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Discovery May Lead to Novel Methods for Promoting Heart Cell Renewal

04:39 EDT 6 Jun 2017 | Genetic Engineering News

Scientists from the Baylor College of Medicine and the Texas Heart Institute studying pathways underlying heart cell functions say they have discovered a previously unknown connection between processes that keep the heart from repairing itself. This finding ("Dystrophin glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation"), published in Nature , may lead to new approaches that will promote heart cell renewal in the future. "We are investigating the question of why the heart muscle doesn't renew," says senior author James Martin, M.D., Ph.D., professor and Vivian L. Smith Chair in Regenerative Medicine at Baylor College of Medicine. "In this study, we focused on two pathways of cardiomyocytes or heart cells; the Hippo pathway, which is involved in stopping renewal of adult cardiomyocytes, and the dystrophin glycoprotein complex (DGC) pathway, essential for cardiomyocyte normal functions. "We are also interested in studying mutations in DGC components because patients with these mutations ...

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