION PUMPS.
Estrogenic Steroids, Alkylated
Estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties.
Haemophilus Parainfluenzae
A species of gram-negative bacteria in the genus HAEMOPHILUS, ubiquitous in the human ORAL CAVITY and PHARYNX. It has low pathogenicity but is occasionally implicated in ENDOCARDITIS in humans.
Haemophilus Paraphrophilus
A species of gram-negative bacteria in the genus HAEMOPHILUS, found in the normal flora of the human ORAL CAVITY and PHARYNX. It can cause SUBACUTE BACTERIAL ENDOCARDITIS; and BRAIN ABSCESS, among other conditions.
