Raynaud's Syndrome - Biotech, Pharma and Life Science Channel

17:00 EDT 1st September 2014 | BioPortfolio

PubMed Articles [5535 Associated PubMed Articles listed on BioPortfolio]

Cardiac troponin I levels in patients with non-ST-elevation acute coronary syndrome-The importance of gender.

Measurement of high-sensitivity cardiac troponin levels is increasingly used in non-ST-elevation acute coronary syndrome (NSTE-ACS). However, studies investigating the distribution and prognostic impl...

The hepatopulmonary syndrome.

The hepatopulmonary syndrome has been acknowledged as an important vascular complication in lungs developing systemic hypoxemia in patients with cirrhosis and portal hypertension. Is formed by arteria...

Terson syndrome in subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury.

This prospective trial was designed to evaluate the incidence of Terson syndrome in patients suffering from subarachnoid hemorrhage, intracerebral hemorrhage, or traumatic brain injury and whether con...

Significant expressivity of Wolfram syndrome: phenotypic assessment of two known and one novel mutation in the WFS1 gene in three Iranian families.

Wolfram syndrome also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness) is a rare neurodegenerative autosomal recessive disorder. There is evidence of variable expr...

Obstructive sleep apnea syndrome and gastroesophageal reflux disease: the importance of obesity and gender.

It is claimed that gastroesophageal reflux disease (GERD) increases in patients with obstructive sleep apnea syndrome (OSAS). We aimed to evaluate the prevalence of GERD in patients with OSAS and prim...

Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome: The SOLID-TIMI 52 Randomized Clinical Trial.

Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been hypothesized to be involved in atherogenesis through pathways related to inflammation. Darapladib is an oral, selective inhibitor of the Lp-P...

Mismatch repair deficient-crypts in non-neoplastic colonic mucosa in Lynch syndrome: insights from an illustrative case.

Mono-allelic germline mutations in DNA mismatch repair (MMR) genes lead to Lynch syndrome (LS). Questions remain as to the timing of the inactivation of the wild-type allele in LS-associated tumorigen...

The Scc2-Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions.

The cohesin complex is at the heart of many chromosomal activities, including sister chromatid cohesion and transcriptional regulation. Cohesin loading onto chromosomes depends on the Scc2-Scc4 cohesi...

Management of Strongyloides stercoralis: a puzzling parasite.

Strongyloides stercoralis is one of the common parasites in tropical areas. It can result in severe clinical syndromes, hyperinfection syndrome or disseminated strongyloidiasis in immunocompromised pa...

TLR2/TLR4-dependent exaggerated cytokine production in hyperimmunoglobulinaemia D and periodic fever syndrome.

The autoinflammatory hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS) is characterized by recurrent episodes of fever and inflammation. As part of the mevalonate kinase deficiency spectru...

News Articles [1497 Associated News Articles listed on BioPortfolio]

DICER1: mutations, microRNAs and mechanisms

Germline mutations in DICER1 can lead to DICER1 syndrome, which is characterised by the predisposition of various types of cancer in childhood and during early adulthood. Additionally, specific DICER1...

Darapladib drug fails to reduce risk of recurrent major coronary events

In patients who experienced an acute coronary syndrome (ACS) event (such as heart attack or unstable angina), use of the drug darapladib to inhibit the enzyme lipoprotein-associated phospholipase A2 (...

After a Rare Diagnosis Threatened Their Boys’ Lives, Parents Build Awareness About TTTS and Fetal Surgery Options at The SSM St. Louis Fetal Care Institute.

Twin-to-twin transfusion syndrome awareness nights to be held with the St. Louis Cardinals and at University City Market Pub House St. Louis (PRWEB) August 31, 2014 Twin to twin transfusion syndrome ...

A nucleotide change could initiate fragile X syndrome

(Rockefeller University Press) Researchers reveal how the alteration of a single nucleotide -- the basic building block of DNA -- could initiate fragile X syndrome, the most common inherited form of i...

ESC: Darapladib Fails in ACS Trial (CME/CE)

BARCELONA (MedPage Today) -- Inhibiting an enzyme involved in inflammation has once again failed to reduce cardiovascular events, this time in patients who had been hospitalized with an acute coronary...

Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome The SOLID-TIMI 52 Randomized Clinical Trial

ImportanceLipoprotein-associated phospholipase A2 (Lp-PLA2) has been hypothesized to be involved in atherogenesis through pathways related to inflammation. Darapladib is an oral, selective inhibitor o...

Medical News Today: 'Mixed results' from use of medicine for cardiac surgery patients

Colchicine causes mixed results in cardiac surgery patients - reducing the incidence of postpericardiotomy syndrome, yet increasing incidence of gastrointestinal intolerance.

Inhibiting inflammatory enzyme after heart attack does not reduce risk of subsequent event

(The JAMA Network Journals) In patients who experienced an acute coronary syndrome event -- such as heart attack or unstable angina -- use of the drug darapladib to inhibit the enzyme lipoprotein-asso...

ESC: Gout Drug Little Help in Heart Surgery (CME/CE)

BARCELONA (MedPage Today) -- Giving the gout drug colchicine perioperatively to cardiac surgery patients reduced the incidence of postpericardiotomy syndrome, but didn't protect against later atrial f...

ESC: Gout Drug Some Help in Heart Surgery (CME/CE)

BARCELONA (MedPage Today) -- Giving the gout drug colchicine perioperatively to cardiac surgery patients reduced the incidence of postpericardiotomy syndrome, but didn't protect against later atrial f...

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Companies [44 Associated Companies listed on BioPortfolio]

Sea-licious™

Karlene Karst, a Registered Dietician, is a leading health specialist in both nutrition and natural medicine. She is the co-author of the national best seller “Healthy ...

Synergy Pharmaceuticals Inc.

Synergy Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development of new drugs to treat patients with gastrointestinal (GI) diseases and disorders. Synergyâ...

Sturge-Weber Foundation

Since its founding in 1987, the Sturge-Weber Foundation (SWF) has provided information, education and friendly support to adults and families of children with Sturge-Weber syndrom...

Horizon Science

Horizon Science is an Australian-based company that develops natural innovative sugar cane molasses extracts enriched with polyphenols for health benefits in blood glucose managem...

Nathealth Solutions

Nathealth Solutions is the U.S.-based distributor of BergaMet MEGA, the most powerful, natural agent for the management of lipid disorders. Derived from the Citrus bergamia Risso ...

Ironwood Pharmaceuticals, Inc. and Bionomics Limited

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood’s GC-C agonis...

Shionogi & Co., Ltd.

Headquartered in Osaka, Japan, Shionogi & Co., Ltd. is a major research-driven pharmaceutical company dedicated to placing the highest value on patients. Shionogi’s Research ...

Akebia Therapeutics, Inc.

Akebia Therapeutics is a discovery and development company focused on anemia and vascular disorders. Akebia’s lead program, AKB-6548, an orally bioavailable HIF-prolyl hydrox...

Aviir, Inc.

Founded in 2005 by cardiologists and researchers from the Stanford University School of Medicine , Aviir is focused on the discovery, development and commercialization of innovati...

AltheRx Pharmaceuticals

Formed in 2010, AltheRx Pharmaceuticals is a privately held development company whose business model is to advance projects through clinical development and create partnerships wi...

Clinical Trials [1807 Associated Clinical Trials listed on BioPortfolio]

Efficacy of Minoxidil in Children With Williams-Beuren Syndrome

The Williams-Beuren syndrome (WBS) is a sporadic congenital disorder characterized by a multisystem developmental impairment. This syndrome is caused by a microdeletion in chromosome 7q11....

Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess Blasts

The primary objective of this study is to compare overall survival (OS) in patients receiving ON 01910.Na + best supportive care (BSC) to OS of patients receiving BSC in a population of pa...

Safety and Pharmacokinetics of Ifetroban in Hepatorenal Syndrome Patients

Cumberland Pharmaceuticals Inc. (CPI) is developing ifetroban for treatment of hepatorenal syndrome (HRS) and proposes to conduct a study in hospitalized adult patients with HRS to assess...

MAESTRO-OL: Macitentan in Eisenmenger Syndrome To Restore Exercise Capacity (Open-Label)

Long-term study to evaluate if macitentan is safe, tolerable and efficient enough to be used for treatment of Eisenmenger syndrome.

Development of a Blood Test for Marfan Syndrome

The objective of this study is to determine whether a simple blood test can be a useful clinical tool for monitoring aortic disease in Marfan syndrome and Marfan-related disorders.

The Use of Heliox in Obstructive Sleep Apnea Syndrome

The goals of the project is to evaluate the effects of Heliox therapy on obstructive sleep apnea syndrome (OSAS).

Tart Cherry, Metabolic Syndrome, and Cardiovascular Risk

The hypothesis of this study is that the daily consumption of 480 ml tart cherry juice for twelve weeks will improve blood pressure and arterial stiffness by improving endothelial-mediated...

Observational Study to Investigate the Effectiveness of Eprosartan on Pulse Pressure (Teveten_MS)

The study is to identify the effectiveness of Eprosartan on pulse pressure in hypertensive patients with metabolic syndrome -Definition of pulse pressure (PP): Difference between systolic...

Investigation of the Efficacy of tDCS in the Treatment of Complex Regional Pain Syndrome (CRPS) Type 1

The efficacy of the current standard non-pharmacological treatments for complex regional pain syndrome (CRPS), a painful syndrome mostly occurring after musculoskeletal trauma, is suboptim...

Efficacy of Azithromycin to Prevent Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

The occurrence of bronchiolitis obliterans syndrome (SBO) after allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be a chronic pulmonary graft versus host disease ...

Medical and Biotech [MESH] Definitions

An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.

A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.

A selective adrenergic alpha-1 antagonist used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.

A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.

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