Collateral Therapeutics Incorporated Company Profile

03:38 EDT 26th September 2017 | BioPortfolio

Collateral's initial non-surgical gene therapy products under investigation are designed to promote and enhance angiogenesis, a natural biological process which results in the growth of additional blood vessels, to increase levels of blood flow to oxygen-deprived tissues.

The Company's angiogenic products are administered using methods of gene therapy based on non-surgical adenoviral vector delivery of angiogenic genes. In addition to the Company's angiogenic product candidates, the Company is actively researching gene therapy products designed to increase responsiveness of the heart to adrenergic stimulation and to stimulate heart muscle regeneration.

The Company's lead product candidate, GENERX™ (Ad5-FGF4) is a non-surgical angiogenic gene therapy, which is being developed as a potential treatment for patients with stable exertional angina (chest pain) due to coronary artery disease (CAD).


11622 El Camino Real
San Diego
United States of America


Phone: 858.794.3400
Fax: 858.794.3440

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PubMed Articles [659 Associated PubMed Articles listed on BioPortfolio]

Stroke etiology and collaterals: atheroembolic strokes have greater collateral recruitment than cardioembolic strokes.

Chronic hypoperfusion from athero-stenotic lesions is thought to lead to better collateral recruitment compared to cardioembolic strokes. It was sought to compare collateral flow in stroke patients wi...

The effectiveness of super-selective injection with anchor balloon technique for collateral channel assessment.

The careful assessment of collateral channels is important for a retrograde approach for a chronic total coronary occlusion (CTO). This case report describes a percutaneous coronary intervention for C...

Clinical significance of mesenteric arterial collateral circulation in patients with celiac artery compression syndrome.

Although extensive collateral arterial circulation will prevent ischemia in most patients with stenosis of a single mesenteric artery, mesenteric ischemia may occur in these patients, for example, in ...

Collateral artery pathways of the femoral and popliteal artery.

The role of collateral artery circulation in the lower limb is under debate but clinically relevant, particularly when using covered stents for occlusive disease. Covered stents seem to outperform nit...

Simultaneous Reconstruction of the Medial and Lateral Collateral Ligaments for Chronic Combined Ligament Injuries of the Ankle.

Objective data on chronic injuries of the medial collateral ligament (MCL) of the ankle are scarce. Chronic MCL injuries are frequently associated with lateral collateral ligament (LCL) injuries. For ...

Clinical Trials [163 Associated Clinical Trials listed on BioPortfolio]

Comparison of Coronary Wedge Pressure and Collateral Flow Index Between Main Branch and Side Branch Vessels

The purpose of this trial is to compare the degree of collateral flow in the main vessel and the side branch vessel. Specifically, the trial will address the superiority of the recruitable...

the Effects of Cerebral Collateral Circulation on the Outcome of Leukoaraiosis in High-risk Population

This study observed the relationship between cerebral collateral circulation and the prognosis of leukoaraiosis in high-risk population. Cerebral collateral circulation and leukoaraiosis l...

The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion

Stroke is the first leading cause of death in China, and is responsible for almost 22.4% of deaths. In approximately 80% of cases stroke is ischaemic, i.e. caused by disruption of blood fl...

MR-based Collateral Imaging to Predict Response to Endovascular Treatment of Stroke (FAST-COLL Study)

Based on the results of recent randomized controlled trials, current international guidelines recommend the initiation of endovascular treatment within 6 hours of symptom onset for acute i...

Ultrasound Study of Season-Long Joint Changes to College Baseball Players

The purpose of this study is to use ultrasound imaging to determine if there are certain frequencies, durations, and intensities of baseball pitching that expose a college baseball player ...

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Gene Therapy
Gene therapy is the use of DNA as a pharmaceutical agent to treat disease. It derives its name from the idea that DNA can be used to supplement or alter genes within an individual's cells as a therapy to treat disease. The most common form of gene th...

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