Eight months of continuous positive airway pressure (CPAP) decrease tumor necrosis factor alpha (TNFA) in men with obstructive sleep apnea syndrome.

17:27 EDT 3rd September 2015 | BioPortfolio

Summary of "Eight months of continuous positive airway pressure (CPAP) decrease tumor necrosis factor alpha (TNFA) in men with obstructive sleep apnea syndrome."


OBJECTIVES:
The aim of this study was to assess serum tumor necrosis factor alpha (TNFA) concentrations 8 months of continuous positive airway pressure (CPAP) therapy.
DESIGN:
This study used prospective, observational clinical trial.
PATIENTS:
Sixty-six patients with newly diagnosed sleep apnea syndrome (12 women, 54 men), age 52.3 ± 9.8 (mean ± SD) with a body mass index of 29.7 ± 4.4 and an apnea-hypopnea index of 39.7 ± 26.8, were studied.
INTERVENTION:
CPAP was administered for a mean of 7.8 ± 1.3 months. MEASUREMENTS AND
RESULTS:
TNFA concentrations using an ultrasensitive ELISA assay at baseline and follow-up. TNFA decreased in men with high (5.2 ± 1.7 h/night, -0.46 ± 1.1 ng/l, p = 0.001) and with low (2.5 ± 1.0 h/night -0.63 ± 0.77 ng/l, p = 0.001) adherence but not in women. Average number of hours of CPAP use correlated positively with delta TNFA (R (2) 0.08, p = 0.04)
CONCLUSION:
Long-term CPAP positively affects TNFA even in men with poor adherence to CPAP.

Affiliation

Geriatrische Klinik, Kompetenzzentrum Gesundheit und Alter, St. Gallen, Switzerland.

Journal Details

This article was published in the following journal.

Name: Sleep & breathing = Schlaf & Atmung
ISSN: 1522-1709
Pages:

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