Effect of Oral Prednisolone on Esophageal Stricture after Complete Circular Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma: A Case Report.

06:33 EDT 2nd September 2015 | BioPortfolio

Summary of "Effect of Oral Prednisolone on Esophageal Stricture after Complete Circular Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Carcinoma: A Case Report."

A 74-year-old man with nausea underwent upper gastrointestinal endoscopy, and a 0-IIb type tumor was found in the middle thoracic esophagus. Histological examination with endoscopic biopsies revealed squamous cell carcinoma (SCC), and chromoendoscopy with iodine staining revealed that the superficial SCC involved nearly the entire circumference of the esophageal lumen. There were neither nodal nor distant metastases. Complete circular endoscopic submucosal dissection (ESD) was successfully achieved with tumor-free margins in an en bloc fashion. The histopathological examination confirmed a diagnosis of intramucosal invasive carcinoma limited to the lamina propria mucosae without angiolymphatic invasion. Oral prednisolone was started with 0.5 mg/kg daily on the 3rd post-ESD day, tapered gradually, and then discontinued 8 weeks later without adverse effects. There were no complaints of dysphagia following ESD. On follow-up endoscopy with iodine staining, which was scheduled at 1, 3 and 6 months after ESD, there was no postprocedural esophageal stricture, and neither recurrent nor metachronous lesions were found. Thus, the patient required no sessions of endoscopic balloon dilatation. At the last outpatient clinic visit 7 months after ESD, he remained well without dysphagia. Oral prednisolone administration may offer an effective therapeutic strategy to prevent the post-ESD esophageal stricture after complete circular ESD.


Department of Endoscopy, Nagasaki University Hospital, Nagasaki, Japan.

Journal Details

This article was published in the following journal.

Name: Digestion
ISSN: 1421-9867
Pages: 291-295


PubMed Articles [15371 Associated PubMed Articles listed on BioPortfolio]

Outcomes of the use of fully covered esophageal self-expandable stent in the management of colorectal anastomotic strictures and leaks.

Introduction. Colorectal anastomotic leak or stricture is a dreaded complication leading to significant morbidity and mortality. The novel use of self-expandable metal stents (SEMS) in the management ...

Retrograde dilation of a complex radiation-induced esophageal stricture through percutaneous gastrostomy.

Upper esophageal strictures occur in approximately 3-4% of patients who receive radiotherapy for head and neck cancers. The standart initial treatment is dilation by using bougie or through-the-scope ...

Beneficial effect of the 5-HT1A receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: A pilot study.

Esophageal involvement in systemic sclerosis (SSc) carries significant morbidity and is empirically managed with domperidone, albeit with questionable efficacy. The oral 5-HT1A receptor agonist buspir...

Endoscopic Vacuum-assisted Closure With Sponge for Esophagotracheal Fistula After Esophagectomy.

We experienced a case of endoscopic vacuum-assisted closure with sponge for esophagotracheal fistula diagnosed after esophagectomy due to squamous cell esophageal cancer. The patient, who had undergon...

Eosinophilic esophagitis in patients with esophageal atresia and chronic dysphagia.

Esophageal atresia (EA) is defined as a discontinuity of the lumen of the esophagus repaired soon after birth. Dysphagia is a common symptom in these patients, usually related to stricture, dysmotilit...

Clinical Trials [3816 Associated Clinical Trials listed on BioPortfolio]

Evaluation of Topical Mitomycin C as Adjuvant Drug to Esophageal Dilation in Children

This study aims to evaluate mitomycin C as an adjunct to endoscopic treatment of esophageal strictures. This is a crossover, controlled, clinical trial in which children with esophageal s...

Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae

The purpose of this study is to determine whether low doses of prednisolone, or colchicine are effective in the treatment of oral aphthae.

Use of Montelukast to Treat Children With Mild to Moderate Acute Asthma

The primary objective of this study is to evaluate if children with acute asthma given a single dose of oral prednisolone with a subsequent daily five-day course of oral Montelukast will a...

Trial Using 125I Embedded Stent in Patients With Advanced Esophageal Cancer

More than half of patients with esophageal cancer are inoperable because of late stage cancer or metastasis and they have to undergo palliative treatments. Dysphagia is the major symptom o...

Effect of Steroids on Post-tonsillectomy Morbidities

This study aims to evaluate the effect of postoperative systemic rapid onset and short acting dexamethasone followed by a tapering dose of oral prednisolone on post-tonsillectomy morbiditi...

Medical and Biotech [MESH] Definitions

A stricture of the ESOPHAGUS. Most are acquired but can be congenital.

A complete denture replacing all the natural mandibular teeth and associated structures. It is completely supported by the oral tissue and underlying mandibular bone.

A class of unsegmented helminths with fundamental bilateral symmetry and secondary triradiate symmetry of the oral and esophageal structures. Many species are parasites.

A pathological condition characterized by the presence of a number of ESOPHAGEAL DIVERTICULA in the ESOPHAGUS.

A complete denture replacing all the natural maxillary teeth and associated maxillary structures. It is completely supported by the oral tissue and underlying maxillary bone.


Relevant Topics

Skin cancers
Latest News Clinical Trials Research Drugs Reports Corporate
There are three main types of skin cancer: basal cell carcinoma, squamous cell carcinoma and malignant melanoma. Basal cell carcinoma Basal cell carcinoma, or BCC, is a cancer of the basal cells at the bottom of the epidermis. It’s very common ...

Barrett's Esophagus
Latest News Clinical Trials Research Drugs Reports Corporate
Barrett’s esophagus is a condition in which the tissue lining the esophagus—the muscular tube that carries food and liquids from the mouth to the stomach—is replaced by tissue that is similar to the intestinal lining. This process is ca...