Prostate Cancer Pub Med - Biotech, Pharma and Life Science Channel
Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers.The cancer cells may metastasize (spread) from the prostate to other parts of the body, particularly the bones and lymph nodes. Prostate cancer may cause pain, difficulty in urinating, problems during sexual intercourse, or erectile dysfunction. Other symptoms can potentially develop during later stages of the disease.
Rates of detection of prostate cancers vary widely across the world, with South and East Asia detecting less frequently than in Europe, and especially the United States. Prostate cancer tends to develop in men over the age of fifty and although it is one of the most prevalent types of cancer in men, many never have symptoms, undergo no therapy, and eventually die of other causes. This is because cancer of the prostate is, in most cases, slow-growing, symptom-free, and since men with the condition are older they often die of causes unrelated to the prostate cancer, such as heart/circulatory disease, pneumonia, other unconnected cancers, or old age. About 2/3 of cases are slow growing, the other third more aggressive and fast developing.
Many factors, including genetics and diet, have been implicated in the development of prostate cancer. The presence of prostate cancer may be indicated by symptoms, physical examination, prostate specific antigen (PSA), or biopsy. The PSA test increases cancer detection but does not decrease mortality. Suspected prostate cancer is typically confirmed by taking a biopsy of the prostate and examining it under a microscope. Further tests, such as CT scans and bone scans, may be performed to determine whether prostate cancer has spread.
Treatment options for prostate cancer with intent to cure are primarily surgery, radiation therapy, and proton therapy. Other treatments, such as hormonal therapy, chemotherapy, cryosurgery, and high intensity focused ultrasound (HIFU) also exist, depending on the clinical scenario and desired outcome.
The age and underlying health of the man, the extent of metastasis, appearance under the microscope, and response of the cancer to initial treatment are important in determining the outcome of the disease. The decision whether or not to treat localized prostate cancer (a tumor that is contained within the prostate) with curative intent is a patient trade-off between the expected beneficial and harmful effects in terms of patient survival and quality of life.
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PubMed Articles
Clinical significance of tumor cavitation (TC) prior to and following first-line chemotherapy of lung cancer is unclear. An evaluation of the incidence and prognostic role of TC among treatment naive...
Antisense oligonucleotides (oligos) have been employed against prostate cancer models in both in vivo and in vitro systems. While most target growth factors or their receptors, other oligos are direct...
Prognostic value of TMPRSS4 expression in patients with breast cancer.
Transmembrane protease, serine 4 (TMPRSS4), is a novel type II transmembrane serine protease that is highly expressed on the cell surface in pancreatic, thyroid, lung, and other cancer tissues, althou...
Breast cancer is the most common cancer in women worldwide. The disease remains a public health concern as recent evidence indicates that the breast cancer burden has increased mainly in developing an...
Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer.
GATA-binding protein 2 (GATA2) is a nuclear transcription factor that plays a critical role in tumorigenesis. High levels of GATA2 expression are correlated with poor survival outcomes in many types o...
Clinical significance of serum adipokines levels in lung cancer.
Adipokines have a significant effect on metabolism, immunoinflammatory responses as well as on carcinogenesis; therefore, we aimed at evaluating their potential predictive and prognostic significance...
p73 gene shares structural and functional similarities to p53 and plays an important role in modulating cell cycle arrest and apoptosis. A common non-coding polymorphism of p73 G4C14-to-A4T14 (rs22739...
Prognostic value of proliferation markers expression in breast cancer.
In this study, immunohistochemical expression of five proliferation markers: Ki-67, aurora-A kinase, survivin, B-Myb and cyclin B1, was analyzed. Consecutive 215 tumor samples from breast cancer patie...
Clinical implications of CIP2A protein expression in breast cancer.
The aim of this work is to study the expression and regulatory effects of CIP2A protein in breast cancer and the correlation between CIP2A protein expression and the prognosis of breast cancer. The CI...
CYP2A6, CYP1A1, and CYP2D6 polymorphisms in lung cancer patients from Central South China.
Lung cancer is a common cause of cancer-related death. The link between risk of lung cancer susceptibility and genetic polymorphisms in metabolic enzymes is well documented. In this study, the relatio...
News Articles
Promising method to distinguish pancreatic cancer from chronic pancreatitis
Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis - two disorders that are difficult to tell apart. A molecular marker obta...
AGA announces first AGA-Caroline Craig Augustyn and Damian Augustyn Award in Digestive Cancer
The AGA Research Foundation is honored to announce the first AGA-Caroline Craig Augustyn and Damian Augustyn Award in Digestive Cancer, which will support Andrew D. Rhim, MD, from the Perelman School...
EndoChoice's new Fuse system improves accuracy of colonoscopy procedure
Although colonoscopy exams prevent many colon cancer deaths and are considered the most sensitive method for detecting colorectal cancers, the procedure is not completely effective in preventing cance...
PONCE, Puerto Rico, May 17, 2013 /PRNewswire/ -- Serving a region of 650,000 inhabitants in southern, central and western Puerto Rico, Caribbean Imaging and Radiation Therapy (CIRT, Ponce, PR) Ce...
How To Find Out Your Genetic Risk Factors Like Angelina Jolie Did
SAN FRANCISCO, May 17, 2013 /PRNewswire/ -- When Angelina Jolie told the world about her double mastectomy, she expressed a wish for all women with a family history of breast cancer: "It is my ho...
Molecular marker from pancreatic 'juices' helps identify pancreatic cancer
Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis—two disorders that are difficult to tell apart. A molecular marker obta...
[Comment] Peripherally inserted catheters: all that glitters is not gold
Indwelling central venous catheters are used widely for a range of indications, such as cancer treatment, diagnostic monitoring, and cardiac pacing; and administration of fluids, parenteral nutrition,...
Argos Therapeutics to Present at the Sachs Cancer Bio Partnering Forum
DURHAM, N.C., May 20, 2013 (GLOBE NEWSWIRE) -- Argos Therapeutics Inc., a biopharmaceutical company focused on the development and commercialization of fully personalized immunotherapies for the trea...
Prima BioMed to Present at the Second Annual Marcum LLP MicroCap Conference
SYDNEY, AUSTRALIA -- (Marketwired) -- 05/20/13 -- Prima BioMed Ltd (ASX: PRR) (NASDAQ: PBMD) (ISIN: US74154B2034) ("Prima," the "Company") has announced today that Matthew Lehman, its Chief Executive...
Spanish Smoking Relapse Prevention
Researchers from Moffitt Cancer Center and the University of South Florida have evaluated how Florida health care and social service agencies distribute "Libres para Siempre" ("Forever Free®"), a Spa...
Events
Cancer Vaccines will provide attendees with a complete view of the cancer immunotherapy field. Focusing on the discovery of new vaccines, developments in target identification
Academic Screening Workshop 2013
Select Bio is pleased to present the 3rd Screening Asia conference, which will take place at the Biopolis, Singapore, on November 12th & 13th
3rd Annual Oncology Biomarkers Congress 2013
Over 150 oncology focused industry delegates Over 50 presentations/roundtables/panel discussions
3rd World Congress on Cancer Science & Therapy
3rd world congress on Cancer Science & Therapy serves as a reunion land for scientists in the area of cancer research.
Webinar - Oncology Clinical Trials in Eastern Europe
Main focus on Breast cancer, Prostate cancer, Ovarian cancer, Lung cancer, Colorectal cancer
Companies
Loma Linda University Medical Center
Loma Linda University Medical Center (LLUMC), a Seventh-Day Adventist institution, is among the largest private medical educational centers in the United States and the only one in inland Southern...
Bio-Path is developing a patented, liposomal drug delivery system and products developed at The University of Texas M. D. Anderson Cancer Center, with two clinical cancer drug can...
Cancer Genetics, Inc. (CGI) is an emerging leader in the field of personalized medicine, offering products and services that enable cancer diagnostics as well as treatments that are tailored to the...
Foundation Medicine is dedicated to the development of comprehensive tests that will help physicians personalize cancer treatment for their patients. Foundation Medicineâs la...
Eutropics Pharmaceuticals Inc.
Eutropics is addressing the need for improving the treatment of aggressive forms of leukemia, myeloma, lymphoma, and other cancers. The company is developing a novel diagnostic te...
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The companyâs lead drug candidate, TOK-001, is the first i...
OncoMed Pharmaceuticals is a clinical-stage company that discovers and develops novel therapeutics targeting cancer stem cells, the cells believed to be capable of driving tumor growth, recurrence and...
Provectus Pharmaceuticals, Inc.
Provectus Pharmaceuticals specializes in developing oncology and dermatology therapies. Its lead oncology agent, PV-10, is designed to selectively target and destroy cancer cells...
Onconova, based in Newtown, PA and Lawrenceville, NJ, discovers and develops novel patent- protected small molecule therapeutic agents for cancer, radiation protection and hematol...
Fry Construction Company, Inc., is a leader in the precision construction of medical facilities. Since completing Dallasâ first magnetic resonance imaging center in 1984, Fry...
Clinical Trials
Cell Lines From High-Risk Breast Tissue
Background: - Many risk factors for breast cancer have been identified, including family history, endocrine background, changes in breast tissue, cancer in one breast, radiation...
RATIONALE: Dutasteride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dutasteride works in tr...
This is a phase 3, randomized, double-blind, placebo-controlled study to evaluate new or worsening lens opacifications in subjects with non-metastatic prostate cancer receiving denosumab f...
Phase 2A Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer
The purpose of the phase 2A component of this study is to determine if giving the immune molecule NPC-1C to individuals who have cancer of the pancreas or gastrointestinal tract (colon or...
Exercise and Metformin in Colorectal and Breast Cancer Survivors
Metformin is a medication that is commonly used in the treatment of diabetes. Recently small studies in cancer patients without diabetes suggest that metformin may benefit in lowering ins...
This prospective, multi-center, non-interventional study will evaluate the efficacy and safety of Herceptin (trastuzumab) in routine clinical practice in Chinese patients with gastric or g...
Neoadjuvant Axitinib in Prostate Cancer
The goal of this clinical research study is learn if adding axitinib to hormonal therapy can help to control prostate cancer when given before surgery. The safety of this drug will also be...
Testing the Helpfulness of 2 Decision Aids for Prostate Cancer
The purpose of this study is to test different methods for communicating information about prostate cancer treatment to men. The investigators are studying how best to present information...
Collecting and Storing Tissue Samples From Women With or Without Breast Cancer
RATIONALE: Collecting and storing samples of tissue, blood, and urine from patients with or without breast cancer to study in the laboratory may help the study of cancer. PURPOSE: This re...
Vemurafenib, Cetuximab, and Irinotecan in Advanced Solid Cancers
The goal of this clinical research study is to find the highest tolerable dose of vemurafenib that can be given in combination with cetuximab and irinotecan to patients with advanced cance...
Videos
Prostate Cancer (Understanding Disease: Infectious Diseases & Oncology)
Get the facts on Prostate Cancer with this 100%-accurate animated video. Part of Focus Apps' Understanding Disease: Infectious Diseases & Oncology series, th...
Medical and Biotech [MESH] Definitions
Ultrasound, High-intensity Focused, Transrectal
Tissue ablation of the PROSTATE performed by ultrasound from a transducer placed in the RECTUM. The procedure is used to treat prostate cancer (PROSTATIC NEOPLASMS) and benign prostatic hypertrophy (PROSTATIC HYPERPLASIA).
Enterocolitis, Neutropenic
A syndrome characterized by inflammation in the ILEUM, the CECUM, and the ASCENDING COLON. It is observed in cancer patients with CHEMOTHERAPY-induced NEUTROPENIA or in other immunocompromised individuals (IMMUNOCOMPROMISED HOST).
Carcinoma, Ductal
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
Positron-emission Tomography
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Nijmegen Breakage Syndrome
A chromosome instability syndrome resulting from a defective response to DNA double-strand breaks. In addition to characteristic FACIES and MICROCEPHALY, patients have a range of findings including RADIOSENSITIVITY, immunodeficiency, increased cancer risk, and growth retardation. Causative mutations occur in the NBS1 gene, located on human chromosome 8q21. NBS1 codes for nibrin, the key regulator protein of the R/M/N (RAD50/MRE11/NBS1) protein complex which senses and mediates cellular response to DNA DAMAGE caused by IONIZING RADIATION.
