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Why, why would you run a trial of an antisense oligonucleotide without running a control group? That’s what everyone is asking Celgene after they reported results (which Adam Feuerstein correctly calls “uninterpretable”) for their GED-0301 (mongersen) against Crohn’s disease. The response rate was about 15%, but other Crohn’s therapies, ones run in proper trials, have shown
Original Article: Who Needs A Control Arm?NEXT ARTICLE
Most human diseases are caused by production of abnormal proteins or malfunctioning proteins. Antisense therapy involves inhibiting production of these proteins. When a gene is known to cause a specific disease and the genetic sequence ...
Crohn's Disease (CD)
Crohn’s disease (CD) is a long-term condition that causes inflammation of the lining of the digestive system. Inflammation can affect any part of the digestive system, from the mouth to the back passage, but most commonly occurs in the last s...