Topical drugs - Biotech, Pharma and Life Science Channel
PubMed Articles
TL-118-anti-angiogenic treatment in pancreatic cancer: a case report.
Pancreatic cancer is one of the most aggressive malignant tumors. In recent years, little progress has been made in understanding and treatment of the disease. The two most commonly used chemotherapy...
Abnormal releases of neurotransmitters result in movement disorders such as dystonia, chorea, tics, blepharospasm and wrinkle formation, and intra-muscular injection of Botulinum neurotoxin is widely...
Tuberculosis (TB) disease is treated in most cases with a regimen of several drugs taken for 6-9 months. Currently, 10 drugs are approved by the Food and Drug Administration (FDA) for treatment of TB....
Tetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa Drugs.
The introduction of sulfa drugs for the chemotherapy of bacterial infections in 1935 revolutionized medicine. Although their mechanism of action is understood, the molecular bases for most of their si...
Femtosecond laser-assisted lamellar keratoplasty (FSLK) for anterior corneal stromal diseases.
Our objective was to study the outcome of femtosecond-assisted lamellar keratoplasty (FSLK) in stromal corneal diseases. This is a retrospective chart review of 17 patients (20 eyes) who underwent FSL...
Supramolecular complexations of natural products.
Complexations of natural products with synthetic receptors as well as the use of natural products as host compounds are reviewed, with an emphasis on possible practical uses or on biomedical significa...
The HMG-CoA reductase inhibitors are a class of drugs also known as statins. These drugs are effective and widely prescribed for the treatment of hypercholesterolemia and prevention of cardiovascular...
Ginkgo biloba Extracts: A Review of the Pharmacokinetics of the Active Ingredients.
Ginkgo biloba is among the most favourite and best explored herbal drugs. Standardized extracts of Ginkgo biloba represent the only herbal alternative to synthetic antidementia drugs in the therapy of...
Topical calcineurin inhibitors (TCIs), commercially available since 2000-2001, are the first and only topical medications approved for chronic treatment of atopic dermatitis (AD) in pediatric patients...
In Vitro Assessment of NSAIDs-Membrane Interactions: Significance for Pharmacological Actions.
PURPOSE: To study interactions between nonsteroidal anti-inflammatory drugs (NSAIDs) and membrane mimetic models. METHODS: The interactions of indomethacin and nimesulide with liposomes of dipalmitoyl...
News Articles
Albany, NY, May 25, 2013 --(PR.com)-- Antipsychotics are drugs used in the treatment of brain disorders such as schizophrenia, bipolar disorder, and severe depression. According to the New York Times...
Macmillan survey highlights cancer drug errors
Over 10,000 cancer patients in England could have been given the wrong drugs in hospital, according to new research from Macmillan Cancer Support, which aims to highlight which hospital trusts need...
High Price: A Neuroscientist's Journey of Self-Discovery That Challenges Everything You Know about Drugs and Society [More]
FDA panel backs Merck insomnia drug, but cites safety concerns
The US Food and Drug Administration’s Peripheral and Central Nervous System Drugs Advisory Committee has recommended Merck’s insomnia drug suvorexant when given in low dosages, [...]
New Drugs Aim to Increase Female Desire
Studies show up to 15 percent of women between the ages of 20 and 60 have a sexual desire disorder. This interview with relationship experts Ian Kernerand Logan Levkoff discusses the new drugs being d...
Howard University and TNI BioTech sign drug development deal
Howard University College of Pharmacy and US-based immunotherapies developer TNI BioTech have signed a multi-year deal to develop new drugs in Africa.
Scientists identify molecular trigger for Alzheimer’s disease
Researchers have pinpointed a catalytic trigger for the onset of Alzheimer’s disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to...
Girls Who Are Sexually Abused More Likely to Start Using Substances before Age 10
Many studies have confirmed the link between childhood sexual abuse and substance-related problems in adulthood. But a new investigation finds that being raped or molested at a young age also makes yo...
A new report indicates that more than one in five parents of teens aged 12 to 17 (22.3 percent) think what they say has little influence on whether or not their child uses illicit substances, tobacco,...
A new strategy required in the search for Alzheimer's drugs?
In the search for medication against Alzheimer's disease, scientists have focused – among other factors – on drugs that can break down Amyloid beta (A-beta). After all, it is the accumulation of A...
Events
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Companies
BioInvent International is a unique company dedicated to working with clients to ensure their success in the discovery, development and manufacture of antibody drugs. The discovery of new drug targets...
Perosphere is a specialty pharmaceutical company that identifies and develops new chemical entities and other therapeutics that can be used as ârescueâ drugs. For more i...
Aradigm Corporation and Grifols S.A.
Aradigm is an emerging specialty pharmaceutical company focused on the development and commercialization of drugs delivered by inhalation for the prevention and treatment of sever...
Monarch Medical Technologies is a privately held medical technology company founded by clinicians with a vision of dramatically improving hospital-based glucose management by repl...
R-Tech Ueno is a bio-venture company established in September 1989 for the purpose of marketing and R&D of drugs. Under leadership of the president, also a medical doctor, the company is developing ne...
Provectus Pharmaceuticals, Inc.
Provectus Pharmaceuticals specializes in developing oncology and dermatology therapies. Its lead oncology agent, PV-10, is designed to selectively target and destroy cancer cells...
InSite Vision is an ophthalmic products company currently focused on ocular infection, glaucoma, and retinal disease. The Company specializes in three platform technologies: topical drug delivery (Dur...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
Verastem, Inc. is a private biopharmaceutical company focused on discovering and developing novel drugs that selectively target cancer stem cells. Cancer stem cells are an underly...
Etubics Corporation, based in Seattle, Wash., is a clinical stage bio-pharmaceutical company, which has developed a proprietary platform technology consisting of a next generation...
Clinical Trials
A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-181)(COMPLETED)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury
Imprimis Pharmaceuticals is investigating a proprietary, topical cream formulation consisting of 10% ketoprofen (containing 100 mg of ketoprofen in 1gram of cream) for the local treatment...
Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel in Scalp Psoriasis
The purpose of the study is to evaluate whether once daily topical treatment for up to 8 weeks of calcipotriol 50 mcg/g plus betamethasone 0.5 mg/g (as dipropionate) gel is safe and more e...
Topical treatment of mild to moderate actinic keratosis located on the face and head with Solaraze® is known to be a safe and efficient treatment option. However, it is unclear if an expa...
Ocular Blood Flow in Early Glaucoma Patients Before and After Treatment With Dorzolamide
Impaired ocular blood flow is an important risk factor in the pathogenesis of primary open angle glaucoma (POAG). A few studies suggest that topical dorzolamide 2% may increase optic nerve...
The purpose of this study is to compare the safety and efficacy of 5% Dapsone Topical Gel, (DTG) twice daily in combination with once daily vehicle control, adapalene gel 0.1% or benzoyl p...
NY-ESO-1 Protein Vaccine With Imiquimod in Melanoma (Adjuvant Setting)
This study evaluates a cancer vaccine in melanoma patients who have resected melanoma but are at high risk for recurrence (stages IIB-III). This is a single arm, open label, pilot/phase I...
The purpose of this study is to determine if a single application of Lidocaine gel topical anesthesia is as effective in decreasing the discomfort associated with urinary catheterization a...
Study of Antibiotic Prophylaxis for Endophthalmitis Following Cataract Surgery
Cataract is the most important cause of visual impairment and decreased mobility in the elderly. While surgery is usually successful, it is also responsible for permanent loss of vision i...
S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Vascular Access Procedures in Children
The pain associated with medical procedures is often under-treated in children. Children often undergo painful procedures with little or no anesthetic, even when effective therapy is avai...
Videos
Sepineo P600 - A multifunctional polymer for Topical drugs formulation
SEPINEO P600 is a 3-in-1 polymer: thickener, emulsifier and stabilizing agent. It is a ready-to-use product designed for gels or creams formulations and is e...
Medical and Biotech [MESH] Definitions
Cinnamomum Aromaticum
A plant species of the genus CINNAMOMUM that contains CINNAMATES and has been used in traditional Chinese medicine (DRUGS, CHINESE HERBAL).
Epimedium
A plant genus of the family BERBERIDACEAE which is used in DRUGS, CHINESE HERBAL. Members contain flavonol glycosides including epimedins, icariin and noricariin.
Cuscuta
A plant genus of the family Cuscutaceae. It is a threadlike climbing parasitic plant that is used in DRUGS, CHINESE HERBAL.
Histamine H1 Antagonists, Non-sedating
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Herb-drug Interactions
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
