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HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

13:56 EDT 20 Mar 2017 | Nature Publishing

HRDetect represents a model integrating whole-genome sequencing mutation signatures associated with BRCA1 and BRCA2 deficiency. The implementation of this predictor across different tumor types identifies a larger proportion of patients displaying ‘BRCAness’ than previously recognized; they might derive benefit from platinum and PARP-inhibitor therapies.

Original Article: HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

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