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Uveitis - Biotech, Pharma and Life Science Channel

00:01 EDT 23rd September 2017 | BioPortfolio

There are many different types of Uveitis. This is because:

* The Uvea is made up of different parts. So if the iris is affected, the condition and its treatment could be totally different to when the choroid is affected.
* The inflammation in the Uvea very often affects other parts of the eye such as the retina and so a variety of other problems can be present to complicate the picture.
* there are a large number of medical conditions where Uveitis is a feature amongst the other symptoms of the disease, eg Behcet's Disease, Sarcoidosis and Toxoplasmosis, to name just three of them.
* There are many different types of causes of Uveitis (see Causes of Uveitis below).

The term intraocular inflammation is often used to cover the spectrum of uveitis conditions. As there is this wide variety of different conditions and complications, it follows that there are numerous ways that it presents itself. The degree and type of sight loss and the type of treatment may vary considerably from patient to patient.
 

Uveitis may result from an infection such as a virus (eg herpes), fungus (eg histoplasmosis) or a parasite such as toxoplasmosis. It may be related to Autoimmune Disease (with or without involvement of other parts of the body). Trauma to the eye, or even the other eye in the past, can lead to Uveitis. The word "idiopathic" may often be used to describe this group.

Another important way of classifying the different types of Uveitis is by describing the part of the eye that is affected.
*Anterior Uveitis; affecting the front of the eye, normally the iris (iritis) or the ciliary body (iridocyclitis). Iritis is by far the most common type of Uveitis and also the most readily treated. Close monitoring is needed because complications such as raised eye pressure and cataracts can occur.
*Intermediate Uveitis; affecting the area just behind the ciliary body (pars plana) and also the most forward edge of the retina. This is the next most common type of Uveitis.                                                                                                                                                                                  *Posterior Uveitis; when the inflammation affects the part of the uvea at the back of the eye, the choroid. Often the retina is affected much more in this group.

Like the varied nature of Uveitis, the treatment of it may differ from case to case quite considerably. Corticosteroids are often the mainstay of treatment but now are, importantly, being joined by some other newer drugs, usually used along with the steroids. Various eye-drops are used, particularly to treat Anterior Uveitis. There is a growing confidence, especially with the newer drug treatments, that the eyesight can be stabilised over the long term. Uveitis as a disease should be regarded as incurable in the sense that it will never completely go away, but that is not to say that it can not be controlled. Uveitis is estimated to be responsible for approximately 10% of the blindness in the United States.

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PubMed Articles [107 Associated PubMed Articles listed on BioPortfolio]

The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack.

To measure changes in the choroidal vascularity index (CVI) in chronic Vogt-Koyanagi-Harada (VKH) disease during a recurrent anterior uveitis attack.

Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Decrease the Development of Severe Experimental Autoimmune Uveitis in B10.RIII Mice.

We investigated the effect of exogenously administered human embryonic stem cell-derived mesenchymal stromal cells (hESC-MSCs) in experimental autoimmune uveitis (EAU) in B10.RIII mice, a murine model...

Ocular Self-Microemulsifying Drug Delivery System of Prednisolone Improves Therapeutic Effectiveness in the Treatment of Experimental Uveitis.

The purpose of this study was to investigate the self-microemulsifying drug delivery systems (SMEDDS) for ophthalmic delivery of Prednisolone (PDN) to treat uveitis.

Chronic Uveitis Following Neodymium-Doped Yttrium Aluminum Garnet Laser Peripheral Iridotomy.

Assessment of a chronic uveitis entity in nonuveitic patients following neodymium-doped yttrium aluminum garnet (Nd:YAG) laser peripheral iridotomy.

Ahmed Valve Upstream Obstruction Caused by Fibrous Ingrowth: Surgical Approach.

Glaucoma secondary to penetrating keratoplasty can be challenging and multiple surgeries may be needed to control the intraocular pressure (IOP), including the use of glaucoma drainage implants. Howev...

Proteome dynamics in biobanked horse peripheral blood derived lymphocytes (PBL) with induced autoimmune uveitis.

Equine recurrent uveitis (ERU) is the only spontaneous model for recurrent autoimmune uveitis in humans, where T cells target retinal proteins. Differences between normal and autoaggressive lymphocyte...

Cumulative retention rate of adalimumab in patients with Behçet's disease-related uveitis: a four-year follow-up study.

Adalimumab (ADA) has been shown to be an effective treatment for Behçet's disease (BD)-related uveitis. We aimed at evaluating the cumulative retention rate of ADA during a 48-month follow-up period ...

Adalimumab for Uveitis in Juvenile Idiopathic Arthritis.

Update upon efficacy and safety of etanercept for the treatment of spondyloarthritis and juvenile idiopathic arthritis.

TNF-α inhibitors have demonstrated efficacy both as monotherapy and in combination with disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of chronic inflammatory immune-mediated diseas...

Sustained release of intravitreal flurbiprofen from a novel drug-in-liposome-in-hydrogel formulation.

A novel Flurbiprofen (FLB)-in-liposome-in-hydrogel formulation was developed, as a method to sustain the release and increase the ocular bioavailability of FLB following intravitreal injection. For th...

News Articles [106 Associated News Articles listed on BioPortfolio]

Elevated IOP, glaucoma complications of herpetic anterior uveitis

A study confirmed that elevated IOP and secondary glaucoma are frequent complications of herpetic anterior uveitis and that the number of IOP peaks is correlated with the risk for glaucoma.The medical...

Aldeyra nets $23.5mm via FOPO

Aldeyra Therapeutics Inc. (developing therapies for diseases related to endogenous aldehyde toxicity) netted $23.5mm through the follow-on offering of 3.45mm common shares priced at $7.25. The company...

Aldeyra Therapeutics, Inc. Announces Closing of Public Offering of Common Stock and Full Exercise of Option to Purchase Additional Shares

LEXINGTON, Mass., Sept. 21, 2017 /PRNewswire/ -- Aldeyra Therapeutics, Inc. (Nasdaq: ALDX) (Aldeyra), a clinical-stage biotechnology company devoted to treating inflammation, inborn errors of met...

Aldeyra Therapeutics to Present at the Annual Cantor Fitzgerald Global Healthcare Conference

LEXINGTON, Mass., Sept. 20, 2017 /PRNewswire/ -- Aldeyra Therapeutics, Inc. (NASDAQ:ALDX) (Aldeyra), a clinical-stage biotechnology company devoted to treating inflammation, inborn errors of meta...

The Balancing Act of Managing Spondyloarthropathies

Clinicians treating patients with spondyloarthropathies are required to walk many tightropes. One is the prevention of infections while treating patients with immunosuppressive drugs. Another is deter...

Santen Inc Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 23082017] Prices from USD $250

SummarySanten Inc Santen, a subsidiary of Santen Pharmaceutical Co Ltd is a developer, manufacturer and distributor of ophthalmic pharmaceutical products. The company offers products in therapeutic ar...

EC approves AbbVie's pediatric anterior uveitis drug

AbbVie received approval from the European Commission for the use of Humira to treat children at least 2 years old with chron -More- 

Anterior uveitis impacted physical QoL, particularly with underlying SpA

Humira handed EU approval in pediatric uveitis

The world’s best-selling drug has been approved by the European Commission in a new indication, offering…

Humira gets EC approval for anterior uveitis

Humira is now the only EU biologic treatment option for children with the disease

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Companies [4 Associated Companies listed on BioPortfolio]

AbbVie

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the exp...

Apitope

Apitope International NV, based in Belgium and the UK, is a world-class drug developer of immunotherapies for the treatment of autoimmune and allergic diseases, including multiple...

pSivida Corp.

pSivida Corp. is a world leader in the development of tiny, sustained release, drug delivery products and technologies that are administered by implantation, insertion or injectio...

Lux Biosciences, Inc.

Lux Biosciences, Inc. is a privately held biotechnology company focused on the treatment of ophthalmic diseases. Lux Biosciences has exclusive worldwide rights to voclosporin for ...

Clinical Trials [128 Associated Clinical Trials listed on BioPortfolio]

CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections

MAC lung infections are a growing public health problem. The ATS / IDSA 2007 guidelines for the treatment of these non-tuberculous mycobacterial infections recommend the use of a macrolide...

Patient Registry of Posner-Schlossman Syndrome

Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a condition characterized by recurrent, acute attacks of mild, nongranulomatous, anterior uveitis accompanied by markedly eleva...

Interferon α2a Versus Cyclosporine for Refractory Behçet`s Disease Uveitis

Brief summary: This study compares the long-term efficacy and safety of interferon (IFN) α2a and cyclosporine (cyclosporin A, CsA) following suppression of acute attack by high-dose oral ...

Efficacy and Safety of Filgotinib in Adults With Active Non-Infectious Uveitis

The primary objective of this study is to evaluate the efficacy of filgotinib versus placebo for the treatment of the signs and symptoms of non-infectious uveitis in participants failing t...

RNFL Thickness Measurements Obtained Using SD-OCT and SLP Using GDx Variable Corneal Compensation

The aim of this study is to evaluate the correlation of retinal nerve fiber layer (RNFL) thickness measured using spectral domain optical coherence tomography (SD-OCT) and scanning laser p...

Chronic Inflammatory Disease, Lifestyle and Treatment Response

Chronic inflammatory diseases (CID) - including inflammatory bowel diseases (Crohn's disease and ulcerative colitis), rheumatic conditions (rheumatoid arthritis, axial spondyloarthritis, p...

Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis

Open-label safety study of suprachoroidal triamcinolone acetone injectable suspension in patients with non-infectious uveitis.

Metabolomics in Surgical Ophthalmological Patients

Metabolomics consists in the study of metabolites in body fluids or tissues. It investigates the consequences of the activity of genes and proteins. One of its advantages is that it is abl...

Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS)

This study will evaluate the Efficacy and Safety of Infliximab versus Cyclophosphamide in Subjects with Idiopathic Refractory Scleritis. The term scleritis describes a chronic inflammatio...

A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU

The purpose of the study is to demonstrate the effect of Certolizumab Pegol (CZP) treatment on the reduction of Anterior Uveitis (AU) flares in subjects with active axial Spondyloarthritis...

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Medical and Biotech [MESH] Definitions

Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is strongly associated with acute anterior uveitis (UVEITIS, ANTERIOR); ANKYLOSING SPONDYLITIS; and REACTIVE ARTHRITIS.

Inflammation of the choroid as well as the retina and vitreous body. Some form of visual disturbance is usually present. The most important characteristics of posterior uveitis are vitreous opacities, choroiditis, and chorioretinitis.

Abnormally low intraocular pressure often related to chronic inflammation (uveitis).

Inflammation of the pars plana, ciliary body, and adjacent structures.

Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)

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