Bicycle Therapeutics Ltd. Company Profile

03:47 EDT 25th September 2017 | BioPortfolio

Bicycle Therapeutics is a biotechnology company developing a platform technology that enables the creation of a new generation of biotherapeutics which combine the desirable features of small molecules and biopharmaceuticals to create highly specific and highly stable drugs.

Applying phage selection techniques to repertoires of chemically constrained cyclic peptides allows the identification and optimisation of molecules with high target specificity and binding affinity that are also stable to unfolding and to the action of proteases. These peptides could be regarded as a mini-antibodies with covalent organic cores, and as such should overcome the weaknesses of previous generations of peptide based therapeutics.

Bicycle Therapeutics is a spin-out from the Medical Research Council Laboratory of Molecular Biology, Cambridge, based on the pioneering work of the founding scientists Sir Gregory Winter and Dr.Christian Heinis. Bicycle Therapeutics is managed by Dr. John Tite (Chief Executive Officer) and is based in Cambridge.


Meditrina Building
Babraham Research Campus
CB22 3AT
United Kingdom


Phone: +44 (0)1223 497 390
Fax: +44 (0)7798 791 337

News Articles [1568 Associated News Articles listed on BioPortfolio]

A €344M Partnership will Develop Bicycle Drugs for Hemophilia

Bicycle Therapeutics has partnered with Bioverativ to develop a new class of drugs for patients with rare blood disorders like hemophilia and sickle cell disease. Bicycle Therapeutics, a money-magnet ...

Bioverativ and Bicycle Therapeutics partner on hemophilia and sickle cell disease

Biotech companies Bioverativ and Bicycle Therapeutics, based in the USA and UK respectively, have entered…

Bicycle Therapeutics picks up speed with $52M Series B

With a fresh financing from a Series B, Bicycle Therapeutics needs to begin translating its high-potential peptide-based platform into a portfolio of clinically-proven drugs.

Bicycle Therapeutics picks up speed with £40m fundraising

UK biotech Bicycle Therapeutics has raised £40 million ($52m) in a new funding round to help it progress its pipeline, including its lead compound, a first-in-class cancer treatment. The company is ...

Bioverativ and Bicycle Therapeutics Enter into Strategic Research Collaboration to Develop ...

Bicycle to receive an upfront payment of $10 million, with potential for future milestones Read more...

Bicycle Therapeutics Maps Course to Clinic Backed by $52M Investment

One of the problems with cancer drugs is their broad effect: Besides killing cancer cells, they also harm healthy tissue. Bicycle Therapeutics is developing a new class of drugs that it says can offer...

Bicycle Gains Funds for Cancer Drug Trials

UK biotech Bicycle Therapeutics has raised £40 million from a Series B financing round to advance the development of multiple candidate drugs to treat cancers with a high unmet need.

Bicycle raises £40m to advance pipeline

UK biotech Bicycle Therapeutics has raised an impressive £40 million to help advance its lead candidate, cancer drug BT1718, into the clinic trials later this year.

PubMed Articles [607 Associated PubMed Articles listed on BioPortfolio]

How bicycle level of traffic stress correlate with reported cyclist accidents injury severities: A geospatial and mixed logit analysis.

Transportation agencies need efficient methods to determine how to reduce bicycle accidents while promoting cycling activities and prioritizing safety improvement investments. Many studies have used s...

Commuting mode specific exposure to PM(2.5) in urban area of Guangzhou.

Objective: To find the differences in PM(2.5) exposure level in the context of four commuting modes (by walk, bicycle, bus and subway) in Guangzhou. Methods: The PM(2.5) exposure assessment was carrie...

Trends in the incidence and outcomes of bicycle-related injury in the emergency department: A nationwide population-based study in South Korea, 2012-2014.

This study aimed to examine trends in the incidence and outcomes of bicycle-related injuries in emergency departments (ED) in South Korea.

Impacts on air pollution and health by changing commuting from car to bicycle.

Our study is based on individual data on people's home and work addresses, as well as their age, sex and physical capacity, in order to establish realistic bicycle-travel distances. A transport model ...

Driver braking behavior analysis to improve autonomous emergency braking systems in typical Chinese vehicle-bicycle conflicts.

Bicycling is one of the fundamental modes of transportation especially in developing countries. Because of the lack of effective protection for bicyclists, vehicle-bicycle (V-B) accident has become a ...

Clinical Trials [159 Associated Clinical Trials listed on BioPortfolio]

Nurse Managed Sequential Strength Training and Bicycle Training in Chronic Obstructive Pulmonary Disease (COPD)

This is a 16 week exercise training program for people with severe to very severe chronic obstructive pulmonary disease (COPD). The purpose of this study is to find out if performing stren...

Measuring Ability of Volunteers to Power a Bicycle-powered Oxygen Concentrator

We would like to test how well human volunteers power a modified oxygen concentrator. We modified the oxygen concentrator to be powered by a bicycle instead of wall power so that it can be...

Impact of Ibis on Patients With Advanced COPD

The purpose of this research is to determine if Ibis™, a digital therapeutics solution developed by Senscio Systems, reduces the emergency room visits and hospitalizations of patients wi...

HDL Acute Lipid Optimization in Homozygous Familial Hypercholesterolemia

Assess the effect on coronary atheroma of serial infusions of autologous selectively delipidated HDL/preβ enriched plasma following use of HDL Therapeutics PDS-2™ System

Complex Motor Learning With Motor Imaginery

Subjects participate in a motor learning training with a special bicycle. The experimental group proceed with 15 minutes of physical training with the bicycle and 15 minutes of rest where ...

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