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Genotyping MRSA Identifies Patients Most at Risk of Death

04:41 EDT 8 Aug 2017 | Genetic Engineering News

A team led by researchers at the Milner Center for Evolution at the University of Bath report that sequencing the DNA of the MRSA bacterium ( Staphylococcus aureus) can help identify patients most at risk of death and may lead to the development of new therapies. Their study (“Clonal differences in Staphylococcus aureus bacteraemia-associated mortality”) appears in Nature Microbiology . “…we phenotyped a collection of sequenced clinical S. aureus isolates from [about 300] patients with bloodstream infections, representing two globally important clonal types, CC22 and CC30,” write the investigators. “By adopting a genome-wide association study approach we identified and functionally verified several genetic loci that affect the expression of cytolytic toxicity and biofilm formation. By analyzing the pooled data comprising bacterial genotype and phenotype together with clinical metadata within a machine-learning framework, we found significant clonal differences in the determinants most predictive of poor infection outcome.” ...

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