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Who Needs A Control Arm?

11:09 EDT 19 Oct 2016 | Science

Why, why would you run a trial of an antisense oligonucleotide without running a control group? That’s what everyone is asking Celgene after they reported results (which Adam Feuerstein correctly calls “uninterpretable”) for their GED-0301 (mongersen) against Crohn’s disease. The response rate was about 15%, but other Crohn’s therapies, ones run in proper trials, have shown

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