Three Cases of Severe Ulcerative Esophagitis Induced by SUTENT(R).
Summary of "Three Cases of Severe Ulcerative Esophagitis Induced by SUTENT(R)."
The development of SUTENT(R) revolutionized the care of metastatic renal carcinoma and of non-operable GIST. The tolerance is quite good with mostly mild side effects grade 1 or 2.
We report the case of three severe esophagitis stage 4 responsible for digestive bleeding. Two patients were taking anti-coagulant that could worsen the bleeding, but none were taking either antiplatelet or non-steroidal anti-inflammatory or corticosteroid that could favour erosion or ulceration of the digestive mucosa. It seems that SUTENT(R) is responsible for the digestive bleeding.
Cases of esophagitis induced by SUTENT(R) have already been reported but are rare and of mild severity. Our three cases of esophagitis are severe with SUTENT(R) treatment as only risk factor and worsened by anti-coagulant treatment for two patients. It might be of interest preventively to treat these patients with inhibitors of proton pump.
Department of Oncological Medico-Surgical Explorations, Institut Paoli-Calmettes, Marseille, France, firstname.lastname@example.org.
This article was published in the following journal.
Name: Journal of gastrointestinal cancer
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20640604
- DOI: http://dx.doi.org/10.1007/s12029-010-9171-y
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Medical and Biotech [MESH] Definitions
Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.
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