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The support of human genetic evidence for approved drug indications

19:23 EDT 29 Jun 2015 | Nature Publishing

Matthew Nelson and colleagues investigate how well genetic evidence for disease susceptibility predicts drug mechanisms. They find a correlation between gene products that are successful drug targets and genetic loci associated with the disease treated by the drug and predict that selecting genetically supported targets could increase the success rate of drugs in clinical development.

Original Article: The support of human genetic evidence for approved drug indications

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