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RELA
| Symbol: | RELA | | Name(s): | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | MGC131774, NFKB3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18040287 |
These results suggest that overexpression of p28(GANK) prevents the nuclear localization and inhibits the activity of NF-kappaB/RelA. |
| 17242904 |
Unequal alterations in the levels of activated NF-kappaB subunits p50 and p65 might provide insights into the mechanisms of NF-kappaB action and anti-TNF-alpha therapy in AS. |
| 18034190 |
findings identify RelA/NF-kappaB as a critical regulator of T-cell survival by affecting the balance of Bcl-2 family members. |
| 18174252 |
the activation of NF-kappaB in human cancer cell lines and Min mice is inhibited by NO-donating aspirin |
| 18036607 |
Present immunofluorescence microscopy method to follow NF-kappaB nuclear translocation in primary human macrophages stimulated with LPS. |
| 18061975 |
TNF-alpha stimulated tenascin-C expression through NF-kappaB signaling with RelA activation in cultured OA chondrocytes, suggesting involvement of tenascin-C in OA cartilage remodeling. |
| 18163488 |
High levels of TNFRI at the cell surface in patients with the C73R mutation hypersensitizes cells to stimulation by TNF, leading to increased NF-kappaB p65 subunit activation and an exaggerated proinflammatory response |
| 18163503 |
up-regulation of Smad7 by IL-1beta is mediated through the NF-kappaB pathway, especially the p65 subunit in chondrocytes |
| 15885892 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17962362 |
RelA was decreased in PBMC from patients with chronic pancreatitis. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | ADP ribosyl transferase | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| HPRD | amino-terminal enhancer of split isoform b | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| HPRD | amino-terminal enhancer of split isoform b | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| BIND | amino-terminal enhancer of split isoform b | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | AES interacts with p65. | - | Pubmed |
| HPRD | Aryl hydrocarbon receptor | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| HPRD | aryl hydrocarbon receptor | NFKB3 | - | - | Pubmed |
| HPRD | amyloid beta A4 precursor protein-binding, family A, member 2 | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| HPRD | amyloid beta A4 precursor protein-binding, family A, member 2 | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| BIND | Homo sapiens chromosome 11, reference assembly. | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | The cIAP-2 promoter interacts with p65. | - | Pubmed |
| HPRD | androgen receptor isoform 1 | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
Recent Publications on RELA: |  |
The Angiotensin-I-converting Enzyme Inhibitor Enalapril and Aspirin delay progression of Pancreatic Intraepithelial Neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.
BACKGROUND AND AIMS: There are no chemopreventive strategies for... | 3rd November, 2009
| Philipps-University Marburg, Germany;
| Gut. 2009 Nov 1.
DOI Direct Link |
Diclofenac sodium inhibits NFkappaB transcription in osteoclasts.
A non-steroidal anti-inflammatory drug, diclofenac, acts efficiently... | 30th October, 2009
| Department of Pharmacology, Showa University School of Dentistry, 1-5-8
| J Dent Res. 2009 Nov;88(11):1042-7.
DOI Direct Link |
Suppression of IkappaBalpha increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells.
PURPOSE: An increase of matrix metalloproteinase-2 (MMP-2) has been found... | 29th October, 2009
| Department of Ophthalmology, The Second Affiliated Hospital, Sun Yat-sen
| Mol Vis. 2009 Sep 26;15:1977-87.
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IRAK-1 contributes to LPS-induced ROS generation in macrophages by inducing NOX-1 transcription, Rac1 activation, and suppressing the expression of anti-oxidative enzymes.
Inflammatory stimulants such as bacterial endotoxin (LPS) are known to... | 24th October, 2009
| Virginia Tech, United States;
| J Biol Chem. 2009 Oct 22.
DOI Direct Link |
Whole-genome resequencing of Escherichia coli K-12 MG1655 undergoing short-term laboratory evolution in lactate minimal media reveals flexible selection of adaptive mutations.
ABSTRACT: BACKGROUND: Short-term laboratory evolution of bacteria followed... | 24th October, 2009
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| Genome Biol. 2009 Oct 22;10(10):R118.
DOI Direct Link |
→View more research publications. |
RELA results (if any) from reagent suppliers | 
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RELA Antibody
Specific antibody for the gene product of RELA, the protein v-rel-A, NFkB p65. Validated for specificity by gene-silencing with siRNA followed by Western ...
http://www.piercenet.com/products/Browse.cfm?fldID=FEAB8C1B-...
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RelA Antibody Bethyl Laboratories
RelA, also known as p65, is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor ...
http://www.bethyl.com/go/?product/A301-823A...
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PhosphoPlus® NF-κB p65/RelA (Ser536) Antibody Duet #8214
There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50) and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by ...
http://www.cellsignal.com/products/8214.html...
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RelA Antibody / RelA Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. RelA (5G8) Antibody, sc-81622, mouse IgG1, FL (Ec), WB, E. coli ...
http://www.scbt.com/table-rela.html...
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RELA monoclonal antibody (M01)
Immunofluorescence of monoclonal antibody to RELA (AT3616a) on HeLa cell . ... RELA monoclonal antibody (M01), clone 8G3 Western Blot analysis of RELA ...
http://www.abgent.com/products/catalog_no/AT3616a_RELA_monoc...
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RELA antibody, Anti-NFKB p65 (Rel A) phospho specific pS276 ...
Buy quality rabbit RELA antibody (interacts with bovine human mouse rat sheep), anti-RELA, Anti-NFKB p65 (Rel A) phospho specific pS276 antibody, ...
http://www.genwaybio.com/product_info.php?products_id=292083...
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Page 1 of 2 e-mail: info@rockland-inc.com Visit our website at ...
purified anti-p65 (RelA) pS536 antibody was used at 5.0 ... in size corresponding to phosphorylated p65 (RelA) protein is expected in the
appropriate cell ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...
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