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RELA
| Symbol: | RELA | | Name(s): | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | MGC131774, NFKB3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18040287 |
These results suggest that overexpression of p28(GANK) prevents the nuclear localization and inhibits the activity of NF-kappaB/RelA. |
| 17242904 |
Unequal alterations in the levels of activated NF-kappaB subunits p50 and p65 might provide insights into the mechanisms of NF-kappaB action and anti-TNF-alpha therapy in AS. |
| 18034190 |
findings identify RelA/NF-kappaB as a critical regulator of T-cell survival by affecting the balance of Bcl-2 family members. |
| 18174252 |
the activation of NF-kappaB in human cancer cell lines and Min mice is inhibited by NO-donating aspirin |
| 18036607 |
Present immunofluorescence microscopy method to follow NF-kappaB nuclear translocation in primary human macrophages stimulated with LPS. |
| 18061975 |
TNF-alpha stimulated tenascin-C expression through NF-kappaB signaling with RelA activation in cultured OA chondrocytes, suggesting involvement of tenascin-C in OA cartilage remodeling. |
| 18163488 |
High levels of TNFRI at the cell surface in patients with the C73R mutation hypersensitizes cells to stimulation by TNF, leading to increased NF-kappaB p65 subunit activation and an exaggerated proinflammatory response |
| 18163503 |
up-regulation of Smad7 by IL-1beta is mediated through the NF-kappaB pathway, especially the p65 subunit in chondrocytes |
| 15885892 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17962362 |
RelA was decreased in PBMC from patients with chronic pancreatitis. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | ADP ribosyl transferase | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| HPRD | amino-terminal enhancer of split isoform b | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| HPRD | amino-terminal enhancer of split isoform b | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| BIND | amino-terminal enhancer of split isoform b | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | AES interacts with p65. | - | Pubmed |
| HPRD | Aryl hydrocarbon receptor | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| HPRD | aryl hydrocarbon receptor | NFKB3 | - | - | Pubmed |
| HPRD | amyloid beta A4 precursor protein-binding, family A, member 2 | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| HPRD | amyloid beta A4 precursor protein-binding, family A, member 2 | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
| BIND | Homo sapiens chromosome 11, reference assembly. | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | The cIAP-2 promoter interacts with p65. | - | Pubmed |
| HPRD | androgen receptor isoform 1 | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | - | - | Pubmed |
Recent Publications on RELA: |  |
NFkappaB modulators in a model of glucocorticoid resistant, childhood acute lymphoblastic leukemia.
Glucocorticoids (GCs) are pivotal agents in the treatment of childhood... | 29th January, 2010
| Northern Institute for Cancer Research, Newcastle University, Paul
| Leuk Res. 2010 Jan 25.
DOI Direct Link |
Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination.
Stimulation of the NF-kappaB pathway can have proapoptotic or... | 27th January, 2010
| Colon Cancer Genetics Group, University of Edinburgh Cancer Research
| Cancer Res. 2010 Jan 1;70(1):139-49.
DOI Direct Link |
HDAC inhibitors activate NF-{kappa}B in human leukemia cells through an ATM/nemo-related pathway.
Mechanisms underlying HDAC inhibitor (HDACI)-mediated NF-kappaB activation... | 13th January, 2010
| Massey Cancer Center, Virginia Commonwealth University, Richmond, VA,
| J Biol Chem. 2010 Jan 11.
DOI Direct Link |
Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain.
Activation of metabotropic glutamate 2 (mGlu2) receptors inhibits pain... | 13th January, 2010
| Department of Pharmaceutical Sciences, University of Catania, Catania,
| Trends Pharmacol Sci. 2010 Jan 9.
DOI Direct Link |
Nuclear Factor-{kappa}B Contributes to Anaplastic Thyroid Carcinomas through Up-Regulation of miR-146a.
Context: Micro-RNAs (miRNAs) have been recently involved in the modulation... | 12th January, 2010
| Istituto di Endocrinologia ed Oncologia Sperimentale (F.P., E.C., S.M.,
| J Clin Endocrinol Metab. 2010 Jan 8.
DOI Direct Link |
→View more research publications. |
RELA results from Abnova |  | Sponsored Results: |
| RELA polyclonal antibody
Rabbit polyclonal antibody raised against synthetic peptides of RELA. Symbol: RELA Alias: MGC131774, NFKB3, p65
http://www.abnova.com/products/products_detail.asp?catalog_id=PAB10288 |  |
| RELA Recombinant Protein (Q01)
RELA( NP_068810, 432 a.a. - 505 a.a.) partial recombinant protein with GST tag. Symbol: RELA Alias: NFKB3
http://www.abnova.com/products/products_detail.asp?catalog_id=H00005970-Q01 | |
| RELA (phospho T505) polyclonal antibody
Rabbit polyclonal antibody raised against synthetic phosphopeptides of RELA. Symbol: RELA Alias: MGC131774, NFKB3, p65
http://www.abnova.com/products/products_detail.asp?catalog_id=PAB7736 | |
| RELA(phospho S311) & RELA Protein Phosphorylation Antibody Pair
This protein phosphorylation antibody pair set comes with two antibodies, one against the RELA protein, and the other against the specific S311 phosphorylated site of RELA for use in in situ Proximity Ligation Assay (in situ PLA™). See Publication Reference below. Symbol: RELA Alias: MGC131774, NFKB3, p65
http://www.abnova.com/products/products_detail.asp?catalog_id=DP0217 | |
| RELA(phospho T254) & RELA Protein Phosphorylation Antibody Pair
This protein phosphorylation antibody pair set comes with two antibodies, one against the RELA protein, and the other against the specific T254 phosphorylated site of RELA for use in in situ Proximity Ligation Assay (in situ PLA™). See Publication Reference below. Symbol: RELA Alias: MGC131774, NFKB3, p65
http://www.abnova.com/products/products_detail.asp?catalog_id=DP0102 | |
| RELA (phospho S536) polyclonal antibody
Rabbit polyclonal antibody raised against synthetic phosphopeptides of RELA. Symbol: RELA Alias: MGC131774, NFKB3
http://www.abnova.com/products/products_detail.asp?catalog_id=PAB0546 | |
→Search for RELA products at Abnova. |
RELA results (if any) from reagent suppliers | 
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RELA Antibody
Specific antibody for the gene product of RELA, the protein v-rel-A, NFkB p65. Validated for specificity by gene-silencing with siRNA followed by Western ...
http://www.piercenet.com/products/Browse.cfm?fldID=FEAB8C1B-...
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RelA Antibody Antibody Bethyl Laboratories
RelA, also known as p65, is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor ...
http://www.bethyl.com/product/A301-824A...
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PhosphoPlus® NF-κB p65/RelA (Ser536) Antibody Duet #8214
There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50) and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by ...
https://www.cellsignal.com/products/8214.html...
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RELA antibody, Anti-NFKB p65 (Rel A) phospho specific pS276 ...
Buy quality rabbit RELA antibody (interacts with bovine human mouse rat sheep), anti-RELA, Anti-NFKB p65 (Rel A) phospho specific pS276 antibody, ...
http://www.genwaybio.com/product_info.php?products_id=292083...
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Phospho RelA (S536) Antibody Antibody Bethyl Laboratories
Rabbit anti-Phospho RelA (S536) Antibody, Affinity Purified.
http://www.bethyl.com/product/A302-062A/Phospho_RelA_(S536)_...
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RelA Antibody / RelA Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. RelA (5G8) Antibody, sc-81622, mouse IgG1, FL (Ec), WB, E. coli ...
http://www.scbt.com/table-rela.html...
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Phospho RelA (S468) Antibody Antibody Bethyl Laboratories
Rabbit anti-Phospho RelA (S468) Antibody, Affinity Purified.
http://www.bethyl.com/product/A302-064A/Phospho_RelA_(S468)_...
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