Advertisement

Topics

Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids

19:35 EDT 13 Apr 2017 | Nature Publishing

The formation of C–C bonds in an enantioselective fashion to create complex polycyclic scaffolds in the hapalindole- and fischerindole- type alkaloids from Stigonematales cyanobacteria represents a compelling and urgent challenge in adapting microbial biosynthesis as a catalytic platform in drug development. Here we determine the biochemical basis for tri- and tetracyclic core formation in these secondary metabolites, involving a new class of cyclases that catalyze a complex cyclization cascade.

Original Article: Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids

NEXT ARTICLE

More From BioPortfolio on "Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids"

Quick Search
Advertisement
 

Relevant Topic

Pharmacy
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...