Regulatory Mechanisms - Biotech, Pharma and Life Science Channel
PubMed Articles
The TiO2-polyaniline (PANI) core-shell nanofibers with unique ultraviolet (UV) photoresponse were designed and fabricated. When the core-shell nanofibers were tested in an oxygen (O2) and a non-oxygen...
Dynamic histone acetylation, catalyzed by lysine acetyltransferases and HDACs, is critical to IEG expression. Expression of IEGs, such as FOSL1, is induced by several signal transduction pathways resu...
One of the major challenges in stem cell research is to decipher the controlling mechanisms/genes of stem cell homeostasis. Through an RNAi mediated genetic screen of living animals, we identified an...
Model of haplotype and phenotype in the evolution of a duplicated autoregulatory activator.
Gene duplication is believed to play a major role in the evolution of genomic complexity. The presence of a duplicate frees a gene from the constraint of natural selection, leading to its loss of func...
Panax ginseng is a well-known traditional Chinese medicine and has been used for treatment of various diseases for more than four thousand years in Asia. Ginseng saponins or ginsenosides, the active c...
Aerial parts of Heracleum sphondylium L. (HS) are used in traditional medicine to treat hypertension. To provide pharmacological basis for this use, we investigated the vasorelaxant effects of a dichl...
The role of redox signaling in epigenetics and cardiovascular disease.
Abstract Significance: The term epigenetics refers to the changes in the phenotype and gene expression that occur without alterations in the DNA sequence. There is a rapidly growing body of evidence t...
Human embryonic stem cells (hESCs) are pluripotent cells that have the ability of unlimited self-renewal and can be differentiated into different cell lineages, including neural stem (NS) cells. Diver...
Multiple clinical studies have correlated gene expression with survival outcome in cancer on a genome-wide scale. However, in many cases, no obvious correlation between expression of well-known tumour...
BACKGROUND: To establish the consensus about the conditions for undertaking clinical trials in xenocorneal transplantation in Korea, specific issues regarding the xenocorneal transplantation on ethica...
News Articles
Intercell vaccine gets U.S. pediatric approval
VIENNA (Reuters) - Austria's Intercell said on Tuesday it has won U.S. regulatory approval for pediatric use of its Ixiaro vaccine to protect against Japanese Encephalitis (JE), a step it had achieved...
Intercell vaccine gets U.S. paediatric approval
VIENNA, May 21 (Reuters) - Austria's Intercell said on Tuesday it has won U.S. regulatory approval for paediatric use of its Ixiaro vaccine to protect against Japanese Encephalitis (JE), a step it had...
CommunityOne Bank Announces Receipt of Regulatory Approval for Merger With Bank of Granite
ASHEBORO, N.C., May 21, 2013 (GLOBE NEWSWIRE) -- CommunityOne Bank, N.A., the principal bank subsidiary of FNB United Corp. (the "Company") (Nasdaq:FNBN), announced today that it had received approva...
Ginger May Help Asthmatics Breath Easier
Brett Smith for redOrbit.com - Your Universe Online Advocates of homeopathic remedies have been touting the benefits of ginger for years and a new study presented at the American Thoracic Societyâ€...
PIPELINE WATCH - Four approvals, one suspension and another breakthrough
This week’s Pipeline Watch, a snapshot of all the late-stage R&D and regulatory events in the pharma and biotech industries, is now available to view.
Vitamin D could provide new and effective treatments for asthma
(Medical Xpress)—Scientists at King's College London have discovered that Vitamin D has the potential to significantly reduce the symptoms of asthma. The study, led by Professor Catherine Hawrylowic...
Statistical Challenges in Medical Device Trail Evaluation
SHANGHAI, May 17, 2013 /PRNewswire/ -- Medical devices are any medical items that are neither a drug nor a biological product. In light of their different mechanisms, actions and regulato...
Understanding the role of dsRNA in antiviral host defense systems
Animals, insects, and plants use a variety of sensing mechanisms to detect invading pathogens such as viruses. One complex and effective antiviral defense system they share is based on recognition of...
Defective twin boundaries in nanotwinned metals
Coherent twin boundaries, which usually form during the growth, deformation or annealing of crystalline solids, are widely described as perfect interfaces. Experiments and simulations now show that as...
Events
SMi's 2013 RNA Therapeutics conference will address some of the key challenges faced in the design and delivery of inhibitory RNA complexes.
RNA therapeutics is arguably at the forefront of the treatment for a number of complex medical disorders.
Companies
From its establishment in 1977, simply as a Distributor of diagnostic products, IDS has become a globally-recognised innovator and marketeer in the IVD industry.The Company is particularly well-known...
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The company’s lead drug candidate, TOK-001, is the first i...
Devon Medical, Inc. (www.devonmedicalproducts.com) is an ISO 13485 certified medical device manufacturer, designer, and distributor. Since 2005, we have developed innovative and h...
SullivanCotter is the leading independent consulting firm in the assessment and development of tailored total compensation and reward programs for the health care industry. For mo...
Xcovery Vision is an ophthalmology-focused subsidiary of Xcovery Holding, a clinical-stage company developing novel therapies for cancer and inflammatory diseases. Xcovery Vision'...
Cegedim Dendrite is the Life Sciences industry’s leading provider of Customer Relationship Management (CRM) solutions. Designed specifically for Life Sciences, the companyâÂ...
Itero Biopharmaceuticals, Inc.
Itero Biopharmaceuticals, Inc. is a specialty biopharmaceutical company focused on the development and commercialization of protein therapeutics that offer significant clinical an...
Post & Schell, established in 1968, currently has approximately 165 lawyers in seven offices: Allentown, Harrisburg, Lancaster, Philadelphia, Pittsburgh, Pa., Princeton, N.J. a...
HemoShear LLC is a biotechnology research company that combines its scientific expertise with its unique technology in partnership with pharmaceutical companies to accelerate drug...
Flexible Stenting Solutions Inc.
Flexible Stenting Solutions Inc. (FSS) is a leading developer of third-generation flexible peripheral arterial and biliary stents. Its fully connected stent has coupled technology...
Clinical Trials
Pilot Trial to Assess Effect of CNI Conversion of Efalizumab on T Reg Cells
The purpose of this pilot trial is to determine whether a conversion from calcineurin inhibitors (CNI) and mycophenolate mofetil (MMF) to a regimen consisting of efalizumab and sirolimus i...
Regorafenib Post-marketing Surveillance
This study is a regulatory post-marketing surveillance in Japan, and it is a local prospective and observational study of patients who have received Regorafenib for colorectal cancer....
Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders
The purpose of this study is to elucidate the mechanisms underlying eosinophil growth, survival, migration, and function and to investigate and further characterize the pathophysiology of,...
Efficacy of Anti-Tubercular Vaccination in Multiple Sclerosis
The frequency of auto-immune diseases (including multiple sclerosis) is increasing in industrialised countries. According to an hypothesis which is receiving a wide international credit,...
Very premature infants uniformly do not have mature functioning lungs to breathe well nor mature regulation mechanisms to breathe regularly. Assistance with a mechanical respirator is com...
RCT of Cognitive Therapy, Paroxetine, Combined CT and Paroxetine and Placebo
We aim to (1) evaluate the effectiveness of cognitive therapy and paroxetine and their combination, (2) investigate the patterns of change and the mechanisms of action involved during trea...
The aim of this study is to investigate the mechanisms whereby lung function is decreased in asthma and sensitivity to treatment. The hypothesis is that in diseases such as asthma, inflam...
Background: Gastric carcinoma (GC) remains among the most frequent malignancies in Taiwan as well as in the world and also one of leading causes of cancer-related death. Accumulating evid...
Association and Mechanism Between Cyclooxygenase-2 and Interleukin-6 in Gastric Cancer
Evidence is rapidly accumulating that chronic inflammation may contribute to carcinogenesis through multiple mechanisms in a number of malignancies, including gastric carcinoma (GC). Cyclo...
Effects of Daily Home Hemodialysis on Circulation, Mental Functions, and Quality of Life
This study was designed to discover mechanisms responsible for the decrease in (high) blood pressure after starting daily hemodialysis, as has been observed by various investigators. We hy...
Videos
Kevin Ahern's Bite-Sized Biochemistry #14: Enzyme Mechanism and Regulation
1. Contact me at kgahern@davincipress.com / Friend me on Facebook (kevin.g.ahern) 2. Download my new free biochemistry book at http://biochem.science.oregons...
Medical and Biotech [MESH] Definitions
Rna Transport
The process of moving specific RNA molecules from one cellular compartment or region to another by various sorting and transport mechanisms.
Iron-regulatory Proteins
Proteins that regulate cellular and organismal iron homeostasis. They play an important biological role by maintaining iron levels that are adequate for metabolic need, but below the toxicity threshold.
Iron Regulatory Protein 1
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Iron Regulatory Protein 2
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its rate of degradation is increased in the presence of IRON.
Intercellular Signaling Peptides And Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
