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Shifting DNA Damage Dynamics May Temper Immune Response to Cancer

06:39 EDT 1 Aug 2017 | Genetic Engineering News

DNA damage within a cell is known to trip an alarm system that attracts the notice of immune cells, which then descend on the cell, whether it has been infected, deranged by cancer, or disabled by chemotherapy or radiation. Curiously, cells that have been subjected to radiation seem to benefit from a sort of grace period. Days may pass before immune cells show up to tumors that have survived the effects of toxic therapies. The reasons behind this delay have been unclear, but now that they have been revealed by a new study, they may point to new therapeutic strategies, particularly those that combine genotoxicity and immune checkpoint inhibitors. The new study come from the Perelman School of Medicine at the University of Pennsylvania. There, researchers led by Roger Greenberg, M.D., Ph.D., detailed the events that unfold between DNA damage and the immune response. "Having solved ...

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