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[Clinical Picture] Aquagenic wrinkling of the palms: a diagnostic clue to cystic fibrosis carrier status and non-classic disease

20:46 EDT 22 Sep 2016 | The Lancet

In early 2015, a 22-year-old white woman with no medical history and an unrelated 25-year-old white man with an 8-year history of idiopathic chronic pancreatitis requiring Creon supplementation presented independently to two of our dermatology clinics. Within the preceding 12 months both had developed pruritic wrinkling of the palmar skin after even brief contact with water. In both cases, initial examination of the hands was normal but after immersion of the hands in water for 3 min, they developed substantial oedema and wrinkling of the palmar skin (figure).

Original Article: [Clinical Picture] Aquagenic wrinkling of the palms: a diagnostic clue to cystic fibrosis carrier status and non-classic disease

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