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RELA


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Symbol:RELA
Name(s):v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC131774, NFKB3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18040287 These results suggest that overexpression of p28(GANK) prevents the nuclear localization and inhibits the activity of NF-kappaB/RelA.
17242904 Unequal alterations in the levels of activated NF-kappaB subunits p50 and p65 might provide insights into the mechanisms of NF-kappaB action and anti-TNF-alpha therapy in AS.
18034190 findings identify RelA/NF-kappaB as a critical regulator of T-cell survival by affecting the balance of Bcl-2 family members.
18174252 the activation of NF-kappaB in human cancer cell lines and Min mice is inhibited by NO-donating aspirin
18036607 Present immunofluorescence microscopy method to follow NF-kappaB nuclear translocation in primary human macrophages stimulated with LPS.
18061975 TNF-alpha stimulated tenascin-C expression through NF-kappaB signaling with RelA activation in cultured OA chondrocytes, suggesting involvement of tenascin-C in OA cartilage remodeling.
18163488 High levels of TNFRI at the cell surface in patients with the C73R mutation hypersensitizes cells to stimulation by TNF, leading to increased NF-kappaB p65 subunit activation and an exaggerated proinflammatory response
18163503 up-regulation of Smad7 by IL-1beta is mediated through the NF-kappaB pathway, especially the p65 subunit in chondrocytes
15885892 Observational study of gene-disease association. (HuGE Navigator)
17962362 RelA was decreased in PBMC from patients with chronic pancreatitis.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDADP ribosyl transferasev-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65--Pubmed
HPRDamino-terminal enhancer of split isoform bv-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65--Pubmed
HPRDamino-terminal enhancer of split isoform bv-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65--Pubmed
BINDamino-terminal enhancer of split isoform bv-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65AES interacts with p65.-Pubmed
HPRDAryl hydrocarbon receptorv-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65--Pubmed
HPRDaryl hydrocarbon receptorNFKB3--Pubmed
HPRDamyloid beta A4 precursor protein-binding, family A, member 2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65--Pubmed
HPRDamyloid beta A4 precursor protein-binding, family A, member 2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65--Pubmed
BINDHomo sapiens chromosome 11, reference assembly.v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65The cIAP-2 promoter interacts with p65.-Pubmed
HPRDandrogen receptor isoform 1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65--Pubmed

Recent Publications on RELA:

Pubmed Logo
The Angiotensin-I-converting Enzyme Inhibitor Enalapril and Aspirin delay progression of Pancreatic Intraepithelial Neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.
BACKGROUND AND AIMS: There are no chemopreventive strategies for...
3rd November, 2009
Philipps-University Marburg, Germany; Gut. 2009 Nov 1.
DOI Direct Link
Diclofenac sodium inhibits NFkappaB transcription in osteoclasts.
A non-steroidal anti-inflammatory drug, diclofenac, acts efficiently...
30th October, 2009
Department of Pharmacology, Showa University School of Dentistry, 1-5-8 J Dent Res. 2009 Nov;88(11):1042-7.
DOI Direct Link
Suppression of IkappaBalpha increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells.
PURPOSE: An increase of matrix metalloproteinase-2 (MMP-2) has been found...
29th October, 2009
Department of Ophthalmology, The Second Affiliated Hospital, Sun Yat-sen Mol Vis. 2009 Sep 26;15:1977-87.
IRAK-1 contributes to LPS-induced ROS generation in macrophages by inducing NOX-1 transcription, Rac1 activation, and suppressing the expression of anti-oxidative enzymes.
Inflammatory stimulants such as bacterial endotoxin (LPS) are known to...
24th October, 2009
Virginia Tech, United States; J Biol Chem. 2009 Oct 22.
DOI Direct Link
Whole-genome resequencing of Escherichia coli K-12 MG1655 undergoing short-term laboratory evolution in lactate minimal media reveals flexible selection of adaptive mutations.
ABSTRACT: BACKGROUND: Short-term laboratory evolution of bacteria followed...
24th October, 2009
Genome Biol. 2009 Oct 22;10(10):R118.
DOI Direct Link

View more research publications.

BioNews Results for RELA

: RSS Logo
BioPortfolio Logo
Teva Files Amended Complaint Against Momenta/Sandoz to Include Infringement of Three COPAXONE-Rela
Financial 24:  Nov 10 2009 7:58AM Matching: rela
Global Hospitals, Chennai performs split liver transplantation using ALT technique
PharmaBiz:  Oct 22 2009 4:02AM Matching: rela

Clinical Trials:

Clinical Trials Logo
Topical NF-kappaB Decoy in the Treatment of Atopic Dermatitis

Patents:

Patents logo
US Patent No.Title
7511156 Analogs of Salinosporamide A
7550576 Nucleic acid sequences encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor
7550578 Rice promoters for regulation of plant expression
7553494 WT1 fusion proteins
7553868 Thiophene carboxamides as inhibitors of the enzyme IKK-2

View more patents.

RELA results (if any) from reagent suppliers

Google CSE Logo
RELA Antibody
Specific antibody for the gene product of RELA, the protein v-rel-A, NFkB p65. Validated for specificity by gene-silencing with siRNA followed by Western ...
http://www.piercenet.com/products/Browse.cfm?fldID=FEAB8C1B-...

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RelA Antibody Bethyl Laboratories
RelA, also known as p65, is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor ...
http://www.bethyl.com/go/?product/A301-823A...

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PhosphoPlus® NF-κB p65/RelA (Ser536) Antibody Duet #8214
There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50) and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by ...
http://www.cellsignal.com/products/8214.html...

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RelA Antibody / RelA Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. RelA (5G8) Antibody, sc-81622, mouse IgG1, FL (Ec), WB, E. coli ...
http://www.scbt.com/table-rela.html...

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RELA monoclonal antibody (M01)
Immunofluorescence of monoclonal antibody to RELA (AT3616a) on HeLa cell . ... RELA monoclonal antibody (M01), clone 8G3 Western Blot analysis of RELA ...
http://www.abgent.com/products/catalog_no/AT3616a_RELA_monoc...

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RELA antibody, Anti-NFKB p65 (Rel A) phospho specific pS276 ...
Buy quality rabbit RELA antibody (interacts with bovine human mouse rat sheep), anti-RELA, Anti-NFKB p65 (Rel A) phospho specific pS276 antibody, ...
http://www.genwaybio.com/product_info.php?products_id=292083...

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Page 1 of 2 e-mail: info@rockland-inc.com Visit our website at ...
purified anti-p65 (RelA) pS536 antibody was used at 5.0 ... in size corresponding to phosphorylated p65 (RelA) protein is expected in the
appropriate cell ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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