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Calorie-Controlled Diet Restores Youthful Rhythmic Control of Metabolism in Old Mice

04:15 EDT 11 Aug 2017 | Genetic Engineering News

Keeping a check on how many calories we consume helps to keep us looking trim from the outside. New research by collaborating scientists in the U.S. and Spain suggests that restricting calorie intake can also help to keep us more youthful on the inside, by preventing age-related changes in how the natural rhythmical biological clocks within our cells work to control essential functions. The two sets of studies in mice, by Paolo Sassone-Corsi’s team at the University of California, Irvine (UCI), and by a research group headed by Salvador Aznar Benitah, at the Barcelona Institute of Science and Technology, have found that a low calorie diet prevents age-related changes in the normal daily rhythmic oscillations in liver cell metabolism and adult stem cell functioning.  They report their work in separate papers in the journal, Cell , which are entitled, “ Circadian Reprogramming in the Liver Identifies Metabolic Pathways ...

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