Uveitis - Biotech, Pharma and Life Science Channel
There are many different types of Uveitis. This is because:
* The Uvea is made up of different parts. So if the iris is affected, the condition and its treatment could be totally different to when the choroid is affected.
* The inflammation in the Uvea very often affects other parts of the eye such as the retina and so a variety of other problems can be present to complicate the picture.
* there are a large number of medical conditions where Uveitis is a feature amongst the other symptoms of the disease, eg Behcet's Disease, Sarcoidosis and Toxoplasmosis, to name just three of them.
* There are many different types of causes of Uveitis (see Causes of Uveitis below).
The term intraocular inflammation is often used to cover the spectrum of uveitis conditions. As there is this wide variety of different conditions and complications, it follows that there are numerous ways that it presents itself. The degree and type of sight loss and the type of treatment may vary considerably from patient to patient.
Uveitis may result from an infection such as a virus (eg herpes), fungus (eg histoplasmosis) or a parasite such as toxoplasmosis. It may be related to Autoimmune Disease (with or without involvement of other parts of the body). Trauma to the eye, or even the other eye in the past, can lead to Uveitis. The word "idiopathic" may often be used to describe this group.
Another important way of classifying the different types of Uveitis is by describing the part of the eye that is affected.
*Anterior Uveitis; affecting the front of the eye, normally the iris (iritis) or the ciliary body (iridocyclitis). Iritis is by far the most common type of Uveitis and also the most readily treated. Close monitoring is needed because complications such as raised eye pressure and cataracts can occur.
*Intermediate Uveitis; affecting the area just behind the ciliary body (pars plana) and also the most forward edge of the retina. This is the next most common type of Uveitis. *Posterior Uveitis; when the inflammation affects the part of the uvea at the back of the eye, the choroid. Often the retina is affected much more in this group.
Like the varied nature of Uveitis, the treatment of it may differ from case to case quite considerably. Corticosteroids are often the mainstay of treatment but now are, importantly, being joined by some other newer drugs, usually used along with the steroids. Various eye-drops are used, particularly to treat Anterior Uveitis. There is a growing confidence, especially with the newer drug treatments, that the eyesight can be stabilised over the long term. Uveitis as a disease should be regarded as incurable in the sense that it will never completely go away, but that is not to say that it can not be controlled. Uveitis is estimated to be responsible for approximately 10% of the blindness in the United States.
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PubMed Articles
Infliximab, a monoclonal antibody directed against human tumor necrosis factor-alpha (TNF-α), effectively treats anterior uveitis, which can accompany Behçet's disease. Here, we investigated the und...
Ocular histiocytic sarcoma in a cat.
A 13-year-old male neutered British blue cat presented with uveitis, hyphema, and dyscoria in the right eye. Light microscopic examination revealed that the ciliary body, iris root, drainage angle, an...
A giant left ventricular pseudoaneurysm in Behçet's disease: a case report.
Behçet's disease is a chronic autoimmune disease with vascular complications that are most frequently manifested as thromboembolism in veins and pseudoaneurysm in arteries. We report the case of a 13...
The aim of our study is to investigate ocular involvement in juvenile idiopathic arthritis (JIA) and its relationship with disease activity and quality of life in Moroccan patients who suffer from JIA...
Clinical features of human T lymphotropic virus type 1-associated uveitis in Hokkaido, Japan.
PURPOSE: To clarify the clinical features of human lymphotropic virus type 1 (HTLV-1)-associated uveitis (HAU) in patients of Hokkaido University Hospital, Hokkaido, northern Japan. METHODS: We review...
Effect of air bubble on inflammation after cataract surgery in rabbit eyes.
Purpose: Intense inflammation after cataract surgery can cause cystoid macular edema, posterior synechia and posterior capsule opacification. This experimental study was performed to investigate the e...
Implantation of iris-claw Artisan intraocular lens (IOL) is a surgical option for correction of aphakia; however, these IOLs have not been used in eyes with uveitis including Fuchs' heterochromic irid...
TNF Inhibition for Ophthalmic Indications: Current Status and Outlook.
BACKGROUND: Tumor necrosis factors (TNF) are a group of cytokines that play a role in systemic inflammation, stimulating the acute phase reaction. They are involved in systemic rheumatologic condition...
Chronic uveitis with secondary glaucoma?
OBJECTIVES: The aim of this study was to investigate the possible role of angiogenin, vascular endothelial growth factor, (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD. DE...
News Articles
pSivida Corp. (NASDAQ:PSDV - News), a leader in developing sustained release, drug delivery products for treatment of back-of-the-eye diseases, today announced that the Uni...
Adalimumab more effective when given as first-line anti-TNF therapy for uveitis
A drug called adalimumab appears to be more effective when given as a first-line treatment for childhood chronic uveitis than when administered after other similar drugs have failed, researchers have...
pSivida Corp. Reports Third Quarter Fiscal Year 2013 Results
pSivida Corp. (NASDAQ: PSDV)(ASX: PVA), a leader in developing sustained release, drug delivery products for treatment of back-of-the-eye diseases, today announced financial resul...
PETACH TIKVA, Israel, May 10, 2013 /PRNewswire/ -- OphthaliX, Inc. (OTC BB: OPLI), announced today that it has come to its knowledge that Professor M. Francesca Cordeiro, a Professor of Glaucoma...
pSivida Corp. Announces Commercial Launch of ILUVIEN® in Germany with First Patient Treated
pSivida Corp. (NASDAQ:PSDV- News), a leader in developing sustained release, drug delivery products for treatment of back-of-the-eye diseases, today announced that ILUVIENÂ...
pSivida Corp. (NASDAQ:PSDV) (ASX:PVA), a leader in developing sustained release, drug delivery products for treatment of back-of-the-eye diseases, today announced that its financi...
pSivida Corp. Announces New ILUVIEN® PDUFA Date of October 17, 2013
pSivida Corp. (NASDAQ:PSDV - News), a leader in developing sustained release, drug delivery products for treatment of back-of-the-eye diseases, announced today that the U.S...
pSivida Reports ILUVIEN® Available in UK
pSivida Corp. (NASDAQ:PSDV; ASX:PVA), a specialty pharmaceutical company that is a leader in the development of sustained release ophthalmic drug treatments, today announced ILUVI...
Retina Institute of Hawaii Participating in Day of Giving: Vision
HONOLULU, April 24, 2013 /PRNewswire/ -- The Retina Institute of Hawaii is proud to be a part of Surgicare of Hawaii's "Day of Giving" on May 11, 2013. Dr. Karl E. Waite, MD and Sara Lynn Doolin,...
EyeGate reports PIII uveitis data; seeks partner or buyer
EyeGate Pharma reported that EGP-437 (dexamethasone) administered via iontophoresis achieved the same response rate as the standard of care for patients with anterior uveitis in a Phase III clinical...
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Companies
Apitope International NV, based in Belgium and the UK, is a world-class drug developer of immunotherapies for the treatment of autoimmune and allergic diseases, including multiple...
Lux Biosciences, Inc. is a privately held biotechnology company focused on the treatment of ophthalmic diseases. Lux Biosciences has exclusive worldwide rights to voclosporin for...
pSivida Corp. is a world leader in the development of tiny, sustained release, drug delivery products and technologies that are administered by implantation, insertion or injectio...
Clinical Trials
Human Anti-Tac (Daclizumab) to Treat JIA-associated Uveitis
This study will examine the safety and effectiveness of a monoclonal antibody called humanized anti-Tac (HAT, also called daclizumab) to treat children and adolescents with uveitis (chroni...
This study will try to identify markers of immune activity in uveitis patients that correlate with the state of disease activity. Uveitis is a group of inflammatory eye diseases that can c...
Daclizumab to Treat HIV-Infected Patients
This study will examine the safety and effectiveness of daclizumab (also called Zenapax or anti-CD25) in reducing viral replication in patients with HIV infection. Although HAART, an inte...
Daclizumab to Treat Non-Infectious Sight-Threatening Uveitis
This study will examine the safety and effectiveness of treating uveitis, an eye inflammation, with a monoclonal antibody called daclizumab. Monoclonal antibodies are genetically engineere...
Daclizumab Injections to Treat Non-Infectious Sight-Threatening Uveitis
This study will examine the safety and effectiveness of a monoclonal antibody called daclizumab in treating uveitis, an eye inflammation. Monoclonal antibodies are genetically engineered p...
Research Study in Patients With Persistent Macular Edema
The purpose of this clinical research study is to evaluate the safety and effectiveness of an investigational medication to treat macular edema that persists despite current treatment meth...
Vitamin E to Treat Uveitis-Associated Macular Edema
This study will evaluate whether vitamin E can help treat swelling of the macular area of the retina (the back part of the eye) associated with uveitis (inflammatory eye disease). The macu...
The purpose of this protocol is to develop a valid, reliable, better standardized, and more efficient test of visual acuity (ability to see fine details) for use in clinical trials. Recent...
Effect of Pregnancy on Uveitis
The purpose of this study is to gain information about the course of uveitis (a type of eye inflammation) during pregnancy and the postpartum period (six months after delivery). Some repo...
HAT in Eye Complications of Behcet's Disease
This study will evaluate the safety and effectiveness of Zenapax in controlling recurrent eye inflammations associated with Behcet's disease. Behcet's disease is usually treated with cort...
Videos
Medical and Biotech [MESH] Definitions
Vitreoretinal Surgery
Specialized ophthalmic technique used in the surgical repair and or treatment of disorders that include retinal tears or detachment; MACULAR HOLES; hereditary retinal disease; AIDS-related retinal infections; ocular tumors; MACULAR DEGENERATION; DIABETIC RETINOPATHY; and UVEITIS.
Sacroiliitis
Inflammation of the SACROILIAC JOINT. It is characterized by lower back pain, especially upon walking, fever, UVEITIS; PSORIASIS; and decreased range of motion. Many factors are associated with and cause sacroiliitis including infection; injury to spine, lower back, and pelvis; DEGENERATIVE ARTHRITIS; and pregnancy.
Stevens-johnson Syndrome
A variant of bullous erythema multiforme. It ranges from mild skin and mucous membrane lesions to a severe, sometimes fatal systemic disorder. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis, and sometimes blindness. The cause of the disease is unknown.
Uveitis
Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
Uveitis, Anterior
Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.
