Why Testicular Tumors Are So Vulnerable to Getting Hit with Chemo

06:05 EST 1 Dec 2016 | Genetic Engineering News

It’s the oncological version of the groin attack, but unlike the groin attacks seen in America’s Funniest Home Videos, it’s no laughing matter. The “it” in this case is testicular cancer’s extreme sensitivity to chemotherapy. Given the potentially grave consequences of testicular cancer, the effectiveness of a chemotherapeutic groin attack does not inspire guffaws or even sympathetic winces, but rather expressions of grim satisfaction—and a determination to learn whether other types of cancer could also be made to suffer chemotherapy’s blows so badly. To learn why testicular cancer is, in most cases, highly curable with chemotherapy, scientists based at the Dana-Farber Cancer Institute examined the genomic features of germ-cell tumors (GCTs), which are derived from germ cells and occur most frequently in testes. Genomic features identified in previous studies included mutations and chromosome damage, but none of these studies managed to pinpoint specific alterations or events linked to ...

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