Transforming growth factor beta TGF beta - Biotech, Pharma and Life Science Channel
Transforming growth factor-beta (TGF-beta) family members are secreted multifunctional cytokines that play pivotal roles in development and disease. The prototypic member of this family, TGF-beta, plays a dual role in carcinogenesis, acting as a tumor suppressor in early stages and as tumor promoter in late stages of tumor progression. Aberrant TGF-beta expression is implicated in the pathogenesis of fibrosis in systemic sclerosis; thus, TGF-beta represents a molecular therapeutic target in this disease. Small-molecule inhibitors of TGF-beta-receptor activity are effective in animal models of fibrosis. TGF-beta1 is believed to play an important role in wound healing and repair, as it is a key regulator of the production and remodelling of the extracellular matrix through its effect on mesenchymal cells. Over the last few years, it has become evident that the signalling pathway of TGF-beta is complex with numerous receptor-ligand interactions, intracellular pathways and a number of mechanisms, which not only control the signalling but may also decide the response to the TGFbeta signal.
TGF and its receptor are targets for agonists and antagonists which are under development in a variety of diseases ranging from prevention of scarring and osteoarthritis to cancer (e.g., NSCLC; astrocytoma, melanoma, pancreatic cancer) and scleroderma, chronic kidney disease - glomerulosclerosis. Most of the molecules are biologics (antibodies, proteins, peptides, antisense, vaccine, cells). The most advanced projects are in phase III development.
News Articles
PARIS and TARRYTOWN, N.Y., May 21, 2013 /PRNewswire/ -- Sanofi (EURONEXT: SAN and NYSE: SNY) and Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the New England Journal of Medicine...
— EMA Submission Planned in the Coming Weeks — Today Biogen Idec (NASDAQ: BIIB) announced it has submitted a Biologics License Application (BLA) to the U.S. Food an...
Ceregene Reports Additional Efficacy Data From Parkinson's Disease Phase 2b Study
SAN DIEGO, May 21, 2013 /PRNewswire/ -- Ceregene, Inc. today announced additional efficacy data from a secondary analysis of its double-blind, randomized, controlled Phase 2b clinical study of CERE-12...
LA JOLLA, Calif., May 21, 2013 (GLOBE NEWSWIRE) -- Innovus Pharmaceuticals, Inc., ("Innovus Pharma") www.innovuspharma.com (OTCBB:INNV), today announced that Dr. Bassam Damaj, Chief Executive Officer...
Acetylon Pharmaceuticals to Present at UBS Global Healthcare Conference
Acetylon Pharmaceuticals Inc., the leader in targeted epigenetic drug discovery and development for enhanced therapeutic outcomes, today announced that Walter C. Ogier, President...
RIDGEFIELD, Conn., May 17, 2013 /PRNewswire/ -- Boehringer Ingelheim will contribute to advancing the scientific discussion in respiratory disease at the American Thoracic Society International C...
RIDGEFIELD, Conn., May 17, 2013 /PRNewswire/ -- As part of the company's commitment to chronic obstructive pulmonary disease (COPD) patients, Boehringer Ingelheim Pharmaceuticals, Inc., a leader in re...
Hang w/ Sees 2,363% Growth as Celebs Embrace the Live Streaming Video Platform
FOUNTAIN VALLEY, Calif., May 20, 2013 (GLOBE NEWSWIRE) -- MEDL Mobile, Inc. (OTCBB:MEDL) – a pioneer in the creation, development, marketing and monetization of mobile apps – announced today that...
BAGSVAERD, DENMARK -- (Marketwired) -- 05/17/13 -- Novo Nordisk today announced the completion of paradigm 2, the first phase 3 trial with a long-acting FIX derivative, N9-GP (glycopegylated recomb...
Cerapedics, Inc. announced today that its Board of Directors has appointed Glen A. Kashuba as the company’s new chief executive officer, effective June 1, 2013....
Events
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Ribosomes Napa Valley Conference 2013
Protein synthesis by the ribosome plays a central role in connecting genotypes to phenotypes in biology.
Companies
Based in Princeton, N.J., and Paris, Stentys has developed a new generation of stents for the treatment of acute myocardial infarction. Founded by Jacques Séguin, M.D., Ph.D.,...
Cerapedics is a privately-held medical device company focused on developing and commercializing novel osteobiologic products based on its proprietary anorganic bone mineral (ABM)...
IRI Consulting provides strategic insights and actionable recommendations to leverage growth with support from IRIâs proprietary, granular data, analytics and technology asse...
BIO and ABFA and ABO and A4A and AFBF and Growth Energy and Pew Charitable Trusts
BIO represents more than 1,100 biotechnology companies, academic institutions, state biotechnology centers and related organizations across the United States and in more than 30 o...
Scientific excellence that achieves new standards of care drives the company's work. 17 products are currently in clinical development addressing a variety of key medical needs.With patients in more t...
RXi Pharmaceuticals Corporation
RXi Pharmaceuticals Corporation (OTC: RXII) is a biotechnology company focused on discovering, developing and commercializing innovative therapies based on its proprietary, next-generation RNAi plat...
FDB provides drug knowledge that helps healthcare professionals make precise medication-related decisions. With thousands of customers worldwide, FDB enables our information syste...
BioNova - The Nova Scotia Biotechnology and Life Sciences Industry Association
BioNova was incorporated in 1993 in response to rapid growth in Nova Scotia’s biotechnology and life sciences sector. Since that time, we have advanced alongside our members to offer advocacy and de...
The GfK Group (GfK = Growth from Knowledge) is a well-respected member of the global market research industry. Established more than 70 years ago, originally as the non-profit "Association for Consume...
Cellmid is an Australian biotechnology company developing innovative novel therapies and diagnostic tests for inflammatory diseases, heart attack and cancer. Cellmid holds the lar...
Clinical Trials
Pamidronate to Treat Osteogenesis Imperfecta in Children
This study will evaluate the effect of pamidronate-a drug that decreases bone resorption (breakdown)-on osteogenesis imperfecta. This is a genetic disorder of collagen, the major protein...
Effects of Exenatide and Insulin Glargine in Subjects With Type 2 Diabetes
This Phase 3, open-label, multicenter study is designed to compare the effects of exenatide and insulin glargine (Lantus® injection) on beta-cell function in patients with type 2 diabetes...
RATIONALE: Dutasteride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dutasteride works in tr...
Vorinostat and Gemcitabine in Treating Patients With Metastatic or Unresectable Solid Tumors
This phase I trial is studying the side effects and best dose of vorinostat and gemcitabine in treating patients with metastatic or unresectable solid tumors. Drugs used in chemotherapy, s...
RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dasatinib works in treati...
This study will evaluate the safety and effectiveness of insulin-like growth factor-1 (IGF-1) to treat patients with X-linked severe combined immunodeficiency (XSCID). Those who have XSCID...
Tipifarnib may stop the growth of breast cancer by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as paclitax...
Exercise and Metformin in Colorectal and Breast Cancer Survivors
Metformin is a medication that is commonly used in the treatment of diabetes. Recently small studies in cancer patients without diabetes suggest that metformin may benefit in lowering ins...
Study assessing cognitive function and physical activity in people with relapsing remitting multiple sclerosis.
This trial is conducted globally. The aim of the trial is to investigate safety, efficacy and pharmacokinetics (the exposure of the trial drug in the body) of NNC 0129-0000-1003 (N8-GP) in...
PubMed Articles
KCNN4 Channels participate in the EMT induced by PRL-3 in colorectal cancer.
Studies have shown that phosphatase of regenerating liver-3 (PRL-3) promotes the invasion, migration, and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition (EMT). Ho...
Hepatoma-derived growth factor (HDGF), a heparin-binding growth factor, has a wide range of biological functions, including mitogenic activity and vascular development. Recent studies demonstrated tha...
PTPN4 negatively regulates CrkI in human cell lines.
PTPN4 is a widely expressed non-receptor protein tyrosine phosphatase. Although its overexpression inhibits cell growth, the proteins with which it interacts to regulate cell growth are unknown. In th...
Alpha (α) particles and low-energy beta (β) particles present minimal risk for external exposure. While these particles can induce leukemia and bone cancer due to internal exposure, they can also be...
Several positive transcription factors regulate Arabidopsis anthocyanin biosynthesis. HY5, a component of light-signaling pathways, and PAP1, an R2R3-MYB transcription factor, share common regulatory...
Direct chemical vapor deposition (CVD) growth of single-layer graphene on CVD-grown hexagonal boron nitride (h-BN) film can suggest a large-scale and high-quality graphene/h-BN film hybrid structure w...
Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds.
Diabetes mellitus, characterised by hyperglycemia and altered β-cell function, is an increasingly common disorder affecting millions of individuals world-wide. While therapeutic regimens exist to man...
Optimal control oriented to therapy for a free-boundary tumor growth model.
This paper is devoted to present and solve some optimal control problems, oriented to therapy, for a particular model of tumor growth. In the considered systems, the state is given by one or several f...
The importance of contact network topology for the success of vaccination strategies.
The effects of a number of vaccination strategies on the spread of an SIR type disease are numerically investigated for several common network topologies including random, scale-free, small world, and...
TIF1γ (transcription intermediary factor 1 gamma), which belongs to transcription intermediary factor 1 family, is an inhibitor of the TGF-β/Smad signaling pathway and could inhibit the signal trans...
Videos
Growth factors for cartilage repair and healing - TGF Beta
http://stemcellsarthritistreatment.com For stem cells to adequately repair cartilage in arthritis, they need help from growth factors. The first growth facto...
Medical and Biotech [MESH] Definitions
Boehmeria
A plant genus of the family URTICACEAE. Members contain cryptopleurine, beta-sitosterol, daucosterol and 19 alpha-hydroxyursolic acid.
Adaptor Protein Complex Beta Subunits
A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.
Thrombopoiesis
The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The humoral factor with thrombopoiesis-stimulating activity is designated THROMBOPOIETIN.
Viridans Streptococci
A large heterogeneous group of mostly alpha-hemolytic streptococci. They colonize the respiratory tract at birth and generally have a low degree of pathogenicity. This group of species includes STREPTOCOCCUS MITIS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS ORALIS; STREPTOCOCCUS SANGUIS; STREPTOCOCCUS SOBRINUS; and the STREPTOCOCCUS MILLERI GROUP. The latter are often beta-hemolytic and commonly produce invasive pyogenic infections including brain and abdominal abscesses.
Streptococcus Milleri Group
A subset of VIRIDANS STREPTOCOCCI, but the species in this group differ in their hemolytic pattern and diseases caused. These species are often beta-hemolytic and produce pyogenic infections.
